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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:prostate cancer pathway
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Accession:PW:0000609 term browser browse the term
Definition:Prostate cancer is a frequent form of cancer in men over the age of fifty. It is usually asymptomatic but when in an advanced stage, it may spread to other parts of the body, causing symptoms others than those sometimes observed. Several susceptibility as well as defective genes have been identified.
Synonyms:exact_synonym: familial prostate cancer pathway;   hereditary prostate cancer pathway;   malignant tumor of the prostate pathway;   prostatic cancer pathway
 related_synonym: KEGG:05215;   prostate neoplasm pathway
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prostate cancer pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 IEA KEGG rno:05215 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 IEA KEGG rno:05215 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 IEA KEGG rno:05215 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Ar androgen receptor ISO
IEA		 KEGG
RGD		 PMID:18008377 PMID:23759327 rno:05215, RGD:2326139, RGD:8693397 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atf4 activating transcription factor 4 IEA KEGG rno:05215 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Bad BCL2-associated agonist of cell death IEA KEGG rno:05215 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bcl2 BCL2, apoptosis regulator IEA KEGG rno:05215 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase IEA KEGG rno:05215 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Casp9 caspase 9 IEA KEGG rno:05215 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnd1 cyclin D1 IEA KEGG rno:05215 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 IEA KEGG rno:05215 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccne2 cyclin E2 IEA KEGG rno:05215 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Cdk2 cyclin dependent kinase 2 IEA KEGG rno:05215 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A IEA KEGG rno:05215 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B IEA KEGG rno:05215 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex IEA KEGG rno:05215 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 IEA KEGG rno:05215 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Creb3l1 cAMP responsive element binding protein 3-like 1 IEA KEGG rno:05215 NCBI chr 3:77,952,589...77,993,513
Ensembl chr 3:77,952,540...77,993,456 		JBrowse link
G Creb3l2 cAMP responsive element binding protein 3-like 2 IEA KEGG rno:05215 NCBI chr 4:65,907,570...66,112,078
Ensembl chr 4:65,907,655...66,023,763 		JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 IEA KEGG rno:05215 NCBI chr 7:8,622,614...8,631,053
Ensembl chr 7:8,622,614...8,631,048 		JBrowse link
G Creb3l4 cAMP responsive element binding protein 3-like 4 IEA KEGG rno:05215 NCBI chr 2:175,690,340...175,695,846
Ensembl chr 2:175,690,335...175,695,932 		JBrowse link
G Crebbp CREB binding protein IEA KEGG rno:05215 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Ctnnb1 catenin beta 1 IEA KEGG rno:05215 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G E2f1 E2F transcription factor 1 IEA KEGG rno:05215 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f3 E2F transcription factor 3 IEA KEGG rno:05215 NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253 		JBrowse link
G Egf epidermal growth factor IEA KEGG rno:05215 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor IEA KEGG rno:05215 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Ep300 E1A binding protein p300 IEA KEGG rno:05215 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 IEA KEGG rno:05215 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 IEA KEGG rno:05215 NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 IEA KEGG rno:05215 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Foxo1 forkhead box O1 IEA KEGG rno:05215 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Grb2 growth factor receptor bound protein 2 IEA KEGG rno:05215 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IEA KEGG rno:05215 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 IEA KEGG rno:05215 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hras HRas proto-oncogene, GTPase IEA KEGG rno:05215 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 IEA KEGG rno:05215 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 IEA KEGG rno:05215 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 IEA KEGG rno:05215 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Igf1 insulin-like growth factor 1 IEA KEGG rno:05215 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor IEA KEGG rno:05215 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta IEA KEGG rno:05215 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma IEA KEGG rno:05215 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Ins1 insulin 1 IEA KEGG rno:05215 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 IEA KEGG rno:05215 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Insrr insulin receptor-related receptor IEA KEGG rno:05215 NCBI chr 2:173,255,335...173,274,800
Ensembl chr 2:173,255,414...173,274,800 		JBrowse link
G Kras KRAS proto-oncogene, GTPase IEA KEGG rno:05215 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lef1 lymphoid enhancer binding factor 1 IEA KEGG rno:05215 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 IEA KEGG rno:05215 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 IEA KEGG rno:05215 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IEA KEGG rno:05215 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 IEA KEGG rno:05215 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mdm2 MDM2 proto-oncogene IEA KEGG rno:05215 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IEA KEGG rno:05215 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 ISO RGD PMID:23759327 RGD:8693397 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 ISO RGD PMID:23759327 RGD:8693397 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 IEA KEGG rno:05215 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha IEA KEGG rno:05215 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nkx3-1 NK3 homeobox 1 IEA KEGG rno:05215 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441 		JBrowse link
G Nras NRAS proto-oncogene, GTPase IEA KEGG rno:05215 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626 		JBrowse link
G Pdgfa platelet derived growth factor subunit A IEA KEGG rno:05215 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497 		JBrowse link
G Pdgfb platelet derived growth factor subunit B IEA KEGG rno:05215 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pdgfc platelet derived growth factor C IEA KEGG rno:05215 NCBI chr 2:166,316,870...166,493,449
Ensembl chr 2:166,316,803...166,493,433 		JBrowse link
G Pdgfd platelet derived growth factor D IEA KEGG rno:05215 NCBI chr 8:3,488,448...3,722,395
Ensembl chr 8:3,488,423...3,722,395 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha IEA KEGG rno:05215 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta IEA KEGG rno:05215 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 IEA KEGG rno:05215 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha IEA
ISO		 KEGG
RGD		 PMID:23759327 rno:05215, RGD:8693397 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta IEA KEGG rno:05215 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta IEA KEGG rno:05215 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IEA KEGG rno:05215 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG rno:05215 NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG rno:05215 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA KEGG rno:05215 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374 		JBrowse link
G Pten phosphatase and tensin homolog ISO
IEA		 KEGG
RGD		 PMID:18008377 PMID:23759327 rno:05215, RGD:2326139, RGD:8693397 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase IEA KEGG rno:05215 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rb1 RB transcriptional corepressor 1 IEA KEGG rno:05215 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IEA KEGG rno:05215 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 IEA KEGG rno:05215 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 IEA KEGG rno:05215 NCBI chr 6:88,042,966...88,156,140
Ensembl chr 6:88,042,966...88,156,692 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 IEA KEGG rno:05215 NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112 		JBrowse link
G Tcf3 transcription factor 3 IEA KEGG rno:05215 NCBI chr 7:9,280,571...9,302,315
Ensembl chr 7:9,280,571...9,302,314 		JBrowse link
G Tcf7 transcription factor 7 IEA KEGG rno:05215 NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 IEA KEGG rno:05215 NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967 		JBrowse link
G Tgfa transforming growth factor alpha IEA KEGG rno:05215 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
G Tp53 tumor protein p53 IEA
ISO		 KEGG
RGD		 PMID:23759327 rno:05215, RGD:8693397 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    disease pathway 1954
      cancer pathway 369
        urogenital cancer pathway 159
          prostate cancer pathway 86
paths to the root