GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp17a1 | decreases expression | EXP | | 6480464 | CTD | Dibutyl Phthalate results in decreased expression of CYP17A1 mRNA; Dibutyl Phthalate results in decreased expression of CYP17A1 protein | PMID:14617579 PMID:15141095 PMID:15987825 PMID:17379624 PMID:17884934 PMID:21266533 PMID:21745491 PMID:22615892 PMID:26472102 PMID:26706031 PMID:33086118 PMID:33983380 | Cyp17a1 | multiple interactions | EXP | | 6480464 | CTD | [Dexamethasone co-treated with Dibutyl Phthalate] results in decreased expression of CYP17A1 mRNA; [diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate] results in decreased expression of CYP17A1 mRNA; Dibutyl Phthalate inhibits the reaction [CEBPB binds to CYP17A1 promoter]; Dibutyl Phthalate inhibits the reaction [NR5A1 binds to CYP17A1 promoter]; Dibutyl Phthalate inhibits the reaction [NR5A1 protein binds to CYP17A1 promoter] | PMID:17884934 PMID:22615892 PMID:23358192 PMID:37788136 | Cyp17a1 | decreases expression | ISO | Cyp17a1 (Mus musculus) | 6480464 | CTD | Dibutyl Phthalate results in decreased expression of CYP17A1 mRNA | PMID:22511013 | Cyp17a1 | increases expression | ISO | Cyp17a1 (Mus musculus) | 6480464 | CTD | Dibutyl Phthalate results in increased expression of CYP17A1 mRNA | PMID:25765776 | Cyp17a1 | multiple interactions | ISO | Cyp17a1 (Mus musculus) | 6480464 | CTD | [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in increased expression of CYP17A1 mRNA; [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased expression of CYP17A1 mRNA; [Nanotubes, Carbon co-treated with Dibutyl Phthalate] affects the expression of CYP17A1 mRNA | PMID:29029336 PMID:30802670 PMID:37505531 | |
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