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Gene Ontology AnnotationsGene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | cAMP biosynthetic process | | IMP | | 2312769 | | RGD | | cAMP biosynthetic process | | IDA | | 7241269 | | RGD | | cAMP biosynthetic process | | ISO | RGD:736586 | 1624291 | MGI:MGI:99677 | RGD | MGI:MGI:1344240 PMID:10482244 | cAMP biosynthetic process | | IMP | | 2312785 | | RGD | | cAMP-mediated signaling | | IDA | | 69741 | | RGD | | cellular response to calcium ion | | IEP | | 7241269 | | RGD | | diterpenoid metabolic process | | IEP | | 7241269 | forskolin | RGD | | intracellular signal transduction | | IEA | InterPro:IPR001054|InterPro:IPR018297 | 1600115 | GO_REF:0000002 | InterPro | GO_REF:0000002 | long-term memory | | ISO | RGD:736586 | 1624291 | MGI:MGI:99677 | RGD | MGI:MGI:1344240 PMID:10482244 | long-term memory | | IEA | Ensembl:ENSMUSP00000023007 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | negative regulation of cAMP biosynthetic process | | IMP | | 7241269 | | RGD | | positive regulation of cAMP biosynthetic process | | IMP | | 7241269 | | RGD | | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Pathway AnnotationsGene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Bile secretion |
| Calcium signaling pathway | |
| Chemokine signaling pathway | |
| Cholinergic synapse | |
| Circadian entrainment | |
| Dilated cardiomyopathy | |
| Estrogen signaling pathway | |
| GABAergic synapse | |
| Gap junction | |
| Gastric acid secretion | |
| Glutamatergic synapse | |
| GnRH signaling pathway | |
| HTLV-I infection | |
| Insulin secretion | |
| Long-term potentiation | |
| Melanogenesis | |
| Morphine addiction | |
| Oocyte meiosis | |
| Ovarian steroidogenesis | |
| Pancreatic secretion | |
| Progesterone-mediated oocyte maturation | |
| Purine metabolism | |
| Retrograde endocannabinoid signaling | |
| Salivary secretion | |
| Taste transduction | |
| Vascular smooth muscle contraction | |
| Pathway Interaction Database | Endothelins (PID:200005) |
| LPA receptor mediated events (PID:200013) | |
| LPA4-mediated signaling events (PID:200047) | |
References - curated| 1. |
Cali JJ, etal., J Biol Chem 1994 Apr 22;269(16):12190-5. |
| 2. |
Clement N, etal., J Cell Physiol. 2006 Sep;208(3):495-505. |
| 3. |
Delmeire D, etal., Diabetologia. 2003 Oct;46(10):1383-93. Epub 2003 Sep 17. |
| 4. |
GOA data from the GO Consortium |
| 5. |
KEGG |
| 6. |
Macdougall DA, etal., J Biol Chem. 2009 Jun 5;284(23):15573-88. doi: 10.1074/jbc.M809585200. Epub 2009 Mar 21. |
| 7. |
MGD data from the GO Consortium |
| 8. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 9. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 10. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 11. |
RGD automated data pipeline |
| 12. |
RGD automated import pipeline for gene-chemical interactions |
| 13. |
Sadana R and Dessauer CW, Neurosignals. 2009;17(1):5-22. Epub 2008 Oct 24. |
| 14. |
Strazzabosco M, etal., Hepatology. 2009 Jul;50(1):244-52. |
| 15. |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
References - uncuratedRGD Disease Portals| Adcy8 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Adcy8 (Rattus norvegicus) |
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| ADCY8 (Homo sapiens) |
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| Adcy8 (Mus musculus) |
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Position Markers| AW060868 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_017142 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06051492 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06051493 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06051494 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06051495 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06051496 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06051497 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06051498 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06051499 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01051223 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01051224 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01051225 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01051226 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01051227 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01051228 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01051229 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01051230 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01051231 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01051232 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01051233 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01051234 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473950 | (Get FASTA) | Search GEO for Microarray Profiles | |
| L26986 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_017142 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_058838 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_058838 | (Get FASTA) |
| GenBank Protein | AAA20504 | (Get FASTA) |
| EDM16168 | (Get FASTA) | |
| EDM16169 | (Get FASTA) | |
| P40146 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000004890 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000006789 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000006789 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 29241 | ENTREZGENE |
| Gene3D-CATH | A/G_cyclase | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000004890 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 37443 | ENTREZGENE |
| InterPro | A/G_cyclase | UniProtKB/Swiss-Prot |
| A/G_cyclase_CS | UniProtKB/Swiss-Prot | |
| Aden_cycl-like | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:29241 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | DUF1053 | UniProtKB/Swiss-Prot |
| Guanylate_cyc | UniProtKB/Swiss-Prot | |
| PharmGKB | ADCY8 | RGD |
| PROSITE | GUANYLATE_CYCLASE_1 | UniProtKB/Swiss-Prot |
| GUANYLATE_CYCLASE_2 | UniProtKB/Swiss-Prot | |
| SMART | CYCc | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | A/G_cyclase | UniProtKB/Swiss-Prot |
| TIGR | TC207966 | |
| UniGene | Rn.10382 | ENTREZGENE |
| UniProt | ADCY8_RAT | UniProtKB/Swiss-Prot |
| G3V6N0_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-09-18 | Adcy8 | adenylate cyclase 8 (brain) | Adcy8 | adenylate cyclase 8 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2006-03-30 | Adcy8 | adenylate cyclase 8 | adenylyl cyclase 8 | Name updated | 10779 | APPROVED | |
| 2002-06-10 | Adcy8 | adenylyl cyclase 8 | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | expressed in several regions in brain | 69741 |
| gene_function | has adenylyl cyclase activity that is induced by intracellular calcium/calmodulin | 69741 |
| gene_process | may play a role in intracellular signaling and long term potentiation | 69741 |
| gene_regulation | activity is induced by calcuim/calmodulin | 69741 |
| gene_regulation | induction by calcium/calmodulin is enhanced by addition of Gs alpha | 69741 |
| gene_transcript | mRNA transcripts of 4.4 and 5.5 kB are detected | 69741 |
| More on Adcy8 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2036 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.