Adcy2 (adenylate cyclase 2) - Rat Genome Database

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Gene: Adcy2 (adenylate cyclase 2) Rattus norvegicus
Analyze
Symbol: Adcy2
Name: adenylate cyclase 2
RGD ID: 619965
Description: Enables several functions, including G-protein beta/gamma-subunit complex binding activity; adenylate cyclase binding activity; and metal ion binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; and cellular response to forskolin. Located in membrane raft and plasma membrane. Part of protein-containing complex. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to human ADCY2 (adenylate cyclase 2); PARTICIPATES IN adenosine signaling pathway; dopamine signaling pathway via D1 family of receptors; endothelin signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AC2; adenylate cyclase 2 (brain); adenylate cyclase type 2; adenylate cyclase type II; adenylyl cyclase 2; ATP pyrophosphate-lyase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8136,204,054 - 36,650,645 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl136,204,054 - 36,650,645 (+)EnsemblGRCr8
mRatBN7.2134,375,639 - 34,822,252 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl134,375,895 - 34,822,236 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx134,237,007 - 34,683,571 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0140,227,844 - 40,674,423 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0134,402,593 - 34,849,151 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd135,796,518 - 36,243,925 (+)NCBI
Lyon_Normotensive135,144,955 - 35,592,366 (+)NCBI
Lyon_Hypertensive136,305,324 - 36,752,740 (+)NCBI
F344_StmMcwi134,562,867 - 35,009,473 (+)NCBI
Rnor_6.0137,043,071 - 37,698,390 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl137,507,276 - 37,698,390 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.0138,434,800 - 39,001,909 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0139,075,253 - 39,080,014 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4174,543,466 - 5,040,433 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera132,960,049 - 33,391,637 (+)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
allethrin  (EXP)
alpha-amanitin  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Butylbenzyl phthalate  (EXP)
caffeine  (EXP,ISO)
choline  (ISO)
clofibrate  (ISO)
clothianidin  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dextran sulfate  (ISO)
diazinon  (EXP)
dichlorine  (EXP)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fonofos  (ISO)
genistein  (EXP,ISO)
L-methionine  (ISO)
lead(0)  (ISO)
maneb  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
miconazole  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP)
pyrethrins  (EXP)
raloxifene  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sunitinib  (ISO)
terbufos  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO,ISS)
dendrite  (ISO,ISS)
membrane  (EXP,IDA,IEA,ISO,ISS)
membrane raft  (IDA)
plasma membrane  (EXP,IBA,IDA,IEA,ISO)
protein-containing complex  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Heterodimers of adenylyl cyclases 2 and 5 show enhanced functional responses in the presence of Galpha s. Baragli A, etal., Cell Signal. 2008 Mar;20(3):480-92. doi: 10.1016/j.cellsig.2007.10.033. Epub 2007 Nov 22.
2. Non-raft adenylyl cyclase 2 defines a cAMP signaling compartment that selectively regulates IL-6 expression in airway smooth muscle cells: differential regulation of gene expression by AC isoforms. Bogard AS, etal., Naunyn Schmiedebergs Arch Pharmacol. 2014 Apr;387(4):329-39. doi: 10.1007/s00210-013-0950-4. Epub 2013 Dec 22.
3. Identification of new Gβγ interaction sites in adenylyl cyclase 2. Boran AD, etal., Cell Signal. 2011 Sep;23(9):1489-95. doi: 10.1016/j.cellsig.2011.05.002. Epub 2011 May 8.
4. A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits. Chen J, etal., Science. 1995 May 26;268(5214):1166-9.
5. Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain. Feinstein PG, etal., Proc Natl Acad Sci U S A 1991 Nov 15;88(22):10173-7.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex. Halls ML and Cooper DM, EMBO J. 2010 Aug 18;29(16):2772-87. doi: 10.1038/emboj.2010.168. Epub 2010 Jul 27.
9. CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland. Hardin M, etal., Am J Respir Cell Mol Biol. 2012 Aug;47(2):203-8. doi: 10.1165/rcmb.2012-0011OC. Epub 2012 Mar 29.
10. Characterization of adenylyl cyclase isoforms in rat peripheral pulmonary arteries. Jourdan KB, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1359-69.
11. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Structural basis for inhibition of mammalian adenylyl cyclase by calcium. Mou TC, etal., Biochemistry. 2009 Apr 21;48(15):3387-97. doi: 10.1021/bi802122k.
14. Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate. Mou TC, etal., J Biol Chem. 2005 Feb 25;280(8):7253-61. doi: 10.1074/jbc.M409076200. Epub 2004 Dec 9.
15. Broad specificity of mammalian adenylyl cyclase for interaction with 2',3'-substituted purine- and pyrimidine nucleotide inhibitors. Mou TC, etal., Mol Pharmacol. 2006 Sep;70(3):878-86. doi: 10.1124/mol.106.026427. Epub 2006 Jun 9.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. Ostrom RS, etal., J Biol Chem. 2003 Jul 4;278(27):24461-8. Epub 2003 Apr 23.
18. The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain. Piggott LA, etal., Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13835-40. Epub 2008 Sep 4.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies. Sadana R and Dessauer CW, Neurosignals. 2009;17(1):5-22. Epub 2008 Oct 24.
26. Differences in type II, IV, V and VI adenylyl cyclase isoform expression between rat preadipocytes and adipocytes. Serazin-Leroy V, etal., Biochim Biophys Acta. 2001 Nov 26;1550(1):37-51.
27. Muscarinic receptors stimulate AC2 by novel phosphorylation sites, whereas Gβγ subunits exert opposing effects depending on the G-protein source. Shen JX, etal., Biochem J. 2012 Nov 1;447(3):393-405. doi: 10.1042/BJ20120279.
28. Molecular basis for P-site inhibition of adenylyl cyclase. Tesmer JJ, etal., Biochemistry. 2000 Nov 28;39(47):14464-71. doi: 10.1021/bi0015562.
29. Two-metal-Ion catalysis in adenylyl cyclase. Tesmer JJ, etal., Science. 1999 Jul 30;285(5428):756-60.
30. Gbetagamma that interacts with adenylyl cyclase in opioid tolerance originates from a Gs protein. Wang HY and Burns LH, J Neurobiol. 2006 Oct;66(12):1302-10.
Additional References at PubMed
PMID:9069282   PMID:9417641   PMID:9870949   PMID:11549699   PMID:19008230   PMID:22871113  


Genomics

Comparative Map Data
Adcy2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8136,204,054 - 36,650,645 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl136,204,054 - 36,650,645 (+)EnsemblGRCr8
mRatBN7.2134,375,639 - 34,822,252 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl134,375,895 - 34,822,236 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx134,237,007 - 34,683,571 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0140,227,844 - 40,674,423 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0134,402,593 - 34,849,151 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd135,796,518 - 36,243,925 (+)NCBI
Lyon_Normotensive135,144,955 - 35,592,366 (+)NCBI
Lyon_Hypertensive136,305,324 - 36,752,740 (+)NCBI
F344_StmMcwi134,562,867 - 35,009,473 (+)NCBI
Rnor_6.0137,043,071 - 37,698,390 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl137,507,276 - 37,698,390 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.0138,434,800 - 39,001,909 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0139,075,253 - 39,080,014 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4174,543,466 - 5,040,433 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera132,960,049 - 33,391,637 (+)NCBICelera
Cytogenetic Map1p11NCBI
ADCY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3857,396,138 - 7,830,081 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl57,395,681 - 7,830,638 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh3757,396,251 - 7,830,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3657,449,343 - 7,883,194 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3457,449,344 - 7,883,194NCBI
Celera57,439,102 - 7,871,262 (+)NCBICelera
Cytogenetic Map5p15.31NCBI
HuRef57,725,521 - 7,811,956 (+)NCBIHuRef
HuRef57,378,757 - 7,709,814 (+)NCBIHuRef
CHM1_157,396,258 - 7,830,278 (+)NCBICHM1_1
T2T-CHM13v2.057,334,987 - 7,769,222 (+)NCBIT2T-CHM13v2.0
Adcy2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391368,768,162 - 69,147,719 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1368,758,255 - 69,147,818 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381368,620,043 - 68,999,600 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1368,620,043 - 68,999,541 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371368,758,920 - 69,138,419 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361369,087,431 - 69,466,658 (-)NCBIMGSCv36mm8
Celera1370,976,336 - 71,362,097 (-)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1335.55NCBI
Adcy2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555045,004,903 - 5,376,328 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_0049555044,990,634 - 5,376,990 (+)NCBIChiLan1.0ChiLan1.0
ADCY2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v247,647,272 - 8,082,790 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan155,800,880 - 6,236,399 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v057,718,581 - 8,154,006 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.157,540,762 - 7,975,853 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl57,540,790 - 7,975,853 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
ADCY2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1346,139,931 - 6,527,677 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl346,140,276 - 6,527,677 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3410,648,056 - 11,035,866 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0346,045,474 - 6,434,089 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl346,045,476 - 6,434,095 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1346,095,233 - 6,483,250 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0346,075,965 - 6,464,063 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0346,288,901 - 6,677,489 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Adcy2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap11256,999,657 - 257,376,991 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_024407213239,063,958 - 239,560,683 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493664347,837 - 339,007 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493664347,830 - 338,891 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1674,306,418 - 74,729,974 (-)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.11674,305,729 - 74,729,999 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21680,359,861 - 80,498,999 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADCY2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap1486,639,835 - 87,066,356 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366606421,200,037 - 21,628,571 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.146,989,077 - 7,415,282 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl46,989,169 - 7,414,617 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Adcy2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247515,004,186 - 5,409,891 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046247515,004,263 - 5,413,994 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl1618,504,939 - 18,911,176 (-)Ensembl
Adcy2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12199,950,682 - 200,361,187 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in Adcy2
6460 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:500
Count of miRNA genes:246
Interacting mature miRNAs:313
Transcripts:ENSRNOT00000047627
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat

Markers in Region
RH132673  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2134,821,898 - 34,822,099 (+)MAPPERmRatBN7.2
Rnor_6.0137,698,053 - 37,698,253NCBIRnor6.0
Rnor_5.0139,079,677 - 39,079,877UniSTSRnor5.0
RGSC_v3.4175,040,096 - 5,040,296UniSTSRGSC3.4
Celera133,391,300 - 33,391,500UniSTS
Cytogenetic Map17p14UniSTS
RH129915  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2134,722,815 - 34,723,021 (+)MAPPERmRatBN7.2
mRatBN7.21529,079,099 - 29,079,905 (+)MAPPERmRatBN7.2
Rnor_6.01534,266,157 - 34,266,962NCBIRnor6.0
Rnor_6.0137,559,558 - 37,559,763NCBIRnor6.0
Rnor_5.01538,156,352 - 38,157,157UniSTSRnor5.0
Rnor_5.0138,939,804 - 38,940,009UniSTSRnor5.0
RGSC_v3.41533,722,975 - 33,723,780UniSTSRGSC3.4
RGSC_v3.4174,920,805 - 4,921,010UniSTSRGSC3.4
Celera1528,655,020 - 28,655,825UniSTS
Celera133,295,388 - 33,295,593UniSTS
Cytogenetic Map17p14UniSTS
Cytogenetic Map15p13UniSTS
RH71322  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2134,722,825 - 34,722,996 (+)MAPPERmRatBN7.2
mRatBN7.21338,190,170 - 38,190,341 (+)MAPPERmRatBN7.2
Rnor_6.01343,080,194 - 43,080,364NCBIRnor6.0
Rnor_6.0137,559,568 - 37,559,738NCBIRnor6.0
Rnor_5.01348,181,613 - 48,181,783UniSTSRnor5.0
Rnor_5.0138,939,814 - 38,939,984UniSTSRnor5.0
RGSC_v3.41339,308,325 - 39,308,495UniSTSRGSC3.4
RGSC_v3.4174,920,815 - 4,920,985UniSTSRGSC3.4
Celera1338,513,040 - 38,513,210UniSTS
Celera133,295,398 - 33,295,568UniSTS
Cytogenetic Map13q11UniSTS
Cytogenetic Map17p14UniSTS
Cytogenetic Map15p13UniSTS
MARC_4677-4678:996679594:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2134,722,607 - 34,722,680 (+)MAPPERmRatBN7.2
mRatBN7.21529,080,316 - 29,081,409 (+)MAPPERmRatBN7.2
Rnor_6.01534,267,374 - 34,268,466NCBIRnor6.0
Rnor_6.0137,559,350 - 37,559,422NCBIRnor6.0
Rnor_5.01538,157,569 - 38,158,661UniSTSRnor5.0
Rnor_5.0138,939,596 - 38,939,668UniSTSRnor5.0
RGSC_v3.41533,724,192 - 33,725,284UniSTSRGSC3.4
RGSC_v3.4174,920,597 - 4,920,669UniSTSRGSC3.4
Celera1528,656,237 - 28,657,329UniSTS
Celera133,295,180 - 33,295,252UniSTS
Cytogenetic Map17p14UniSTS
Cytogenetic Map15p13UniSTS
D5S1607E  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2134,693,066 - 34,694,119 (+)MAPPERmRatBN7.2
Rnor_6.0137,516,712 - 37,517,764NCBIRnor6.0
Rnor_5.0138,896,677 - 38,897,729UniSTSRnor5.0
RGSC_v3.4174,888,656 - 4,889,708UniSTSRGSC3.4
Celera133,265,638 - 33,266,690UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
276 156 729 1552 4034 721 1437 112 584 237 566 156 4673 2296 446 3934 38 1255 715 908 160 158

Sequence


Ensembl Acc Id: ENSRNOT00000047627   ⟹   ENSRNOP00000038994
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl136,204,054 - 36,650,645 (+)Ensembl
mRatBN7.2 Ensembl134,375,895 - 34,822,236 (+)Ensembl
Rnor_6.0 Ensembl137,507,276 - 37,698,390 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099050   ⟹   ENSRNOP00000090092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl136,204,338 - 36,650,629 (+)Ensembl
mRatBN7.2 Ensembl134,375,895 - 34,822,236 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000127647   ⟹   ENSRNOP00000109970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl136,204,144 - 36,650,630 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000173264   ⟹   ENSRNOP00000101380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl136,204,054 - 36,650,645 (+)Ensembl
RefSeq Acc Id: NM_031007   ⟹   NP_112269
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,204,054 - 36,650,645 (+)NCBI
mRatBN7.2134,375,641 - 34,822,252 (+)NCBI
Dahl_SR_JrHsd135,796,518 - 36,243,925 (+)NCBI
Lyon_Normotensive135,144,955 - 35,592,366 (+)NCBI
Lyon_Hypertensive136,305,324 - 36,752,740 (+)NCBI
F344_StmMcwi134,562,867 - 35,009,473 (+)NCBI
Rnor_6.0137,043,071 - 37,698,390 (+)NCBI
Rnor_5.0138,434,800 - 39,001,909 (+)NCBI
Rnor_5.0139,075,253 - 39,080,014 (+)NCBI
RGSC_v3.4174,543,466 - 5,040,433 (+)RGD
Celera132,960,049 - 33,391,637 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039092032   ⟹   XP_038947960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,204,057 - 36,650,629 (+)NCBI
mRatBN7.2134,375,641 - 34,822,237 (+)NCBI
RefSeq Acc Id: XM_039092037   ⟹   XP_038947965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,204,058 - 36,650,629 (+)NCBI
mRatBN7.2134,375,642 - 34,822,237 (+)NCBI
RefSeq Acc Id: XM_039092038   ⟹   XP_038947966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,204,056 - 36,604,774 (+)NCBI
mRatBN7.2134,375,640 - 34,783,103 (+)NCBI
RefSeq Acc Id: XM_039092044   ⟹   XP_038947972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,204,055 - 36,596,659 (+)NCBI
mRatBN7.2134,375,639 - 34,762,623 (+)NCBI
RefSeq Acc Id: NP_112269   ⟸   NM_031007
- UniProtKB: P26769 (UniProtKB/Swiss-Prot),   F1LV12 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038994   ⟸   ENSRNOT00000047627
RefSeq Acc Id: XP_038947972   ⟸   XM_039092044
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038947966   ⟸   XM_039092038
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038947960   ⟸   XM_039092032
- Peptide Label: isoform X1
- UniProtKB: P26769 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038947965   ⟸   XM_039092037
- Peptide Label: isoform X2
- UniProtKB: P26769 (UniProtKB/Swiss-Prot),   A0ABK0LGM5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090092   ⟸   ENSRNOT00000099050
Ensembl Acc Id: ENSRNOP00000109970   ⟸   ENSRNOT00000127647
Ensembl Acc Id: ENSRNOP00000101380   ⟸   ENSRNOT00000173264
Protein Domains
Guanylate cyclase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26769-F1-model_v2 AlphaFold P26769 1-1090 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619965 AgrOrtholog
BioCyc Gene G2FUF-61858 BioCyc
Ensembl Genes ENSRNOG00000032150 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000047627 ENTREZGENE
  ENSRNOT00000127647 ENTREZGENE
Gene3D-CATH 3.30.70.1230 UniProtKB/Swiss-Prot
InterPro A/G_cyclase UniProtKB/Swiss-Prot
  A/G_cyclase_CS UniProtKB/Swiss-Prot
  AC_N UniProtKB/Swiss-Prot
  Adcy UniProtKB/Swiss-Prot
  Adcy_conserved_dom UniProtKB/Swiss-Prot
  Nucleotide_cyclase UniProtKB/Swiss-Prot
KEGG Report rno:81636 UniProtKB/Swiss-Prot
NCBI Gene 81636 ENTREZGENE
PANTHER ADENYLATE CYCLASE TYPE 1 UniProtKB/Swiss-Prot
  ADENYLATE CYCLASE TYPE 2 UniProtKB/Swiss-Prot
Pfam AC_N UniProtKB/Swiss-Prot
  DUF1053 UniProtKB/Swiss-Prot
  Guanylate_cyc UniProtKB/Swiss-Prot
PhenoGen Adcy2 PhenoGen
PIRSF Ade_cyc UniProtKB/Swiss-Prot
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032150 RatGTEx
SMART CYCc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55073 UniProtKB/Swiss-Prot
UniProt A0A8I6AMB0_RAT UniProtKB/TrEMBL
  A0ABK0L0K3_RAT UniProtKB/TrEMBL
  A0ABK0LGM5 ENTREZGENE, UniProtKB/TrEMBL
  ADCY2_RAT UniProtKB/Swiss-Prot
  F1LV12 ENTREZGENE, UniProtKB/TrEMBL
  P26769 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Adcy2  adenylate cyclase 2  Adcy2  adenylate cyclase 2 (brain)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Adcy2  adenylate cyclase 2 (brain)  Adcy2  adenylate cyclase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Adcy2  adenylate cyclase 2    adenylyl cyclase 2  Name updated 1299863 APPROVED
2002-08-07 Adcy2  adenylyl cyclase 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the membrane 724707
gene_regulation activity is insensitive to Ca2+/calmodulin 724792