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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2456 Species: Rattus norvegicus RGD Object: Gene Symbol: Cyp17a1 Name: cytochrome P450, family 17, subfamily a, polypeptide 1

Acc ID: CHEBI:34317 Term: 3,3',4,4',5-pentachlorobiphenyl Definition: A pentachlorobiphenyl that has formula C12H5Cl5. CasRN: 57465-28-8 Chemical ID: MESH:C023035

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases activity	ISO	RGD:1350540	6480464	CTD	3,4,5,3',4'-pentachlorobiphenyl results in decreased activity of CYP17A1 protein	PMID:15703266
increases expression	ISO	RGD:737222	6480464	CTD	3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP17A1 mRNA	PMID:12781204
decreases expression	ISO	RGD:1350540	6480464	CTD	3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CYP17A1 mRNA	PMID:15703266
increases expression	ISO	RGD:1350540	6480464	CTD	3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP17A1 mRNA	PMID:16216300
increases expression	EXP		6480464	CTD	3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP17A1 mRNA	PMID:20959002