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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2456
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:17252
Term: 17alpha-hydroxyprogesterone
Definition: A 17alpha-hydroxy steroid that is the 17alpha-hydroxy derivative of progesterone.
Chemical ID: MESH:D019326
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp17a1affects abundanceISOCYP17A1 (Homo sapiens)6480464CTDCYP17A1 protein affects the abundance of 17-alpha-HydroxyprogesteronePMID:21427057
Cyp17a1affects chemical synthesisISOCYP17A1 (Homo sapiens)6480464CTDCYP17A1 protein affects the chemical synthesis of 17-alpha-HydroxyprogesteronePMID:16030167
Cyp17a1affects metabolic processingISOCYP17A1 (Homo sapiens)6480464CTDCYP17A1 protein affects the metabolism of 17-alpha-HydroxyprogesteronePMID:16030167
Cyp17a1increases metabolic processingISOCYP17A1 (Homo sapiens)6480464CTDCYP17A1 protein results in increased metabolism of 17-alpha-HydroxyprogesteronePMID:29100959
Cyp17a1multiple interactionsISOCYP17A1 (Homo sapiens)6480464CTD[[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone; [CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone; [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone]; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]; Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone]; TNF protein inhibits the reaction [CYP17A1 protein affects the metabolism of 17-alpha-Hydroxyprogesterone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone]PMID:16030167 PMID:17194026 PMID:29100959
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