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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2456
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:68642
Term: abiraterone
Definition: A 3beta-sterol that is androsta-5,16-dien-3beta-ol substituted at position 17 by a 3-pyridyl group. Administered as the O-acetate, it is used for treatment of metastatic castrate-resistant prostate cancer.
Chemical ID: MESH:C089740
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp17a1decreases activityEXP 6480464CTDabiraterone results in decreased activity of CYP17A1 proteinPMID:25993309
Cyp17a1decreases activityISOCYP17A1 (Homo sapiens)6480464CTDabiraterone analog results in decreased activity of CYP17A1 protein; abiraterone results in decreased activity of CYP17A1 proteinPMID:17194026 PMID:29100959
Cyp17a1multiple interactionsISOCYP17A1 (Homo sapiens)6480464CTD[[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone; [[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone; [abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Pregnenolone; [abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of ProgesteronePMID:29100959
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