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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2456
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp17a1decreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of CYP17A1 mRNA; Cadmium Chloride results in decreased expression of CYP17A1 proteinPMID:25993096 PMID:29214744
Cyp17a1multiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which affects the expression of CYP17A1 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CYP17A1 mRNAPMID:31654709
Cyp17a1decreases expressionISOCyp17a1 (Mus musculus)6480464CTDCadmium Chloride results in decreased expression of CYP17A1 mRNA; Cadmium Chloride results in decreased expression of CYP17A1 proteinPMID:19897027 PMID:24982889
Cyp17a1multiple interactionsISOCyp17a1 (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CYP17A1 mRNAPMID:37325564
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