PPP2CB (protein phosphatase 2 catalytic subunit beta) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: PPP2CB (protein phosphatase 2 catalytic subunit beta) Homo sapiens
Analyze
Symbol: PPP2CB
Name: protein phosphatase 2 catalytic subunit beta
RGD ID: 736927
HGNC Page HGNC:9300
Description: Predicted to enable protein serine/threonine phosphatase activity. Acts upstream of or within negative regulation of gene expression. Predicted to be located in several cellular components, including chromosome, centromeric region; nucleus; and spindle pole. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: PP2A-beta; PP2Abeta; PP2CB; protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform; protein phosphatase 2, catalytic subunit, beta isoform; protein phosphatase 2A catalytic subunit, beta isoform; protein phosphatase 2a, catalytic subunit, beta isoform; protein phosphatase type 2A catalytic subunit; serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; testicular tissue protein Li 146
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: PPP2CBP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38830,785,616 - 30,812,818 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl830,774,457 - 30,814,314 (-)EnsemblGRCh38hg38GRCh38
GRCh37830,643,132 - 30,670,334 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36830,762,668 - 30,789,894 (-)NCBINCBI36Build 36hg18NCBI36
Build 34830,762,668 - 30,789,894NCBI
Celera829,603,219 - 29,630,439 (-)NCBICelera
Cytogenetic Map8p12NCBI
HuRef829,189,574 - 29,216,794 (-)NCBIHuRef
CHM1_1830,844,570 - 30,871,782 (-)NCBICHM1_1
T2T-CHM13v2.0831,066,636 - 31,093,832 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP)
acrylamide  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
atrazine  (EXP)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bufalin  (EXP)
cadmium dichloride  (ISO)
chlorpyrifos  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP)
diarsenic trioxide  (EXP)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
Echimidine  (EXP)
enniatin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
fenthion  (ISO)
finasteride  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
gentamycin  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (EXP)
ionomycin  (EXP)
ivermectin  (EXP)
ketoconazole  (ISO)
Lasiocarpine  (EXP)
lead(0)  (EXP)
menadione  (EXP)
methidathion  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
miconazole  (ISO)
monocrotaline  (EXP)
Morroniside  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nefazodone  (ISO)
nickel atom  (EXP)
niclosamide  (EXP)
nitroglycerin  (ISO)
obeticholic acid  (EXP)
okadaic acid  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (EXP)
potassium chromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
riddelliine  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP)
sulindac  (ISO)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (ISO)
tetrahydropalmatine  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
tunicamycin  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer. Seshacharyulu P, etal., Cancer Lett. 2013 Jul 10;335(1):9-18. doi: 10.1016/j.canlet.2013.02.036. Epub 2013 Feb 20.
5. DARPP-32, Jack of All Trades... Master of Which? Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.
Additional References at PubMed
PMID:1330687   PMID:1846293   PMID:2153055   PMID:2555176   PMID:2837763   PMID:2849765   PMID:7616230   PMID:8206937   PMID:8383590   PMID:8749392   PMID:9009195   PMID:9013886  
PMID:9276686   PMID:9400615   PMID:9647778   PMID:9920888   PMID:10318862   PMID:10600115   PMID:10640627   PMID:10698523   PMID:10781942   PMID:11007961   PMID:11113010   PMID:11259605  
PMID:11371618   PMID:11531413   PMID:11588171   PMID:11591705   PMID:12370081   PMID:12435421   PMID:12477932   PMID:12912990   PMID:14633983   PMID:14676191   PMID:14702039   PMID:14744259  
PMID:15147202   PMID:15489334   PMID:15936019   PMID:16085932   PMID:16262633   PMID:16541024   PMID:16541025   PMID:17210576   PMID:17266553   PMID:17353931   PMID:17604273   PMID:18460741  
PMID:18483222   PMID:18782753   PMID:18971272   PMID:19156129   PMID:20133760   PMID:20360068   PMID:20562864   PMID:20811636   PMID:20969868   PMID:21072166   PMID:21081503   PMID:21081666  
PMID:21317290   PMID:21351466   PMID:21784977   PMID:21873635   PMID:21900206   PMID:21988832   PMID:22190034   PMID:22422068   PMID:22623428   PMID:22863883   PMID:23022380   PMID:23047923  
PMID:23287597   PMID:23376485   PMID:23383273   PMID:23443559   PMID:23455922   PMID:23555304   PMID:23602568   PMID:23851495   PMID:24189400   PMID:24337577   PMID:24390425   PMID:24412244  
PMID:24981860   PMID:25531779   PMID:25546391   PMID:25693804   PMID:25756610   PMID:25798074   PMID:26186194   PMID:26280018   PMID:26344197   PMID:26389696   PMID:26496610   PMID:26499835  
PMID:26618866   PMID:26760575   PMID:26811472   PMID:27034005   PMID:27107014   PMID:27173435   PMID:27705803   PMID:27780869   PMID:27880917   PMID:28159925   PMID:28330616   PMID:28386764  
PMID:28514442   PMID:29028833   PMID:29117863   PMID:29331416   PMID:29509190   PMID:29704455   PMID:29844126   PMID:29845934   PMID:29955894   PMID:30021884   PMID:30945288   PMID:31091453  
PMID:31298480   PMID:31332168   PMID:31796584   PMID:31980649   PMID:32235678   PMID:32393512   PMID:32529326   PMID:32687490   PMID:32707033   PMID:32814053   PMID:32989298   PMID:33731348  
PMID:33961781   PMID:34004147   PMID:34147029   PMID:34428256   PMID:34902541   PMID:34921745   PMID:34964862   PMID:35142023   PMID:35216969   PMID:35271311   PMID:35509820   PMID:35562734  
PMID:35748872   PMID:35768646   PMID:35831314   PMID:36168628   PMID:36215168   PMID:36339263   PMID:36526897   PMID:36538041   PMID:36736316   PMID:36929488   PMID:37536630  


Genomics

Comparative Map Data
PPP2CB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38830,785,616 - 30,812,818 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl830,774,457 - 30,814,314 (-)EnsemblGRCh38hg38GRCh38
GRCh37830,643,132 - 30,670,334 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36830,762,668 - 30,789,894 (-)NCBINCBI36Build 36hg18NCBI36
Build 34830,762,668 - 30,789,894NCBI
Celera829,603,219 - 29,630,439 (-)NCBICelera
Cytogenetic Map8p12NCBI
HuRef829,189,574 - 29,216,794 (-)NCBIHuRef
CHM1_1830,844,570 - 30,871,782 (-)NCBICHM1_1
T2T-CHM13v2.0831,066,636 - 31,093,832 (-)NCBIT2T-CHM13v2.0
Ppp2cb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39834,089,672 - 34,109,831 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl834,089,653 - 34,109,469 (+)EnsemblGRCm39 Ensembl
GRCm38833,599,621 - 33,619,804 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl833,599,625 - 33,619,441 (+)EnsemblGRCm38mm10GRCm38
MGSCv37834,710,093 - 34,730,276 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36835,065,560 - 35,085,738 (+)NCBIMGSCv36mm8
Celera836,244,600 - 36,253,763 (+)NCBICelera
Cytogenetic Map8A4NCBI
cM Map820.63NCBI
Ppp2cb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81665,261,178 - 65,282,658 (-)NCBIGRCr8
mRatBN7.21658,558,119 - 58,579,325 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1658,558,122 - 58,579,576 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1663,895,707 - 63,916,635 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01667,309,372 - 67,330,300 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01662,529,938 - 62,550,866 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01662,273,276 - 62,294,767 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1662,273,276 - 62,294,769 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01661,933,984 - 61,955,475 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41662,330,513 - 62,351,968 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11662,330,587 - 62,352,043 (-)NCBI
Celera1656,594,208 - 56,615,135 (-)NCBICelera
Cytogenetic Map16q12.3NCBI
Ppp2cb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554637,226,912 - 7,249,490 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554637,229,717 - 7,249,490 (-)NCBIChiLan1.0ChiLan1.0
PPP2CB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2749,358,884 - 49,386,294 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1825,074,866 - 25,102,081 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0830,099,605 - 30,126,917 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1827,288,250 - 27,302,606 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl827,288,263 - 27,302,606 (-)Ensemblpanpan1.1panPan2
PPP2CB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11633,532,703 - 33,567,011 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1633,532,958 - 33,566,640 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1633,992,179 - 34,026,212 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01635,558,843 - 35,592,945 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1635,558,838 - 35,592,943 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11633,657,510 - 33,691,593 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01634,231,924 - 34,265,951 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01634,350,519 - 34,384,589 (+)NCBIUU_Cfam_GSD_1.0
Ppp2cb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494356,729,981 - 56,742,299 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936792622,105 - 633,800 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP2CB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1554,296,113 - 54,325,213 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11554,295,786 - 54,325,220 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21561,676,897 - 61,697,557 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP2CB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1828,903,074 - 28,930,300 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl828,903,240 - 28,930,376 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605213,168,625 - 13,195,901 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp2cb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478013,332,636 - 13,369,301 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PPP2CB
8 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8p23.1-11.21(chr8:12609975-42085703)x3 copy number gain See cases [RCV000050294] Chr8:12609975..42085703 [GRCh38]
Chr8:12467484..41943221 [GRCh37]
Chr8:12511855..42062378 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p12-q11.21(chr8:29719897-48521849)x3 copy number gain See cases [RCV000050995] Chr8:29719897..48521849 [GRCh38]
Chr8:29577413..49434409 [GRCh37]
Chr8:29633332..49596962 [NCBI36]
Chr8:8p12-q11.21		 pathogenic
GRCh38/hg38 8p21.2-q11.21(chr8:25832130-48521849)x3 copy number gain See cases [RCV000050904] Chr8:25832130..48521849 [GRCh38]
Chr8:25689646..49434409 [GRCh37]
Chr8:25745563..49596962 [NCBI36]
Chr8:8p21.2-q11.21		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12728904-43673207)x3 copy number gain See cases [RCV000050912] Chr8:12728904..43673207 [GRCh38]
Chr8:12586413..43528350 [GRCh37]
Chr8:12630784..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12383584-36370018)x3 copy number gain See cases [RCV000051145] Chr8:12383584..36370018 [GRCh38]
Chr8:12241093..36227536 [GRCh37]
Chr8:12285464..36347088 [NCBI36]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12728904-41928741)x3 copy number gain See cases [RCV000051110] Chr8:12728904..41928741 [GRCh38]
Chr8:12586413..41786259 [GRCh37]
Chr8:12630784..41905416 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p23.1-11.23(chr8:12609975-37892000)x3 copy number gain See cases [RCV000053629] Chr8:12609975..37892000 [GRCh38]
Chr8:12467484..37749518 [GRCh37]
Chr8:12511855..37868676 [NCBI36]
Chr8:8p23.1-11.23		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43336172)x3 copy number gain See cases [RCV000053630] Chr8:12609975..43336172 [GRCh38]
Chr8:12467484..43191315 [GRCh37]
Chr8:12511855..43310472 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43255410)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053631]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053631]|See cases [RCV000053631] Chr8:12609975..43255410 [GRCh38]
Chr8:12467484..43110553 [GRCh37]
Chr8:12511855..43229710 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12750796-43532444)x3 copy number gain See cases [RCV000053632] Chr8:12750796..43532444 [GRCh38]
Chr8:12608305..43387587 [GRCh37]
Chr8:12652676..43506744 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p22-q11.21(chr8:14940110-47929925)x3 copy number gain See cases [RCV000053635] Chr8:14940110..47929925 [GRCh38]
Chr8:14797619..48842485 [GRCh37]
Chr8:14841990..49005038 [NCBI36]
Chr8:8p22-q11.21		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p21.2-12(chr8:24910364-31210737)x1 copy number loss See cases [RCV000054237] Chr8:24910364..31210737 [GRCh38]
Chr8:24767877..31068253 [GRCh37]
Chr8:24823781..31187795 [NCBI36]
Chr8:8p21.2-12		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43673207)x3 copy number gain See cases [RCV000135786] Chr8:12609975..43673207 [GRCh38]
Chr8:12467484..43528350 [GRCh37]
Chr8:12511855..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12383584-43673207)x3 copy number gain See cases [RCV000135566] Chr8:12383584..43673207 [GRCh38]
Chr8:12241093..43528350 [GRCh37]
Chr8:12285464..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12728904-40169194)x3 copy number gain See cases [RCV000136516] Chr8:12728904..40169194 [GRCh38]
Chr8:12586413..40026713 [GRCh37]
Chr8:12630784..40145870 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p21.2-12(chr8:24910364-31196357)x1 copy number loss See cases [RCV000136120] Chr8:24910364..31196357 [GRCh38]
Chr8:24767877..31053873 [GRCh37]
Chr8:24823781..31173415 [NCBI36]
Chr8:8p21.2-12		 pathogenic
GRCh38/hg38 8p12-11.21(chr8:29362097-40231708)x1 copy number loss See cases [RCV000136878] Chr8:29362097..40231708 [GRCh38]
Chr8:29219614..40089227 [GRCh37]
Chr8:29275533..40208384 [NCBI36]
Chr8:8p12-11.21		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12182421-43673207)x3 copy number gain See cases [RCV000137249] Chr8:12182421..43673207 [GRCh38]
Chr8:12039930..43528350 [GRCh37]
Chr8:12077339..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12698495-35476082)x3 copy number gain See cases [RCV000138058] Chr8:12698495..35476082 [GRCh38]
Chr8:12556004..35333600 [GRCh37]
Chr8:12600375..35453142 [NCBI36]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p21.2-12(chr8:25171103-31750600)x1 copy number loss See cases [RCV000138081] Chr8:25171103..31750600 [GRCh38]
Chr8:25028618..31608116 [GRCh37]
Chr8:25084535..31727658 [NCBI36]
Chr8:8p21.2-12		 pathogenic
GRCh38/hg38 8p23.3-11.23(chr8:226452-38021728)x3 copy number gain See cases [RCV000137807] Chr8:226452..38021728 [GRCh38]
Chr8:176452..37879246 [GRCh37]
Chr8:166452..37998403 [NCBI36]
Chr8:8p23.3-11.23		 pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-12(chr8:241605-31091074)x3 copy number gain See cases [RCV000138831] Chr8:241605..31091074 [GRCh38]
Chr8:191605..30948590 [GRCh37]
Chr8:181605..31068132 [NCBI36]
Chr8:8p23.3-12		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p12(chr8:30368765-36421541)x3 copy number gain See cases [RCV000139926] Chr8:30368765..36421541 [GRCh38]
Chr8:30226281..36279059 [GRCh37]
Chr8:30345823..36398222 [NCBI36]
Chr8:8p12		 uncertain significance
GRCh38/hg38 8p23.1-11.22(chr8:7141697-38695546)x3 copy number gain See cases [RCV000139891] Chr8:7141697..38695546 [GRCh38]
Chr8:6999219..38553064 [GRCh37]
Chr8:6986629..38672221 [NCBI36]
Chr8:8p23.1-11.22		 pathogenic
GRCh38/hg38 8p23.1-11.22(chr8:12729023-39235934)x3 copy number gain See cases [RCV000139770] Chr8:12729023..39235934 [GRCh38]
Chr8:12586532..39093453 [GRCh37]
Chr8:12630903..39212610 [NCBI36]
Chr8:8p23.1-11.22		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12646123-43686843)x3 copy number gain See cases [RCV000139796] Chr8:12646123..43686843 [GRCh38]
Chr8:12503632..43541986 [GRCh37]
Chr8:12548003..43661143 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.23(chr8:11851113-37216333)x3 copy number gain See cases [RCV000139549] Chr8:11851113..37216333 [GRCh38]
Chr8:11708622..37073851 [GRCh37]
Chr8:11746031..37193009 [NCBI36]
Chr8:8p23.1-11.23		 pathogenic
GRCh38/hg38 8p23.3-12(chr8:226452-34491890)x3 copy number gain See cases [RCV000141410] Chr8:226452..34491890 [GRCh38]
Chr8:176452..34349408 [GRCh37]
Chr8:166452..34468950 [NCBI36]
Chr8:8p23.3-12		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p22-12(chr8:18972996-33619264)x1 copy number loss See cases [RCV000142747] Chr8:18972996..33619264 [GRCh38]
Chr8:18830506..33476782 [GRCh37]
Chr8:18874786..33596324 [NCBI36]
Chr8:8p22-12		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12633490-40685533)x3 copy number gain See cases [RCV000143508] Chr8:12633490..40685533 [GRCh38]
Chr8:12490999..40543052 [GRCh37]
Chr8:12535370..40662209 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12609975-42085703)x3 copy number gain See cases [RCV000148249] Chr8:12609975..42085703 [GRCh38]
Chr8:12467484..41943221 [GRCh37]
Chr8:12511855..42062378 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12728904-43673207)x3 copy number gain See cases [RCV000148237] Chr8:12728904..43673207 [GRCh38]
Chr8:12586413..43528350 [GRCh37]
Chr8:12630784..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh37/hg19 8p23.1-11.22(chr8:12528482-39593802)x3 copy number gain See cases [RCV000511325] Chr8:12528482..39593802 [GRCh37]
Chr8:8p23.1-11.22		 pathogenic
GRCh37/hg19 8p21.2-q12.1(chr8:24772064-24813176)x3 copy number gain See cases [RCV000446588] Chr8:24772064..24813176 [GRCh37]
Chr8:8p21.2-q12.1		 uncertain significance
GRCh37/hg19 8p12(chr8:30565641-30704649)x1 copy number loss See cases [RCV000446856] Chr8:30565641..30704649 [GRCh37]
Chr8:8p12		 uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.3-11.1(chr8:158048-43786723)x3 copy number gain See cases [RCV000447909] Chr8:158048..43786723 [GRCh37]
Chr8:8p23.3-11.1		 pathogenic
GRCh37/hg19 8p23.1-11.1(chr8:12580132-43388233)x3 copy number gain See cases [RCV000447913] Chr8:12580132..43388233 [GRCh37]
Chr8:8p23.1-11.1		 pathogenic
GRCh37/hg19 8p21.2-12(chr8:24514488-34808438) copy number gain See cases [RCV000448582] Chr8:24514488..34808438 [GRCh37]
Chr8:8p21.2-12		 pathogenic
GRCh37/hg19 8p22-12(chr8:16992973-32612724)x1 copy number loss not provided [RCV000509389] Chr8:16992973..32612724 [GRCh37]
Chr8:8p22-12		 not provided
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.1-12(chr8:12528482-33684786)x3 copy number gain See cases [RCV000510571] Chr8:12528482..33684786 [GRCh37]
Chr8:8p23.1-12		 pathogenic
GRCh37/hg19 8p23.1-11.1(chr8:11935023-43824035)x3 copy number gain See cases [RCV000511028] Chr8:11935023..43824035 [GRCh37]
Chr8:8p23.1-11.1		 pathogenic
GRCh37/hg19 8p23.1-12(chr8:11945855-34875355)x3 copy number gain See cases [RCV000510899] Chr8:11945855..34875355 [GRCh37]
Chr8:8p23.1-12		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3		 pathogenic
GRCh37/hg19 8p23.1-12(chr8:12552775-35935825)x3 copy number gain not provided [RCV000683043] Chr8:12552775..35935825 [GRCh37]
Chr8:8p23.1-12		 pathogenic
GRCh37/hg19 8p12(chr8:30335124-33770070)x1 copy number loss not provided [RCV000683024] Chr8:30335124..33770070 [GRCh37]
Chr8:8p12		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.1-12(chr8:12556004-34374150)x3 copy number gain not provided [RCV000762735] Chr8:12556004..34374150 [GRCh37]
Chr8:8p23.1-12		 likely pathogenic
Single allele duplication not provided [RCV000768452] Chr8:12546855..35816855 [GRCh37]
Chr8:8p23.1-12		 likely pathogenic
GRCh37/hg19 8p12(chr8:29103983-35728509)x1 copy number loss not provided [RCV000846377] Chr8:29103983..35728509 [GRCh37]
Chr8:8p12		 uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
NM_001009552.2(PPP2CB):c.98A>G (p.Glu33Gly) single nucleotide variant Inborn genetic diseases [RCV002748767] Chr8:30812324 [GRCh38]
Chr8:30669840 [GRCh37]
Chr8:8p12		 uncertain significance
GRCh37/hg19 8p12(chr8:30308545-30873238)x3 copy number gain not provided [RCV001259471] Chr8:30308545..30873238 [GRCh37]
Chr8:8p12		 uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771) copy number gain Polydactyly [RCV002280629] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.3-11.1(chr8:176814-43396776) copy number gain Abnormal fetal cardiovascular morphology [RCV001291977] Chr8:176814..43396776 [GRCh37]
Chr8:8p23.3-11.1		 pathogenic
NC_000008.10:g.(?_30436438)_(31030618_?)dup duplication not provided [RCV001975849] Chr8:30436438..31030618 [GRCh37]
Chr8:8p12		 uncertain significance
Single allele complex See cases [RCV002292428] Chr8:6999114..11935023 [GRCh37]
Chr8:8p23.3-11.21		 pathogenic
Single allele complex 8p inverted duplication/deletion syndrome [RCV002280753] Chr8:158048..43019304 [GRCh37]
Chr8:8p23.3-11.21		 pathogenic
NM_001009552.2(PPP2CB):c.859C>G (p.Leu287Val) single nucleotide variant Inborn genetic diseases [RCV003258245] Chr8:30786306 [GRCh38]
Chr8:30643822 [GRCh37]
Chr8:8p12		 uncertain significance
GRCh37/hg19 8p21.2-11.22(chr8:26808969-38346383)x1 copy number loss not provided [RCV002472596] Chr8:26808969..38346383 [GRCh37]
Chr8:8p21.2-11.22		 pathogenic
NM_001009552.2(PPP2CB):c.316C>T (p.Arg106Cys) single nucleotide variant Inborn genetic diseases [RCV002808372] Chr8:30797751 [GRCh38]
Chr8:30655267 [GRCh37]
Chr8:8p12		 uncertain significance
NM_001009552.2(PPP2CB):c.485A>G (p.Gln162Arg) single nucleotide variant Inborn genetic diseases [RCV002878948] Chr8:30797582 [GRCh38]
Chr8:30655098 [GRCh37]
Chr8:8p12		 uncertain significance
NM_001009552.2(PPP2CB):c.197T>C (p.Met66Thr) single nucleotide variant Inborn genetic diseases [RCV003178393] Chr8:30799661 [GRCh38]
Chr8:30657177 [GRCh37]
Chr8:8p12		 uncertain significance
NM_001009552.2(PPP2CB):c.55G>A (p.Glu19Lys) single nucleotide variant Inborn genetic diseases [RCV003195554] Chr8:30812367 [GRCh38]
Chr8:30669883 [GRCh37]
Chr8:8p12		 uncertain significance
NM_001009552.2(PPP2CB):c.19A>G (p.Thr7Ala) single nucleotide variant Inborn genetic diseases [RCV003378797] Chr8:30812403 [GRCh38]
Chr8:30669919 [GRCh37]
Chr8:8p12		 uncertain significance
Single allele duplication not provided [RCV003448693] Chr8:12530550..43483193 [GRCh37]
Chr8:8p23.1-11.1		 pathogenic
GRCh37/hg19 8p23.1-11.22(chr8:12560782-38748763)x3 copy number gain not provided [RCV003484724] Chr8:12560782..38748763 [GRCh37]
Chr8:8p23.1-11.22		 pathogenic
GRCh37/hg19 8p22-11.1(chr8:14240573-43824035)x3 copy number gain not provided [RCV003484725] Chr8:14240573..43824035 [GRCh37]
Chr8:8p22-11.1		 pathogenic
GRCh37/hg19 8p23.1-11.23(chr8:11945856-37902453)x3 copy number gain not provided [RCV003484722] Chr8:11945856..37902453 [GRCh37]
Chr8:8p23.1-11.23		 pathogenic
GRCh37/hg19 8p23.2-11.21(chr8:2201405-41723095)x3 copy number gain not provided [RCV003484713] Chr8:2201405..41723095 [GRCh37]
Chr8:8p23.2-11.21		 pathogenic
NM_001009552.2(PPP2CB):c.480T>C (p.Asp160=) single nucleotide variant not provided [RCV003436842] Chr8:30797587 [GRCh38]
Chr8:30655103 [GRCh37]
Chr8:8p12		 likely benign
GRCh37/hg19 8p21.2-q21.3(chr8:27024288-89410121)x3 copy number gain not specified [RCV003986754] Chr8:27024288..89410121 [GRCh37]
Chr8:8p21.2-q21.3		 pathogenic
GRCh37/hg19 8p12(chr8:30398461-30957178)x1 copy number loss not specified [RCV003986734] Chr8:30398461..30957178 [GRCh37]
Chr8:8p12		 uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not specified [RCV003986742] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.3-11.21(chr8:158048-41600696)x3 copy number gain not specified [RCV003986756] Chr8:158048..41600696 [GRCh37]
Chr8:8p23.3-11.21		 pathogenic
GRCh37/hg19 8p21.3-11.1(chr8:20136266-43786723)x3 copy number gain not specified [RCV003986767] Chr8:20136266..43786723 [GRCh37]
Chr8:8p21.3-11.1		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1299
Count of miRNA genes:712
Interacting mature miRNAs:831
Transcripts:ENST00000221138, ENST00000518243, ENST00000518532, ENST00000518564, ENST00000520056, ENST00000520334, ENST00000520500, ENST00000522113, ENST00000523023, ENST00000523804
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH46279  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37830,653,352 - 30,653,537UniSTSGRCh37
Build 36830,772,894 - 30,773,079RGDNCBI36
Celera829,613,439 - 29,613,624RGD
Cytogenetic Map8p12UniSTS
HuRef829,199,794 - 29,199,979UniSTS
GeneMap99-GB4 RH Map8117.53UniSTS
NCBI RH Map8410.4UniSTS
STS-N68423  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37830,653,392 - 30,653,533UniSTSGRCh37
Build 36830,772,934 - 30,773,075RGDNCBI36
Celera829,613,479 - 29,613,620RGD
Cytogenetic Map8p12UniSTS
HuRef829,199,834 - 29,199,975UniSTS
GeneMap99-GB4 RH Map8118.6UniSTS
D8S2146  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37830,668,893 - 30,669,017UniSTSGRCh37
Build 36830,788,435 - 30,788,559RGDNCBI36
Celera829,628,980 - 29,629,104RGD
HuRef829,215,335 - 29,215,459UniSTS
D8S2190  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37830,643,891 - 30,644,011UniSTSGRCh37
Build 36830,763,433 - 30,763,553RGDNCBI36
Celera829,603,984 - 29,604,104RGD
HuRef829,190,339 - 29,190,459UniSTS
D8S2268  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37830,671,016 - 30,671,189UniSTSGRCh37
Build 36830,790,558 - 30,790,731RGDNCBI36
Celera829,631,103 - 29,631,276RGD
HuRef829,217,458 - 29,217,631UniSTS
D8S1928  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371631,818,043 - 31,818,392UniSTSGRCh37
GRCh37830,643,386 - 30,643,731UniSTSGRCh37
Build 36830,762,928 - 30,763,273RGDNCBI36
Celera1628,490,426 - 28,490,775UniSTS
Celera829,603,479 - 29,603,824RGD
Cytogenetic Map8p12UniSTS
Cytogenetic Map16p11.2UniSTS
HuRef1629,378,423 - 29,378,772UniSTS
HuRef829,189,834 - 29,190,179UniSTS
Whitehead-YAC Contig Map8 UniSTS
G20287  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37830,643,194 - 30,643,311UniSTSGRCh37
Build 36830,762,736 - 30,762,853RGDNCBI36
Celera829,603,287 - 29,603,404RGD
Cytogenetic Map8p12UniSTS
HuRef829,189,642 - 29,189,759UniSTS
A005K33  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37830,643,194 - 30,643,311UniSTSGRCh37
Build 36830,762,736 - 30,762,853RGDNCBI36
Celera829,603,287 - 29,603,404RGD
Cytogenetic Map8p12UniSTS
HuRef829,189,642 - 29,189,759UniSTS
GeneMap99-GB4 RH Map8118.6UniSTS
D8S2038  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37830,643,159 - 30,643,368UniSTSGRCh37
GRCh371631,818,410 - 31,818,612UniSTSGRCh37
Build 36830,762,701 - 30,762,910RGDNCBI36
Celera829,603,252 - 29,603,461RGD
Celera1628,490,206 - 28,490,408UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map8p12UniSTS
HuRef829,189,607 - 29,189,816UniSTS
HuRef1629,378,790 - 29,378,992UniSTS
PPP2CB_3846  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371631,818,005 - 31,818,627UniSTSGRCh37
GRCh37830,643,144 - 30,643,769UniSTSGRCh37
Build 36830,762,686 - 30,763,311RGDNCBI36
Celera1628,490,191 - 28,490,813UniSTS
Celera829,603,237 - 29,603,862RGD
HuRef1629,378,385 - 29,379,007UniSTS
HuRef829,189,592 - 29,190,217UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2431 2342 1712 613 1318 455 4355 2140 3708 410 1445 1606 171 1204 2788 4
Low 6 646 14 10 630 10 54 25 9 13 6 3 1 1
Below cutoff 1 2 1 1 1 1 1 2 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000221138   ⟹   ENSP00000221138
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl830,785,616 - 30,812,818 (-)Ensembl
RefSeq Acc Id: ENST00000518243   ⟹   ENSP00000428618
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl830,793,962 - 30,812,878 (-)Ensembl
RefSeq Acc Id: ENST00000518532
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl830,786,109 - 30,791,563 (-)Ensembl
RefSeq Acc Id: ENST00000518564   ⟹   ENSP00000428142
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl830,785,616 - 30,812,597 (-)Ensembl
RefSeq Acc Id: ENST00000520056   ⟹   ENSP00000428866
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl830,794,198 - 30,810,276 (-)Ensembl
RefSeq Acc Id: ENST00000520334   ⟹   ENSP00000430758
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl830,790,990 - 30,794,281 (-)Ensembl
RefSeq Acc Id: ENST00000520500
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl830,799,581 - 30,814,314 (-)Ensembl
RefSeq Acc Id: ENST00000522113
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl830,786,129 - 30,786,488 (-)Ensembl
RefSeq Acc Id: ENST00000523023   ⟹   ENSP00000429927
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl830,774,457 - 30,791,280 (-)Ensembl
RefSeq Acc Id: ENST00000523804
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl830,793,116 - 30,794,490 (-)Ensembl
RefSeq Acc Id: NM_001009552   ⟹   NP_001009552
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38830,785,616 - 30,812,818 (-)NCBI
GRCh37830,643,126 - 30,670,352 (-)ENTREZGENE
Build 36830,762,668 - 30,789,894 (-)NCBI Archive
HuRef829,189,574 - 29,216,794 (-)ENTREZGENE
CHM1_1830,844,570 - 30,871,782 (-)NCBI
T2T-CHM13v2.0831,066,636 - 31,093,832 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001009552   ⟸   NM_001009552
- UniProtKB: P11082 (UniProtKB/Swiss-Prot),   D3DSV4 (UniProtKB/Swiss-Prot),   Q6FHK5 (UniProtKB/Swiss-Prot),   P62714 (UniProtKB/Swiss-Prot),   A0A140VJS0 (UniProtKB/TrEMBL),   B3KRM2 (UniProtKB/TrEMBL),   Q5U0I7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000428142   ⟸   ENST00000518564
RefSeq Acc Id: ENSP00000428618   ⟸   ENST00000518243
RefSeq Acc Id: ENSP00000428866   ⟸   ENST00000520056
RefSeq Acc Id: ENSP00000430758   ⟸   ENST00000520334
RefSeq Acc Id: ENSP00000429927   ⟸   ENST00000523023
RefSeq Acc Id: ENSP00000221138   ⟸   ENST00000221138
Protein Domains
Serine/threonine specific protein phosphatases

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62714-F1-model_v2 AlphaFold P62714 1-309 view protein structure

Promoters
RGD ID:6806961
Promoter ID:HG_KWN:61057
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000397308,   ENST00000406655,   NM_001009552
Position:
Human AssemblyChrPosition (strand)Source
Build 36830,789,601 - 30,790,101 (-)MPROMDB
RGD ID:7213045
Promoter ID:EPDNEW_H12268
Type:initiation region
Name:PPP2CB_2
Description:protein phosphatase 2 catalytic subunit beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12269  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38830,812,473 - 30,812,533EPDNEW
RGD ID:7213047
Promoter ID:EPDNEW_H12269
Type:initiation region
Name:PPP2CB_1
Description:protein phosphatase 2 catalytic subunit beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12268  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38830,812,800 - 30,812,860EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9300 AgrOrtholog
COSMIC PPP2CB COSMIC
Ensembl Genes ENSG00000104695 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000221138 ENTREZGENE
  ENST00000221138.9 UniProtKB/Swiss-Prot
  ENST00000518243.5 UniProtKB/TrEMBL
  ENST00000518564.1 UniProtKB/TrEMBL
  ENST00000520056.1 UniProtKB/TrEMBL
  ENST00000520334.5 UniProtKB/TrEMBL
  ENST00000523023.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.21.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000104695 GTEx
HGNC ID HGNC:9300 ENTREZGENE
Human Proteome Map PPP2CB Human Proteome Map
InterPro Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metallo-depent_PP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPA2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr-sp_prot-phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5516 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5516 ENTREZGENE
OMIM 176916 OMIM
PANTHER SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Metallophos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33664 PharmGKB
PRINTS STPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SER_THR_PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PP2Ac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140VJS0 ENTREZGENE, UniProtKB/TrEMBL
  B3KRM2 ENTREZGENE, UniProtKB/TrEMBL
  D3DSV4 ENTREZGENE
  E5RFI3_HUMAN UniProtKB/TrEMBL
  E5RHC1_HUMAN UniProtKB/TrEMBL
  E5RJX4_HUMAN UniProtKB/TrEMBL
  H0YBN9_HUMAN UniProtKB/TrEMBL
  H0YC23_HUMAN UniProtKB/TrEMBL
  P11082 ENTREZGENE
  P62714 ENTREZGENE, UniProtKB/Swiss-Prot
  Q5U0I7 ENTREZGENE, UniProtKB/TrEMBL
  Q6FHK5 ENTREZGENE
UniProt Secondary D3DSV4 UniProtKB/Swiss-Prot
  P11082 UniProtKB/Swiss-Prot
  Q6FHK5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-16 PPP2CB  protein phosphatase 2 catalytic subunit beta  PPP2CB  protein phosphatase 2, catalytic subunit, beta isozyme  Symbol and/or name change 5135510 APPROVED
2011-07-27 PPP2CB  protein phosphatase 2, catalytic subunit, beta isozyme  PPP2CB  protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform  Symbol and/or name change 5135510 APPROVED