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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:731425 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GNAQ mRNA | CTD | PMID:22079256 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1550022 | 6480464 | Tetrachlorodibenzodioxin affects the expression of GNAQ mRNA | CTD | PMID:21570461 | 2-methylcholine | affects expression | ISO | RGD:731425 | 6480464 | beta-methylcholine affects the expression of GNAQ mRNA | CTD | PMID:21179406 | 2-nitrotoluene | decreases expression | EXP | | 6480464 | 2-nitrotoluene results in decreased expression of GNAQ mRNA | CTD | PMID:16460773 | 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine | increases response to substance | ISO | RGD:1550022 | 6480464 | GNAQ protein results in increased susceptibility to Puromycin Aminonucleoside | CTD | PMID:16267159 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:1550022 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GNAQ mRNA | CTD | PMID:20188158 | 4-hydroxynon-2-enal | increases expression | ISO | RGD:1550022 | 6480464 | 4-hydroxy-2-nonenal results in increased expression of GNAQ mRNA | CTD | PMID:19191707 | 4-vinylcyclohexene dioxide | affects expression | ISO | RGD:1550022 | 6480464 | 4-vinyl-1-cyclohexene dioxide affects the expression of GNAQ mRNA | CTD | PMID:20829426 | aflatoxin B1 | increases expression | ISO | RGD:1550022 | 6480464 | Aflatoxin B1 results in increased expression of GNAQ mRNA | CTD | PMID:19770486 | all-trans-retinoic acid | decreases expression | ISO | RGD:731425 | 6480464 | Tretinoin results in decreased expression of GNAQ mRNA | CTD | PMID:15498508 | aluminium atom | increases response to substance | ISO | RGD:1550022 | 6480464 | GNAQ protein results in increased susceptibility to Aluminum | CTD | PMID:15068510 | aluminium(0) | increases response to substance | ISO | RGD:1550022 | 6480464 | GNAQ protein results in increased susceptibility to Aluminum | CTD | PMID:15068510 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of GNAQ mRNA | CTD | PMID:16483693 | benzo[a]pyrene | decreases expression | ISO | RGD:1550022 | 6480464 | Benzo(a)pyrene results in decreased expression of GNAQ mRNA | CTD | PMID:19770486 PMID:21715664 | benzo[a]pyrene | decreases expression | ISO | RGD:1550022 | 6480464 | Benzo(a)pyrene results in decreased expression of GNAQ mRNA | CTD | PMID:21715664 PMID:19770486 | benzo[a]pyrene | multiple interactions | ISO | RGD:1550022 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of GNAQ mRNA | CTD | PMID:21715664 | benzo[a]pyrene | decreases expression | ISO | RGD:1550022 | 6480464 | Benzo(a)pyrene results in decreased expression of GNAQ mRNA | CTD | PMID:21715664 | bromochloroacetic acid | decreases expression | EXP | | 6480464 | bromochloroacetic acid results in decreased expression of GNAQ mRNA | CTD | PMID:16460773 | caffeine | decreases expression | EXP | | 6480464 | Caffeine results in decreased expression of GNAQ protein | CTD | PMID:15998294 | chlorpyrifos | increases expression | ISO | RGD:1550022 | 6480464 | Chlorpyrifos results in increased expression of GNAQ mRNA | CTD | PMID:20350560 | cobalt dichloride | decreases expression | ISO | RGD:731425 | 6480464 | cobaltous chloride results in decreased expression of GNAQ mRNA | CTD | PMID:19320972 | coumestrol | decreases expression | ISO | RGD:731425 | 6480464 | Coumestrol results in decreased expression of GNAQ mRNA | CTD | PMID:19167446 | cyclosporin A | increases expression | ISO | RGD:1550022 | 6480464 | Cyclosporine results in increased expression of GNAQ mRNA | CTD | PMID:19770486 | diazinon | decreases expression | EXP | | 6480464 | Diazinon results in decreased expression of GNAQ mRNA | CTD | PMID:17452286 | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of GNAQ mRNA | CTD | PMID:20655511 | fluoxetine | increases expression | EXP | | 6480464 | Fluoxetine results in increased expression of GNAQ mRNA | CTD | PMID:1426031 | gadolinium atom | increases response to substance | ISO | RGD:1550022 | 6480464 | GNAQ protein results in increased susceptibility to Gadolinium | CTD | PMID:15068510 | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | RGD:1550022 | 6480464 | Ethylnitrosourea results in increased mutagenesis of GNAQ gene | CTD | PMID:16724327 | phenobarbital | decreases expression | ISO | RGD:1550022 | 6480464 | Phenobarbital results in decreased expression of GNAQ mRNA | CTD | PMID:23091169 | phenylephrine | multiple interactions | EXP | | 6480464 | tyrphostin AG 1478 inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; more ... | CTD | PMID:14676212 | strontium atom | increases response to substance | ISO | RGD:1550022 | 6480464 | GNAQ protein results in increased susceptibility to Strontium | CTD | PMID:15068510 | tamibarotene | affects expression | ISO | RGD:731425 | 6480464 | Am 80 affects the expression of GNAQ mRNA; more ... | CTD | PMID:15498508 | theophylline | decreases expression | EXP | | 6480464 | Theophylline results in decreased expression of GNAQ protein | CTD | PMID:15998294 | UTP | multiple interactions | EXP | | 6480464 | Uridine Triphosphate inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]] | CTD | PMID:14676212 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | African trypanosomiasis |
| Alzheimer's disease | |
| Amoebiasis | |
| Calcium signaling pathway | |
| Chagas disease (American trypanosomiasis) | |
| Cholinergic synapse | |
| Circadian entrainment | |
| Dopaminergic synapse | |
| Endocrine and other factor-regulated calcium reabsorption | |
| Gap junction | |
| Gastric acid secretion | |
| Glutamatergic synapse | |
| GnRH signaling pathway | |
| Huntington's disease | |
| Insulin secretion | |
| Long-term depression | |
| Long-term potentiation | |
| Melanogenesis | |
| Pancreatic secretion | |
| Retrograde endocannabinoid signaling | |
| Salivary secretion | |
| Serotonergic synapse | |
| Vascular smooth muscle contraction | |
| Pathway Interaction Database | Arf6 signaling events (PID:200073) |
| Endothelins (PID:200005) | |
| LPA receptor mediated events (PID:200013) | |
| PAR1-mediated thrombin signaling events (PID:200189) | |
| PAR4-mediated thrombin signaling events (PID:200110) | |
| Plasma membrane estrogen receptor signaling (PID:200034) | |
| S1P2 pathway (PID:200211) | |
| S1P3 pathway (PID:200046) | |
| Sphingosine 1-phosphate (S1P) pathway (PID:200123) | |
| Thromboxane A2 receptor signaling (PID:200082) | |
References - curated| 1. |
Bangasser DA, etal., Mol Psychiatry. 2010 Sep;15(9):877, 896-904. Epub 2010 Jun 15. |
| 2. |
Carrasco GA, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):1012-9. Epub 2003 Oct 8. |
| 3. |
Carrasco GA, etal., J Pharmacol Exp Ther. 2004 Oct;311(1):349-55. Epub 2004 Jun 2. |
| 4. |
GOA data from the GO Consortium |
| 5. |
Haley JE, etal., J Neurosci. 1998 Jun 15;18(12):4521-31. |
| 6. |
Holmes CL, etal., Crit Care. 2003 Dec;7(6):427-34. Epub 2003 Jun 26. |
| 7. |
Howes AL, etal., J Biol Chem 2003 Oct 10;278(41):40343-51. Epub 2003 Aug 4. |
| 8. |
Howes AL, etal., J Mol Cell Cardiol. 2006 May;40(5):597-604. Epub 2006 Feb 8. |
| 9. |
Hunyady L and Catt KJ, Mol Endocrinol. 2006 May;20(5):953-70. Epub 2005 Sep 1. |
| 10. |
Mannoury La Cour C, etal., Synapse. 2009 Feb;63(2):95-105. |
| 11. |
Mende U, etal., Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13893-8. |
| 12. |
MGD data from the GO Consortium |
| 13. |
Morris JB, etal., J Mol Cell Cardiol. 2006 Jul;41(1):17-25. Epub 2006 May 30. |
| 14. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 15. |
Offermanns S, etal., EMBO J 1998 Aug 3;17(15):4304-12. |
| 16. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 17. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 18. |
Rahman MA, etal., Philos Trans R Soc Lond B Biol Sci. 1999 Feb 28;354(1381):379-86. |
| 19. |
RGD automated data pipeline |
| 20. |
RGD automated import pipeline for gene-chemical interactions |
| 21. |
Rhee SG Annu Rev Biochem. 2001;70:281-312. |
| 22. |
Saitoh O, etal., Proc Natl Acad Sci U S A 2002 Jul 23;99(15):10138-43. |
| 23. |
Takashima N, etal., Genes Cells. 2006 Sep;11(9):1039-49. |
| 24. |
Tall GG, etal., J Biol Chem 2003 Mar 7;278(10):8356-62. |
| 25. |
Tanski WJ, etal., J Vasc Surg. 2004 Mar;39(3):639-44. |
| 26. |
Ushio-Fukai M, etal., J Biol Chem. 1998 Jul 31;273(31):19772-7. |
| 27. |
Zhu Y, etal., J Pharmacol Sci. 2003 Jul;92(3):259-66. |
References - uncurated| PubMed | 1299289 |
| 1333286 | |
| 15574748 | |
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| 16380388 | |
| 17166350 | |
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| 18208547 | |
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| 18480127 | |
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| 18665079 | |
| 18712054 | |
| 18820027 | |
| 18952607 | |
| 18987636 | |
| 19095737 | |
| 19879871 | |
| 20036247 | |
| 20194499 | |
| 20393598 | |
| 20691780 | |
| 21124736 | |
| 21463572 | |
| 21464134 | |
| 22672634 | |
| 23161540 |
RGD Disease Portals| Gnaq has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Gnaq (Rattus norvegicus) |
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| GNAQ (Homo sapiens) |
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| Gnaq (Mus musculus) |
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Position Markers| D1Rat117 |
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| BM387879 |
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| UniSTS:496675 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_031036 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06010031 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06010032 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009728 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009729 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009730 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009731 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009732 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009733 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009734 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009735 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009736 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009737 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009738 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009739 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF234260 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473953 | (Get FASTA) | Search GEO for Microarray Profiles | |
| DQ120477 | (Get FASTA) | Search GEO for Microarray Profiles | |
| DQ120478 | (Get FASTA) | Search GEO for Microarray Profiles | |
| L37294 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_031036 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_112298 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_112298 | (Get FASTA) |
| GenBank Protein | AAB02848 | (Get FASTA) |
| AAF59930 | (Get FASTA) | |
| AAZ23816 | (Get FASTA) | |
| AAZ23817 | (Get FASTA) | |
| EDM12961 | (Get FASTA) | |
| EDM12962 | (Get FASTA) | |
| P82471 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000014183 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000019174 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000019174 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 81666 | ENTREZGENE |
| Gene3D-CATH | GproteinA_insert | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000014183 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 1566 | ENTREZGENE |
| InterPro | Gprotein_alpha_Q | UniProtKB/Swiss-Prot |
| Gprotein_alpha_su | UniProtKB/Swiss-Prot | |
| GproteinA_insert | UniProtKB/Swiss-Prot | |
| IPI | IPI00230868 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:81666 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | Gprotein_alph_bd | UniProtKB/Swiss-Prot |
| Pfam | G-alpha | UniProtKB/Swiss-Prot |
| PRINTS | GPROTEINA | UniProtKB/Swiss-Prot |
| GPROTEINAQ | UniProtKB/Swiss-Prot | |
| SMART | G_alpha | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Transducn_insert | UniProtKB/Swiss-Prot |
| UniGene | Rn.22817 | ENTREZGENE |
| UniProt | D4AE68_RAT | UniProtKB/TrEMBL |
| GNAQ_RAT | UniProtKB/Swiss-Prot | |
| Q45QM4_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2011-04-29 | Gnaq | guanine nucleotide binding protein (G protein), q polypeptide | Gnaq | guanine nucleotide binding protein, alpha q polypeptide | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2005-01-20 | Gnaq | guanine nucleotide binding protein, alpha q polypeptide | heterotrimeric guanine nucleotide-binding protein alpha q subunit | Name updated | 10779 | APPROVED | |
| 2002-08-07 | Gnaq | heterotrimeric guanine nucleotide-binding protein alpha q subunit | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on Gnaq | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 620770 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.