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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Morroniside
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Accession:CHEBI:80852 term browser browse the term
Definition:A glycoside that has formula C17H26O11.
Synonyms:related_synonym: Formula=C17H26O11;   InChI=1S/C17H26O11/c1-6-11-7(3-10(19)26-6)8(15(23)24-2)5-25-16(11)28-17-14(22)13(21)12(20)9(4-18)27-17/h5-7,9-14,16-22H,3-4H2,1-2H3/t6-,7+,9+,10+,11+,12+,13-,14+,16-,17-/m0/s1;   InChIKey=YTZSBJLNMIQROD-SFBCHFHNSA-N;   SMILES=COC(=O)C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H]2[C@H](C)O[C@@H](O)C[C@H]12
 xref: CAS:25406-64-8;   KEGG:C17000
 xref_mesh: MESH:C488401


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Morroniside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 multiple interactions ISO morroniside inhibits the reaction [Glucose results in decreased expression of ABCA1 mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of ABCA1 protein]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of ABCA1 mRNA]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of ABCA1 protein] CTD PMID:34485530 NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155 		JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 multiple interactions ISO morroniside inhibits the reaction [Glucose results in decreased expression of ABCG1 mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of ABCG1 protein]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of ABCG1 mRNA]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of ABCG1 protein] CTD PMID:34485530 NCBI chr21:42,199,689...42,297,244
Ensembl chr21:42,199,689...42,297,244 		JBrowse link
G ACP5 acid phosphatase 5, tartrate resistant decreases expression ISO morroniside results in decreased expression of ACP5 mRNA CTD PMID:34638983 NCBI chr19:11,574,660...11,578,975
Ensembl chr19:11,574,653...11,579,993 		JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions ISO LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
morroniside inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; morroniside inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]		 CTD PMID:35279615 PMID:35679793 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339 		JBrowse link
G ADORA2A adenosine A2a receptor increases expression ISO morroniside results in increased expression of ADORA2A mRNA CTD PMID:35848187 NCBI chr22:24,423,597...24,442,357
Ensembl chr22:24,417,879...24,442,357 		JBrowse link
G ALPL alkaline phosphatase, biomineralization associated increases expression
multiple interactions		 ISO morroniside results in increased expression of ALPL mRNA
morroniside inhibits the reaction [Glucose results in decreased expression of ALPL mRNA]		 CTD PMID:32643284 PMID:34638983 PMID:35848187 NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410 		JBrowse link
G ANG angiogenin increases expression ISO morroniside results in increased expression of ANG protein CTD PMID:24979385 NCBI chr14:20,684,177...20,694,186
Ensembl chr14:20,684,177...20,698,971 		JBrowse link
G APOE apolipoprotein E multiple interactions ISO morroniside inhibits the reaction [Glucose results in decreased expression of APOE mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of APOE protein]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of APOE mRNA]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of APOE protein] CTD PMID:34485530 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393 		JBrowse link
G ARG1 arginase 1 increases expression ISO morroniside results in increased expression of ARG1 mRNA CTD PMID:34867417 NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332 		JBrowse link
G ASIP agouti signaling protein multiple interactions ISO morroniside inhibits the reaction [A mutant form results in increased expression of FAS protein]; morroniside inhibits the reaction [A mutant form results in increased expression of SCD1 protein]; morroniside inhibits the reaction [A mutant form results in increased expression of SREBF1 protein]; morroniside inhibits the reaction [A mutant form results in increased expression of TNF protein]; morroniside inhibits the reaction [A mutant form results in increased phosphorylation of RELA protein] CTD PMID:37769864 NCBI chr20:34,186,493...34,269,344
Ensembl chr20:34,194,569...34,269,344 		JBrowse link
G ATG13 autophagy related 13 multiple interactions
increases expression		 ISO MTOR inhibits the reaction [morroniside results in increased expression of ATG13 protein] CTD PMID:35957534 NCBI chr11:46,617,553...46,674,518
Ensembl chr11:46,617,527...46,674,818 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator affects expression
multiple interactions		 ISO morroniside affects the expression of BAX protein
[morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in increased expression of BAX protein]; morroniside inhibits the reaction [Glucose results in increased expression of BAX protein]		 CTD PMID:21963495 PMID:28106847 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression
multiple interactions		 ISO morroniside results in increased expression of BCL2 mRNA
[morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in decreased expression of BCL2 protein]; morroniside inhibits the reaction [Glucose results in decreased expression of BCL2 protein]		 CTD PMID:20966881 PMID:28106847 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BECN1 beclin 1 increases expression
multiple interactions		 ISO morroniside results in increased expression of BECN1 protein
MTOR inhibits the reaction [morroniside results in increased expression of BECN1 protein]		 CTD PMID:35957534 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350 		JBrowse link
G BGLAP bone gamma-carboxyglutamate protein multiple interactions ISO morroniside inhibits the reaction [Glucose results in decreased expression of BGLAP mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of BGLAP protein] CTD PMID:32643284 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317 		JBrowse link
G BMP2 bone morphogenetic protein 2 increases expression
multiple interactions		 ISO morroniside results in increased expression of BMP2 mRNA
morroniside inhibits the reaction [Glucose results in decreased expression of BMP2 mRNA]		 CTD PMID:32643284 PMID:35848187 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246 		JBrowse link
G CASP1 caspase 1 multiple interactions
affects expression		 ISO morroniside inhibits the reaction [IL1B protein results in increased expression of CASP1]
morroniside affects the expression of CASP1		 CTD PMID:33022338 NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250 		JBrowse link
G CASP3 caspase 3 multiple interactions
decreases expression		 ISO [morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in increased expression of and results in increased activity of CASP3 protein]; morroniside inhibits the reaction [Glucose results in increased expression of and results in increased activity of CASP3 protein]
morroniside results in decreased expression of CASP3 mRNA		 CTD PMID:20966881 PMID:28106847 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP9 caspase 9 decreases expression ISO morroniside results in decreased expression of CASP9 mRNA CTD PMID:20966881 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 affects expression ISO morroniside affects the expression of CCL2 protein CTD PMID:21963495 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCND1 cyclin D1 increases expression ISO morroniside results in increased expression of CCND1 mRNA CTD PMID:35848187 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression ISO morroniside results in increased expression of CDKN1A mRNA CTD PMID:35848187 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions ISO LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] CTD PMID:35679793 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G COL3A1 collagen type III alpha 1 chain multiple interactions ISO LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA] CTD PMID:35679793 NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746 		JBrowse link
G CTNNB1 catenin beta 1 increases expression ISO morroniside results in increased expression of CTNNB1 protein CTD PMID:24876057 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096 		JBrowse link
G CTSK cathepsin K decreases expression ISO morroniside results in decreased expression of CTSK mRNA CTD PMID:34638983 NCBI chr 1:150,796,208...150,808,260
Ensembl chr 1:150,794,880...150,809,577 		JBrowse link
G CYBA cytochrome b-245 alpha chain affects expression ISO morroniside affects the expression of CYBA protein CTD PMID:21963495 NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083 		JBrowse link
G FAS Fas cell surface death receptor multiple interactions EXP
ISO		 morroniside inhibits the reaction [Palmitic Acid results in increased expression of FAS protein]
morroniside inhibits the reaction [A mutant form results in increased expression of FAS protein]		 CTD PMID:37769864 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FGF2 fibroblast growth factor 2 increases expression ISO morroniside results in increased expression of FGF2 protein CTD PMID:24979385 NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236 		JBrowse link
G GATA3 GATA binding protein 3 affects binding
multiple interactions		 ISO morroniside binds to GATA3 protein
morroniside inhibits the reaction [TGFB1 protein results in increased expression of GATA3 mRNA]		 CTD PMID:35679793 NCBI chr10:8,045,333...8,075,198
Ensembl chr10:8,045,378...8,075,198 		JBrowse link
G GLO1 glyoxalase I multiple interactions ISO morroniside inhibits the reaction [Glucose results in decreased expression of GLO1 mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of GLO1 protein] CTD PMID:32643284 NCBI chr 6:38,675,925...38,703,145
Ensembl chr 6:38,675,925...38,703,145 		JBrowse link
G GLP1R glucagon like peptide 1 receptor affects response to substance EXP GLP1R affects the susceptibility to morroniside CTD PMID:28098360 NCBI chr 6:39,048,781...39,091,303
Ensembl chr 6:39,048,781...39,091,303 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
affects expression		 ISO morroniside promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; morroniside results in increased expression of and results in increased phosphorylation of HMOX1 protein
morroniside affects the expression of HMOX1 protein		 CTD PMID:21963495 PMID:34029560 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 affects expression ISO morroniside affects the expression of ICAM1 protein CTD PMID:21963495 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IL10 interleukin 10 increases expression
multiple interactions		 ISO morroniside results in increased expression of IL10 mRNA; morroniside results in increased expression of IL10 protein
SB 203580 inhibits the reaction [morroniside results in increased expression of IL10 mRNA]		 CTD PMID:32595037 PMID:34867417 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO morroniside inhibits the reaction [Glucose results in increased secretion of IL1B protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; S-4-bromobenzylglutathione cyclopentyl diester inhibits the reaction [morroniside inhibits the reaction [Glucose results in increased secretion of IL1B protein]]
morroniside inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; morroniside inhibits the reaction [IL1B protein results in increased expression of CASP1]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of NLRP3]; morroniside inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of RELA protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]		 CTD PMID:32643284 PMID:33022338 PMID:33804203 PMID:35279615 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL4 interleukin 4 increases expression ISO morroniside results in increased expression of IL4 mRNA CTD PMID:34867417 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO morroniside inhibits the reaction [Glucose results in increased secretion of IL6 protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; S-4-bromobenzylglutathione cyclopentyl diester inhibits the reaction [morroniside inhibits the reaction [Glucose results in increased secretion of IL6 protein]] CTD PMID:32643284 PMID:35279615 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G KDR kinase insert domain receptor multiple interactions ISO morroniside results in increased expression of and results in increased phosphorylation of KDR protein CTD PMID:31991140 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595 		JBrowse link
G LIPA lipase A, lysosomal acid type multiple interactions ISO LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]; LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]]; morroniside inhibits the reaction [TGFB1 protein results in decreased expression of LIPA mRNA]; morroniside inhibits the reaction [TGFB1 protein results in decreased expression of LIPA protein] CTD PMID:35679793 NCBI chr10:89,213,572...89,251,775
Ensembl chr10:89,213,569...89,414,557 		JBrowse link
G LY96 lymphocyte antigen 96 affects binding ISO morroniside binds to [TLR4 protein binds to LY96 protein] CTD PMID:34029560 NCBI chr 8:73,991,392...74,099,857
Ensembl chr 8:73,991,392...74,029,079 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO morroniside results in increased expression of and results in increased phosphorylation of MAPK1 protein CTD PMID:31991140 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO morroniside results in increased expression of and results in increased phosphorylation of MAPK3 protein CTD PMID:31991140 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPT microtubule associated protein tau multiple interactions EXP morroniside inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPT protein] CTD PMID:26836014 NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334 		JBrowse link
G MMP13 matrix metallopeptidase 13 multiple interactions
affects expression		 ISO morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13]
morroniside affects the expression of MMP13		 CTD PMID:33022338 PMID:33804203 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732 		JBrowse link
G MMP3 matrix metallopeptidase 3 multiple interactions ISO morroniside inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP3 protein] CTD PMID:33804203 NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609 		JBrowse link
G MMP9 matrix metallopeptidase 9 decreases expression ISO morroniside results in decreased expression of MMP9 mRNA CTD PMID:34638983 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MRC1 mannose receptor C-type 1 increases expression ISO morroniside results in increased expression of MRC1 mRNA CTD PMID:34867417 NCBI chr10:17,809,348...17,911,164
Ensembl chr10:17,809,348...17,911,164 		JBrowse link
G MTOR mechanistic target of rapamycin kinase increases activity
multiple interactions		 ISO morroniside results in increased activity of MTOR protein
MTOR inhibits the reaction [morroniside results in increased expression of ATG13 protein]; MTOR inhibits the reaction [morroniside results in increased expression of BECN1 protein]		 CTD PMID:35957534 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor multiple interactions ISO morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein] CTD PMID:34029560 NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,552...38,143,024 		JBrowse link
G NEUROG2 neurogenin 2 increases expression ISO morroniside results in increased expression of NEUROG2 protein CTD PMID:24876057 NCBI chr 4:112,513,516...112,516,180
Ensembl chr 4:112,513,516...112,516,180 		JBrowse link
G NFATC1 nuclear factor of activated T cells 1 decreases expression ISO morroniside results in decreased expression of NFATC1 mRNA CTD PMID:34638983 NCBI chr18:79,395,930...79,529,323
Ensembl chr18:79,395,856...79,529,325 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions
affects expression		 ISO morroniside promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of and affects the localization of NFE2L2 protein]; morroniside results in increased expression of and results in increased phosphorylation of NFE2L2 protein
morroniside affects the expression of NFE2L2 protein		 CTD PMID:21963495 PMID:34029560 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions
affects expression		 ISO morroniside inhibits the reaction [IL1B protein results in increased expression of NLRP3]
morroniside affects the expression of NLRP3		 CTD PMID:33022338 NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,332,331...247,449,108 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
affects expression
decreases expression		 ISO morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
morroniside affects the expression of NOS2 protein
morroniside results in decreased expression of NOS2 protein		 CTD PMID:20487222 PMID:21963495 PMID:34029560 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NOX4 NADPH oxidase 4 affects expression ISO morroniside affects the expression of NOX4 protein CTD PMID:21963495 NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187 		JBrowse link
G NR1H2 nuclear receptor subfamily 1 group H member 2 multiple interactions ISO morroniside inhibits the reaction [Glucose results in decreased expression of NR1H2 mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of NR1H2 protein]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of NR1H2 mRNA]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of NR1H2 protein] CTD PMID:34485530 NCBI chr19:50,376,457...50,383,388
Ensembl chr19:50,329,653...50,383,388 		JBrowse link
G NRP1 neuropilin 1 increases expression ISO morroniside results in increased expression of NRP1 protein CTD PMID:24979385 NCBI chr10:33,177,493...33,334,667
Ensembl chr10:33,177,492...33,336,262 		JBrowse link
G PAX6 paired box 6 increases expression ISO morroniside results in increased expression of PAX6 protein CTD PMID:24876057 NCBI chr11:31,789,026...31,817,961
Ensembl chr11:31,784,779...31,817,961 		JBrowse link
G PCNA proliferating cell nuclear antigen increases expression ISO morroniside results in increased expression of PCNA mRNA CTD PMID:35848187 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626 		JBrowse link
G POMC proopiomelanocortin increases expression ISO morroniside results in increased expression of POMC mRNA alternative form CTD PMID:32595037 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions ISO morroniside inhibits the reaction [Glucose results in decreased expression of PPARGC1A mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of PPARGC1A mRNA]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of PPARGC1A protein] CTD PMID:34485530 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G PPME1 protein phosphatase methylesterase 1 multiple interactions EXP morroniside inhibits the reaction [Okadaic Acid results in increased expression of PPME1 protein] CTD PMID:26836014 NCBI chr11:74,171,289...74,254,703
Ensembl chr11:74,171,267...74,254,703 		JBrowse link
G PPP2CA protein phosphatase 2 catalytic subunit alpha multiple interactions EXP morroniside inhibits the reaction [Okadaic Acid results in decreased methylation of and results in increased phosphorylation of and results in decreased activity of [PPP2CA protein binds to PPP2CB protein]]; morroniside results in increased activity of [PPP2CA protein binds to PPP2CB protein] CTD PMID:26836014 NCBI chr 5:134,194,332...134,226,073
Ensembl chr 5:134,194,035...134,226,073 		JBrowse link
G PPP2CB protein phosphatase 2 catalytic subunit beta multiple interactions EXP morroniside inhibits the reaction [Okadaic Acid results in decreased methylation of and results in increased phosphorylation of and results in decreased activity of [PPP2CA protein binds to PPP2CB protein]]; morroniside results in increased activity of [PPP2CA protein binds to PPP2CB protein] CTD PMID:26836014 NCBI chr 8:30,785,616...30,812,818
Ensembl chr 8:30,774,457...30,814,314 		JBrowse link
G PRKCD protein kinase C delta multiple interactions ISO morroniside results in increased expression of and results in increased phosphorylation of PRKCD protein CTD PMID:31991140 NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
affects expression		 ISO morroniside inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
morroniside results in decreased expression of PTGS2 protein
morroniside affects the expression of PTGS2 protein		 CTD PMID:20487222 PMID:21963495 PMID:33804203 PMID:34029560 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
affects expression
decreases expression		 ISO
EXP		 morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of RELA protein]
morroniside inhibits the reaction [A mutant form results in increased phosphorylation of RELA protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of RELA protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of RELA protein]
morroniside affects the expression of RELA protein
morroniside results in decreased expression of RELA protein
morroniside inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]		 CTD PMID:20487222 PMID:21963495 PMID:33804203 PMID:35279615 PMID:37769864 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RUNX2 RUNX family transcription factor 2 affects expression
multiple interactions
increases expression		 ISO morroniside affects the expression of RUNX2 protein
morroniside inhibits the reaction [Glucose results in decreased expression of RUNX2 mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of RUNX2 protein]
morroniside results in increased expression of RUNX2 mRNA		 CTD PMID:32643284 PMID:34638983 PMID:35848187 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349 		JBrowse link
G SCD stearoyl-CoA desaturase multiple interactions EXP morroniside inhibits the reaction [Palmitic Acid results in increased expression of SCD protein] CTD PMID:37769864 NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826 		JBrowse link
G SP7 Sp7 transcription factor increases expression ISO morroniside results in increased expression of SP7 mRNA CTD PMID:34638983 NCBI chr12:53,326,575...53,344,793
Ensembl chr12:53,326,575...53,345,315 		JBrowse link
G SPP1 secreted phosphoprotein 1 multiple interactions
affects expression		 ISO morroniside inhibits the reaction [Glucose results in decreased expression of SPP1 mRNA]
morroniside affects the expression of SPP1 protein		 CTD PMID:32643284 PMID:35848187 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO
EXP		 morroniside results in increased expression of and results in increased phosphorylation of SRC protein
morroniside inhibits the reaction [Okadaic Acid results in increased phosphorylation of and results in increased activity of SRC protein]		 CTD PMID:26836014 PMID:31991140 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 affects expression
multiple interactions		 ISO
EXP		 morroniside affects the expression of SREBF1 protein
morroniside inhibits the reaction [A mutant form results in increased expression of SREBF1 protein]
morroniside inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]		 CTD PMID:20487222 PMID:37769864 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002 		JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 affects expression ISO morroniside affects the expression of SREBF2 protein CTD PMID:20487222 NCBI chr22:41,833,105...41,907,305
Ensembl chr22:41,833,105...41,907,306 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions ISO morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of STAT3 protein]
morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of STAT3 protein]		 CTD PMID:35279615 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
G TCF7L2 transcription factor 7 like 2 increases expression ISO morroniside results in increased expression of TCF7L2 protein CTD PMID:24876057 NCBI chr10:112,950,247...113,167,678
Ensembl chr10:112,950,247...113,167,678 		JBrowse link
G TEK TEK receptor tyrosine kinase increases expression ISO morroniside results in increased expression of TEK protein CTD PMID:24979385 NCBI chr 9:27,109,141...27,230,178
Ensembl chr 9:27,109,141...27,230,174 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO morroniside inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]
LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]; LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]]; morroniside inhibits the reaction [TGFB1 protein results in decreased expression of LIPA mRNA]; morroniside inhibits the reaction [TGFB1 protein results in decreased expression of LIPA protein]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of GATA3 mRNA]		 CTD PMID:35279615 PMID:35679793 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TLR4 toll like receptor 4 affects binding
multiple interactions		 ISO morroniside binds to [TLR4 protein binds to LY96 protein]
morroniside inhibits the reaction [Lipopolysaccharides binds to TLR4 protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]		 CTD PMID:34029560 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO
EXP		 morroniside inhibits the reaction [Glucose results in increased secretion of TNF protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; S-4-bromobenzylglutathione cyclopentyl diester inhibits the reaction [morroniside inhibits the reaction [Glucose results in increased secretion of TNF protein]]
morroniside inhibits the reaction [A mutant form results in increased expression of TNF protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
morroniside inhibits the reaction [Palmitic Acid results in increased expression of TNF protein]		 CTD PMID:32643284 PMID:35279615 PMID:37769864 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFSF11 TNF superfamily member 11 decreases expression ISO morroniside results in decreased expression of TNFSF11 mRNA CTD PMID:20966881 NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013 		JBrowse link
G VEGFA vascular endothelial growth factor A increases expression ISO morroniside results in increased expression of VEGFA protein CTD PMID:24979385 PMID:31991140 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G WNT3A Wnt family member 3A increases expression ISO morroniside results in increased expression of WNT3A protein CTD PMID:24876057 NCBI chr 1:228,006,998...228,061,271
Ensembl chr 1:228,006,998...228,061,271 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26089
    chemical entity 26068
      atom 26064
        nonmetal atom 25556
          oxygen atom 24812
            oxygen molecular entity 24852
              organooxygen compound 24093
                carbohydrates and carbohydrate derivatives 16793
                  carbohydrate derivative 15653
                    glycosyl compound 13731
                      glycoside 12289
                        Morroniside 84
Path 2
Term Annotations click to browse term
  CHEBI ontology 26089
    subatomic particle 26064
      composite particle 26064
        hadron 26064
          baryon 26064
            nucleon 26016
              atomic nucleus 26064
                atom 26064
                  main group element atom 25891
                    p-block element atom 25891
                      carbon group element atom 25478
                        carbon atom 25437
                          organic molecular entity 25437
                            heteroorganic entity 24805
                              organochalcogen compound 24413
                                organooxygen compound 24093
                                  carbohydrates and carbohydrate derivatives 16793
                                    carbohydrate 16793
                                      carbohydrate derivative 15653
                                        glycosyl compound 13731
                                          glycoside 12289
                                            Morroniside 84
paths to the root