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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:endothelin signaling pathway
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Accession:PW:0000506 term browser browse the term
Definition:Endothelins represent a family of three vasoconstrictor peptides that play a role in several intracellular signaling pathways and have been associated with hypertension, heart failure and myocardial infarction.
Synonyms:related_synonym: endothelin receptor signaling pathway


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endothelin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy1 adenylate cyclase 1 ISO PID PID:200005 NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969 		JBrowse link
G Adcy2 adenylate cyclase 2 ISO PID PID:200005 NCBI chr 1:34,375,639...34,822,252
Ensembl chr 1:34,375,895...34,822,236 		JBrowse link
G Adcy3 adenylate cyclase 3 ISO PID PID:200005 NCBI chr 6:27,100,089...27,203,686
Ensembl chr 6:27,124,828...27,203,686 		JBrowse link
G Adcy4 adenylate cyclase 4 ISO PID PID:200005 NCBI chr15:29,266,280...29,282,153
Ensembl chr15:29,266,287...29,282,108 		JBrowse link
G Adcy5 adenylate cyclase 5 ISO PID PID:200005 NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974 		JBrowse link
G Adcy6 adenylate cyclase 6 ISO PID PID:200005 NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754 		JBrowse link
G Adcy7 adenylate cyclase 7 ISO PID PID:200005 NCBI chr19:18,740,875...18,798,924
Ensembl chr19:18,740,875...18,776,311 		JBrowse link
G Adcy8 adenylate cyclase 8 ISO PID PID:200005 NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911 		JBrowse link
G Adcy9 adenylate cyclase 9 ISO PID PID:200005 NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200005 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member ISO PID PID:200005 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Cdc42 cell division cycle 42 ISO PID PID:200005 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Col1a2 collagen type I alpha 2 chain ISO PID PID:200005 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Col3a1 collagen type III alpha 1 chain ISO PID PID:200005 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Crk CRK proto-oncogene, adaptor protein ISO PID PID:200005 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406 		JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 ISO PID PID:200005 NCBI chr  X:71,661,421...71,690,012
Ensembl chr  X:71,663,821...71,690,121 		JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 ISO PID PID:200005 NCBI chr15:48,189,476...48,228,750
Ensembl chr15:48,189,073...48,304,136 		JBrowse link
G Ece1 endothelin converting enzyme 1 IMP RGD PMID:15733912 RGD:1581735 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371 		JBrowse link
G Edn1 endothelin 1 ISO PID
RGD		 PMID:15124920 PID:200005, RGD:1580323 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Edn2 endothelin 2 ISO PID PID:200005 NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814 		JBrowse link
G Edn3 endothelin 3 ISO PID PID:200005 NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093 		JBrowse link
G Ednra endothelin receptor type A IMP
ISO		 PID
RGD		 PMID:20409845 PID:200005, RGD:4892591 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Ednrb endothelin receptor type B IMP
ISO		 PID
RGD		 PMID:20409845 PID:200005, RGD:4892591 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200005 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gna11 G protein subunit alpha 11 ISO PID PID:200005 NCBI chr 7:8,163,520...8,177,863
Ensembl chr 7:8,162,750...8,179,812 		JBrowse link
G Gna12 G protein subunit alpha 12 ISO PID PID:200005 NCBI chr12:13,805,580...13,886,255
Ensembl chr12:13,805,698...13,886,255 		JBrowse link
G Gna14 G protein subunit alpha 14 ISO PID PID:200005 NCBI chr 1:213,714,993...213,900,083
Ensembl chr 1:213,716,020...213,897,423 		JBrowse link
G Gna15 G protein subunit alpha 15 ISO PID PID:200005 NCBI chr 7:8,184,632...8,205,508
Ensembl chr 7:8,184,861...8,205,508 		JBrowse link
G Gnai1 G protein subunit alpha i1 ISO PID PID:200005 NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417 		JBrowse link
G Gnai2 G protein subunit alpha i2 ISO PID PID:200005 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979 		JBrowse link
G Gnai3 G protein subunit alpha i3 ISO PID PID:200005 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742 		JBrowse link
G Gnal G protein subunit alpha L ISO PID PID:200005 NCBI chr18:60,622,311...60,762,599
Ensembl chr18:60,622,311...60,762,599 		JBrowse link
G Gnao1 G protein subunit alpha o1 ISO PID PID:200005 NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493 		JBrowse link
G Gnaq G protein subunit alpha q ISO PID PID:200005 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672 		JBrowse link
G Gnaz G protein subunit alpha z ISO PID PID:200005 NCBI chr20:13,643,473...13,694,240
Ensembl chr20:13,644,640...13,669,907 		JBrowse link
G Hras HRas proto-oncogene, GTPase ISO PID PID:200005 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Jak2 Janus kinase 2 ISO PID PID:200005 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200005 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 ISO PID PID:200005 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 ISO PID PID:200005 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO PID PID:200005 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 ISO PID PID:200005 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO PID PID:200005 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO PID PID:200005 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mmp1 matrix metallopeptidase 1 ISO PID PID:200005 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 IMP RGD PMID:15016802 RGD:1581961 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150 		JBrowse link
G Nos2 nitric oxide synthase 2 IEP RGD PMID:16552365 RGD:1582119 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pla2g4a phospholipase A2 group 4A ISO PID PID:200005 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Plcb1 phospholipase C beta 1 ISO PID PID:200005 NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869 		JBrowse link
G Plcb2 phospholipase C, beta 2 ISO PID PID:200005 NCBI chr 3:105,683,676...105,704,384
Ensembl chr 3:105,684,815...105,704,302 		JBrowse link
G Plcb3 phospholipase C beta 3 ISO PID PID:200005 NCBI chr 1:204,143,257...204,160,384
Ensembl chr 1:204,144,956...204,160,228 		JBrowse link
G Prkca protein kinase C, alpha ISO PID PID:200005 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcd protein kinase C, delta ISO PID PID:200005 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prkce protein kinase C, epsilon ISO PID PID:200005 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Prkcg protein kinase C, gamma ISO PID PID:200005 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384 		JBrowse link
G Prkch protein kinase C, eta ISO PID PID:200005 NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654 		JBrowse link
G Prkcq protein kinase C, theta ISO PID PID:200005 NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta ISO PID PID:200005 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Rac1 Rac family small GTPase 1 ISO PID PID:200005 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO PID PID:200005 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rhoa ras homolog family member A ISO PID PID:200005 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 ISO PID PID:200005 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624 		JBrowse link
G Slc9a3 solute carrier family 9 member A3 ISO PID PID:200005 NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO PID PID:200005 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 ISO PID PID:200005 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2634
      hormone signaling pathway 624
        peptide and protein hormone signaling pathway 439
          endothelin signaling pathway 65
paths to the root