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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2456 Species: Rattus norvegicus RGD Object: Gene Symbol: Cyp17a1 Name: cytochrome P450, family 17, subfamily a, polypeptide 1

Acc ID: CHEBI:3750 Term: clofibrate Definition: A propanoate ester that has formula C12H15ClO3. CasRN: 637-07-0 Chemical ID: MESH:D002994

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:737222	6480464	CTD	[Clofibrate co-treated with Acetaminophen] affects the expression of CYP17A1 mRNA PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CYP17A1 mRNA]	PMID:17585979
decreases expression	ISO	RGD:737222	6480464	CTD	Clofibrate results in decreased expression of CYP17A1 mRNA	PMID:17585979
increases expression	EXP		6480464	CTD	Clofibrate results in increased expression of CYP17A1 mRNA	PMID:15033592