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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2456
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:6842
Term: methoxychlor
Definition: An organochlorine insecticide that has formula C16H15Cl3O2.
Chemical ID: MESH:D008731
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp17a1decreases expressionISOCyp17a1 (Mus musculus)6480464CTDMethoxychlor metabolite results in decreased expression of CYP17A1 mRNA; Methoxychlor results in decreased expression of CYP17A1 mRNAPMID:11509743 PMID:21514315
Cyp17a1multiple interactionsISOCyp17a1 (Mus musculus)6480464CTD[Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of CYP17A1 mRNAPMID:11509743
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