GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp17a1 | affects chemical synthesis | ISO | CYP17A1 (Homo sapiens) | 6480464 | CTD | CYP17A1 protein affects the chemical synthesis of 17-alpha-Hydroxypregnenolone | PMID:16030167 | Cyp17a1 | affects metabolic processing | ISO | CYP17A1 (Homo sapiens) | 6480464 | CTD | CYP17A1 protein affects the metabolism of 17-alpha-Hydroxypregnenolone | PMID:16030167 | Cyp17a1 | decreases acetylation | ISO | CYP17A1 (Homo sapiens) | 6480464 | CTD | CYP17A1 protein results in decreased acetylation of 17-alpha-Hydroxypregnenolone | PMID:15562394 | Cyp17a1 | increases metabolic processing | ISO | CYP17A1 (Homo sapiens) | 6480464 | CTD | CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone | PMID:29100959 | Cyp17a1 | multiple interactions | ISO | CYP17A1 (Homo sapiens) | 6480464 | CTD | [[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone; [CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone; [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]; Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] | PMID:17194026 PMID:29100959 | | ||||||||||||||||||||||
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