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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2456
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:34680
Term: dipentyl phthalate
Definition: A phthalate ester that is the dipentyl ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C034171
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp17a1decreases activityEXP 6480464CTDdi-n-pentyl phthalate results in decreased activity of CYP17A1 proteinPMID:6829050
Cyp17a1decreases expressionEXP 6480464CTDdi-n-pentyl phthalate results in decreased expression of CYP17A1 mRNA; di-n-pentyl phthalate results in decreased expression of CYP17A1 proteinPMID:22112501 PMID:25055962 PMID:26472102 PMID:33798595 PMID:33983380
Cyp17a1multiple interactionsEXP 6480464CTD[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP17A1 mRNAPMID:25055962
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