GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Lep | decreases expression | EXP | | 6480464 | CTD | troglitazone results in decreased expression of LEP mRNA; troglitazone results in decreased expression of LEP protein | PMID:11909685 PMID:15824971 PMID:9502777 | Lep | decreases expression | ISO | LEP (Homo sapiens) | 6480464 | CTD | troglitazone results in decreased expression of LEP protein | PMID:10946865 PMID:9727893 | Lep | decreases expression | ISO | Lep (Mus musculus) | 6480464 | CTD | troglitazone results in decreased expression of LEP mRNA | PMID:10753628 | Lep | increases secretion | ISO | LEP (Homo sapiens) | 6480464 | CTD | troglitazone results in increased secretion of LEP protein | PMID:11092516 | Lep | multiple interactions | ISO | LEP (Homo sapiens) | 6480464 | CTD | [Dexamethasone co-treated with troglitazone] results in decreased secretion of LEP protein; troglitazone inhibits the reaction [Dexamethasone results in increased expression of LEP mRNA]; troglitazone inhibits the reaction [Dexamethasone results in increased secretion of LEP protein] | PMID:10946865 PMID:11092516 | |
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