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Gene Ontology AnnotationsGene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | activation of adenylate cyclase activity | | ISO | RGD:69021 | 1624291 | MGI:MGI:2450485|PMID:12488442 | RGD | MGI:MGI:2450485 PMID:12488442 | adenylate cyclase-activating dopamine receptor signaling pathway | | ISO | RGD:69021 | 1624291 | MGI:MGI:95777|MGI:MGI:99578 | RGD | MGI:MGI:3701153 PMID:17194762 | adenylate cyclase-activating dopamine receptor signaling pathway | | IBA | PANTHER:PTN000026754 | 1600115 | GO_REF:0000033 | RefGenome | GO_REF:0000033 | adenylate cyclase-activating G-protein coupled receptor signaling pathway | | TAS | | 728578 | | RGD | | adenylate cyclase-activating G-protein coupled receptor signaling pathway | | ISO | RGD:69021 | 1624291 | MGI:MGI:78329|PMID:2499043 | RGD | MGI:MGI:78329 PMID:2499043 | cAMP biosynthetic process | | IBA | PANTHER:PTN000026758 | 1600115 | GO_REF:0000033 | GOC | GO_REF:0000033 | G-protein coupled receptor signaling pathway | | IEA | InterPro:IPR000367|InterPro:IPR001019 | 1600115 | GO_REF:0000002 | InterPro | GO_REF:0000002 | response to amphetamine | | ISO | RGD:69021 | 1624291 | MGI:MGI:2151207 | RGD | MGI:MGI:3719553 PMID:11404425 | response to caffeine | | ISO | RGD:69021 | 1624291 | MGI:MGI:2151207 | RGD | MGI:MGI:3719553 PMID:11404425 | sensory perception of smell | | ISO | RGD:69021 | 1624291 | MGI:MGI:2151207 | RGD | MGI:MGI:1195583 PMID:9459443 | sensory perception of smell | | IBA | PANTHER:PTN000026758 | 1600115 | GO_REF:0000033 | RefGenome | GO_REF:0000033 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Amoebiasis |
| Calcium signaling pathway | |
| Chagas disease (American trypanosomiasis) | |
| Dopaminergic synapse | |
| Olfactory transduction | |
| Pathway Interaction Database | Endothelins (PID:200005) |
| LPA4-mediated signaling events (PID:200047) | |
| Plasma membrane estrogen receptor signaling (PID:200034) | |
| Rapid glucocorticoid signaling (PID:200106) | |
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Amoebiasis |
| Calcium signaling pathway | |
| Chagas disease (American trypanosomiasis) | |
| Dopaminergic synapse | |
| Olfactory transduction | |
| Pathway Interaction Database | Endothelins (PID:200005) |
| LPA4-mediated signaling events (PID:200047) | |
| Plasma membrane estrogen receptor signaling (PID:200034) | |
| Rapid glucocorticoid signaling (PID:200106) | |
References - curated| 1. |
GOA data from the GO Consortium |
| 2. |
Herve D, etal., Brain Res Mol Brain Res 1995 Aug;32(1):125-34. |
| 3. |
Lelianova VG, etal., J Biol Chem 1997 Aug 22;272(34):21504-8. |
| 4. |
MGD data from the GO Consortium |
| 5. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 6. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 7. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 8. |
RGD automated data pipeline |
| 9. |
RGD automated import pipeline for gene-chemical interactions |
| 10. |
Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34 |
References - uncuratedRGD Disease Portals| Gnal has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Gnal (Rattus norvegicus) |
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| GNAL (Homo sapiens) |
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| Gnal (Mus musculus) |
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Position Markers| D18Wox11 |
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| D18Mit17 |
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| D18Rat89 |
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| D18Arb5 |
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| RH129239 |
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| RH129499 |
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| RH144614 |
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| BF417987 |
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| UniSTS:237833 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001191836 | (Get FASTA) | Search GEO for Microarray Profiles |
| XM_001060758 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06095622 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06095623 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06095624 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06095625 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095653 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095654 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095655 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473971 | (Get FASTA) | Search GEO for Microarray Profiles | |
| S80330 | (Get FASTA) | Search GEO for Microarray Profiles | |
| S80376 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | XM_001060701 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
| Position: |
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| RefSeq Acc Id: | XM_001060758 |
| RefSeq Status: | |
| Type: | CODING |
| Protein Acc Id: | XP_001060758 |
| Peptide Label: | isoform 2 |
| Position: | No map positions available. |
| RefSeq Acc Id: | XM_341626 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
| Position: |
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| RefSeq Acc Id: | XM_002728555 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001191836 | ||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||
| Type: | CODING | ||||||||||
| Protein Acc Id: | NP_001178765 | ||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001178765 | (Get FASTA) |
| XP_001060758 | (Get FASTA) | |
| GenBank Protein | AAP32222 | (Get FASTA) |
| AAP32223 | (Get FASTA) | |
| EDM14716 | (Get FASTA) | |
| P38406 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000010440 | UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000025172 | UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000025172 | UniProtKB/TrEMBL |
| Entrez Gene | 24611 | ENTREZGENE |
| Gene3D-CATH | GproteinA_insert | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000010440 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 68222 | ENTREZGENE |
| InterPro | Gprotein_alpha_S | UniProtKB/Swiss-Prot |
| Gprotein_alpha_su | UniProtKB/Swiss-Prot | |
| GproteinA_insert | UniProtKB/Swiss-Prot | |
| IPI | IPI00210346 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:24611 | ENTREZGENE, UniProtKB/TrEMBL |
| PANTHER | Gprotein_alph_bd | UniProtKB/Swiss-Prot |
| Pfam | G-alpha | UniProtKB/Swiss-Prot |
| PRINTS | GPROTEINA | UniProtKB/Swiss-Prot |
| GPROTEINAS | UniProtKB/Swiss-Prot | |
| SMART | G_alpha | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Transducn_insert | UniProtKB/Swiss-Prot |
| UniGene | Rn.203753 | ENTREZGENE |
| Rn.215691 | ENTREZGENE | |
| UniProt | G3V8E8_RAT | UniProtKB/TrEMBL |
| GNAL_RAT | UniProtKB/Swiss-Prot | |
| Q80WZ0_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2009-01-07 | Gnal | guanine nucleotide binding protein, alpha stimulating, olfactory type | RGD1305940 | similar to RIKEN cDNA 9630020G10 gene | Data Merged | 9333 | APPROVED |
| 2008-04-30 | RGD1305940 | similar to RIKEN cDNA 9630020G10 gene | RGD1305940_predicted | similar to RIKEN cDNA 9630020G10 gene (predicted) | 'predicted' is removed | 24709 | APPROVED |
| 2005-01-20 | RGD1305940_predicted | similar to RIKEN cDNA 9630020G10 gene (predicted) | LOC361343_predicted | Symbol and Name status set to approved | 12407 | APPROVED | |
| 2005-01-20 | Gnal | guanine nucleotide binding protein, alpha stimulating, olfactory type | Symbol and Name status set to approved | 10779 | APPROVED | ||
| 2005-01-12 | LOC361343_predicted | similar to RIKEN cDNA 9630020G10 gene (predicted) | Symbol and Name status set to provisional | 1724 | PROVISIONAL | ||
| 2002-06-10 | Gnal | guanine nucleotide binding protein, alpha stimulating, olfactory type | Name updated | 1489 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | expressed primarily in brain tissue, olfactory neurons but not in liver, eye, kidney or testis | 61489 |
| gene_process | activates adenylate cyclase |
| More on Gnal | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2715 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.