RGD Reference Report - CYP17 MspA1 polymorphism and risk of biliary tract cancers and gallstones: a population-based study in Shanghai, China. - Rat Genome Database

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CYP17 MspA1 polymorphism and risk of biliary tract cancers and gallstones: a population-based study in Shanghai, China.

Authors: Hou, L  Xu, J  Gao, YT  Rashid, A  Zheng, SL  Sakoda, LC  Shen, MC  Wang, BS  Deng, J  Han, TQ  Zhang, BH  Meyers, DA  Fraumeni JF, JR  Hsing, AW 
Citation: Hou L, etal., Int J Cancer. 2006 Jun 1;118(11):2847-53.
RGD ID: 2317619
Pubmed: PMID:16381022   (View Abstract at PubMed)
DOI: DOI:10.1002/ijc.21708   (Journal Full-text)

Biliary tract cancers, encompassing cancers of the gallbladder, extrahepatic bile duct and ampulla of Vater, are rare but highly fatal malignancies. Other than gallstones, little is known about the risk factors for biliary tract cancers. Endogenous estrogens are thought to play a role in the etiology of gallstones and gallbladder cancer, since both conditions predominate in females and are associated with parity and obesity. In view of reports linking the CYP17 MspA1 polymorphism to high circulating levels of estrogens and a predisposition to other hormonally related cancers, we examined the relationship between CYP17 MspA1 variants and risk of biliary disease in a population-based case-control study in Shanghai. The study included 446 cancer cases (254 gallbladder, 139 extrahepatic bile duct, 53 ampullary cancers), 929 biliary stone cases (691 gallbladder, 238 bile duct) and 818 population controls. Genomic DNA from peripheral blood lymphocytes was used for genotyping. Relative to those with the A2/A2 genotype, A1 carriers (A1/A1 and A1/A2 genotypes) had an increased risk of gallbladder cancer (odds ratio (OR) = 1.5, 95% confidence interval (CI) = 1.1-2.1). In addition, women with the A1 allele and high parity (> or =3) had a 3-fold risk of gallbladder cancer (OR = 3.3, 95% CI = 1.6-6.9), compared to those with the A2/A2 genotype and lower parity, with the highest risk seen for those also having biliary stones (OR = 4.6, 95% CI = 1.8-11.7, P(interaction) = 0.04). The A1 allele was not associated with a higher risk of gallstones except among those with body mass index (BMI) greater than 25 kg/m2 (OR = 3.1, 95% CI = 2.0-4.8, P(interaction) = 0.02) and among those with a history of diabetes (OR = 2.5, 95% CI = 1.4-4.3, P interaction = 0.09). No clear relation was seen between the CYP17 polymorphism and cancers of the bile duct or ampulla of Vater. The association of the CYP17 MspA1 polymorphism with an increased risk of gallbladder cancer, as well as biliary stones among overweight and diabetic individuals, suggests an interplay between genetic and hormonal risk factors in gallbladder disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cholelithiasis  IAGP 2317619associated with Diabetes Mellitus and DNA:transition:5' utr:-34T>C rs743572 (human)RGD 
cholelithiasis  ISOCYP17A1 (Homo sapiens)2317619; 2317619associated with Diabetes Mellitus and DNA:transition:5' utr:-34T>C rs743572 (human)RGD 
gallbladder cancer susceptibilityIAGP 2317619DNA:transition:5' utr:-34T>C rs743572 (human)RGD 
gallbladder cancer susceptibilityISOCYP17A1 (Homo sapiens)2317619; 2317619DNA:transition:5' utr:-34T>C rs743572 (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cyp17a1  (cytochrome P450, family 17, subfamily a, polypeptide 1)

Genes (Mus musculus)
Cyp17a1  (cytochrome P450, family 17, subfamily a, polypeptide 1)

Genes (Homo sapiens)
CYP17A1  (cytochrome P450 family 17 subfamily A member 1)


Additional Information