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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2456
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp17a1decreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in decreased expression of CYP17A1 mRNA; Diethylhexyl Phthalate results in decreased expression of CYP17A1 proteinPMID:26472102 PMID:29325824 PMID:29777495 PMID:33983380 PMID:34197824
Cyp17a1increases expressionEXP 6480464CTDDiethylhexyl Phthalate results in increased expression of CYP17A1 mRNAPMID:35970509
Cyp17a1multiple interactionsEXP 6480464CTD[diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate] results in decreased expression of CYP17A1 mRNA; [Genistein co-treated with Diethylhexyl Phthalate] results in decreased expression of CYP17A1 mRNA; [Plant Extracts co-treated with Diethylhexyl Phthalate] affects the expression of CYP17A1 mRNA; Isoflavones inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CYP17A1 protein]; Plant Preparations inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CYP17A1 protein]PMID:29777495 PMID:34197824 PMID:36674726 PMID:37788136
Cyp17a1decreases expressionISOCyp17a1 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased expression of CYP17A1 mRNA; Diethylhexyl Phthalate results in decreased expression of CYP17A1 proteinPMID:25701202 PMID:25975992 PMID:27405655 PMID:28085963 PMID:28123099 PMID:28286118 PMID:32619501
Cyp17a1increases expressionISOCYP17A1 (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in increased expression of CYP17A1 mRNAPMID:36774801
Cyp17a1increases expressionISOCyp17a1 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased expression of CYP17A1 mRNAPMID:36774801
Cyp17a1multiple interactionsISOCyp17a1 (Mus musculus)6480464CTD[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in increased expression of CYP17A1 mRNA; [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased expression of CYP17A1 mRNAPMID:29029336 PMID:30802670
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