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Gene Ontology AnnotationsGene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | | IDA | | | PMID:18164588 | BHF-UCL | PMID:18164588 | cAMP biosynthetic process | | IDA | | 2312641 | | RGD | | cAMP biosynthetic process | | IDA | | | PMID:18164588 | BHF-UCL | PMID:18164588 | cAMP biosynthetic process | | IDA | | 2312685 | | RGD | | cAMP biosynthetic process | | IDA | | 2312674 | | RGD | | intracellular signal transduction | | IEA | InterPro:IPR001054|InterPro:IPR018297 | 1600115 | GO_REF:0000002 | InterPro | GO_REF:0000002 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Pathway AnnotationsGene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Bile secretion |
| Calcium signaling pathway | |
| Chemokine signaling pathway | |
| Cholinergic synapse | |
| Circadian entrainment | |
| Dilated cardiomyopathy | |
| GABAergic synapse | |
| Gap junction | |
| Gastric acid secretion | |
| Glutamatergic synapse | |
| GnRH signaling pathway | |
| HTLV-I infection | |
| Insulin secretion | |
| Melanogenesis | |
| Morphine addiction | |
| Oocyte meiosis | |
| Pancreatic secretion | |
| Progesterone-mediated oocyte maturation | |
| Purine metabolism | |
| Retrograde endocannabinoid signaling | |
| Salivary secretion | |
| Vascular smooth muscle contraction | |
| Pathway Interaction Database | Endothelins (PID:200005) |
| LPA receptor mediated events (PID:200013) | |
| LPA4-mediated signaling events (PID:200047) | |
References - curated| 1. |
Feinstein PG, etal., Proc Natl Acad Sci U S A 1991 Nov 15;88(22):10173-7. |
| 2. |
GOA data from the GO Consortium |
| 3. |
Jourdan KB, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1359-69. |
| 4. |
KEGG |
| 5. |
MGD data from the GO Consortium |
| 6. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 7. |
Ostrom RS, etal., J Biol Chem. 2003 Jul 4;278(27):24461-8. Epub 2003 Apr 23. |
| 8. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 9. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 10. |
RGD automated data pipeline |
| 11. |
RGD automated import pipeline for gene-chemical interactions |
| 12. |
Sadana R and Dessauer CW, Neurosignals. 2009;17(1):5-22. Epub 2008 Oct 24. |
| 13. |
Serazin-Leroy V, etal., Biochim Biophys Acta. 2001 Nov 26;1550(1):37-51. |
| 14. |
Wang HY and Burns LH, J Neurobiol. 2006 Oct;66(12):1302-10. |
References - uncuratedRGD Disease Portals| Adcy2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Adcy2 (Rattus norvegicus) |
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| ADCY2 (Homo sapiens) |
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| Adcy2 (Mus musculus) |
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Position Markers| RH132673 |
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| RH129915 |
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| RH71322 |
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| MARC_4677-4678:996679594:1 |
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| D5S1607E |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_031007 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06001636 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06001637 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001638 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001639 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001640 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001641 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001642 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001643 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001644 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001645 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001646 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001647 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001648 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001649 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001650 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001651 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001652 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001653 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001654 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001655 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001656 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001657 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001658 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001659 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001660 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001661 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001662 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001663 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001664 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001665 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001666 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001667 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06001674 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01002480 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01002481 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01002482 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01002483 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01002484 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01002485 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01002486 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01002487 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01002488 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01002489 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01002490 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01002491 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01002492 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M80550 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_031007 | |||||||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_112269 | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_112269 | (Get FASTA) |
| GenBank Protein | AAA40682 | (Get FASTA) |
| P26769 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000032150 | UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000038994 | UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000047627 | UniProtKB/TrEMBL |
| Entrez Gene | 81636 | ENTREZGENE |
| Gene3D-CATH | A/G_cyclase | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000032150 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 75133 | ENTREZGENE |
| InterPro | A/G_cyclase | UniProtKB/Swiss-Prot |
| A/G_cyclase_CS | UniProtKB/Swiss-Prot | |
| Aden_cycl-like | UniProtKB/Swiss-Prot | |
| IPI | IPI00196228 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:81636 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | DUF1053 | UniProtKB/Swiss-Prot |
| Guanylate_cyc | UniProtKB/Swiss-Prot | |
| PROSITE | GUANYLATE_CYCLASE_1 | UniProtKB/Swiss-Prot |
| GUANYLATE_CYCLASE_2 | UniProtKB/Swiss-Prot | |
| SMART | CYCc | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | A/G_cyclase | UniProtKB/Swiss-Prot |
| UniGene | Rn.10731 | ENTREZGENE |
| UniProt | ADCY2_RAT | UniProtKB/Swiss-Prot |
| F1LV12_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-09-18 | Adcy2 | adenylate cyclase 2 (brain) | Adcy2 | adenylate cyclase 2 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2004-12-14 | Adcy2 | adenylate cyclase 2 | adenylyl cyclase 2 | Name updated | 10779 | APPROVED | |
| 2002-08-07 | Adcy2 | adenylyl cyclase 2 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_cellular_localization | localized to the membrane | 724707 |
| gene_regulation | activity is insensitive to Ca2+/calmodulin | 724792 |
| More on Adcy2 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 619965 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.