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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3000
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lep
Name: leptin
Acc ID: CHEBI:2700
Term: anandamide
Definition: An N-acylethanolamine 20:4 resulting from the formal condensation of carboxy group of arachidonic acid with the amino group of ethanolamine.
Chemical ID: MESH:C078814
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lepdecreases abundanceISOLEP (Homo sapiens)6480464CTDLEP protein results in decreased abundance of anandamidePMID:16154199
Lepdecreases abundanceISOLep (Mus musculus)6480464CTDLEP protein results in decreased abundance of anandamidePMID:29967158
Lepdecreases activityISOLEP (Homo sapiens)6480464CTDLEP protein results in decreased activity of anandamidePMID:16154199
Lepdecreases transportISOLEP (Homo sapiens)6480464CTDLEP protein results in decreased transport of anandamidePMID:16154199
Lepmultiple interactionsISOLep (Mus musculus)6480464CTDDietary Fats inhibits the reaction [LEP protein results in decreased abundance of anandamide]PMID:29967158
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