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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ethylene glycol
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Accession:CHEBI:30742 term browser browse the term
Definition:A 1,2-glycol compound produced via reaction of ethylene oxide with water.
Synonyms:related_synonym: 1,2-Dihydroxyethane;   1,2-ETHANEDIOL;   2-Hydroxyethanol;   Ethane-1,2-diol;   Ethanediol;   Formula=C2H6O2;   Glycol;   HO-CH2-CH2-OH;   InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2;   InChIKey=LYCAIKOWRPUZTN-UHFFFAOYSA-N;   Monoethylene glycol;   SMILES=OCCO
 alt_id: CHEBI:21317;   CHEBI:42277;   CHEBI:5473
 xref: Beilstein:505945;   CAS:107-21-1;   Gmelin:943;   KEGG:C01380;   KEGG:C15588;   KNApSAcK:C00007409
 xref_mesh: MESH:D019855
 xref: MetaCyc:GLYCOL;   PDBeChem:EDO;   PMID:10349109;   PMID:15716482;   PMID:16901854;   PMID:17186009;   PMID:17336832;   PMID:17439666;   PMID:17979222;   PMID:18612987;   PMID:23764541;   PMID:23827374;   PMID:24045699;   PMID:24643482;   PMID:25108762;   PMID:9463526;   PPDB:1310;   Reaxys:505945;   UM-BBD_compID:c0542;   Wikipedia:Ethylene_Glycol


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ethylene glycol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide increases oxidation ISO ADH1C protein results in increased oxidation of Ethylene Glycol CTD PMID:21167143 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide increases oxidation ISO ADH4 protein results in increased oxidation of Ethylene Glycol CTD PMID:21167143 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide increases oxidation ISO ADH7 protein results in increased oxidation of Ethylene Glycol CTD PMID:21167143 NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO Ethylene Glycol results in decreased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Atf4 activating transcription factor 4 increases expression
multiple interactions		 EXP Ethylene Glycol results in increased expression of ATF4 mRNA
caryophyllene inhibits the reaction [Ethylene Glycol results in increased expression of ATF4 mRNA]		 CTD PMID:34468068 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression		 EXP caryophyllene inhibits the reaction [Ethylene Glycol results in decreased expression of BAX protein] CTD PMID:34468068 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression		 EXP caryophyllene inhibits the reaction [Ethylene Glycol results in increased expression of BCL2 protein] CTD PMID:34468068 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G C5 complement C5 multiple interactions ISO [Ethylene Glycol co-treated with Asbestos, Crocidolite] results in increased cleavage of C5 protein; [Ethylene Glycol co-treated with Asbestos, Serpentine] results in increased cleavage of C5 protein CTD PMID:10777245 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression		 EXP caryophyllene inhibits the reaction [Ethylene Glycol results in decreased expression of CASP3 protein] CTD PMID:34468068 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions
decreases expression		 EXP caryophyllene inhibits the reaction [Ethylene Glycol results in decreased expression of CASP9 protein] CTD PMID:34468068 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases activity
increases activity
multiple interactions		 EXP Ethylene Glycol results in decreased activity of CAT protein
Ethylene Glycol results in increased activity of CAT protein
acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased activity of CAT protein]; caryophyllene inhibits the reaction [Ethylene Glycol results in decreased activity of CAT protein]		 CTD PMID:24145091 PMID:27018375 PMID:34468068 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
affects expression
multiple interactions		 ISO
EXP		 Ethylene Glycol results in increased expression of CCL2 mRNA
Ethylene Glycol affects the expression of CCL2 mRNA
Ethylene Glycol results in increased expression of CCL2 mRNA; Ethylene Glycol results in increased expression of CCL2 protein
[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 mRNA; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 protein; acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 mRNA]; benazepril inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 protein]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 mRNA]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 protein]; caryophyllene inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 mRNA]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 protein]; Vitamin K 1 affects the reaction [Ethylene Glycol affects the expression of CCL2 mRNA]		 CTD PMID:16284884 PMID:21907259 PMID:27018375 PMID:31639794 PMID:34468068 More... NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression
multiple interactions		 EXP Ethylene Glycol results in increased expression of CCL5 protein
benazepril inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein]; PD 123319 inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein]		 CTD PMID:16284884 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cd44 CD44 molecule increases expression
multiple interactions		 EXP Ethylene Glycol results in increased expression of CD44 mRNA; Ethylene Glycol results in increased expression of CD44 protein
[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 mRNA; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 protein; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 mRNA]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 protein]		 CTD PMID:37244400 PMID:37414240 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 multiple interactions EXP [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CYP2C9 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CYP2C9 mRNA] CTD PMID:37414240 NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 decreases expression
multiple interactions		 EXP Ethylene Glycol results in decreased expression of DDIT3 mRNA
caryophyllene inhibits the reaction [Ethylene Glycol results in decreased expression of DDIT3 mRNA]		 CTD PMID:34468068 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 decreases expression ISO Ethylene Glycol results in decreased expression of EYA1 mRNA CTD PMID:31711903 NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483 		JBrowse link
G Foxc2 forkhead box C2 decreases expression ISO Ethylene Glycol results in decreased expression of FOXC2 mRNA CTD PMID:31711903 NCBI chr19:49,186,034...49,188,736
Ensembl chr19:49,185,662...49,188,737 		JBrowse link
G Gh1 growth hormone 1 affects folding ISO Ethylene Glycol affects the folding of GH1 protein CTD PMID:11064379 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression
multiple interactions		 ISO
EXP		 Ethylene Glycol results in increased expression of HAVCR1 mRNA
caryophyllene inhibits the reaction [Ethylene Glycol results in increased expression of HAVCR1 mRNA]		 CTD PMID:21907259 PMID:34468068 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions EXP [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC1 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC1 mRNA] CTD PMID:37414240 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac2 histone deacetylase 2 multiple interactions EXP [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC2 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC2 mRNA] CTD PMID:37414240 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hdac3 histone deacetylase 3 multiple interactions EXP [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC3 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC3 mRNA] CTD PMID:37414240 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Hdac8 histone deacetylase 8 multiple interactions EXP [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC8 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC8 mRNA] CTD PMID:37414240 NCBI chr  X:67,385,288...67,593,014
Ensembl chr  X:67,385,289...67,592,923 		JBrowse link
G Hoxb7 homeo box B7 increases expression ISO Ethylene Glycol results in increased expression of HOXB7 mRNA CTD PMID:31711903 NCBI chr10:81,252,616...81,256,034
Ensembl chr10:81,252,553...81,256,034 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression		 EXP caryophyllene inhibits the reaction [Ethylene Glycol results in increased expression of HSPA5 mRNA] CTD PMID:34468068 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 EXP Ethylene Glycol results in increased expression of IL6 mRNA; Ethylene Glycol results in increased expression of IL6 protein
[Flavonoids co-treated with Plant Extracts] inhibits the reaction [Ethylene Glycol results in increased expression of IL6 protein]; acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of IL6 mRNA]; benazepril inhibits the reaction [Ethylene Glycol results in increased expression of IL6 protein]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of IL6 protein]		 CTD PMID:16284884 PMID:27018375 PMID:27241030 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Meox1 mesenchyme homeobox 1 decreases expression ISO Ethylene Glycol results in decreased expression of MEOX1 mRNA CTD PMID:31711903 NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660 		JBrowse link
G Mgp matrix Gla protein multiple interactions
increases expression		 EXP [Vitamin K 1 co-treated with Ethylene Glycol] results in increased expression of MGP protein
Ethylene Glycol results in increased expression of MGP protein		 CTD PMID:31639794 NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667 		JBrowse link
G Nefh neurofilament heavy chain affects expression EXP Ethylene Glycol affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Neurog2 neurogenin 2 increases expression ISO Ethylene Glycol results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 2:216,092,709...216,095,276
Ensembl chr 2:216,093,363...216,094,154 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases expression		 EXP benazepril inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein]; PD 123319 inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein] CTD PMID:16284884 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Ocln occludin decreases expression EXP Ethylene Glycol results in decreased expression of OCLN mRNA CTD PMID:37244400 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Olig3 oligodendrocyte transcription factor 3 increases expression ISO Ethylene Glycol results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr 1:14,081,259...14,083,336
Ensembl chr 1:14,081,328...14,082,149 		JBrowse link
G Pax3 paired box 3 decreases expression ISO Ethylene Glycol results in decreased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression		 EXP acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of RELA mRNA]; caryophyllene inhibits the reaction [Ethylene Glycol results in increased expression of RELA mRNA] CTD PMID:27018375 PMID:34468068 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc26a1 solute carrier family 26 member 1 increases expression EXP Ethylene Glycol results in increased expression of SLC26A1 protein CTD PMID:26526882 NCBI chr14:1,040,565...1,045,851
Ensembl chr14:1,040,243...1,045,849 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
increases expression		 EXP [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 mRNA; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 protein; [Flavonoids co-treated with Plant Extracts] inhibits the reaction [Ethylene Glycol results in increased expression of SPP1 protein]; acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of SPP1 protein]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 mRNA]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 protein]
Ethylene Glycol results in increased expression of SPP1 mRNA; Ethylene Glycol results in increased expression of SPP1 protein		 CTD PMID:24145091 PMID:27018375 PMID:27241030 PMID:37244400 PMID:37414240 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Tcf15 transcription factor 15 decreases expression ISO Ethylene Glycol results in decreased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr 3:140,638,984...140,644,766
Ensembl chr 3:140,638,984...140,644,766 		JBrowse link
G Tf transferrin multiple interactions
increases expression		 EXP [Flavonoids co-treated with Plant Extracts] inhibits the reaction [Ethylene Glycol results in increased expression of TF protein]; acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of TF protein] CTD PMID:27018375 PMID:27241030 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression EXP Ethylene Glycol results in decreased expression of TJP1 mRNA CTD PMID:37244400 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 EXP Ethylene Glycol results in increased expression of TNF mRNA; Ethylene Glycol results in increased expression of TNF protein
[Flavonoids co-treated with Plant Extracts] inhibits the reaction [Ethylene Glycol results in increased expression of TNF protein]; acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of TNF mRNA]		 CTD PMID:27018375 PMID:27241030 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Umod uromodulin multiple interactions
increases expression		 EXP [Flavonoids co-treated with Plant Extracts] inhibits the reaction [Ethylene Glycol results in increased expression of UMOD protein]; acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of and affects the localization of UMOD protein]; Ethylene Glycol results in increased expression of and affects the localization of UMOD protein CTD PMID:27018375 PMID:27241030 NCBI chr 1:173,816,341...173,829,681
Ensembl chr 1:173,816,339...173,830,302 		JBrowse link
G Uncx UNC homeobox decreases expression ISO Ethylene Glycol results in decreased expression of UNCX mRNA CTD PMID:31711903 NCBI chr12:15,092,779...15,097,300
Ensembl chr12:15,092,784...15,097,300 		JBrowse link
G Vnn1 vanin 1 increases expression EXP
ISO		 Ethylene Glycol results in increased expression of VNN1 mRNA; Ethylene Glycol results in increased expression of VNN1 protein CTD PMID:21907259 NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression
multiple interactions		 EXP Ethylene Glycol results in increased expression of XBP1 mRNA
caryophyllene inhibits the reaction [Ethylene Glycol results in increased expression of XBP1 mRNA]		 CTD PMID:34468068 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
2-ethoxyethanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt2 AKT serine/threonine kinase 2 increases expression EXP 2-ethoxyethanol results in increased expression of AKT2 mRNA CTD PMID:19643169 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 increases expression EXP 2-ethoxyethanol results in increased expression of AKT3 mRNA CTD PMID:19643169 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member increases reaction ISO ALDH2 protein promotes the reaction 2-ethoxyethanol CTD PMID:17878629 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G App amyloid beta precursor protein increases expression EXP 2-ethoxyethanol results in increased expression of APP mRNA CTD PMID:19643169 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Arf3 ADP-ribosylation factor 3 increases expression EXP 2-ethoxyethanol results in increased expression of ARF3 mRNA CTD PMID:19643169 NCBI chr 7:129,886,082...129,912,022
Ensembl chr 7:129,886,082...129,912,002 		JBrowse link
G Atf2 activating transcription factor 2 increases expression EXP 2-ethoxyethanol results in increased expression of ATF2 mRNA CTD PMID:19643169 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Bag6 BAG cochaperone 6 increases expression EXP 2-ethoxyethanol results in increased expression of BAG6 mRNA CTD PMID:19643169 NCBI chr20:3,675,938...3,690,414
Ensembl chr20:3,675,938...3,688,657 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression EXP 2-ethoxyethanol results in increased expression of BCL2L1 mRNA CTD PMID:19643169 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Cat catalase decreases activity EXP 2-ethoxyethanol results in decreased activity of CAT protein CTD PMID:20172899 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cav1 caveolin 1 increases expression EXP 2-ethoxyethanol results in increased expression of CAV mRNA CTD PMID:19643169 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma increases expression EXP 2-ethoxyethanol results in increased expression of CEBPG mRNA CTD PMID:19643169 NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569 		JBrowse link
G Cel carboxyl ester lipase increases expression EXP 2-ethoxyethanol results in increased expression of CEL mRNA CTD PMID:19643169 NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035 		JBrowse link
G Chp1 calcineurin-like EF-hand protein 1 increases expression EXP 2-ethoxyethanol results in increased expression of CHP1 mRNA CTD PMID:19643169 NCBI chr 3:106,536,009...106,571,255
Ensembl chr 3:106,536,004...106,571,251 		JBrowse link
G Cltc clathrin heavy chain increases expression EXP 2-ethoxyethanol results in increased expression of CLTC mRNA CTD PMID:19643169 NCBI chr10:71,517,661...71,574,591
Ensembl chr10:71,517,663...71,573,737 		JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 increases expression EXP 2-ethoxyethanol results in increased expression of CSNK1A1 mRNA CTD PMID:19643169 NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271 		JBrowse link
G Csnk1d casein kinase 1, delta increases expression EXP 2-ethoxyethanol results in increased expression of CSNK1D mRNA CTD PMID:19643169 NCBI chr10:106,221,992...106,256,620
Ensembl chr10:106,221,992...106,256,614 		JBrowse link
G Csnk1g3 casein kinase 1, gamma 3 increases expression EXP 2-ethoxyethanol results in increased expression of CSNK1G3 mRNA CTD PMID:19643169 NCBI chr18:47,299,547...47,386,538
Ensembl chr18:47,299,579...47,386,535 		JBrowse link
G Cttn cortactin increases expression EXP 2-ethoxyethanol results in increased expression of CTTN mRNA CTD PMID:19643169 NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase increases expression EXP 2-ethoxyethanol results in increased expression of DHCR7 mRNA CTD PMID:19643169 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055 		JBrowse link
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 decreases expression EXP 2-ethoxyethanol results in decreased expression of DYNC1LI1 mRNA CTD PMID:19643169 NCBI chr 8:114,376,649...114,410,297
Ensembl chr 8:114,376,662...114,410,934 		JBrowse link
G Eloa elongin A increases expression EXP 2-ethoxyethanol results in increased expression of ELOA mRNA CTD PMID:19643169 NCBI chr 5:148,231,600...148,246,760
Ensembl chr 5:148,231,596...148,246,765 		JBrowse link
G Eno2 enolase 2 increases expression EXP 2-ethoxyethanol results in increased expression of ENO2 mRNA CTD PMID:19643169 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980 		JBrowse link
G Epn2 epsin 2 increases expression EXP 2-ethoxyethanol results in increased expression of EPN2 mRNA CTD PMID:19643169 NCBI chr10:46,197,785...46,259,673
Ensembl chr10:46,197,785...46,259,642 		JBrowse link
G Gata4 GATA binding protein 4 increases expression EXP 2-ethoxyethanol results in increased expression of GATA4 mRNA CTD PMID:19643169 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gata6 GATA binding protein 6 increases expression EXP 2-ethoxyethanol results in increased expression of GATA6 mRNA CTD PMID:19643169 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532 		JBrowse link
G Gdi2 GDP dissociation inhibitor 2 increases expression EXP 2-ethoxyethanol results in increased expression of GDI2 mRNA CTD PMID:19643169 NCBI chr17:66,649,616...66,676,299
Ensembl chr17:66,649,619...66,676,366 		JBrowse link
G Hk1 hexokinase 1 increases expression EXP 2-ethoxyethanol results in increased expression of HK1 mRNA CTD PMID:19643169 NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131 		JBrowse link
G Hk2 hexokinase 2 increases expression EXP 2-ethoxyethanol results in increased expression of HK2 mRNA CTD PMID:19643169 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Igf2 insulin-like growth factor 2 increases expression EXP 2-ethoxyethanol results in increased expression of IGF2 mRNA CTD PMID:19643169 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018 		JBrowse link
G Jak2 Janus kinase 2 increases expression EXP 2-ethoxyethanol results in increased expression of JAK2 mRNA CTD PMID:19643169 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase increases expression EXP 2-ethoxyethanol results in increased expression of LYN mRNA CTD PMID:19643169 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 decreases expression EXP 2-ethoxyethanol results in decreased expression of MAP3K12 mRNA CTD PMID:19643169 NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression EXP 2-ethoxyethanol results in increased expression of MAPK1 mRNA CTD PMID:19643169 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 increases expression EXP 2-ethoxyethanol results in increased expression of MAPK10 mRNA CTD PMID:19643169 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201 		JBrowse link
G Mxi1 MAX interactor 1, dimerization protein increases expression EXP 2-ethoxyethanol results in increased expression of MXI1 mRNA CTD PMID:19643169 NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681 		JBrowse link
G Nab1 Ngfi-A binding protein 1 increases expression EXP 2-ethoxyethanol results in increased expression of NAB1 mRNA CTD PMID:19643169 NCBI chr 9:49,053,579...49,093,078
Ensembl chr 9:49,053,758...49,092,098 		JBrowse link
G Nfia nuclear factor I/A increases expression EXP 2-ethoxyethanol results in increased expression of NFIA mRNA CTD PMID:19643169 NCBI chr 5:112,436,655...112,781,878
Ensembl chr 5:112,436,644...112,775,885 		JBrowse link
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 increases expression EXP 2-ethoxyethanol results in increased expression of NR2F2 mRNA CTD PMID:19643169 NCBI chr 1:124,008,282...124,022,521
Ensembl chr 1:124,009,181...124,022,031 		JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 increases expression EXP 2-ethoxyethanol results in increased expression of PAK2 mRNA CTD PMID:19643169 NCBI chr11:68,707,940...68,768,816
Ensembl chr11:68,707,969...68,768,816 		JBrowse link
G Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 increases expression EXP 2-ethoxyethanol results in increased expression of PFKFB2 mRNA CTD PMID:19643169 NCBI chr13:42,147,473...42,174,699
Ensembl chr13:42,147,478...42,174,699 		JBrowse link
G Pla2g4a phospholipase A2 group 4A increases expression EXP 2-ethoxyethanol results in increased expression of PLA2G4A mRNA CTD PMID:19643169 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Plcb3 phospholipase C beta 3 increases expression EXP 2-ethoxyethanol results in increased expression of PLCB3 mRNA CTD PMID:19643169 NCBI chr 1:204,143,257...204,160,384
Ensembl chr 1:204,144,956...204,160,228 		JBrowse link
G Pou2f3 POU class 2 homeobox 3 increases expression EXP 2-ethoxyethanol results in increased expression of POU2F3 mRNA CTD PMID:19643169 NCBI chr 8:43,495,408...43,577,795
Ensembl chr 8:43,495,527...43,577,795 		JBrowse link
G Prkar2a protein kinase cAMP-dependent type II regulatory subunit alpha increases expression EXP 2-ethoxyethanol results in increased expression of PRKAR2A mRNA CTD PMID:19643169 NCBI chr 8:109,393,189...109,458,832
Ensembl chr 8:109,395,833...109,455,628 		JBrowse link
G Rab5a RAB5A, member RAS oncogene family increases expression EXP 2-ethoxyethanol results in increased expression of RAB5A mRNA CTD PMID:19643169 NCBI chr 9:6,483,906...6,512,877
Ensembl chr 9:6,484,469...6,512,873 		JBrowse link
G Rnf4 ring finger protein 4 increases expression EXP 2-ethoxyethanol results in increased expression of RNF4 mRNA CTD PMID:19643169 NCBI chr14:76,401,292...76,423,270
Ensembl chr14:76,401,299...76,422,566 		JBrowse link
G Ros1 ROS proto-oncogene 1 , receptor tyrosine kinase increases expression EXP 2-ethoxyethanol results in increased expression of ROS1 mRNA CTD PMID:19643169 NCBI chr20:31,432,636...31,583,998
Ensembl chr20:31,432,637...31,583,865 		JBrowse link
G Sec14l2 SEC14-like lipid binding 2 increases expression EXP 2-ethoxyethanol results in increased expression of SEC14L2 mRNA CTD PMID:19643169 NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788 		JBrowse link
G Sik1 salt-inducible kinase 1 increases expression EXP 2-ethoxyethanol results in increased expression of SIK1 mRNA CTD PMID:19643169 NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991 		JBrowse link
G Snrk SNF related kinase increases expression EXP 2-ethoxyethanol results in increased expression of SNRK mRNA CTD PMID:19643169 NCBI chr 8:121,779,704...121,833,949
Ensembl chr 8:121,793,302...121,832,323 		JBrowse link
G Snx16 sorting nexin 16 increases expression EXP 2-ethoxyethanol results in increased expression of SNX16 mRNA CTD PMID:19643169 NCBI chr 2:91,335,896...91,357,622
Ensembl chr 2:91,336,092...91,357,619 		JBrowse link
G Soat1 sterol O-acyltransferase 1 increases expression EXP 2-ethoxyethanol results in increased expression of SOAT1 mRNA CTD PMID:19643169 NCBI chr13:68,552,274...68,597,529
Ensembl chr13:68,552,317...68,597,494 		JBrowse link
G Stk17b serine/threonine kinase 17b increases expression EXP 2-ethoxyethanol results in increased expression of STK17B mRNA CTD PMID:19643169 NCBI chr 9:55,307,485...55,338,085
Ensembl chr 9:55,307,668...55,338,031 		JBrowse link
G Stx2 syntaxin 2 increases expression EXP 2-ethoxyethanol results in increased expression of STX2 mRNA CTD PMID:19643169 NCBI chr12:27,678,744...27,714,751
Ensembl chr12:27,689,819...27,714,751 		JBrowse link
G Stxbp1 syntaxin binding protein 1 increases expression EXP 2-ethoxyethanol results in increased expression of STXBP1 mRNA CTD PMID:19643169 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369 		JBrowse link
G Sycp1 synaptonemal complex protein 1 decreases expression EXP 2-ethoxyethanol results in decreased expression of SYCP1 mRNA CTD PMID:19643169 NCBI chr 2:190,296,688...190,456,687
Ensembl chr 2:190,296,954...190,456,737 		JBrowse link
G Sycp2 synaptonemal complex protein 2 decreases expression EXP 2-ethoxyethanol results in decreased expression of SYCP2 mRNA CTD PMID:19643169 NCBI chr 3:165,431,715...165,502,134
Ensembl chr 3:165,436,331...165,498,789 		JBrowse link
G Sycp3 synaptonemal complex protein 3 decreases expression EXP 2-ethoxyethanol results in decreased expression of SYCP3 mRNA CTD PMID:19643169 NCBI chr 7:22,874,055...22,888,512
Ensembl chr 7:22,874,055...22,888,511 		JBrowse link
G Tle4 TLE family member 4, transcriptional corepressor increases expression EXP 2-ethoxyethanol results in increased expression of TLE4 mRNA CTD PMID:19643169 NCBI chr 1:211,661,738...211,798,458
Ensembl chr 1:211,661,746...211,797,862 		JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 increases expression EXP 2-ethoxyethanol results in increased expression of TMED2 mRNA CTD PMID:19643169 NCBI chr12:32,052,542...32,061,628
Ensembl chr12:32,052,543...32,071,903 		JBrowse link
G Wt1 WT1 transcription factor increases expression EXP 2-ethoxyethanol results in increased expression of WT1 mRNA CTD PMID:19643169 NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643 		JBrowse link
G Yy1 YY1 transcription factor increases expression EXP 2-ethoxyethanol results in increased expression of YY1 mRNA CTD PMID:19643169 NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747 		JBrowse link
2-hydroxyethyl methacrylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin increases expression ISO hydroxyethyl methacrylate results in increased expression of ADM mRNA CTD PMID:30497689 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO hydroxyethyl methacrylate results in increased expression of AKR1C2 mRNA CTD PMID:30497689 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO hydroxyethyl methacrylate results in increased expression of AKR1C3 mRNA CTD PMID:30497689 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 increases expression ISO hydroxyethyl methacrylate results in increased expression of ALDH3A2 mRNA CTD PMID:30497689 NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281 		JBrowse link
G Atg5 autophagy related 5 increases expression
multiple interactions		 ISO hydroxyethyl methacrylate results in increased expression of ATG5 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]		 CTD PMID:28184909 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions		 ISO hydroxyethyl methacrylate results in increased expression of BECN1 mRNA; hydroxyethyl methacrylate results in increased expression of BECN1 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]		 CTD PMID:28184909 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO hydroxyethyl methacrylate results in increased activity of CASP3 protein
Ascorbic Acid inhibits the reaction [hydroxyethyl methacrylate results in increased activity of CASP3 protein]		 CTD PMID:33248029 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression		 ISO 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA] CTD PMID:28184909 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions ISO Ascorbic Acid inhibits the reaction [hydroxyethyl methacrylate results in increased degradation of CAT mRNA]; hydroxyethyl methacrylate results in increased expression of and results in increased degradation of CAT mRNA CTD PMID:33248029 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO hydroxyethyl methacrylate results in decreased expression of COL1A1 mRNA; hydroxyethyl methacrylate results in decreased expression of COL1A1 protein CTD PMID:20668299 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO hydroxyethyl methacrylate results in decreased expression of CXCL12 protein CTD PMID:30517439 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO hydroxyethyl methacrylate results in increased expression of DNAJB4 mRNA CTD PMID:30497689 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089 		JBrowse link
G Fbxo30 F-box protein 30 increases expression ISO hydroxyethyl methacrylate results in increased expression of FBXO30 mRNA CTD PMID:30497689 NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases secretion		 ISO Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate results in increased secretion of FGF2 protein]; pyrazolanthrone inhibits the reaction [hydroxyethyl methacrylate results in increased secretion of FGF2 protein] CTD PMID:19176594 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of FTH1 mRNA CTD PMID:30497689 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO hydroxyethyl methacrylate results in increased expression of GCLC mRNA; hydroxyethyl methacrylate results in increased expression of GCLC protein CTD PMID:30497689 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO hydroxyethyl methacrylate results in increased expression of GCLM mRNA; hydroxyethyl methacrylate results in increased expression of GCLM protein CTD PMID:30497689 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of HMOX1 mRNA; hydroxyethyl methacrylate results in increased expression of HMOX1 protein CTD PMID:30497689 PMID:33248029 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO hydroxyethyl methacrylate results in increased expression of HSPA1A mRNA CTD PMID:30497689 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO hydroxyethyl methacrylate results in increased expression of HSPA1B mRNA CTD PMID:30497689 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 2-oxothiazolidine-4-carboxylic acid inhibits the reaction [hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; Buthionine Sulfoximine promotes the reaction [hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; hydroxyethyl methacrylate promotes the reaction [triethylene glycol dimethacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; triethylene glycol dimethacrylate promotes the reaction [hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]] CTD PMID:23182953 PMID:28188892 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases secretion ISO hydroxyethyl methacrylate results in decreased secretion of IL6 protein CTD PMID:19176594 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions		 ISO hydroxyethyl methacrylate results in increased expression of MAP1LC3B mRNA; hydroxyethyl methacrylate results in increased expression of MAP1LC3B protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of MAP1LC3B mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of MAP1LC3B protein]		 CTD PMID:28184909 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 increases expression ISO hydroxyethyl methacrylate results in increased expression of MAP3K14 mRNA CTD PMID:30497689 NCBI chr10:88,165,349...88,215,558
Ensembl chr10:88,165,351...88,215,523 		JBrowse link
G Mrpl19 mitochondrial ribosomal protein L19 increases expression ISO hydroxyethyl methacrylate results in increased expression of MRPL19 mRNA CTD PMID:30497689 NCBI chr 4:114,521,824...114,526,053
Ensembl chr 4:114,521,824...114,526,053 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO hydroxyethyl methacrylate results in increased expression of NFE2L2 protein CTD PMID:30497689 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases response to substance
multiple interactions		 ISO NFKBIA protein results in increased susceptibility to hydroxyethyl methacrylate
NFKBIA protein affects the reaction [Acetylcysteine results in decreased susceptibility to hydroxyethyl methacrylate]		 CTD PMID:19176594 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of NQO1 mRNA; hydroxyethyl methacrylate results in increased expression of NQO1 protein CTD PMID:30497689 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of OSGIN1 mRNA CTD PMID:30497689 NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased cleavage of PARP1 protein] CTD PMID:28184909 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate affects the localization of and results in decreased activity of RELA protein]; hydroxyethyl methacrylate affects the localization of and results in decreased activity of RELA protein; hydroxyethyl methacrylate affects the localization of and results in increased phosphorylation of and results in increased activity of RELA protein; hydroxyethyl methacrylate inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:19176594 PMID:28184909 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Spsb1 splA/ryanodine receptor domain and SOCS box containing 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of SPSB1 mRNA CTD PMID:30497689 NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of SQSTM1 mRNA; hydroxyethyl methacrylate results in increased expression of SQSTM1 protein CTD PMID:30497689 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of SRXN1 mRNA CTD PMID:30497689 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO hydroxyethyl methacrylate inhibits the reaction [TNF protein results in increased activity of RELA protein]
hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; hydroxyethyl methacrylate promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]		 CTD PMID:19176594 PMID:23182953 PMID:28188892 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of TXNRD1 mRNA CTD PMID:30497689 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase increases expression ISO hydroxyethyl methacrylate results in increased expression of UGDH mRNA CTD PMID:30497689 NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases secretion		 ISO Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate results in decreased secretion of VEGFA protein]; pyrazolanthrone inhibits the reaction [hydroxyethyl methacrylate results in decreased secretion of VEGFA protein] CTD PMID:19176594 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
ethylene glycol dimethacrylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c2 aldo-keto reductase family 1, member C2 increases activity ISO ethylene dimethacrylate results in increased activity of AKR1C2 promoter CTD PMID:21195160 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO ethylene dimethacrylate results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Bach1 BTB domain and CNC homolog 1 multiple interactions ISO BACH1 mRNA promotes the reaction [ethylene dimethacrylate results in increased expression of HMOX1 mRNA] CTD PMID:26244607 NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447 		JBrowse link
G Cd86 CD86 molecule increases expression ISO ethylene dimethacrylate results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression ISO ethylene dimethacrylate results in decreased expression of CXCL14 protein CTD PMID:31734321 NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO ethylene dimethacrylate results in increased expression of CXCL2 protein CTD PMID:23178550 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO ethylene dimethacrylate results in increased expression of GCLM mRNA CTD PMID:27965148 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression ISO ethylene dimethacrylate results in increased expression of GPX4 CTD PMID:29107684 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO ethylene dimethacrylate results in increased expression of HMOX1 mRNA
BACH1 mRNA promotes the reaction [ethylene dimethacrylate results in increased expression of HMOX1 mRNA]; NFE2L2 mRNA promotes the reaction [ethylene dimethacrylate results in increased expression of HMOX1 mRNA]		 CTD PMID:26244607 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO ethylene dimethacrylate results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 mRNA promotes the reaction [ethylene dimethacrylate results in increased expression of HMOX1 mRNA] CTD PMID:26244607 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO ethylene dimethacrylate results in increased expression of SOD2 CTD PMID:29107684 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
macitentan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO macitentan results in decreased expression of ABCB1 mRNA CTD PMID:28369585 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO macitentan results in decreased expression of ABCC2 mRNA CTD PMID:28369585 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases expression ISO macitentan results in decreased expression of ABCC3 mRNA CTD PMID:28369585 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO macitentan results in decreased expression of SLC10A1 mRNA CTD PMID:28369585 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      chemical role 19420
        solvent 17012
          ethylene glycol 151
            1,2-dimethoxyethane 0
            2-ethoxyethanol + 62
            2-hydroxyethyl hexadecanoate 0
            2-hydroxyethyl methacrylate 38
            2-hydroxyethyl octadecanoate 0
            2-hydroxyethyl salicylate 0
            2-hydroxyethyl sulfonate 0
            4-[(2-hydroxyethoxy)carbonyl]benzoic acid 0
            6-(2-hydroxyethoxy)-6-oxohexanoic acid 0
            ACT-132577 + 4
            TCA-ethadyl 0
            ethylene glycol bis(2-aminoethyl)tetraacetate 0
            ethylene glycol dimethacrylate 12
            ethylene glycol monododecyl ether 0
            ethylene glycol monophosphate 0
            macitentan 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      chalcogen 19513
                        oxygen atom 19488
                          oxygen molecular entity 19488
                            hydroxides 19299
                              organic hydroxy compound 18923
                                polyol 11684
                                  diol 3915
                                    glycol 3684
                                      ethylene glycol 151
                                        1,2-dimethoxyethane 0
                                        2-ethoxyethanol + 62
                                        2-hydroxyethyl hexadecanoate 0
                                        2-hydroxyethyl methacrylate 38
                                        2-hydroxyethyl octadecanoate 0
                                        2-hydroxyethyl salicylate 0
                                        2-hydroxyethyl sulfonate 0
                                        4-[(2-hydroxyethoxy)carbonyl]benzoic acid 0
                                        6-(2-hydroxyethoxy)-6-oxohexanoic acid 0
                                        ACT-132577 + 4
                                        TCA-ethadyl 0
                                        ethylene glycol bis(2-aminoethyl)tetraacetate 0
                                        ethylene glycol dimethacrylate 12
                                        ethylene glycol monododecyl ether 0
                                        ethylene glycol monophosphate 0
                                        macitentan 4
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