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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2456
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp17a1decreases expressionEXP 6480464CTDDibutyl Phthalate results in decreased expression of CYP17A1 mRNA; Dibutyl Phthalate results in decreased expression of CYP17A1 proteinPMID:14617579 PMID:15141095 PMID:15987825 PMID:17379624 PMID:17884934 PMID:21266533 PMID:21745491 PMID:22615892 PMID:26472102 PMID:26706031 PMID:33086118 PMID:33983380
Cyp17a1multiple interactionsEXP 6480464CTD[Dexamethasone co-treated with Dibutyl Phthalate] results in decreased expression of CYP17A1 mRNA; [diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate] results in decreased expression of CYP17A1 mRNA; Dibutyl Phthalate inhibits the reaction [CEBPB binds to CYP17A1 promoter]; Dibutyl Phthalate inhibits the reaction [NR5A1 binds to CYP17A1 promoter]; Dibutyl Phthalate inhibits the reaction [NR5A1 protein binds to CYP17A1 promoter]PMID:17884934 PMID:22615892 PMID:23358192 PMID:37788136
Cyp17a1decreases expressionISOCyp17a1 (Mus musculus)6480464CTDDibutyl Phthalate results in decreased expression of CYP17A1 mRNAPMID:22511013
Cyp17a1increases expressionISOCyp17a1 (Mus musculus)6480464CTDDibutyl Phthalate results in increased expression of CYP17A1 mRNAPMID:25765776
Cyp17a1multiple interactionsISOCyp17a1 (Mus musculus)6480464CTD[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in increased expression of CYP17A1 mRNA; [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased expression of CYP17A1 mRNA; [Nanotubes, Carbon co-treated with Dibutyl Phthalate] affects the expression of CYP17A1 mRNAPMID:29029336 PMID:30802670 PMID:37505531
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