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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2456 Species: Rattus norvegicus RGD Object: Gene Symbol: Cyp17a1 Name: cytochrome P450, family 17, subfamily a, polypeptide 1

Acc ID: CHEBI:46195 Term: paracetamol Definition: A derivative of phenol which has an acetamido substituent located para to the phenolic -OH group. CasRN: 103-90-2 Chemical ID: MESH:D000082

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:737222	6480464	CTD	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CYP17A1 mRNA]	PMID:17585979
affects expression	ISO	RGD:737222	6480464	CTD	Acetaminophen affects the expression of CYP17A1 mRNA	PMID:17562736
decreases expression	EXP		6480464	CTD	Acetaminophen results in decreased expression of CYP17A1 mRNA	PMID:17202762