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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | affects expression | ISO | RGD:737548 | 6480464 | Ethinyl Estradiol affects the expression of EDN2 mRNA | CTD | PMID:20170705 | 17alpha-ethynylestradiol | decreases expression | ISO | RGD:737548 | 6480464 | Ethinyl Estradiol results in decreased expression of EDN2 mRNA | CTD | PMID:18936297 | 17beta-estradiol | increases expression | ISO | RGD:737548 | 6480464 | Estradiol results in increased expression of EDN2 mRNA | CTD | PMID:19153601 | 17beta-estradiol | decreases expression | ISO | RGD:737548 | 6480464 | Estradiol results in decreased expression of EDN2 mRNA | CTD | PMID:20106945 | all-trans-retinoic acid | increases expression | ISO | RGD:737548 | 6480464 | Tretinoin results in increased expression of EDN2 mRNA | CTD | PMID:15498508 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of EDN2 mRNA | CTD | PMID:16483693 | arsenic atom | increases expression | ISO | RGD:737548 | 6480464 | Arsenic results in increased expression of EDN2 mRNA | CTD | PMID:11134558 | benzo[a]pyrene | multiple interactions | ISO | RGD:737549 | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to EDN2 promoter] | CTD | PMID:19654925 | bisphenol A | affects expression | ISO | RGD:737548 | 6480464 | bisphenol A affects the expression of EDN2 mRNA | CTD | PMID:20170705 | cadmium dichloride | increases expression | ISO | RGD:737548 | 6480464 | Cadmium Chloride results in increased expression of EDN2 mRNA | CTD | PMID:12160620 | calcium atom | increases uptake | ISO | RGD:737549 | 6480464 | EDN2 protein results in increased uptake of Calcium | CTD | PMID:11425647 | calcium atom | multiple interactions | ISO | RGD:737549 | 6480464 | EDN2 protein affects the localization of and affects the abundance of Calcium | CTD | PMID:11425647 | calcium(0) | increases uptake | ISO | RGD:737549 | 6480464 | EDN2 protein results in increased uptake of Calcium | CTD | PMID:11425647 | calcium(0) | multiple interactions | ISO | RGD:737549 | 6480464 | EDN2 protein affects the localization of and affects the abundance of Calcium | CTD | PMID:11425647 | cisplatin | multiple interactions | ISO | RGD:737548 | 6480464 | Folic Acid affects the reaction [Cisplatin affects the expression of EDN2 mRNA] | CTD | PMID:16898872 | cobalt atom | multiple interactions | ISO | RGD:737548 | 6480464 | [tungsten carbide binds to Cobalt] which results in increased expression of EDN2 mRNA | CTD | PMID:20105288 | cobalt dichloride | increases expression | ISO | RGD:737548 | 6480464 | cobaltous chloride results in increased expression of EDN2 mRNA | CTD | PMID:20105288 | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of EDN2 mRNA | CTD | PMID:15948191 | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of EDN2 mRNA | CTD | PMID:15948191 | corticosterone | increases secretion | EXP | | 6480464 | EDN2 results in increased secretion of Corticosterone | CTD | PMID:1659878 | cyclosporin A | decreases expression | ISO | RGD:737548 | 6480464 | Cyclosporine results in decreased expression of EDN2 mRNA | CTD | PMID:20106945 | dextran sulfate | increases expression | ISO | RGD:737549 | 6480464 | Dextran Sulfate results in increased expression of EDN2 protein | CTD | PMID:16216902 | dimethyl sulfoxide | decreases expression | ISO | RGD:737548 | 6480464 | Dimethyl Sulfoxide results in decreased expression of EDN2 mRNA | CTD | PMID:15619356 | ethanol | increases expression | ISO | RGD:737549 | 6480464 | Ethanol results in increased expression of EDN2 mRNA | CTD | PMID:12193144 | folic acid | multiple interactions | ISO | RGD:737548 | 6480464 | Folic Acid affects the reaction [Cisplatin affects the expression of EDN2 mRNA] | CTD | PMID:16898872 | genistein | decreases expression | ISO | RGD:737548 | 6480464 | Genistein results in decreased expression of EDN2 mRNA | CTD | PMID:16399490 | naphthalene | decreases expression | ISO | RGD:737549 | 6480464 | naphthalene results in decreased expression of EDN2 mRNA | CTD | PMID:18757308 | nickel dichloride | increases expression | ISO | RGD:737548 | 6480464 | nickel chloride results in increased expression of EDN2 mRNA | CTD | PMID:21455298 | paracetamol | affects expression | ISO | RGD:737549 | 6480464 | Acetaminophen affects the expression of EDN2 mRNA | CTD | PMID:17562736 | pirinixic acid | decreases expression | ISO | RGD:737549 | 6480464 | pirinixic acid results in decreased expression of EDN2 mRNA | CTD | PMID:17426115 | tamibarotene | increases expression | ISO | RGD:737548 | 6480464 | Am 80 results in increased expression of EDN2 mRNA; more ... | CTD | PMID:15498508 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of EDN2 mRNA | CTD | PMID:16644059 | ursodeoxycholic acid | decreases expression | ISO | RGD:737548 | 6480464 | Ursodeoxycholic Acid results in decreased expression of EDN2 protein | CTD | PMID:15691296 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Neuroactive ligand-receptor interaction |
| Vascular smooth muscle contraction | |
| Pathway Interaction Database | Direct p53 effectors (PID:200120) |
| Endothelins (PID:200005) | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Neuroactive ligand-receptor interaction |
| Vascular smooth muscle contraction | |
| Pathway Interaction Database | Direct p53 effectors (PID:200120) |
| Endothelins (PID:200005) | |
References - curated| 1. |
Bloch KD, etal., Genomics 1991 May;10(1):236-42. |
| 2. |
Brown MJ, etal., J Cardiovasc Pharmacol. 2000;35(4 Suppl 2):S41-43. |
| 3. |
Brunner F, etal., J Mol Cell Cardiol. 1992 Nov;24(11):1291-305. |
| 4. |
Chon H, etal., Hypertension. 2004 May;43(5):947-51. Epub 2004 Mar 8. |
| 5. |
de la Monte SM, etal., J Histochem Cytochem. 1995 Feb;43(2):203-9. |
| 6. |
Deng AY Mamm Genome 1997 Feb;8(2):157. |
| 7. |
Deng AY, etal., J Clin Invest 1994 Jun;93(6):2701-9 |
| 8. |
Dlugosz JW, etal., Rocz Akad Med Bialymst. 2004;49:85-92. |
| 9. |
Gardiner SM, etal., Br J Pharmacol. 1992 Oct;107(2):584-90. |
| 10. |
Garrett MR, etal., Genome Res 1998 Jul;8(7):711-23 |
| 11. |
GOA data from the GO Consortium |
| 12. |
Guimaraes CL, etal., Hypertension. 1992 Feb;19(2 Suppl):II79-86. |
| 13. |
Kakinuma Y, etal., Life Sci. 1999;65(16):1671-83. |
| 14. |
Kim D Circ Res. 1991 Jul;69(1):250-5. |
| 15. |
Ko C, etal., Endocrinology. 2006 Apr;147(4):1770-9. Epub 2006 Jan 12. |
| 16. |
Leszczynska-Gorzelak B, etal., Gynecol Obstet Invest. 1997;43(1):37-40. |
| 17. |
Mattera GG, etal., Br J Pharmacol. 1993 Sep;110(1):331-7. |
| 18. |
Mazzocchi G, etal., Endocrinology. 1997 Jun;138(6):2333-7. |
| 19. |
MGD data from the GO Consortium |
| 20. |
Mutafova-Yambolieva VN and Westfall DP, Br J Pharmacol. 1998 Jan;123(1):136-42. |
| 21. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 22. |
Oishi K, etal., J Physiol. 2002 Apr 1;540(Pt 1):139-52. |
| 23. |
Oishi K, etal., Jpn J Pharmacol. 2002 Sep;90(1):36-50. |
| 24. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 25. |
Plusczyk T, etal., Dig Dis Sci. 2001 Jun;46(6):1343-51. |
| 26. |
RGD automated data pipeline |
| 27. |
RGD automated import pipeline for gene-chemical interactions |
| 28. |
Salomon P, etal., Pol Merkuriusz Lek. 1999 Sep;7(39):111-3. |
| 29. |
Samson WK and Skala KD, Endocrinology. 1992 May;130(5):2964-70. |
| 30. |
Schroeder AC, etal., Hypertension. 2000 Jan;35(1 Pt 2):280-6. |
| 31. |
Sharma P, etal., J Hypertens. 1999 Sep;17(9):1281-7. |
| 32. |
Sullivan AM and Morton AJ, J Neurochem. 1996 Oct;67(4):1409-18. |
| 33. |
Wagner A, etal., Resuscitation. 2002 Apr;53(1):71-6. |
| 34. |
Watanabe T, etal., Circ Res. 1991 Aug;69(2):370-7. |
References - uncuratedRGD Disease Portals| Edn2 has been annotated in the following RGD Disease Portals. |
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Candidate Gene StatusComparative Map Data| Edn2 (Rattus norvegicus) |
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| EDN2 (Homo sapiens) |
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| Edn2 (Mus musculus) |
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Position Markers| D5Mco19 |
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| D5Mit19 |
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| D5Rat55 |
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| D5Rat86 |
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| RH142434 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_012549 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06039695 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01039475 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473968 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U02091 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U59510 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U64946 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U64947 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U64948 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U64949 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_012549 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_036681 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
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Protein Sequences| Protein RefSeqs | NP_036681 | (Get FASTA) |
| GenBank Protein | AAB39213 | (Get FASTA) |
| EDL80332 | (Get FASTA) | |
| P23943 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000009390 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000012569 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000012569 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 24324 | ENTREZGENE |
| Germonline | ENSRNOG00000009390 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 1477 | ENTREZGENE |
| InterPro | Bibrotoxin/Sarafotoxin-D | UniProtKB/Swiss-Prot |
| Endothelin_toxin_CS | UniProtKB/Swiss-Prot | |
| Endothln_like_toxin | UniProtKB/Swiss-Prot | |
| ET-2 | UniProtKB/Swiss-Prot | |
| IPI | IPI00215502 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:24324 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | ET-2 | UniProtKB/Swiss-Prot |
| Pfam | Endothelin | UniProtKB/Swiss-Prot |
| PRINTS | ENDOTHELIN | UniProtKB/Swiss-Prot |
| PROSITE | ENDOTHELIN | UniProtKB/Swiss-Prot |
| SMART | END | UniProtKB/Swiss-Prot |
| UniGene | Rn.10642 | ENTREZGENE |
| UniProt | EDN2_RAT | UniProtKB/Swiss-Prot |
| G3V771_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2002-06-10 | Edn2 | Endothelin isopeptide 2 | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | mRNA expressed in pituitary and medulla oblongata | 734466 |
| More on Edn2 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2533 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.