GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp17a1 | affects abundance | ISO | CYP17A1 (Homo sapiens) | 6480464 | CTD | CYP17A1 protein affects the abundance of 17-alpha-Hydroxyprogesterone | PMID:21427057 | Cyp17a1 | affects chemical synthesis | ISO | CYP17A1 (Homo sapiens) | 6480464 | CTD | CYP17A1 protein affects the chemical synthesis of 17-alpha-Hydroxyprogesterone | PMID:16030167 | Cyp17a1 | affects metabolic processing | ISO | CYP17A1 (Homo sapiens) | 6480464 | CTD | CYP17A1 protein affects the metabolism of 17-alpha-Hydroxyprogesterone | PMID:16030167 | Cyp17a1 | increases metabolic processing | ISO | CYP17A1 (Homo sapiens) | 6480464 | CTD | CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone | PMID:29100959 | Cyp17a1 | multiple interactions | ISO | CYP17A1 (Homo sapiens) | 6480464 | CTD | [[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone; [CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone; [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone]; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]; Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone]; TNF protein inhibits the reaction [CYP17A1 protein affects the metabolism of 17-alpha-Hydroxyprogesterone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] | PMID:16030167 PMID:17194026 PMID:29100959 | |
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