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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2456
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:32234
Term: titanium dioxide
Definition: A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.
Chemical ID: MESH:C009495
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp17a1decreases expressionISOCyp17a1 (Mus musculus)6480464CTDtitanium dioxide results in decreased expression of CYP17A1 mRNA; titanium dioxide results in decreased expression of CYP17A1 proteinPMID:24241477
Cyp17a1increases expressionISOCyp17a1 (Mus musculus)6480464CTDtitanium dioxide results in increased expression of CYP17A1 mRNAPMID:23131501
Cyp17a1multiple interactionsISOCyp17a1 (Mus musculus)6480464CTD[[titanium dioxide results in decreased expression of CYP17A1 mRNA] co-treated with [titanium dioxide results in decreased expression of HSD17B10 mRNA]] results in increased chemical synthesis of TestosteronePMID:24241477
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