Adcy2 (adenylate cyclase 2) - Rat Genome Database

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Gene: Adcy2 (adenylate cyclase 2) Rattus norvegicus
Analyze
Symbol: Adcy2
Name: adenylate cyclase 2
RGD ID: 619965
Description: Enables several functions, including G-protein beta/gamma-subunit complex binding activity; adenylate cyclase binding activity; and metal ion binding activity. Involved in several processes, including cAMP biosynthetic process; cAMP-mediated signaling; and cellular response to forskolin. Located in membrane raft and plasma membrane. Part of protein-containing complex. Orthologous to human ADCY2 (adenylate cyclase 2); PARTICIPATES IN adenosine signaling pathway; dopamine signaling pathway via D1 family of receptors; endothelin signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AC2; adenylate cyclase 2 (brain); adenylate cyclase type 2; adenylate cyclase type II; adenylyl cyclase 2; ATP pyrophosphate-lyase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8136,204,054 - 36,650,645 (+)NCBIGRCr8
mRatBN7.2134,375,639 - 34,822,252 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl134,375,895 - 34,822,236 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx134,237,007 - 34,683,571 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0140,227,844 - 40,674,423 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0134,402,593 - 34,849,151 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0137,043,071 - 37,698,390 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl137,507,276 - 37,698,390 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0139,075,253 - 39,080,014 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0138,434,800 - 39,001,909 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4174,543,466 - 5,040,433 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera132,960,049 - 33,391,637 (+)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
choline  (ISO)
clofibrate  (ISO)
clothianidin  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dextran sulfate  (ISO)
diazinon  (EXP)
dichlorine  (EXP)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fonofos  (ISO)
genistein  (EXP,ISO)
L-methionine  (ISO)
lead(0)  (ISO)
maneb  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
miconazole  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenethyl caffeate  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP)
pyrethrins  (EXP)
raloxifene  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sunitinib  (ISO)
terbufos  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
dendrite  (ISO,ISS)
membrane  (IDA,ISO,ISS)
membrane raft  (IDA)
plasma membrane  (IBA,IDA,IEA,ISO)
protein-containing complex  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Heterodimers of adenylyl cyclases 2 and 5 show enhanced functional responses in the presence of Galpha s. Baragli A, etal., Cell Signal. 2008 Mar;20(3):480-92. doi: 10.1016/j.cellsig.2007.10.033. Epub 2007 Nov 22.
2. A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits. Chen J, etal., Science. 1995 May 26;268(5214):1166-9.
3. Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain. Feinstein PG, etal., Proc Natl Acad Sci U S A 1991 Nov 15;88(22):10173-7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex. Halls ML and Cooper DM, EMBO J. 2010 Aug 18;29(16):2772-87. doi: 10.1038/emboj.2010.168. Epub 2010 Jul 27.
7. Characterization of adenylyl cyclase isoforms in rat peripheral pulmonary arteries. Jourdan KB, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1359-69.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. Ostrom RS, etal., J Biol Chem. 2003 Jul 4;278(27):24461-8. Epub 2003 Apr 23.
12. The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain. Piggott LA, etal., Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13835-40. Epub 2008 Sep 4.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies. Sadana R and Dessauer CW, Neurosignals. 2009;17(1):5-22. Epub 2008 Oct 24.
20. Differences in type II, IV, V and VI adenylyl cyclase isoform expression between rat preadipocytes and adipocytes. Serazin-Leroy V, etal., Biochim Biophys Acta. 2001 Nov 26;1550(1):37-51.
21. Two-metal-Ion catalysis in adenylyl cyclase. Tesmer JJ, etal., Science. 1999 Jul 30;285(5428):756-60.
22. Gbetagamma that interacts with adenylyl cyclase in opioid tolerance originates from a Gs protein. Wang HY and Burns LH, J Neurobiol. 2006 Oct;66(12):1302-10.
Additional References at PubMed
PMID:9069282   PMID:9417641   PMID:9870949   PMID:11549699   PMID:19008230   PMID:22871113   PMID:22906005  


Genomics

Comparative Map Data
Adcy2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8136,204,054 - 36,650,645 (+)NCBIGRCr8
mRatBN7.2134,375,639 - 34,822,252 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl134,375,895 - 34,822,236 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx134,237,007 - 34,683,571 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0140,227,844 - 40,674,423 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0134,402,593 - 34,849,151 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0137,043,071 - 37,698,390 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl137,507,276 - 37,698,390 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0139,075,253 - 39,080,014 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0138,434,800 - 39,001,909 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4174,543,466 - 5,040,433 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera132,960,049 - 33,391,637 (+)NCBICelera
Cytogenetic Map1p11NCBI
ADCY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3857,396,138 - 7,830,081 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl57,396,138 - 7,830,081 (+)EnsemblGRCh38hg38GRCh38
GRCh3757,396,251 - 7,830,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3657,449,343 - 7,883,194 (+)NCBINCBI36Build 36hg18NCBI36
Build 3457,449,344 - 7,883,194NCBI
Celera57,439,102 - 7,871,262 (+)NCBICelera
Cytogenetic Map5p15.31NCBI
HuRef57,725,521 - 7,811,956 (+)NCBIHuRef
HuRef57,378,757 - 7,709,814 (+)NCBIHuRef
CHM1_157,396,258 - 7,830,278 (+)NCBICHM1_1
T2T-CHM13v2.057,334,987 - 7,769,222 (+)NCBIT2T-CHM13v2.0
Adcy2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391368,768,162 - 69,147,719 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1368,768,162 - 69,147,660 (-)EnsemblGRCm39 Ensembl
GRCm381368,620,043 - 68,999,600 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1368,620,043 - 68,999,541 (-)EnsemblGRCm38mm10GRCm38
MGSCv371368,758,920 - 69,138,419 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361369,087,431 - 69,466,658 (-)NCBIMGSCv36mm8
Celera1370,976,336 - 71,362,097 (-)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1335.55NCBI
Adcy2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555045,004,903 - 5,376,328 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555044,990,634 - 5,376,990 (+)NCBIChiLan1.0ChiLan1.0
ADCY2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v247,647,272 - 8,082,790 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan155,800,880 - 6,236,399 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v057,718,581 - 8,154,006 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.157,540,762 - 7,975,853 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl57,540,790 - 7,975,853 (+)Ensemblpanpan1.1panPan2
ADCY2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1346,139,931 - 6,527,677 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl346,140,276 - 6,527,677 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3410,648,056 - 11,035,866 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0346,045,474 - 6,434,089 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl346,045,476 - 6,434,095 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1346,095,233 - 6,483,250 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0346,075,965 - 6,464,063 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0346,288,901 - 6,677,489 (-)NCBIUU_Cfam_GSD_1.0
Adcy2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213239,063,958 - 239,560,683 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493664347,837 - 339,007 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493664347,830 - 338,891 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1674,305,736 - 74,524,295 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11674,305,729 - 74,729,999 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21680,359,861 - 80,498,999 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADCY2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.146,989,077 - 7,415,282 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl46,989,169 - 7,414,617 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606421,200,037 - 21,628,571 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adcy2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247515,004,263 - 5,413,994 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247515,004,186 - 5,409,891 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adcy2
1040 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:500
Count of miRNA genes:246
Interacting mature miRNAs:313
Transcripts:ENSRNOT00000047627
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat

Markers in Region
RH132673  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2134,821,898 - 34,822,099 (+)MAPPERmRatBN7.2
Rnor_6.0137,698,053 - 37,698,253NCBIRnor6.0
Rnor_5.0139,079,677 - 39,079,877UniSTSRnor5.0
RGSC_v3.4175,040,096 - 5,040,296UniSTSRGSC3.4
Celera133,391,300 - 33,391,500UniSTS
Cytogenetic Map17p14UniSTS
RH129915  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2134,722,815 - 34,723,021 (+)MAPPERmRatBN7.2
mRatBN7.21529,079,099 - 29,079,905 (+)MAPPERmRatBN7.2
Rnor_6.01534,266,157 - 34,266,962NCBIRnor6.0
Rnor_6.0137,559,558 - 37,559,763NCBIRnor6.0
Rnor_5.01538,156,352 - 38,157,157UniSTSRnor5.0
Rnor_5.0138,939,804 - 38,940,009UniSTSRnor5.0
RGSC_v3.41533,722,975 - 33,723,780UniSTSRGSC3.4
RGSC_v3.4174,920,805 - 4,921,010UniSTSRGSC3.4
Celera1528,655,020 - 28,655,825UniSTS
Celera133,295,388 - 33,295,593UniSTS
Cytogenetic Map17p14UniSTS
Cytogenetic Map15p13UniSTS
RH71322  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2134,722,825 - 34,722,996 (+)MAPPERmRatBN7.2
mRatBN7.21338,190,170 - 38,190,341 (+)MAPPERmRatBN7.2
Rnor_6.01343,080,194 - 43,080,364NCBIRnor6.0
Rnor_6.0137,559,568 - 37,559,738NCBIRnor6.0
Rnor_5.01348,181,613 - 48,181,783UniSTSRnor5.0
Rnor_5.0138,939,814 - 38,939,984UniSTSRnor5.0
RGSC_v3.41339,308,325 - 39,308,495UniSTSRGSC3.4
RGSC_v3.4174,920,815 - 4,920,985UniSTSRGSC3.4
Celera1338,513,040 - 38,513,210UniSTS
Celera133,295,398 - 33,295,568UniSTS
Cytogenetic Map13q11UniSTS
Cytogenetic Map17p14UniSTS
Cytogenetic Map15p13UniSTS
MARC_4677-4678:996679594:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2134,722,607 - 34,722,680 (+)MAPPERmRatBN7.2
mRatBN7.21529,080,316 - 29,081,409 (+)MAPPERmRatBN7.2
Rnor_6.01534,267,374 - 34,268,466NCBIRnor6.0
Rnor_6.0137,559,350 - 37,559,422NCBIRnor6.0
Rnor_5.01538,157,569 - 38,158,661UniSTSRnor5.0
Rnor_5.0138,939,596 - 38,939,668UniSTSRnor5.0
RGSC_v3.41533,724,192 - 33,725,284UniSTSRGSC3.4
RGSC_v3.4174,920,597 - 4,920,669UniSTSRGSC3.4
Celera1528,656,237 - 28,657,329UniSTS
Celera133,295,180 - 33,295,252UniSTS
Cytogenetic Map17p14UniSTS
Cytogenetic Map15p13UniSTS
D5S1607E  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2134,693,066 - 34,694,119 (+)MAPPERmRatBN7.2
Rnor_6.0137,516,712 - 37,517,764NCBIRnor6.0
Rnor_5.0138,896,677 - 38,897,729UniSTSRnor5.0
RGSC_v3.4174,888,656 - 4,889,708UniSTSRGSC3.4
Celera133,265,638 - 33,266,690UniSTS
Cytogenetic Map17p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 11 58 18 19 11 8
Low 3 43 43 27 19 27 16 17 18
Below cutoff 13 13 13 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000047627   ⟹   ENSRNOP00000038994
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl134,375,895 - 34,822,236 (+)Ensembl
Rnor_6.0 Ensembl137,507,276 - 37,698,390 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099050   ⟹   ENSRNOP00000090092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl134,375,895 - 34,822,236 (+)Ensembl
RefSeq Acc Id: NM_031007   ⟹   NP_112269
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,204,054 - 36,650,645 (+)NCBI
mRatBN7.2134,375,641 - 34,822,252 (+)NCBI
Rnor_6.0137,043,071 - 37,698,390 (+)NCBI
Rnor_5.0138,434,800 - 39,001,909 (+)NCBI
Rnor_5.0139,075,253 - 39,080,014 (+)NCBI
RGSC_v3.4174,543,466 - 5,040,433 (+)RGD
Celera132,960,049 - 33,391,637 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039092032   ⟹   XP_038947960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,204,057 - 36,650,629 (+)NCBI
mRatBN7.2134,375,641 - 34,822,237 (+)NCBI
RefSeq Acc Id: XM_039092037   ⟹   XP_038947965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,204,058 - 36,650,629 (+)NCBI
mRatBN7.2134,375,642 - 34,822,237 (+)NCBI
RefSeq Acc Id: XM_039092038   ⟹   XP_038947966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,204,056 - 36,604,774 (+)NCBI
mRatBN7.2134,375,640 - 34,783,103 (+)NCBI
RefSeq Acc Id: XM_039092044   ⟹   XP_038947972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,204,055 - 36,596,659 (+)NCBI
mRatBN7.2134,375,639 - 34,762,623 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_112269   ⟸   NM_031007
- UniProtKB: P26769 (UniProtKB/Swiss-Prot),   F1LV12 (UniProtKB/TrEMBL),   A6JV23 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000038994   ⟸   ENSRNOT00000047627
RefSeq Acc Id: XP_038947972   ⟸   XM_039092044
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038947966   ⟸   XM_039092038
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038947960   ⟸   XM_039092032
- Peptide Label: isoform X1
- UniProtKB: P26769 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038947965   ⟸   XM_039092037
- Peptide Label: isoform X2
- UniProtKB: P26769 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000090092   ⟸   ENSRNOT00000099050
Protein Domains
Guanylate cyclase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26769-F1-model_v2 AlphaFold P26769 1-1090 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619965 AgrOrtholog
BioCyc Gene G2FUF-61858 BioCyc
Ensembl Genes ENSRNOG00000032150 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047627 ENTREZGENE
  ENSRNOT00000047627.4 UniProtKB/TrEMBL
  ENSRNOT00000099050.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.1230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adcy UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adcy_conserved_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81636 UniProtKB/Swiss-Prot
NCBI Gene 81636 ENTREZGENE
PANTHER ADENYLATE CYCLASE TYPE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADENYLATE CYCLASE TYPE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1053 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adcy2 PhenoGen
PIRSF Ade_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032150 RatGTEx
SMART CYCc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AMB0_RAT UniProtKB/TrEMBL
  A6JV23 ENTREZGENE, UniProtKB/TrEMBL
  ADCY2_RAT UniProtKB/Swiss-Prot
  F1LV12 ENTREZGENE, UniProtKB/TrEMBL
  P26769 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Adcy2  adenylate cyclase 2  Adcy2  adenylate cyclase 2 (brain)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Adcy2  adenylate cyclase 2 (brain)  Adcy2  adenylate cyclase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Adcy2  adenylate cyclase 2    adenylyl cyclase 2  Name updated 1299863 APPROVED
2002-08-07 Adcy2  adenylyl cyclase 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the membrane 724707
gene_regulation activity is insensitive to Ca2+/calmodulin 724792