GENE - CHEMICAL INTERACTIONS REPORT
RGD ID:
2456
Species:
Rattus norvegicus
RGD Object:
Gene
Symbol:
Cyp17a1
Name:
cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID:
CHEBI:34317
Term:
3,3',4,4',5-pentachlorobiphenyl
Definition:
A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.
Chemical ID:
MESH:C023035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Cyp17a1 increases expression EXP 6480464 CTD 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP17A1 mRNA PMID:20959002 PMID:34256052 Cyp17a1 multiple interactions EXP 6480464 CTD AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP17A1 mRNA] PMID:34256052 Cyp17a1 decreases activity ISO CYP17A1 (Homo sapiens) 6480464 CTD 3,4,5,3',4'-pentachlorobiphenyl results in decreased activity of CYP17A1 protein PMID:15703266 Cyp17a1 decreases expression ISO CYP17A1 (Homo sapiens) 6480464 CTD 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CYP17A1 mRNA PMID:15703266 Cyp17a1 increases expression ISO CYP17A1 (Homo sapiens) 6480464 CTD 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP17A1 mRNA PMID:16216300 Cyp17a1 increases expression ISO Cyp17a1 (Mus musculus) 6480464 CTD 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP17A1 mRNA PMID:12781204 
