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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2456
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:6954
Term: Mitotane
Definition: null
Chemical ID: MESH:D008939
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp17a1decreases expressionISOCYP17A1 (Homo sapiens)6480464CTDMitotane results in decreased expression of CYP17A1 mRNAPMID:23254310
Cyp17a1multiple interactionsISOCYP17A1 (Homo sapiens)6480464CTDMitotane inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 mRNA]PMID:22546480
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