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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2456
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:83784
Term: galaxolide
Definition: An organic heterotricyclic compound that is 1,3,4,6,7,8-hexahydrocyclopenta[g]isochromene substituted by methyl groups at positions 4, 6, 6, 7, 8 and 8 respectively. It is a synthetic musk used as a fragrance in cosmetics.
Chemical ID: MESH:C033119
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp17a1decreases expressionEXP 6480464CTDgalaxolide results in decreased expression of CYP17A1 mRNAPMID:37797914
Cyp17a1decreases activityISOCYP17A1 (Homo sapiens)6480464CTDgalaxolide results in decreased activity of CYP17A1 proteinPMID:23084589
Cyp17a1increases activityISOCYP17A1 (Homo sapiens)6480464CTDgalaxolide results in increased activity of CYP17A1 proteinPMID:23084589
Cyp17a1multiple interactionsISOCYP17A1 (Homo sapiens)6480464CTD[galaxolide co-treated with Cyclic AMP] results in decreased activity of CYP17A1 protein; [galaxolide co-treated with Cyclic AMP] results in increased activity of CYP17A1 proteinPMID:23084589
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