Edn3 (endothelin 3) - Rat Genome Database

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Gene: Edn3 (endothelin 3) Rattus norvegicus
Analyze
Symbol: Edn3
Name: endothelin 3
RGD ID: 2534
Description: Predicted to enable endothelin B receptor binding activity and hormone activity. Involved in negative regulation of hormone secretion and regulation of neurotransmitter secretion. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Waardenburg syndrome; and Waardenburg syndrome type 4B. Orthologous to human EDN3 (endothelin 3); PARTICIPATES IN endothelin signaling pathway; INTERACTS WITH (R)-noradrenaline; 3',5'-cyclic GMP; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: edn3_mapped; endothelin 3 (mapped); endothelin-3; ET-3; Et3; LOC502697; PPET3; preproendothelin-3; preproET-3; RGD1564825; similar to prepro-endothelin-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SS.SR-(D3Mco19-D3Mco5)/Jr  
QTLs:   Cm14   Bp167  
Candidate Gene For: Bp167
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83183,980,458 - 184,004,958 (+)NCBIGRCr8
mRatBN7.23163,562,307 - 163,586,636 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3163,562,520 - 163,585,093 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3167,361,313 - 167,383,973 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03175,856,634 - 175,879,291 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03173,602,123 - 173,624,707 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03172,856,730 - 172,879,276 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,856,733 - 172,880,450 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03178,903,017 - 178,925,563 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43166,491,368 - 166,514,051 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3162,730,251 - 162,752,801 (+)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3',5'-cyclic GMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7-NITROINDAZOLE  (EXP)
8-bromo-3',5'-cyclic GMP  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bosentan  (EXP)
BQ 123  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
carbamazepine  (ISO)
carbon atom  (EXP)
chlordecone  (ISO)
corticosterone  (EXP)
Cuprizon  (EXP)
D-glucose  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diiodine  (ISO)
domitroban  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental carbon  (EXP)
glucose  (EXP)
hydrogencarbonate  (EXP)
hydroxyurea  (ISO)
KT 5823  (EXP)
L-ascorbic acid  (ISO)
lead(0)  (EXP)
lipopolysaccharide  (ISO)
methamphetamine  (EXP,ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-ethyl-N-nitrosourea  (ISO)
nitroprusside  (EXP)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
picrotoxin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propanal  (ISO)
quartz  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
trichloroethene  (EXP)
U-73122  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Endothelin-3 gene mutations in isolated and syndromic Hirschsprung disease. Bidaud C, etal., Eur J Hum Genet. 1997 Jul-Aug;5(4):247-51.
2. Endothelin-3 frameshift mutation in congenital central hypoventilation syndrome. Bolk S, etal., Nat Genet. 1996 Aug;13(4):395-6.
3. Endothelin-1 and -3 diminish neuronal NE release through an NO mechanism in rat anterior hypothalamus. Di Nunzio AS, etal., Am J Physiol Regul Integr Comp Physiol 2002 Sep;283(3):R615-22.
4. Mutation of the endothelin-3 gene in the Waardenburg-Hirschsprung disease (Shah-Waardenburg syndrome). Edery P, etal., Nat Genet. 1996 Apr;12(4):442-4.
5. Inhibition by phosphoramidon of the regional haemodynamic effects of proendothelin-2 and -3 in conscious rats. Gardiner SM, etal., Br J Pharmacol. 1992 Oct;107(2):584-90.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Potent constrictor actions of endothelin-1, endothelin-2, and endothelin-3 in rat isolated portal vein. Guimaraes CL, etal., Hypertension. 1992 Feb;19(2 Suppl):II79-86.
8. Endothelin activation of an inwardly rectifying K+ current in atrial cells. Kim D Circ Res. 1991 Jul;69(1):250-5.
9. Comparison of the cardiovascular and neural activity of endothelin-1, -2, -3 and respective proendothelins: effects of phosphoramidon and thiorphan. Mattera GG, etal., Br J Pharmacol. 1993 Sep;110(1):331-7.
10. Endothelins stimulate deoxyribonucleic acid synthesis and cell proliferation in rat adrenal zona glomerulosa, acting through an endothelin A receptor coupled with protein kinase C- and tyrosine kinase-dependent signaling pathways. Mazzocchi G, etal., Endocrinology. 1997 Jun;138(6):2333-7.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. Differential effects of ET-1, ET-2, and ET-3 on pancreatic microcirculation, tissue integrity, and inflammation. Plusczyk T, etal., Dig Dis Sci. 2001 Jun;46(6):1343-51.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. Comparison of the pituitary effects of the mammalian endothelins: vasoactive intestinal contractor (endothelin-beta, rat endothelin-2) is a potent inhibitor of prolactin secretion. Samson WK and Skala KD, Endocrinology. 1992 May;130(5):2964-70.
19. Cloning and expression of rat preproendothelin-3 cDNA. Shiba R, etal., Biochem Biophys Res Commun. 1992 Jul 15;186(1):588-94.
20. Endothelins induce Fos expression in neurons and glia in organotypic cultures of rat cerebellum. Sullivan AM and Morton AJ, J Neurochem. 1996 Oct;67(4):1409-18.
21. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
22. Contribution of endogenous endothelin to the extension of myocardial infarct size in rats. Watanabe T, etal., Circ Res. 1991 Aug;69(2):370-7.
Additional References at PubMed
PMID:1299957   PMID:1713452   PMID:1917960   PMID:2649896   PMID:3045827   PMID:8982507   PMID:9012511   PMID:9624616   PMID:9696419   PMID:10770212   PMID:11401406   PMID:12234805  
PMID:14138974   PMID:15093706   PMID:15344879   PMID:15629454   PMID:15691296   PMID:15949640   PMID:16023617   PMID:16287488   PMID:18682267   PMID:18771698   PMID:18850267   PMID:19544475  
PMID:22897442   PMID:23122227   PMID:23370722   PMID:24040226  


Genomics

Comparative Map Data
Edn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83183,980,458 - 184,004,958 (+)NCBIGRCr8
mRatBN7.23163,562,307 - 163,586,636 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3163,562,520 - 163,585,093 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3167,361,313 - 167,383,973 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03175,856,634 - 175,879,291 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03173,602,123 - 173,624,707 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03172,856,730 - 172,879,276 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,856,733 - 172,880,450 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03178,903,017 - 178,925,563 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43166,491,368 - 166,514,051 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3162,730,251 - 162,752,801 (+)NCBICelera
Cytogenetic Map3q43NCBI
EDN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382059,300,611 - 59,325,992 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2059,300,443 - 59,325,992 (+)EnsemblGRCh38hg38GRCh38
GRCh372057,875,666 - 57,901,047 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362057,308,894 - 57,334,442 (+)NCBINCBI36Build 36hg18NCBI36
Build 342057,308,893 - 57,334,441NCBI
Celera2054,616,141 - 54,641,690 (+)NCBICelera
Cytogenetic Map20q13.32NCBI
HuRef2054,662,632 - 54,688,190 (+)NCBIHuRef
CHM1_12057,776,830 - 57,802,379 (+)NCBICHM1_1
T2T-CHM13v2.02061,083,933 - 61,109,315 (+)NCBIT2T-CHM13v2.0
Edn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392174,602,412 - 174,625,835 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2174,602,412 - 174,625,835 (+)EnsemblGRCm39 Ensembl
GRCm382174,760,619 - 174,784,042 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2174,760,619 - 174,784,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv372174,586,274 - 174,609,543 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362174,403,712 - 174,426,981 (+)NCBIMGSCv36mm8
Celera2180,720,524 - 180,743,869 (+)NCBICelera
Cytogenetic Map2H4NCBI
cM Map298.1NCBI
Edn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955445215,859 - 237,760 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955445215,910 - 238,153 (-)NCBIChiLan1.0ChiLan1.0
EDN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22165,065,183 - 65,090,932 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12065,058,300 - 65,084,054 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02055,652,770 - 55,678,486 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12057,012,926 - 57,038,570 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2057,012,926 - 57,038,570 (+)Ensemblpanpan1.1panPan2
EDN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12444,024,553 - 44,054,727 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2444,033,419 - 44,054,050 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2443,279,240 - 43,297,953 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02444,892,278 - 44,922,442 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2444,901,164 - 44,921,767 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12444,002,694 - 44,021,373 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02444,121,425 - 44,140,136 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02444,781,653 - 44,800,349 (+)NCBIUU_Cfam_GSD_1.0
Edn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640181,539,619 - 181,562,016 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365301,744,199 - 1,765,027 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365301,744,216 - 1,766,602 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1759,425,495 - 59,448,362 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11759,418,667 - 59,448,382 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21766,846,562 - 66,867,781 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EDN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.124,814,447 - 4,839,950 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl24,814,140 - 4,839,626 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605052,860,201 - 52,885,678 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Edn3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474125,658,726 - 25,680,763 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Edn3
82 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:79
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000009826
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat

Markers in Region
D3Mco3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23163,577,121 - 163,577,474 (+)MAPPERmRatBN7.2
Rnor_6.03172,871,332 - 172,871,684NCBIRnor6.0
Rnor_5.03178,917,619 - 178,917,971UniSTSRnor5.0
RGSC_v3.43166,505,970 - 166,506,322UniSTSRGSC3.4
RGSC_v3.13166,412,006 - 166,412,358RGD
Celera3162,744,853 - 162,745,205UniSTS
RH 3.4 Map31496.8RGD
RH 3.4 Map31496.8UniSTS
Cytogenetic Map3q43UniSTS
D3Mgh10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23159,898,684 - 159,898,795 (+)MAPPERmRatBN7.2
Rnor_6.03168,732,722 - 168,732,832NCBIRnor6.0
Rnor_5.03174,828,750 - 174,828,860UniSTSRnor5.0
RGSC_v3.43161,985,069 - 161,985,179RGDRGSC3.4
RGSC_v3.43161,985,070 - 161,985,180UniSTSRGSC3.4
RGSC_v3.13161,891,105 - 161,891,215RGD
Celera3159,112,002 - 159,112,112UniSTS
RH 3.4 Map31488.7UniSTS
RH 3.4 Map31488.7RGD
SHRSP x BN Map386.5599UniSTS
SHRSP x BN Map386.5599RGD
Cytogenetic Map3q43UniSTS
D3Mco4  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03172,872,892 - 172,873,190NCBIRnor6.0
Rnor_5.03178,919,179 - 178,919,477UniSTSRnor5.0
RGSC_v3.43166,507,530 - 166,507,965UniSTSRGSC3.4
Celera3162,746,413 - 162,746,715UniSTS
Cytogenetic Map3q43UniSTS
D3Mco79  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23163,577,127 - 163,577,445 (+)MAPPERmRatBN7.2
Rnor_6.03172,871,338 - 172,871,655NCBIRnor6.0
Rnor_5.03178,917,625 - 178,917,942UniSTSRnor5.0
RGSC_v3.43166,505,976 - 166,506,293UniSTSRGSC3.4
Celera3162,744,859 - 162,745,176UniSTS
Cytogenetic Map3q43UniSTS
D3Mco80  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23163,584,479 - 163,584,700 (+)MAPPERmRatBN7.2
Rnor_6.03172,878,661 - 172,878,883NCBIRnor6.0
Rnor_5.03178,924,948 - 178,925,170UniSTSRnor5.0
RGSC_v3.43166,513,436 - 166,513,658UniSTSRGSC3.4
Celera3162,752,186 - 162,752,408UniSTS
Cytogenetic Map3q43UniSTS
Edn3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23163,563,245 - 163,563,545 (+)MAPPERmRatBN7.2
Rnor_6.03172,857,456 - 172,857,755NCBIRnor6.0
Rnor_5.03178,903,743 - 178,904,042UniSTSRnor5.0
RGSC_v3.43166,492,094 - 166,492,393UniSTSRGSC3.4
Celera3162,730,977 - 162,731,276UniSTS
Cytogenetic Map3q43UniSTS


Related Rat Strains
The following Strains have been annotated to Edn3
SS.SR-(D3Mco19-D3Mco5)/Jr    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 17 10 4
Low 3 2 33 20 9 20 8 11 68 18 22 7 8
Below cutoff 20 15 12 10 12 2 9

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009826   ⟹   ENSRNOP00000009826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3163,562,520 - 163,585,093 (+)Ensembl
Rnor_6.0 Ensembl3172,856,733 - 172,880,450 (+)Ensembl
RefSeq Acc Id: NM_001077650   ⟹   NP_001071118
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,980,678 - 184,003,251 (+)NCBI
mRatBN7.23163,562,520 - 163,585,093 (+)NCBI
Rnor_6.03172,856,730 - 172,879,276 (+)NCBI
Rnor_5.03178,903,017 - 178,925,563 (+)NCBI
RGSC_v3.43166,491,368 - 166,514,051 (+)RGD
Celera3162,730,251 - 162,752,801 (+)RGD
Sequence:
RefSeq Acc Id: XM_039105613   ⟹   XP_038961541
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,980,915 - 184,004,958 (+)NCBI
mRatBN7.23163,563,106 - 163,586,636 (+)NCBI
RefSeq Acc Id: XM_039105614   ⟹   XP_038961542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,980,915 - 184,004,958 (+)NCBI
mRatBN7.23163,562,816 - 163,586,636 (+)NCBI
RefSeq Acc Id: XM_039105615   ⟹   XP_038961543
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,980,466 - 184,004,958 (+)NCBI
mRatBN7.23163,562,307 - 163,586,636 (+)NCBI
RefSeq Acc Id: XM_063284294   ⟹   XP_063140364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,980,458 - 184,004,958 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001071118   ⟸   NM_001077650
- Peptide Label: precursor
- UniProtKB: P13207 (UniProtKB/Swiss-Prot),   F1LQB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009826   ⟸   ENSRNOT00000009826
RefSeq Acc Id: XP_038961543   ⟸   XM_039105615
- Peptide Label: isoform X4
- UniProtKB: A6KL41 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961542   ⟸   XM_039105614
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038961541   ⟸   XM_039105613
- Peptide Label: isoform X1
- UniProtKB: A6KL41 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140364   ⟸   XM_063284294
- Peptide Label: isoform X3
Protein Domains
Endothelin-like toxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13207-F1-model_v2 AlphaFold P13207 1-167 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692724
Promoter ID:EPDNEW_R3249
Type:single initiation site
Name:Edn3_1
Description:endothelin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03172,856,720 - 172,856,780EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2534 AgrOrtholog
BioCyc Gene G2FUF-46445 BioCyc
Ensembl Genes ENSRNOG00000007477 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009826 ENTREZGENE
  ENSRNOT00000009826.6 UniProtKB/TrEMBL
InterPro Endothelin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Endothelin_toxin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Endothln-like_toxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:366270 UniProtKB/Swiss-Prot
NCBI Gene Edn3 ENTREZGENE
PANTHER ENDOTHELIN-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Endothelin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Edn3 PhenoGen
PRINTS ENDOTHELIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ENDOTHELIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007477 RatGTEx
SMART END UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KL41 ENTREZGENE, UniProtKB/TrEMBL
  EDN3_RAT UniProtKB/Swiss-Prot
  F1LQB0 ENTREZGENE, UniProtKB/TrEMBL
  P13207 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-01-09 Edn3  endothelin 3  RGD1564825_predicted  similar to prepro-endothelin-3 (predicted)  Data merged from RGD:1564825 1643240 APPROVED
2006-03-14 Edn3  endothelin 3  Edn3_mapped  endothelin 3 (mapped)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1564825_predicted  similar to prepro-endothelin-3 (predicted)  LOC502697  similar to prepro-endothelin-3  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC502697  similar to prepro-endothelin-3      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Edn3_mapped  endothelin 3 (mapped)  Edn3  endothelin 3  Symbol and Name updated 1556543 APPROVED
2002-06-10 Edn3  endothelin 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression 3.0kb prepro-endothelin 3 expressed in eye ball, submandibular gland, brain, kidney, jejunum, stomach and spleen 1578393
gene_expression 2.0kb mRNA is expressed in the eye ball and 3.3kb mRNA is expressed in small intestine 1578393
gene_expression expressed at high levels in hypothalamus 1299957
gene_physical_interaction interaction with the endothelin-B receptor is essential in the development of neural crest-derived cell lineages 61489
gene_process required for development of neural crest-derived cell lineages 61489
gene_transcript 2 isoforms produced by alternative splicing, a long form and a short form 61489