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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2456
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp17a1multiple interactionsEXP 6480464CTDFulvestrant inhibits the reaction [Estradiol affects the expression of CYP17A1 mRNA]PMID:36931579
Cyp17a1increases expressionISOCyp17a1 (Mus musculus)6480464CTDfulvestrant results in increased expression of CYP17A1 mRNAPMID:17158782
Cyp17a1multiple interactionsISOCYP17A1 (Homo sapiens)6480464CTDFulvestrant inhibits the reaction [bisphenol A results in increased expression of CYP17A1 mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of CYP17A1 protein]PMID:34537452
Cyp17a1multiple interactionsISOCyp17a1 (Mus musculus)6480464CTDfulvestrant inhibits the reaction [DDT results in increased expression of CYP17A1 mRNA]PMID:23684557
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