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MELANOCORTIN SYSTEM PATHWAY (PW:0000365)

View Ontology Report

Description

The melanocortin peptides - a collective term for the alpha-, beta- and gamma-melanocyte-stimulating hormones and the adenocorticotropin hormone (ACTH) - are derived from the sequential processing of the pro-opiomelanocortin (POMC) gene product. They bind to specific G-protein coupled melanocortin receptors (Mcr) to elicit a range of responses that include anti-inflammatory and immunomodulatory effects, regulation of energy homeostasis and feeding behavior and induction of melanogenesis. The fiv

Pathway Diagram:

Ariadne Genomics Inc. immunomodulation energy homeostasis cortisol biosynthetic pathway protein kinase A (PKA) signaling pathway G protein mediated signaling pathway via Galphas family Mgrn1 HPA axis POMC processing enzymes MSH peptides stress conditions --+> corticotropin-releasing hormone signaling pathway stress conditions Pomc ---> MSH peptides Atrn corticotropin-releasing hormone signaling pathway MRAP2 Pomc ---> ACTH Agrp Pomc corticotropin-releasing hormone signaling pathway --+> Pomc Gnas Mgrn1 ---| MC1R Mrap --+> Mc2r MC1R ---> melanogenesis melanogenesis steroidogenesis Asip ---| MC1R ACTH ---- Mc3r ACTH ---- MC1R ACTH ---- Mc5r ACTH Mc3r ---> immunomodulation Mc3r Mc3r ---> energy homeostasis Mc4r ---> energy homeostasis Asip ---- Atrn Agrp ---| Mc4r Agrp ---| Mc3r Agrp ---- Mc4r Agrp ---- Mc3r Gnas ---- Mc2r Gnas ---- MC1R Asip Mc2r Gnas ---- Mc3r Atrnl1 ---- Mc4r Mc4r Atrnl1 Mc5r Asip ---- MC1R Mc5r ---> immunomodulation Gnas ---- Mc4r cAMP --+> protein kinase A (PKA) signaling pathway G protein mediated signaling pathway via Galphas family --+> cAMP cAMP Gnas ---- Mc5r ACTH ---- Mc2r MC1R ---- MSH peptides Mc3r ---- MSH peptides Mc4r ---- MSH peptides Mc5r ---- MSH peptides ACTH ---- Mc4r Mc2r --+> cortisol biosynthetic pathway MC1R Mrap
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Genes in Pathway:


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melanocortin system pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy2 adenylate cyclase 2 ISO SMPDB SMP:00310 NCBI chr 1:34,375,639...34,822,252
Ensembl chr 1:34,375,895...34,822,236
JBrowse link
G Agrp agouti related neuropeptide TAS
ISO
RGD PMID:10875247 PMID:15189116 RGD:632165, RGD:1357925 NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584
JBrowse link
G Asip agouti signaling protein ISO RGD PMID:15189116 RGD:1357925 NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171
JBrowse link
G Atrn attractin ISO RGD PMID:20654690 RGD:5144214 NCBI chr 3:118,110,320...118,244,326
Ensembl chr 3:118,110,229...118,244,322
JBrowse link
G Atrnl1 attractin like 1 ISO RGD PMID:20654690 RGD:5144214 NCBI chr 1:256,670,976...257,219,291
Ensembl chr 1:256,670,627...257,213,197
JBrowse link
G Cpe carboxypeptidase E ISS RGD PMID:11874690 RGD:1357926 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233
JBrowse link
G Gnas GNAS complex locus ISO SMPDB
RGD
PMID:20852827 SMP:00310, RGD:5144213 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Gnb1 G protein subunit beta 1 ISO SMPDB SMP:00310 NCBI chr 5:166,075,508...166,142,223
Ensembl chr 5:166,075,629...166,142,124
JBrowse link
G Gng12 G protein subunit gamma 12 ISO SMPDB SMP:00310 NCBI chr 4:96,011,118...96,134,767
Ensembl chr 4:96,010,952...96,134,712
JBrowse link
G Mc1r melanocortin 1 receptor ISO RGD PMID:20852827 RGD:5144213 NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192
JBrowse link
G Mc2r melanocortin 2 receptor ISO SMPDB
RGD
PMID:20852827 SMP:00310, RGD:5144213 NCBI chr18:62,001,980...62,015,567
Ensembl chr18:62,004,948...62,015,488
JBrowse link
G Mc3r melanocortin 3 receptor IDA
ISO
RGD PMID:8415620 PMID:20852827 RGD:69884, RGD:5144213 NCBI chr 3:161,016,347...161,017,444
Ensembl chr 3:161,016,347...161,017,444
JBrowse link
G Mc4r melanocortin 4 receptor TAS
ISO
RGD PMID:11963824 PMID:20852827 RGD:729360, RGD:5144213 NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719
JBrowse link
G Mc5r melanocortin 5 receptor ISO RGD PMID:9512481 PMID:20852827 RGD:1626223, RGD:5144213 NCBI chr18:61,915,188...61,920,229
Ensembl chr18:61,915,188...61,920,229
JBrowse link
G Mgrn1 mahogunin ring finger 1 ISO RGD PMID:20654690 RGD:5144214 NCBI chr10:10,638,881...10,688,332
Ensembl chr10:10,638,880...10,688,315
JBrowse link
G Mrap melanocortin 2 receptor accessory protein ISO RGD PMID:20654690 RGD:5144214 NCBI chr11:29,991,974...30,003,024
Ensembl chr11:29,992,034...30,003,024
JBrowse link
G Mrap2 melanocortin 2 receptor accessory protein 2 ISO RGD PMID:20654690 RGD:5144214 NCBI chr 8:88,088,293...88,144,636
Ensembl chr 8:88,088,272...88,143,886
JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase ISO RGD PMID:11874690 RGD:1357926 NCBI chr 9:97,998,581...98,271,966
Ensembl chr 9:98,122,916...98,271,965
JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 ISS
ISO
RGD PMID:11874690 PMID:15189116 RGD:1357926, RGD:1357925 NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 ISO RGD PMID:11874690 RGD:1357926 NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127
JBrowse link
G Pomc proopiomelanocortin ISS
ISO
SMPDB
RGD
PMID:11874690 PMID:15189116 SMP:00310, RGD:1357926, RGD:1357925 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta ISO SMPDB SMP:00310 NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
JBrowse link
G Sdc1 syndecan 1 ISO RGD PMID:15189116 RGD:1357925 NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264
JBrowse link
G Sdc3 syndecan 3 ISO RGD PMID:15189116 RGD:1357925 NCBI chr 5:142,965,659...142,998,390
Ensembl chr 5:142,965,591...142,996,480
JBrowse link
altered melanocortin system pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agrp agouti related neuropeptide ISO RGD PMID:15189116 RGD:1357925 NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584
JBrowse link
G Mc4r melanocortin 4 receptor ISS RGD PMID:15189116 RGD:1357925 NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719
JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 ISS
ISO
RGD PMID:11874690 PMID:15189116 RGD:1357926, RGD:1357925 NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434
JBrowse link
G Pomc proopiomelanocortin ISS
ISO
RGD PMID:15189116 PMID:11874690 RGD:1357925, RGD:1357926 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Sdc1 syndecan 1 ISO RGD PMID:15189116 RGD:1357925 NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264
JBrowse link

Altered Pathway:

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Pathwaycorticotropin-releasing hormone signaling pathwayActivation of HPA axis by various stresses leads to release of corticotropin-releasing hormone from the hypothalamus and initiation of its signaling pathway which leads to activation of POMC gene expression
PathwayG protein mediated signaling via Gaphas familyBased on sequence similarity, the Galpha genes have been grouped into four classes. Effectors of activated Galphas are adenylyl cyclases that catalyze the formation of cAMP
Small MoleculecAMPcAMP binding to the PKA complex leads to dissociation of the catalytic subunits
Pathwaycortisol biosynthetic pathwayCortisol, the main C21 glucocorticoid, is primarily synthesized in the cortex of the adrenal gland. Like all steroid hormones, glucocorticoids are derived from cholesterol; their biosynthesis is tightly regulated by the hypothalamus-pituitary-gonadal axis. The chronic steroidogenic response involves the change in the expression of steroidogenic genes while the acute response involves the quick delivery of cholesterol to the site of the first enzymatic reaction
Pathwayprotein kinase A (PKA) signaling pathwayProtein kinase A (PKA) signaling is a widely used intracellular pathway and the major route for channeling the second messenger cAMP signal

Pathway Gene Annotations

Disease Annotations Associated with Genes in the melanocortin system pathway
Disease TermsGene Symbols
acromegalyGnas
ACTH Syndrome, EctopicPomc
ACTH-independent macronodular adrenal hyperplasiaGnas
ACTH-independent macronodular adrenal hyperplasia 1Gnas
acute kidney failurePomc
acute kidney tubular necrosisPomc
Acute Liver FailurePomc
acute lymphoblastic leukemiaGnb1
Acute-Phase ReactionMc1r , Mc2r , Mc3r , Mc4r , Mc5r
adrenal cortex diseasePomc
adrenal cortical adenomaPrkacb
adrenal gland diseaseMrap
adrenal gland hyperfunctionGnas
Adrenal Gland NeoplasmsGnas
Adrenal InsufficiencyPomc
adrenocortical carcinomaGnas
Albright's hereditary osteodystrophyGnas
alcohol dependencePomc
alcohol use disorderPomc
allergic contact dermatitisMc1r
Alzheimer's diseaseGnas
amnestic disorderPomc
amyotrophic lateral sclerosis type 1Mrap
anxiety disorderGnb1 , Pam
asthmaAdcy2
atopic dermatitisMc1r
autism spectrum disorderGnb1
autistic disorderAtrn , Pomc
autosomal dominant dyskeratosis congenita 6Agrp
autosomal dominant intellectual developmental disorderGnb1
autosomal dominant intellectual developmental disorder 42Gnb1
autosomal dominant intellectual developmental disorder 7Mrap
autosomal recessive chronic granulomatous disease 4Mc1r
B-Cell Chronic Lymphocytic LeukemiaGnas
bacterial pneumoniaMc1r
basal cell carcinomaAsip , Mc1r
BDV SyndromeCpe
bilateral breast cancerMc1r
biliary tract benign neoplasmPrkacb
Binge-Eating DisorderMc4r
bipolar disorderAdcy2 , Pomc
Body WeightMc4r , Pcsk1 , Pomc
brachydactylyGnas
BradycardiaMc4r , Pomc
Brain HypoxiaPam
brain ischemiaPrkacb
breast cancerMc1r
Breast NeoplasmsGnas
BurnsPomc
CachexiaMc4r
Cafe-au-Lait SpotsGnas
calcinosisPomc
Cardioacrofacial Dysplasia 2Prkacb
CardiomegalyPomc
cardiomyopathyPomc
CatalepsyPomc
cataract 33Pcsk2
Cerebral HemorrhagePomc
cerebral palsyGnb1 , Pomc
cholangiocarcinomaGnas , Prkacb
cholestasisPomc
chondrocalcinosisPomc
chromosome 18p deletion syndromeMc2r , Mc5r
chromosome 18q deletion syndromeMc4r
chromosome 1p36 deletion syndromeGnb1
chronic kidney diseasePcsk2
cleft palateGnb1
Cocaine-Related DisordersPomc
colitisMc1r
Colorectal NeoplasmsGnas
cone-rod dystrophyMc4r
congenital myasthenic syndrome 8Gnb1
congestive heart failureGnb1 , Pomc
ConstipationPomc
COVID-19Sdc1
Cushing SyndromeGnas , Pomc , Prkacb
cystitisPomc
DehydrationPcsk1
depressive disorderGnb1 , Pomc
dermatitisAsip
Developmental DisabilitiesGnb1
diabetes insipidusPomc
diabetes mellitusAsip , Mc4r , Pomc
Diabetic NephropathiesAsip
dilated cardiomyopathy 1LLGnb1
disease by infectious agentPomc
disease of cellular proliferationAsip , Gnas
disease of mental healthPomc
Duane retraction syndromeGnas
DwarfismPcsk1
dystoniaGnb1
EdemaAsip , Pomc
Ehlers-Danlos syndrome spondylodysplastic type 2Gnb1
endocrine system diseaseCpe , Gnas , Pcsk1
EndotoxemiaMc4r , Pcsk1 , Pcsk2
epilepsyGnb1 , Mgrn1 , Pomc
epilepsy with generalized tonic-clonic seizuresGnb1 , Pomc
Experimental ArthritisPam , Pomc
Experimental Diabetes MellitusPcsk1 , Pcsk2
Experimental Liver CirrhosisAtrn , Pomc
Experimental MelanomaMc1r
eye diseasePomc
Eye PainPomc
facial paralysisPomc
Failure to ThriveAsip , Gnb1
familial adenomatous polyposis 1Pam , Pcsk1
familial hyperlipidemiaSdc1
familial mediterranean feverPomc
familial melanomaMc1r
Fanconi anemiaMc1r
Femur Head NecrosisPomc
FeverPomc
FibrosisAsip
focal epilepsyGnb1
FurunculosisAsip
GallstonesGnas
gastric adenocarcinomaGnas
gastrointestinal system diseasePomc
genetic diseaseAdcy2 , Agrp , Asip , Atrn , Atrnl1 , Cpe , Gnas , Gnb1 , Mc1r , Mc2r , Mc3r , Mc4r , Mc5r , Mgrn1 , Mrap , Mrap2 , Pam , Pcsk1 , Pcsk2 , Pomc , Prkacb , Sdc1 , Sdc3
glomerulonephritisPomc
glucocorticoid deficiency 1Mc2r , Mrap
Glucocorticoid Deficiency 2Mrap
glucose intolerancePcsk1
Goldberg-Shprintzen syndromeGnb1
Gouty ArthritisPomc
Growth DisordersGnb1
growth hormone secreting pituitary adenomaGnas
head and neck squamous cell carcinomaGnas
HematuriaPomc
HemorrhagePomc
hemorrhagic diseaseGnas
hepatic veno-occlusive diseaseAsip
hepatocellular carcinomaGnas
Hereditary Neoplastic SyndromesPam , Pcsk1
hereditary spastic paraplegia 4Gnas
heroin dependencePomc
Heterotopic OssificationGnas
HirsutismPomc
Hodgkin's lymphomaSdc1
Huntington's disease-like 1Atrn
HyperalgesiaMc1r , Mc4r
HypercalciuriaPomc
hyperglycemiaAsip , Mgrn1 , Pcsk1 , Sdc1
hyperinsulinismMc4r , Mgrn1
HypernatremiaPomc
HyperoxiaMc1r , Mc2r
HyperphagiaAgrp , Mc4r , Pomc
HyperplasiaAsip , Pam
hypertensionGnas , Mc2r , Pomc
hyperthyroidismPcsk1
hypertrophic cardiomyopathyPomc
HypocalcemiaPomc
Hypoglossal Nerve InjuriesPrkacb
hypogonadismPcsk1
hypokalemiaPomc
HypopigmentationMc1r
HypotensionPomc
hypothyroidismGnb1 , Pam , Pcsk1
HypoxiaGnas , Pomc
idiopathic generalized epilepsyGnb1 , Mgrn1
immune system diseasePomc
immunodeficiency 12Mc4r
immunodeficiency 16Gnb1
immunodeficiency 38Gnb1
InflammationPcsk1 , Pcsk2 , Pomc , Sdc1
inflammatory bowel diseasePomc
Inosine Triphosphatase DeficiencyAtrn
Insulin ResistanceCpe , Gnas , Mc4r
intellectual disabilityGnas , Gnb1 , Gng12 , Mc2r , Mc5r
islet cell tumorPcsk1
isolated microphthalmia 3Mc4r
Joubert syndrome 25Gnb1
keratosisAsip
Kidney CalculiPomc
kidney diseasePomc
Kidney Reperfusion InjuryMc1r
Kohlschutter-Tonz syndromeMgrn1
Language Development DisordersGnb1
Liver NeoplasmsAsip
long QT syndromeAsip , Pomc , Sdc1
lung adenocarcinomaGnas , Sdc1
Lung NeoplasmsCpe
Lymphoma, AIDS-RelatedSdc1
major depressive disorderMc1r
malignant mesotheliomaSdc1
McCune Albright syndromeGnas
melanomaAsip , Gnas , Mc1r , Pomc
Memory DisordersCpe
Metabolic Bone DiseasesGnas
Metabolic Brain Diseases, InbornMc2r
metabolic dysfunction-associated steatohepatitisMc4r
microcephalyGnb1
morbid obesityCpe , Mc4r , Pcsk1 , Pomc
multiple sclerosisPomc
Muscle HypotoniaGnb1
myasthenia gravisPomc
myelodysplastic syndromeGnb1
myocardial infarctionPcsk2 , Sdc1
Myocardial IschemiaPomc
Myoclonic EpilepsiesPomc
NauseaPomc
NecrosisPomc
nephrocalcinosisPomc
Nerve DegenerationAtrn
neuroblastomaGnas
Neurodevelopmental DisordersGnb1 , Pam , Pcsk1
Neurogenic InflammationPomc
Nociceptive PainPomc
obesityAgrp , Asip , Atrn , Cpe , Gnas , Mc3r , Mc4r , Mgrn1 , Pcsk1 , Pomc , Sdc1 , Sdc3
oculocutaneous albinism type IIMc1r
OliguriaPomc
opioid abusePomc
Opsoclonus-Myoclonus SyndromePomc
Orthostatic HypotensionGnas
osteoarthritisPomc
osteoporosisPomc
PainPomc
pancreas diseasePomc
pancreatic adenocarcinomaGnas
pancreatic cancerGnas
pantothenate kinase-associated neurodegenerationAtrn
Parasitic Liver DiseasesGnas
Parkinson's disease 20Mrap
pathologic nystagmusGnb1
penile diseasePomc
Peroxisome Biogenesis Disorder, Complementation Group 7Gnb1
pigmentation diseaseAsip
pituitary adenoma 3Gnas
Pituitary NeoplasmsGnas
pituitary-dependent Cushing's diseasePomc
pneumoniaPomc
polycystic kidney diseaseGnas
polycystic ovary syndromeGnas
Postoperative ComplicationsPomc
Precocious PubertyGnas
Prenatal Exposure Delayed EffectsAsip
primary ciliary dyskinesia 33Mc1r
primary hyperaldosteronismGnas
Primary Pigmented Nodular Adrenocortical Disease, 1Gnas
progressive osseous heteroplasiaGnas
Proopiomelanocortin DeficiencyPomc
proprotein convertase 1/3 deficiencyPcsk1
prostate adenocarcinomaPam
Prostatic NeoplasmsMc2r , Prkacb
proteinuriaPomc , Sdc1
pseudohypoaldosteronismGnas
pseudohypoparathyroidismGnas
pseudohypoparathyroidism type IBGnas
Pseudohypoparathyroidism Type ICGnas
pseudopseudohypoparathyroidismGnas
RecurrencePomc
renal cell carcinomaPomc
Reperfusion InjuryMc1r , Pcsk2
Respiration DisordersGnas
restless legs syndromePomc
RhabdomyomaPomc
Rubinstein-Taybi syndromeMgrn1
SacroiliitisPomc
schizophreniaMc4r
sciatic neuropathyMc4r
Seasonal Allergic RhinitisMc1r
severe acute respiratory syndromePomc
sex cord-gonadal stromal tumorGnas
short-rib thoracic dysplasia 9 with or without polydactylyMgrn1
Shprintzen-Goldberg CraniosynostosisGnb1
sick sinus syndromePomc
skin melanomaGnas
Skin NeoplasmsAsip
SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 2Mc1r
sleep disorderPomc
steatotic liver diseaseMc4r , Pomc
strabismusGnb1
stress-related disorderPomc
subvalvular aortic stenosisPomc
SunburnAsip
synovitisPomc
TachycardiaGnas
Tatton-Brown-Rahman syndromePomc
ThinnessAgrp
toxic shock syndromeMc2r
TremorAtrn
type 1 diabetes mellitusPcsk1
type 2 diabetes mellitusAgrp , Asip , Cpe , Pam , Pcsk1 , Pcsk2
urinary tract infectionPomc
Uterine Cervical NeoplasmsGnas
UV-Induced Skin DamageMc1r
visual epilepsyPcsk1
vitiligoMc1r
Weight GainAsip , Pomc
Weight LossPomc
West syndromeMc2r , Pomc
withdrawal disorderGnas , Pomc
ZTTK SyndromeMrap
Pathway Annotations Associated with Genes in the melanocortin system pathway
Pathway TermsGene Symbols
adenosine signaling pathwayAdcy2 , Gnas , Gnb1 , Gng12 , Prkacb
alfentanil pharmacodynamics pathwayPcsk2 , Pomc
altered energy homeostasis pathwayMc4r , Pcsk1 , Pomc
altered melanocortin system pathwayAgrp , Mc4r , Pcsk1 , Pomc , Sdc1
apoptotic cell death pathwayPrkacb
bile acid transport pathwayAdcy2 , Gnas , Prkacb
bupivacaine pharmacodynamics pathwayPcsk2 , Pomc
buprenorphine pharmacodynamics pathwayPcsk2 , Pomc
calcium/calcium-mediated signaling pathwayAdcy2 , Gnas , Prkacb
cell-extracellular matrix signaling pathwaySdc1 , Sdc3
Chagas disease pathwayGnas
chemokine mediated signaling pathwayAdcy2 , Gnb1 , Gng12 , Prkacb
chloroprocaine pharmacodynamics pathwayPcsk2 , Pomc
citalopram pharmacodynamics pathwayPcsk2 , Pomc
cocaine pharmacodynamics pathwayPcsk2 , Pomc
codeine and morphine pharmacodynamics pathwayPcsk2 , Pomc
corticotropin-releasing hormone signaling pathwayGnas
desipramine pharmacodynamics pathwayPcsk2 , Pomc
dilated cardiomyopathy pathwayAdcy2 , Gnas , Prkacb
diphenoxylate pharmacodynamics pathwayPcsk2 , Pomc
dopamine signaling pathwayPrkacb
dopamine signaling pathway via D1 family of receptorsAdcy2 , Gnas , Gnb1 , Gng12 , Prkacb
eicosanoid signaling pathwayGnb1
endothelin signaling pathwayAdcy2
Entamoebiasis pathwayGnas , Prkacb
epinephrine signaling pathway via adrenergic receptor betaGnas
escitalopram pharmacodynamics pathwayPcsk2 , Pomc
ethylmorphine pharmacodynamics pathwayPcsk2 , Pomc
fentanyl pharmacodynamics pathwayPcsk2 , Pomc
fluoxetine pharmacodynamics pathwayPcsk2 , Pomc
follicle-stimulating hormone signaling pathwayAdcy2 , Gnas , Gnb1 , Gng12 , Prkacb
G protein mediated signaling pathway via Galpha12/Galpha13 familyGnb1
G protein mediated signaling pathway via Galphas familyAdcy2 , Gnas , Mc1r , Mc2r , Mc3r , Mc4r , Mc5r
glucagon signaling pathwayGnas
glutamate signaling pathwayAdcy2 , Gnas , Gnb1 , Gng12 , Prkacb
gonadotropin-releasing hormone signaling pathwayAdcy2 , Gnas , Prkacb
granulocyte-macrophage colony-stimulating factor signaling pathwayPrkacb
Hedgehog signaling pathwayGnb1 , Prkacb
heroin pharmacodynamics pathwayPcsk2 , Pomc
histamine signaling pathway, immunologicalAdcy2 , Gnas , Gnb1 , Gng12 , Prkacb
hydrocodone pharmacodynamics pathwayPcsk2 , Pomc
hydromorphone pharmacodynamics pathwayPcsk2 , Pomc
imipramine pharmacodynamics pathwayPcsk2 , Pomc
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAsip
insulin signaling pathwayPrkacb
interleukin-3 signaling pathwayPrkacb
levacetylmethadol pharmacodynamics pathwayPcsk2 , Pomc
levobupivacaine phgarmacodynamics pathwayPcsk2 , Pomc
levorphanol pharmacodynamics pathwayPcsk2 , Pomc
lidocaine pharmacodynamics pathwayPcsk2 , Pomc
long term depressionGnas
long term potentiationPrkacb
luteinizing hormone signaling pathwayAdcy2 , Gnas , Gnb1 , Gng12 , Prkacb
malaria pathwaySdc1 , Sdc3
melanocortin system pathwayAdcy2 , Agrp , Asip , Atrn , Atrnl1 , Cpe , Gnas , Gnb1 , Gng12 , Mc1r , Mc2r , Mc3r , Mc4r , Mc5r , Mgrn1 , Mrap , Mrap2 , Pam , Pcsk1 , Pcsk2 , Pomc , Prkacb , Sdc1 , Sdc3
mepivacaine pharmacodynamics pathwayPcsk2 , Pomc
methadone pharmacodynamics pathwayPcsk2 , Pomc
mitogen activated protein kinase signaling pathwayGng12 , Prkacb
nalbuphine pharmacodynamics pathwayPcsk2 , Pomc
naloxone pharmacodynamics pathwayPcsk2 , Pomc
naltrexone pharmacodynamics pathwayPcsk2 , Pomc
nicotine pharmacodynamics pathwayPcsk2 , Pomc
obesity pathwayAgrp , Mc4r , Pcsk1 , Pomc , Sdc1
orexin/hypocretin signaling pathwayPcsk1
oxybuprocaine pharmacodynamics pathwayPcsk2 , Pomc
oxycodone pharmacodynamics pathwayPcsk2 , Pomc
oxymorphone pharmacodynamics pathwayPcsk2 , Pomc
pentazocine pharmacodynamics pathwayPcsk2 , Pomc
prilocaine pharmacodynamics pathwayPcsk2 , Pomc
prion disease pathwayPrkacb
procaine pharmacodynamics pathwayPcsk2 , Pomc
prostaglandin D2 signaling pathwayAdcy2 , Gnas , Gnb1 , Gng12 , Prkacb
prostaglandin I2 signaling pathwayAdcy2 , Gnas , Gnb1 , Gng12 , Prkacb
protein kinase A (PKA) signaling pathwayAdcy2 , Prkacb
purine metabolic pathwayAdcy2
remifentanil pharmacodynamics pathwayPcsk2 , Pomc
ropivacaine pharmacodynamics pathwayPcsk2 , Pomc
serotonin signaling pathway via receptors engaging G alphas protein familyAdcy2 , Gnas , Gnb1 , Gng12 , Prkacb
syndecan signaling pathwayAgrp , Mc4r , Pomc , Sdc1 , Sdc3
tramadol pharmacodynamics pathwayPcsk2 , Pomc
type 1 diabetes mellitus pathwayCpe
ubiquitin/proteasome degradation pathwayMgrn1
vasopressin signaling pathwayGnas
vasopressin signaling pathway via receptor type 2Adcy2 , Gnas , Gnb1 , Gng12 , Prkacb
visual phototransduction pathwayGnb1
Wnt signaling pathwayPrkacb
Phenotype Annotations Associated with Genes in the melanocortin system pathway

References Associated with the melanocortin system pathway:

Ontology Path Diagram:

paths to the root
paths to the root

Import into Pathway Studio: