PPME1 (protein phosphatase methylesterase 1) - Rat Genome Database

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Gene: PPME1 (protein phosphatase methylesterase 1) Homo sapiens
Analyze
Symbol: PPME1
Name: protein phosphatase methylesterase 1
RGD ID: 1605082
HGNC Page HGNC:30178
Description: Enables protein C-terminal methylesterase activity and protein phosphatase 2A binding activity. Predicted to be involved in G2/M transition of mitotic cell cycle. Predicted to be located in nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ABDH19; FLJ22226; PME-1; protein phosphatase methylesterase-1; testicular secretory protein Li 39
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381174,171,289 - 74,254,703 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1174,171,267 - 74,254,703 (+)EnsemblGRCh38hg38GRCh38
GRCh371173,882,334 - 73,965,748 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361173,560,016 - 73,643,396 (+)NCBINCBI36Build 36hg18NCBI36
Celera1171,189,163 - 71,272,541 (+)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1170,177,366 - 70,261,026 (+)NCBIHuRef
CHM1_11173,766,364 - 73,849,977 (+)NCBICHM1_1
T2T-CHM13v2.01174,100,633 - 74,184,047 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleoplasm  (TAS)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8125298   PMID:10318862   PMID:12477932   PMID:12665801   PMID:14702039   PMID:14744259   PMID:15489334   PMID:16344560   PMID:17803990   PMID:18782753   PMID:19156129   PMID:19293187  
PMID:20360068   PMID:21398589   PMID:21873635   PMID:22167190   PMID:22443683   PMID:22732552   PMID:22863883   PMID:22939629   PMID:24253382   PMID:24841198   PMID:25468996   PMID:25839665  
PMID:25921289   PMID:26186194   PMID:26344197   PMID:26472760   PMID:26496610   PMID:26499835   PMID:26777405   PMID:27048286   PMID:27810903   PMID:27880917   PMID:27913678   PMID:28330616  
PMID:28514442   PMID:28978906   PMID:29117863   PMID:29577269   PMID:30340029   PMID:30463901   PMID:31332168   PMID:31519766   PMID:31586073   PMID:31714894   PMID:31950832   PMID:32071079  
PMID:32351291   PMID:32687490   PMID:32694731   PMID:33462405   PMID:33916271   PMID:33961781   PMID:34189442   PMID:34349018   PMID:34591612   PMID:35256949   PMID:35271311   PMID:35439318  
PMID:35509820   PMID:35831314   PMID:35914814   PMID:35944360   PMID:36114006   PMID:36215168   PMID:36461911   PMID:36717926   PMID:37774976   PMID:37827155  


Genomics

Comparative Map Data
PPME1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381174,171,289 - 74,254,703 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1174,171,267 - 74,254,703 (+)EnsemblGRCh38hg38GRCh38
GRCh371173,882,334 - 73,965,748 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361173,560,016 - 73,643,396 (+)NCBINCBI36Build 36hg18NCBI36
Celera1171,189,163 - 71,272,541 (+)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1170,177,366 - 70,261,026 (+)NCBIHuRef
CHM1_11173,766,364 - 73,849,977 (+)NCBICHM1_1
T2T-CHM13v2.01174,100,633 - 74,184,047 (+)NCBIT2T-CHM13v2.0
Ppme1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39799,975,944 - 100,021,103 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl799,975,944 - 100,021,514 (-)EnsemblGRCm39 Ensembl
GRCm387100,326,737 - 100,371,896 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7100,326,737 - 100,372,307 (-)EnsemblGRCm38mm10GRCm38
MGSCv377107,475,247 - 107,520,406 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367100,200,820 - 100,245,979 (-)NCBIMGSCv36mm8
Celera7100,664,566 - 100,708,892 (-)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.35NCBI
Ppme1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81164,080,242 - 164,127,261 (-)NCBIGRCr8
mRatBN7.21154,668,099 - 154,715,079 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1154,668,109 - 154,715,110 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1162,662,426 - 162,709,411 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,842,528 - 169,889,513 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01162,716,472 - 162,763,468 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,335,242 - 165,382,216 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,335,242 - 165,382,216 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01171,535,949 - 171,582,923 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,725,633 - 157,773,923 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11157,804,425 - 157,853,055 (-)NCBI
Celera1152,751,690 - 152,798,582 (-)NCBICelera
Cytogenetic Map1q32NCBI
Ppme1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541417,384,695 - 17,444,269 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541417,384,695 - 17,444,269 (-)NCBIChiLan1.0ChiLan1.0
PPME1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2975,113,725 - 75,196,839 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11176,157,953 - 76,240,912 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01169,245,041 - 69,327,957 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11172,551,480 - 72,634,439 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1172,551,480 - 72,634,439 (+)Ensemblpanpan1.1panPan2
PPME1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12124,041,074 - 24,127,178 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2124,042,240 - 24,127,081 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2123,805,986 - 23,892,111 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02124,243,436 - 24,330,874 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2124,243,438 - 24,330,792 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12124,040,753 - 24,126,867 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02124,238,285 - 24,326,664 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02124,155,768 - 24,241,903 (-)NCBIUU_Cfam_GSD_1.0
Ppme1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494761,642,990 - 61,702,729 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364983,242,282 - 3,302,330 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364983,242,413 - 3,302,334 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPME1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl98,513,141 - 8,605,268 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.198,512,791 - 8,605,273 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.299,349,768 - 9,443,424 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPME1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1165,436,109 - 65,516,486 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl165,469,025 - 65,517,288 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604360,344,465 - 60,428,457 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppme1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248172,826,715 - 2,880,597 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248172,827,249 - 2,880,545 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PPME1
9 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q13.4-14.1(chr11:71923251-79662025)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052684]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052684]|See cases [RCV000052684] Chr11:71923251..79662025 [GRCh38]
Chr11:71634297..79373069 [GRCh37]
Chr11:71311945..79050717 [NCBI36]
Chr11:11q13.4-14.1		 pathogenic
GRCh38/hg38 11q13.4-13.5(chr11:71928796-77064521)x1 copy number loss See cases [RCV000052708] Chr11:71928796..77064521 [GRCh38]
Chr11:71639842..76751808 [GRCh37]
Chr11:71317490..76453216 [NCBI36]
Chr11:11q13.4-13.5		 pathogenic
GRCh38/hg38 11q13.4-14.1(chr11:71969881-78232895)x1 copy number loss See cases [RCV000052709] Chr11:71969881..78232895 [GRCh38]
Chr11:71680927..77943941 [GRCh37]
Chr11:71358575..77621589 [NCBI36]
Chr11:11q13.4-14.1		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q13.4-23.3(chr11:71588805-116680918)x3 copy number gain not provided [RCV000683374] Chr11:71588805..116680918 [GRCh37]
Chr11:11q13.4-23.3		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
NM_016147.3(PPME1):c.1091C>G (p.Ala364Gly) single nucleotide variant not specified [RCV004289242] Chr11:74251664 [GRCh38]
Chr11:73962709 [GRCh37]
Chr11:11q13.4		 uncertain significance
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
NC_000011.9:g.(?_71146421)_(75283128_?)dup duplication 3-methylglutaconic aciduria, type VIIB [RCV003122786] Chr11:71146421..75283128 [GRCh37]
Chr11:11q13.4-13.5		 uncertain significance
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25		 pathogenic
NM_016147.3(PPME1):c.1144G>A (p.Val382Met) single nucleotide variant not specified [RCV004195992] Chr11:74253493 [GRCh38]
Chr11:73964538 [GRCh37]
Chr11:11q13.4		 uncertain significance
NM_016147.3(PPME1):c.536T>A (p.Met179Lys) single nucleotide variant not specified [RCV004099948] Chr11:74230382 [GRCh38]
Chr11:73941427 [GRCh37]
Chr11:11q13.4		 uncertain significance
NM_016147.3(PPME1):c.1150C>T (p.Pro384Ser) single nucleotide variant not specified [RCV004124239] Chr11:74253499 [GRCh38]
Chr11:73964544 [GRCh37]
Chr11:11q13.4		 uncertain significance
NM_016147.3(PPME1):c.293C>A (p.Ala98Glu) single nucleotide variant not specified [RCV004157286] Chr11:74222316 [GRCh38]
Chr11:73933361 [GRCh37]
Chr11:11q13.4		 uncertain significance
NM_016147.3(PPME1):c.920A>G (p.Asn307Ser) single nucleotide variant not specified [RCV004232962] Chr11:74246161 [GRCh38]
Chr11:73957206 [GRCh37]
Chr11:11q13.4		 uncertain significance
NM_016147.3(PPME1):c.803T>C (p.Ile268Thr) single nucleotide variant not specified [RCV004248871] Chr11:74239225 [GRCh38]
Chr11:73950270 [GRCh37]
Chr11:11q13.4		 uncertain significance
NM_016147.3(PPME1):c.817A>C (p.Lys273Gln) single nucleotide variant not specified [RCV004350921] Chr11:74239239 [GRCh38]
Chr11:73950284 [GRCh37]
Chr11:11q13.4		 uncertain significance
GRCh37/hg19 11q13.4(chr11:72308632-74236530)x1 copy number loss not provided [RCV003483128] Chr11:72308632..74236530 [GRCh37]
Chr11:11q13.4		 uncertain significance
GRCh37/hg19 11q12.2-13.5(chr11:59923608-76272324)x3 copy number gain not provided [RCV003484842] Chr11:59923608..76272324 [GRCh37]
Chr11:11q12.2-13.5		 pathogenic
NM_016147.3(PPME1):c.691A>G (p.Met231Val) single nucleotide variant not specified [RCV004507228] Chr11:74235947 [GRCh38]
Chr11:73946992 [GRCh37]
Chr11:11q13.4		 uncertain significance
NM_016147.3(PPME1):c.840G>C (p.Lys280Asn) single nucleotide variant not specified [RCV004507230] Chr11:74246081 [GRCh38]
Chr11:73957126 [GRCh37]
Chr11:11q13.4		 uncertain significance
NM_016147.3(PPME1):c.47G>T (p.Arg16Leu) single nucleotide variant not specified [RCV004507227] Chr11:74171468 [GRCh38]
Chr11:73882513 [GRCh37]
Chr11:11q13.4		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4399
Count of miRNA genes:901
Interacting mature miRNAs:1058
Transcripts:ENST00000328257, ENST00000398427, ENST00000535205, ENST00000538501, ENST00000539021, ENST00000541340, ENST00000542710, ENST00000543525, ENST00000544401
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D11S3971  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371173,965,520 - 73,965,747UniSTSGRCh37
Build 361173,643,168 - 73,643,395RGDNCBI36
Celera1171,272,313 - 71,272,540RGD
Cytogenetic Map11q13.4UniSTS
HuRef1170,260,798 - 70,261,025UniSTS
Whitehead-YAC Contig Map11 UniSTS
STS-T95088  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371173,916,580 - 73,916,735UniSTSGRCh37
Build 361173,594,228 - 73,594,383RGDNCBI36
Celera1171,223,374 - 71,223,529RGD
Cytogenetic Map11q13.4UniSTS
HuRef1170,211,838 - 70,211,993UniSTS
GeneMap99-GB4 RH Map11269.66UniSTS
NCBI RH Map11621.8UniSTS
RH122448  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371173,939,785 - 73,940,087UniSTSGRCh37
Build 361173,617,433 - 73,617,735RGDNCBI36
Celera1171,246,578 - 71,246,880RGD
Cytogenetic Map11q13.4UniSTS
HuRef1170,235,061 - 70,235,363UniSTS
TNG Radiation Hybrid Map1133314.0UniSTS
D11S2056  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371173,896,844 - 73,896,954UniSTSGRCh37
Build 361173,574,492 - 73,574,602RGDNCBI36
Celera1171,203,638 - 71,203,748RGD
HuRef1170,192,102 - 70,192,212UniSTS
Stanford-G3 RH Map113263.0UniSTS
RH11842  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371173,965,520 - 73,965,652UniSTSGRCh37
Build 361173,643,168 - 73,643,300RGDNCBI36
Celera1171,272,313 - 71,272,445RGD
Cytogenetic Map11q13.4UniSTS
HuRef1170,260,798 - 70,260,930UniSTS
GeneMap99-GB4 RH Map11271.99UniSTS
NCBI RH Map11631.8UniSTS
D11S2257E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371173,965,520 - 73,965,631UniSTSGRCh37
Build 361173,643,168 - 73,643,279RGDNCBI36
Celera1171,272,313 - 71,272,424RGD
Cytogenetic Map11q13.4UniSTS
HuRef1170,260,798 - 70,260,909UniSTS
GeneMap99-GB4 RH Map11271.31UniSTS
SGC34863  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371173,925,580 - 73,925,729UniSTSGRCh37
GRCh371185,583,429 - 185,583,580UniSTSGRCh37
Build 361183,850,052 - 183,850,203RGDNCBI36
Celera1171,232,374 - 71,232,523UniSTS
Celera1158,694,136 - 158,694,287RGD
HuRef1170,220,838 - 70,220,987UniSTS
HuRef1156,818,517 - 156,818,668UniSTS
GeneMap99-GB4 RH Map11271.52UniSTS
Whitehead-RH Map11370.6UniSTS
MARC_7583-7584:992008525:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371173,914,783 - 73,915,437UniSTSGRCh37
Build 361173,592,431 - 73,593,085RGDNCBI36
Celera1171,221,577 - 71,222,231RGD
HuRef1170,210,041 - 70,210,695UniSTS
D11S2056  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11q13.4UniSTS
Stanford-G3 RH Map113263.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2416 2361 1406 311 1381 153 4348 2043 3581 345 1454 1605 175 1 1203 2781 5 2
Low 23 630 320 313 570 312 9 154 153 74 6 8 1 7 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001271593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017017913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047427116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054369109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054369110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_428916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF111853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF157028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK001381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK022725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK025414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK025879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK123288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP000577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP002392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX537528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA691258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA824678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM005579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000328257   ⟹   ENSP00000329867
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1174,171,289 - 74,254,703 (+)Ensembl
RefSeq Acc Id: ENST00000398427   ⟹   ENSP00000381461
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1174,171,322 - 74,254,703 (+)Ensembl
RefSeq Acc Id: ENST00000535205
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1174,235,725 - 74,251,677 (+)Ensembl
RefSeq Acc Id: ENST00000538501
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1174,238,893 - 74,253,563 (+)Ensembl
RefSeq Acc Id: ENST00000539021
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1174,248,243 - 74,254,702 (+)Ensembl
RefSeq Acc Id: ENST00000541340
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1174,237,788 - 74,254,703 (+)Ensembl
RefSeq Acc Id: ENST00000542710
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1174,171,267 - 74,205,923 (+)Ensembl
RefSeq Acc Id: ENST00000543525
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1174,230,785 - 74,254,703 (+)Ensembl
RefSeq Acc Id: ENST00000544401
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1174,171,343 - 74,222,733 (+)Ensembl
RefSeq Acc Id: NM_001271593   ⟹   NP_001258522
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381174,171,289 - 74,254,703 (+)NCBI
HuRef1170,177,366 - 70,261,026 (+)NCBI
CHM1_11173,766,364 - 73,849,977 (+)NCBI
T2T-CHM13v2.01174,100,633 - 74,184,047 (+)NCBI
Sequence:
RefSeq Acc Id: NM_016147   ⟹   NP_057231
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381174,171,289 - 74,254,703 (+)NCBI
GRCh371173,881,936 - 73,965,748 (+)NCBI
Build 361173,560,016 - 73,643,396 (+)NCBI Archive
Celera1171,189,163 - 71,272,541 (+)RGD
HuRef1170,177,366 - 70,261,026 (+)NCBI
CHM1_11173,766,364 - 73,849,977 (+)NCBI
T2T-CHM13v2.01174,100,633 - 74,184,047 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017017913   ⟹   XP_016873402
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381174,171,289 - 74,245,495 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047427116   ⟹   XP_047283072
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381174,171,289 - 74,251,630 (+)NCBI
RefSeq Acc Id: XM_054369109   ⟹   XP_054225084
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01174,100,633 - 74,180,974 (+)NCBI
RefSeq Acc Id: XM_054369110   ⟹   XP_054225085
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01174,100,633 - 74,175,458 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_057231   ⟸   NM_016147
- Peptide Label: isoform a
- UniProtKB: Q9NVT5 (UniProtKB/Swiss-Prot),   Q8WYG8 (UniProtKB/Swiss-Prot),   J3QT22 (UniProtKB/Swiss-Prot),   B5MEE7 (UniProtKB/Swiss-Prot),   B3KMU6 (UniProtKB/Swiss-Prot),   Q9UI18 (UniProtKB/Swiss-Prot),   Q9Y570 (UniProtKB/Swiss-Prot),   A0A140VK39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258522   ⟸   NM_001271593
- Peptide Label: isoform b
- UniProtKB: Q9Y570 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016873402   ⟸   XM_017017913
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSP00000381461   ⟸   ENST00000398427
RefSeq Acc Id: ENSP00000329867   ⟸   ENST00000328257
RefSeq Acc Id: XP_047283072   ⟸   XM_047427116
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054225084   ⟸   XM_054369109
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054225085   ⟸   XM_054369110
- Peptide Label: isoform X2
Protein Domains
AB hydrolase-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Y570-F1-model_v2 AlphaFold Q9Y570 1-386 view protein structure

Promoters
RGD ID:6789262
Promoter ID:HG_KWN:13696
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000289350,   ENST00000313681,   ENST00000328257,   ENST00000398451,   ENST00000398456,   NM_015531,   NM_016147,   UC001OUV.2
Position:
Human AssemblyChrPosition (strand)Source
Build 361173,559,591 - 73,560,091 (+)MPROMDB
RGD ID:7221523
Promoter ID:EPDNEW_H16507
Type:single initiation site
Name:PPME1_3
Description:protein phosphatase methylesterase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16510  EPDNEW_H16512  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381174,163,594 - 74,163,654EPDNEW
RGD ID:7221531
Promoter ID:EPDNEW_H16510
Type:initiation region
Name:PPME1_2
Description:protein phosphatase methylesterase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16507  EPDNEW_H16512  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381174,171,125 - 74,171,185EPDNEW
RGD ID:7221533
Promoter ID:EPDNEW_H16512
Type:initiation region
Name:PPME1_1
Description:protein phosphatase methylesterase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16507  EPDNEW_H16510  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381174,171,289 - 74,171,349EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:30178 AgrOrtholog
COSMIC PPME1 COSMIC
Ensembl Genes ENSG00000214517 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000328257 ENTREZGENE
  ENST00000328257.13 UniProtKB/Swiss-Prot
  ENST00000398427 ENTREZGENE
  ENST00000398427.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000214517 GTEx
HGNC ID HGNC:30178 ENTREZGENE
Human Proteome Map PPME1 Human Proteome Map
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AB_hydrolase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPase_methylesterase_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:51400 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 51400 ENTREZGENE
OMIM 611117 OMIM
PANTHER PROTEIN PHOSPHATASE METHYLESTERASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14189 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Abhydrolase_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA142671152 PharmGKB
PIRSF PPase_methylesterase_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPASE_SER UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140VK39 ENTREZGENE, UniProtKB/TrEMBL
  B3KMU6 ENTREZGENE
  B5MEE7 ENTREZGENE
  J3QT22 ENTREZGENE
  PPME1_HUMAN UniProtKB/Swiss-Prot
  Q8WYG8 ENTREZGENE
  Q9NVT5 ENTREZGENE
  Q9UI18 ENTREZGENE
  Q9Y570 ENTREZGENE
UniProt Secondary B3KMU6 UniProtKB/Swiss-Prot
  B5MEE7 UniProtKB/Swiss-Prot
  J3QT22 UniProtKB/Swiss-Prot
  Q8WYG8 UniProtKB/Swiss-Prot
  Q9NVT5 UniProtKB/Swiss-Prot
  Q9UI18 UniProtKB/Swiss-Prot