Cyp17a1 (cytochrome P450, family 17, subfamily a, polypeptide 1) - Rat Genome Database

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Gene: Cyp17a1 (cytochrome P450, family 17, subfamily a, polypeptide 1) Rattus norvegicus
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Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
RGD ID: 2456
Description: Enables steroid 17-alpha-monooxygenase activity. Involved in several processes, including Leydig cell differentiation; response to fungicide; and response to herbicide. Located in cell projection and neuronal cell body. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including cholelithiasis; congenital adrenal hyperplasia; gallbladder cancer; osteoporosis; and prostate cancer. Orthologous to human CYP17A1 (cytochrome P450 family 17 subfamily A member 1); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH (+)-schisandrin B; (E)-thiamethoxam; (R)-carnitine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 17-alpha-hydroxyprogesterone aldolase; Cyp17; CYPXVII; cytochrome P450 17A1; Cytochrome P450 subfamily XVII; cytochrome P450, subfamily 17; Cytochrome P450, subfamily XVII; cytochrome P450-C17; cytochrome P450c17; P450-C17; P45017alpha; P450c17; steroid 17-alpha-hydroxylase/17,20 lyase; steroid 17-alpha-monooxygenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Lnnr2 Hcar5
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81255,476,861 - 255,484,547 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1255,476,861 - 255,482,974 (-)EnsemblGRCr8
mRatBN7.21245,535,462 - 245,543,148 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,535,462 - 245,541,573 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1253,668,318 - 253,675,994 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01260,357,408 - 260,365,097 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01253,011,215 - 253,018,898 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01266,422,127 - 266,429,947 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1266,422,132 - 266,428,239 (-)Ensemblrn6Rnor6.0
Rnor_5.01273,852,163 - 273,859,866 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41251,965,458 - 251,971,449 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1241,321,307 - 241,327,254 (-)NCBICelera
RGSC_v3.11252,228,608 - 252,234,604 (-)NCBI
RH 3.4 Map11626.0RGD
Cytogenetic Map1q54NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-matairesinol  (ISO)
(1->4)-beta-D-glucan  (ISO)
(2E,4E)-hexa-2,4-dienoic acid  (ISO)
(E)-thiamethoxam  (EXP)
(R)-carnitine  (EXP)
(R,R)-tramadol  (ISO)
(S)-duloxetine hydrochloride  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,3,4-oxadiazoles  (EXP)
1,3-dinitrobenzene  (ISO)
1-methylnicotinamide  (EXP)
1-naphthylamine  (ISO)
16-Hydroxyprogesterone  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxypregnenolone  (ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-D  (ISO)
2,4-dibromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dibromophenol  (ISO)
2-bromophenol  (ISO)
2-methoxyethanol  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
2-trans,6-trans-farnesyl diphosphate  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,4-dichloroaniline  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
4-nitro-m-cresol  (ISO)
4-nonylphenol  (ISO)
4-octylphenol  (EXP)
4-tert-Octylphenol  (ISO)
5alpha-pregnane-3,20-dione  (ISO)
8-Br-cAMP  (ISO)
abiraterone  (EXP,ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acetamiprid  (ISO)
Acetyl tributyl citrate  (ISO)
aconitine  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
albuterol  (ISO)
alginic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (EXP)
alpha-naphthoflavone  (ISO)
alternariol  (ISO)
aminoglutethimide  (ISO)
ammonium chloride  (EXP)
amoxicillin  (ISO)
androgen antagonist  (EXP)
andrographolide  (ISO)
androst-4-ene-3,17-dione  (ISO)
androsterone  (ISO)
antalarmin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
apigenin  (ISO)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
astressin  (ISO)
atorvastatin calcium  (EXP)
atrazine  (EXP,ISO)
benomyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
berberine  (ISO)
beta-damascenone  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
Bisphenol B  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
bucladesine  (EXP,ISO)
butylated hydroxyanisole  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (EXP)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium telluride  (ISO)
caffeine  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cetrorelix  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chlorohydrocarbon  (EXP)
chloroquine  (EXP)
chlorpyrifos  (ISO)
cholesterol  (ISO)
Chorionic gonadotropin  (EXP,ISO)
chromium(6+)  (EXP)
chrysene  (ISO)
climbazole  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clotrimazole  (ISO)
colforsin daropate hydrochloride  (ISO)
corn oil  (EXP)
corticotropin  (ISO)
cyanamide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
DDE  (EXP)
DDT  (ISO)
decabromodiphenyl ether  (EXP)
dehydroepiandrosterone  (EXP,ISO)
deoxynivalenol  (ISO)
desogestrel  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (EXP)
diarsenic trioxide  (ISO)
dibromoacetic acid  (EXP)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
Dicyclohexyl phthalate  (EXP)
dienestrol  (EXP)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
difenoconazole  (ISO)
diheptyl phthalate  (EXP)
diisobutyl phthalate  (EXP,ISO)
diisononyl phthalate  (EXP,ISO)
dipentyl phthalate  (EXP)
diquat  (ISO)
disulfiram  (ISO)
diuron  (ISO)
drospirenone  (ISO)
elemental selenium  (EXP)
endosulfan  (ISO)
enilconazole  (ISO)
enniatin  (ISO)
Enterolactone  (ISO)
enzacamene  (EXP)
epoxiconazole  (ISO)
equol  (ISO)
estrone  (ISO)
etoxazole  (ISO)
farnesyl diphosphate  (EXP)
fenarimol  (ISO)
fenvalerate  (EXP,ISO)
fisetin  (EXP)
flavonoids  (ISO)
fluconazole  (ISO)
flufenoxuron  (ISO)
flurbiprofen  (EXP,ISO)
flutamide  (EXP,ISO)
folic acid  (ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
galaxolide  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
geldanamycin  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
herbicide  (EXP)
hexane  (EXP)
HT-2 toxin  (ISO)
hydrazine  (EXP)
hydroquinone O-beta-D-glucopyranoside  (EXP)
hydroxyflutamide  (ISO)
imidacloprid  (EXP,ISO)
inulin  (ISO)
iodoacetic acid  (ISO)
isoflavones  (EXP)
isoliquiritigenin  (ISO)
ketoconazole  (EXP,ISO)
lamotrigine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
letrozole  (EXP,ISO)
levetiracetam  (ISO)
levonorgestrel  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
luteolin  (EXP)
melatonin  (ISO)
mestranol  (ISO)
metformin  (EXP,ISO)
methidathion  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
metyrapone  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (EXP,ISO)
monoethyl phthalate  (ISO)
Muraglitazar  (EXP)
mycotoxin  (ISO)
N-acetyl-L-cysteine  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
naringin  (EXP)
nickel sulfate  (EXP)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
Nodularin  (EXP)
okadaic acid  (ISO)
oxycodone  (EXP)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perflubron  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorododecanoic acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP)
Pf-06840003  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phytoestrogen  (ISO)
pioglitazone  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
pregnenolone  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP,ISO)
profenofos  (EXP)
progesterone  (EXP,ISO)
prostaglandin E2  (ISO)
pyrethrins  (EXP)
pyruvic acid  (ISO)
quercetin  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP)
royal jelly  (EXP)
SB 203580  (EXP)
selenium atom  (EXP)
sertraline  (EXP)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sphingosine  (ISO)
sphingosine 1-phosphate  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
terbutylazine  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP,ISO)
Testosterone propionate  (ISO)
testosterone undecanoate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetraphene  (EXP,ISO)
thiamethoxam  (EXP)
thioacetamide  (EXP)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
titanium dioxide  (ISO)
topiramate  (ISO)
torcetrapib  (ISO)
tramadol  (ISO)
trans-cinnamic acid  (ISO)
tributylstannane  (EXP)
trichlorfon  (EXP)
trichloroethene  (EXP)
triclosan  (EXP)
triphenyl phosphate  (ISO)
triphenylstannane  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
uranium atom  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
venlafaxine hydrochloride  (ISO)
vinclozolin  (EXP)
wogonin  (EXP)
zearalenone  (EXP,ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors. Ambrosone CB, etal., Breast Cancer Res. 2003;5(2):R45-51. Epub 2003 Jan 29.
2. Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. Attard G, etal., J Clin Oncol. 2008 Oct 1;26(28):4563-71. Epub 2008 Jul 21.
3. Sensitivity of fetal rat testicular steroidogenesis to maternal prochloraz exposure and the underlying mechanism of inhibition. Blystone CR, etal., Toxicol Sci. 2007 Jun;97(2):512-9. Epub 2007 Mar 15.
4. The rat 17 alpha-hydroxylase-17,20-desmolase (CYP17) active site: computerized homology modeling and site directed mutagenesis. Buczko E, etal., J Steroid Biochem Mol Biol 1995 Mar;52(3):209-18.
5. Role of cytochrome P450c17alpha in dibromoacetic acid-induced testicular toxicity in rats. Carr TL, etal., Arch Toxicol. 2010 Nov 3.
6. Genetic variation in CYP17A1 and pancreatic cancer in a population-based case-control study in the San Francisco Bay Area, California. Duell EJ, etal., Int J Cancer. 2010 Feb 1;126(3):790-5.
7. Rat P450(17 alpha) from testis: characterization of a full-length cDNA encoding a unique steroid hydroxylase capable of catalyzing both delta 4- and delta 5-steroid-17,20-lyase reactions. Fevold HR, etal., Mol Endocrinol 1989 Jun;3(6):968-75.
8. Inhibitory effect of valproic acid on ovarian androgen biosynthesis in rat theca-interstitial cells. Fisseha S, etal., Endocrine. 2010 Feb;37(1):187-93. Epub 2009 Dec 15.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Basic concepts and recent developments in human steroid hormone biosynthesis. Ghayee HK and Auchus RJ, Rev Endocr Metab Disord. 2007 Dec;8(4):289-300.
11. Transcriptional regulation of rat cytochrome P450c17 expression in mouse Leydig MA-10 and adrenal Y-1 cells: identification of a single protein that mediates both basal and cAMP-induced activities. Givens CR, etal., DNA Cell Biol 1994 Nov;13(11):1087-98.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha. Grasfeder LL, etal., Mol Endocrinol. 2009 Aug;23(8):1171-82. Epub 2009 Apr 23.
14. Contamination with depleted or enriched uranium differently affects steroidogenesis metabolism in rat. Grignard E, etal., Int J Toxicol. 2008 Jul-Aug;27(4):323-8.
15. Polychlorinated biphenyls have inhibitory effect on testicular steroidogenesis by downregulation of P450(17alpha) and P450(scc). Han DY, etal., Toxicol Ind Health. 2010 Jun;26(5):287-96. Epub 2010 Mar 31.
16. CYP17 MspA1 polymorphism and risk of biliary tract cancers and gallstones: a population-based study in Shanghai, China. Hou L, etal., Int J Cancer. 2006 Jun 1;118(11):2847-53.
17. Lipopolysaccharide directly stimulates aldosterone production via toll-like receptor 2 and toll-like receptor 4 related PI(3)K/Akt pathway in rat adrenal zona glomerulosa cells. Huang HL, etal., J Cell Biochem. 2010 Nov 1;111(4):872-80.
18. Temporal and anatomical sensitivities to the aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin leading to premature acyclicity with age in rats. Jablonska O, etal., Int J Androl. 2010 Jan 4.
19. Biochemical and functional evidence for the control of pain mechanisms by dehydroepiandrosterone endogenously synthesized in the spinal cord. Kibaly C, etal., FASEB J. 2008 Jan;22(1):93-104. Epub 2007 Aug 24.
20. Molecular and neurochemical evidence for the biosynthesis of dehydroepiandrosterone in the adult rat spinal cord. Kibaly C, etal., J Neurochem. 2005 Jun;93(5):1220-30.
21. Semicomprehensive Analysis of the Postnatal Age-Related Changes in the mRNA Expression of Sex Steroidogenic Enzymes and Sex Steroid Receptors in the Male Rat Hippocampus. Kimoto T, etal., Endocrinology. 2010 Nov 3.
22. Spearmint induced hypothalamic oxidative stress and testicular anti-androgenicity in male rats - altered levels of gene expression, enzymes and hormones. Kumar V, etal., Food Chem Toxicol. 2008 Dec;46(12):3563-70. Epub 2008 Aug 31.
23. Disruption of LH-induced testosterone biosynthesis in testicular Leydig cells by triclosan: probable mechanism of action. Kumar V, etal., Toxicology. 2008 Sep 4;250(2-3):124-31. Epub 2008 Jul 9.
24. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
25. Testicular gene expression profiling following prepubertal rat mono-(2-ethylhexyl) phthalate exposure suggests a common initial genetic response at fetal and prepubertal ages. Lahousse SA, etal., Toxicol Sci. 2006 Oct;93(2):369-81. Epub 2006 Jun 29.
26. Study of RNA interference inhibiting rat ovarian androgen biosynthesis by depressing 17alpha-hydroxylase/17, 20-lyase activity in vivo. Li Y, etal., Reprod Biol Endocrinol. 2009 Jul 17;7:73.
27. Dicyclohexyl phthalate blocks Leydig cell regeneration in adult rat testis. Lv Y, etal., Toxicology. 2019 Jan 1;411:60-70. doi: 10.1016/j.tox.2018.10.020. Epub 2018 Nov 1.
28. Absence of correlation between in situ expression of cytochrome P450 17alpha hydroxylase/lyase and 3beta-hydroxysteroid dehydrogenase/(Delta5-4) isomerase messenger ribonucleic acids and steroidogenesis during pubertal development in the rat testis. Mack SO, etal., J Steroid Biochem Mol Biol. 2000 May;73(1-2):19-28.
29. Effects of dietary fats and proteins on rat testicular steroidogenic enzymes and serum testosterone levels. McVey MJ, etal., Food Chem Toxicol. 2008 Jan;46(1):259-69. Epub 2007 Sep 11.
30. An investigation of the effects of methylmercury in rats fed different dietary fats and proteins: testicular steroidogenic enzymes and serum testosterone levels. McVey MJ, etal., Food Chem Toxicol. 2008 Jan;46(1):270-9. Epub 2007 Aug 14.
31. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
32. Androgen synthesis in adrenarche. Miller WL Rev Endocr Metab Disord. 2009 Mar;10(1):3-17.
33. Testicular toxicity of profenofos in matured male rats. Moustafa GG, etal., Arch Toxicol. 2007 Dec;81(12):875-81. Epub 2007 Jun 14.
34. Retinoic acid stimulates 17beta-estradiol and testosterone synthesis in rat hippocampal slice cultures. Munetsuna E, etal., Endocrinology. 2009 Sep;150(9):4260-9. Epub 2009 Jun 4.
35. Rat testis P-450(17)alpha cDNA: the deduced amino acid sequence, expression and secondary structural configuration. Namiki M, etal., Biochem Biophys Res Commun 1988 Dec 15;157(2):705-12.
36. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
37. The biochemical basis for increased testosterone production in theca cells propagated from patients with polycystic ovary syndrome. Nelson VL, etal., J Clin Endocrinol Metab. 2001 Dec;86(12):5925-33.
38. Hormonal regulation of rat Leydig cell cytochrome P-45017 alpha mRNA levels and characterization of a partial length rat P-45017 alpha cDNA. Nishihara M, etal., Biochem Biophys Res Commun 1988 Jul 15;154(1):151-8.
39. Leydig cell re-generation and expression of cell signaling molecules in the germ cell-free testis. O'Shaughnessy PJ, etal., Reproduction. 2008 Jun;135(6):851-8.
40. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
41. Immunoelectron microscopic localization of three key steroidogenic enzymes (cytochrome P450(scc), 3 beta-hydroxysteroid dehydrogenase and cytochrome P450(c17)) in rat adrenal cortex and gonads. Pelletier G, etal., J Endocrinol. 2001 Nov;171(2):373-83.
42. Adrenarche in the rat. Pignatelli D, etal., J Endocrinol. 2006 Oct;191(1):301-8.
43. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
44. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
45. Upregulation of peripubertal rat Leydig cell steroidogenesis following 24 h in vitro and in vivo exposure to atrazine. Pogrmic-Majkic K, etal., Toxicol Sci. 2010 Nov;118(1):52-60. Epub 2010 Jul 28.
46. GOA pipeline RGD automated data pipeline
47. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
48. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
49. Time-response effects of testicular gene expression profiles in Sprague-Dawley male rats treated with di(n-butyl) phthalate. Ryu JY, etal., J Toxicol Environ Health A. 2008;71(23):1542-9.
50. Alterations in gene expression and testosterone synthesis in the testes of male rats exposed to perfluorododecanoic acid. Shi Z, etal., Toxicol Sci. 2007 Jul;98(1):206-15. Epub 2007 Mar 30.
51. The expression of serum steroid sex hormones and steroidogenic enzymes following intraperitoneal administration of dehydroepiandrosterone (DHEA) in male rats. Song L, etal., Steroids. 2010 Mar;75(3):213-8. Epub 2009 Dec 2.
52. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
53. Effects of resveratrol analogs on steroidogenesis and mitochondrial function in rat Leydig cells in vitro. Svechnikov K, etal., J Appl Toxicol. 2009 Nov;29(8):673-80.
54. Influence of long-term dietary administration of procymidone, a fungicide with anti-androgenic effects, or the phytoestrogen genistein to rats on the pituitary-gonadal axis and Leydig cell steroidogenesis. Svechnikov K, etal., J Endocrinol. 2005 Oct;187(1):117-24.
55. Immunolocalization of androgen receptor and steroidogenic enzymes in cumuli oophori of pre- and post-ovulatory rats. Szoltys M, etal., Acta Histochem. 2010 Nov;112(6):576-82. Epub 2009 Sep 22.
56. Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: a mechanism involving an initial effect on gonadotropin synthesis in the pituitary. Taketoh J, etal., Life Sci. 2007 Mar 13;80(14):1259-67. Epub 2007 Jan 18.
57. Exogenous granulocyte-macrophage colony-stimulating factor promotes follicular development in the newborn rat in vivo. Wang H, etal., Hum Reprod. 2005 Oct;20(10):2749-56. Epub 2005 Jun 15.
58. Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction. Xiong DH, etal., J Bone Miner Res. 2006 Nov;21(11):1678-95.
59. 17 alpha-hydroxylase/17,20-lyase deficiency: from clinical investigation to molecular definition. Yanase T, etal., Endocr Rev. 1991 Feb;12(1):91-108.
60. Effect of bisphenol A on steroid hormone production in rat ovarian theca-interstitial and granulosa cells. Zhou W, etal., Mol Cell Endocrinol. 2008 Feb 13;283(1-2):12-8. Epub 2007 Oct 25.
Additional References at PubMed
PMID:1627653   PMID:2554289   PMID:3436956   PMID:7588219   PMID:7588260   PMID:14651853   PMID:14694190   PMID:15169901   PMID:15261307   PMID:15489334   PMID:18556192   PMID:19213837  
PMID:19403566   PMID:21388459   PMID:22170710   PMID:22266943   PMID:22798247   PMID:22800812   PMID:24140098   PMID:24679120   PMID:32438512  


Genomics

Comparative Map Data
Cyp17a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81255,476,861 - 255,484,547 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1255,476,861 - 255,482,974 (-)EnsemblGRCr8
mRatBN7.21245,535,462 - 245,543,148 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,535,462 - 245,541,573 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1253,668,318 - 253,675,994 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01260,357,408 - 260,365,097 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01253,011,215 - 253,018,898 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01266,422,127 - 266,429,947 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1266,422,132 - 266,428,239 (-)Ensemblrn6Rnor6.0
Rnor_5.01273,852,163 - 273,859,866 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41251,965,458 - 251,971,449 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1241,321,307 - 241,327,254 (-)NCBICelera
RGSC_v3.11252,228,608 - 252,234,604 (-)NCBI
RH 3.4 Map11626.0RGD
Cytogenetic Map1q54NCBI
CYP17A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810102,830,531 - 102,837,413 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10102,830,461 - 102,837,501 (-)Ensemblhg38GRCh38
GRCh3710104,590,288 - 104,597,170 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610104,580,278 - 104,587,280 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3410104,580,283 - 104,587,168NCBI
Celera1098,331,010 - 98,337,873 (-)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1098,225,099 - 98,232,065 (-)NCBIHuRef
CHM1_110104,873,550 - 104,880,507 (-)NCBICHM1_1
T2T-CHM13v2.010103,716,316 - 103,723,198 (-)NCBIT2T-CHM13v2.0
Cyp17a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391946,655,604 - 46,661,439 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1946,655,604 - 46,661,611 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381946,667,165 - 46,673,000 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1946,667,165 - 46,673,172 (-)Ensemblmm10GRCm38
MGSCv371946,741,655 - 46,747,490 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361946,720,491 - 46,726,285 (-)NCBIMGSCv36mm8
Celera1947,437,171 - 47,443,006 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.97NCBI
LOC102011010
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554857,645,363 - 7,650,658 (+)Ensembl
ChiLan1.0NW_0049554857,615,132 - 7,652,899 (+)NCBIChiLan1.0ChiLan1.0
CYP17A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28114,715,581 - 114,722,944 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110114,717,523 - 114,732,296 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01099,431,762 - 99,439,619 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110102,891,280 - 102,901,963 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10102,896,376 - 102,901,514 (-)EnsemblpanPan2panpan1.1
CYP17A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12815,292,959 - 15,298,896 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2815,293,106 - 15,298,852 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2815,464,817 - 15,470,751 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02815,766,953 - 15,772,955 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2815,764,529 - 15,772,909 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12815,310,874 - 15,316,795 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02815,350,683 - 15,356,605 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02815,483,290 - 15,489,212 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101970767
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721331,494,353 - 31,499,609 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366003,097,638 - 3,102,713 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366003,097,620 - 3,102,713 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP17A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14113,805,611 - 113,812,041 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114113,805,616 - 113,820,445 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214123,773,108 - 123,787,947 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP17A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1995,870,098 - 95,877,345 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl995,866,908 - 95,877,180 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604856,981,761 - 56,989,146 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101726496
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248312,157,048 - 2,166,539 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248312,155,851 - 2,166,621 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
LOC116893814
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1246,133,701 - 46,139,722 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cyp17a1
38 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:119
Count of miRNA genes:98
Interacting mature miRNAs:109
Transcripts:ENSRNOT00000027160
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1238398865255849249Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
D1Mgh24  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81255,483,476 - 255,483,777 (+)Marker Load Pipeline
mRatBN7.21245,542,075 - 245,542,378 (+)MAPPERmRatBN7.2
Rnor_6.01266,428,745 - 266,429,045NCBIRnor6.0
Rnor_5.01273,858,783 - 273,859,083UniSTSRnor5.0
RGSC_v3.41251,972,049 - 251,972,350RGDRGSC3.4
RGSC_v3.41251,972,050 - 251,972,350UniSTSRGSC3.4
Celera1241,327,855 - 241,328,155UniSTS
RGSC_v3.11252,235,204 - 252,235,505RGD
RH 3.4 Map11622.6UniSTS
RH 3.4 Map11622.6RGD
Cytogenetic Map1q55UniSTS
D1Arb47  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81255,483,604 - 255,483,789 (+)Marker Load Pipeline
mRatBN7.21245,542,203 - 245,542,390 (+)MAPPERmRatBN7.2
Rnor_6.01266,428,873 - 266,429,057NCBIRnor6.0
Rnor_5.01273,858,911 - 273,859,095UniSTSRnor5.0
RGSC_v3.41251,972,177 - 251,972,362RGDRGSC3.4
RGSC_v3.41251,972,178 - 251,972,362UniSTSRGSC3.4
Celera1241,327,983 - 241,328,167UniSTS
RGSC_v3.11252,235,332 - 252,235,517RGD
FHH x ACI Map1129.1099RGD
FHH x ACI Map1129.1099UniSTS
Cytogenetic Map1q55UniSTS
RH94579  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,535,494 - 245,535,594 (+)MAPPERmRatBN7.2
Rnor_6.01266,422,164 - 266,422,263NCBIRnor6.0
Rnor_5.01273,852,200 - 273,852,299UniSTSRnor5.0
RGSC_v3.41251,965,467 - 251,965,566UniSTSRGSC3.4
Celera1241,321,320 - 241,321,419UniSTS
RH 3.4 Map11626.0UniSTS
Cytogenetic Map1q55UniSTS
RH139173  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,535,595 - 245,535,787 (+)MAPPERmRatBN7.2
Rnor_6.01266,422,265 - 266,422,456NCBIRnor6.0
Rnor_5.01273,852,301 - 273,852,492UniSTSRnor5.0
RGSC_v3.41251,965,568 - 251,965,759UniSTSRGSC3.4
Celera1241,321,421 - 241,321,612UniSTS
RH 3.4 Map11626.7UniSTS
Cytogenetic Map1q55UniSTS
PMC85975P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,535,648 - 245,536,352 (+)MAPPERmRatBN7.2
Rnor_6.01266,422,318 - 266,423,021NCBIRnor6.0
Rnor_5.01273,852,354 - 273,853,057UniSTSRnor5.0
RGSC_v3.41251,965,621 - 251,966,324UniSTSRGSC3.4
Celera1241,321,474 - 241,322,177UniSTS
Cytogenetic Map1q55UniSTS
UniSTS:464662  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,537,627 - 245,537,744 (+)MAPPERmRatBN7.2
Rnor_6.01266,424,299 - 266,424,415NCBIRnor6.0
Rnor_5.01273,854,335 - 273,854,451UniSTSRnor5.0
RGSC_v3.41251,967,602 - 251,967,718UniSTSRGSC3.4
Celera1241,323,454 - 241,323,570UniSTS
Cytogenetic Map1q55UniSTS
UniSTS:257093  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81255,480,448 - 255,480,952 (+)Marker Load Pipeline
mRatBN7.21245,539,047 - 245,539,551 (+)MAPPERmRatBN7.2
Rnor_6.01266,425,719 - 266,426,222NCBIRnor6.0
Rnor_5.01273,855,755 - 273,856,258UniSTSRnor5.0
RGSC_v3.41251,969,022 - 251,969,525UniSTSRGSC3.4
Celera1241,324,875 - 241,325,378UniSTS
Cytogenetic Map1q55UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 5 54 79 87 85 59 12 59 6 230 84 62 68 58 26 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC099420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ515796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M21208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M22204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U14953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X69816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z11902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000027160   ⟹   ENSRNOP00000027160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1255,476,861 - 255,482,974 (-)Ensembl
mRatBN7.2 Ensembl1245,535,462 - 245,541,573 (-)Ensembl
Rnor_6.0 Ensembl1266,422,132 - 266,428,239 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102611   ⟹   ENSRNOP00000086774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1255,477,597 - 255,482,974 (-)Ensembl
mRatBN7.2 Ensembl1245,536,198 - 245,541,573 (-)Ensembl
RefSeq Acc Id: NM_012753   ⟹   NP_036885
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81255,476,861 - 255,484,547 (-)NCBI
mRatBN7.21245,535,462 - 245,543,148 (-)NCBI
Rnor_6.01266,422,151 - 266,428,144 (-)NCBI
Rnor_5.01273,852,163 - 273,859,866 (-)NCBI
RGSC_v3.41251,965,458 - 251,971,449 (-)RGD
Celera1241,321,307 - 241,327,254 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063281295   ⟹   XP_063137365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81255,476,881 - 255,484,542 (-)NCBI
RefSeq Acc Id: NP_036885   ⟸   NM_012753
- UniProtKB: Q6LAE5 (UniProtKB/Swiss-Prot),   Q68FY2 (UniProtKB/Swiss-Prot),   P11715 (UniProtKB/Swiss-Prot),   A0A0G2JSR8 (UniProtKB/TrEMBL),   A6JHN5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027160   ⟸   ENSRNOT00000027160
Ensembl Acc Id: ENSRNOP00000086774   ⟸   ENSRNOT00000102611
RefSeq Acc Id: XP_063137365   ⟸   XM_063281295
- Peptide Label: isoform X1
- UniProtKB: Q6LAE5 (UniProtKB/Swiss-Prot),   Q68FY2 (UniProtKB/Swiss-Prot),   P11715 (UniProtKB/Swiss-Prot),   A0A0G2JSR8 (UniProtKB/TrEMBL),   A6JHN5 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11715-F1-model_v2 AlphaFold P11715 1-507 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690971
Promoter ID:EPDNEW_R1495
Type:multiple initiation site
Name:Cyp17a1_1
Description:cytochrome P450, family 17, subfamily a, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01266,428,155 - 266,428,215EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2456 AgrOrtholog
BioCyc Gene G2FUF-55500 BioCyc
BioCyc Pathway PWY-8200 [backdoor pathway of androgen biosynthesis] BioCyc
  PWY-8202 [11-oxyandrogens biosynthesis] BioCyc
  PWY66-378 [androgen biosynthesis] BioCyc
  PWY66-381 [glucocorticoid biosynthesis] BioCyc
BioCyc Pathway Image PWY-8200 BioCyc
  PWY-8202 BioCyc
  PWY66-378 BioCyc
  PWY66-381 BioCyc
Ensembl Genes ENSRNOG00000020035 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000027160 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7111017 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
KEGG Report rno:25146 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93633 IMAGE-MGC_LOAD
NCBI Gene 25146 ENTREZGENE
PANTHER STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE UniProtKB/Swiss-Prot
  STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp17a1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020035 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A0A0G2JSR8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A2W4_RAT UniProtKB/TrEMBL
  A6JHN5 ENTREZGENE, UniProtKB/TrEMBL
  CP17A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q68FY2 ENTREZGENE
  Q6LAE5 ENTREZGENE
UniProt Secondary Q68FY2 UniProtKB/Swiss-Prot
  Q6LAE5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cyp17a1  cytochrome P450, family 17, subfamily a, polypeptide 1  Cyp17  cytochrome P450, subfamily 17  Symbol and Name updated 1299863 APPROVED
2002-11-06 Cyp17  cytochrome P450, subfamily 17    Cytochrome P450, subfamily XVII  Name updated 625702 APPROVED
2002-06-10 Cyp17  Cytochrome P450, subfamily XVII      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains two trans-membrane regions anchor the N terminus to the ER membrane 1298834
gene_function catalyzes both delta 4- and delta 5-steroid-17,20-lyase reactions when transfected into COS cells 1298835
gene_homology moderate homology to human, bovine and chicken cyp17 1298835
gene_regulation cAMP inducible via a non-CREB pathway 1298833