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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2456
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:38757
Term: isoflavones
Definition: Any isoflavonoid with a 3-aryl-1-benzopyran-4-one (3-aryl-4H-chromen-4-one) skeleton and its substituted derivatives.
Chemical ID: MESH:D007529
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp17a1increases activityEXP 6480464CTDIsoflavones results in increased activity of CYP17A1 proteinPMID:15698548
Cyp17a1multiple interactionsEXP 6480464CTDIsoflavones inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CYP17A1 protein]PMID:34197824
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