Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Myocardial Ischemia | | ISO | RAB5A (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:16214533 | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Myocardial Ischemia | | ISO | RAB5A (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:16214533 | |
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# | Reference Title | Reference Citation |
1. | Critical role for Piccolo in synaptic vesicle retrieval. | Ackermann F, etal., Elife. 2019 May 10;8. pii: 46629. doi: 10.7554/eLife.46629. |
2. | NMDA receptor-dependent activation of the small GTPase Rab5 drives the removal of synaptic AMPA receptors during hippocampal LTD. | Brown TC, etal., Neuron. 2005 Jan 6;45(1):81-94. doi: 10.1016/j.neuron.2004.12.023. |
3. | The involvement of the small GTP-binding protein Rab5a in neuronal endocytosis. | de Hoop MJ, etal., Neuron. 1994 Jul;13(1):11-22. |
4. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
5. | Endosomal sorting of readily releasable synaptic vesicles. | Hoopmann P, etal., Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19055-60. doi: 10.1073/pnas.1007037107. Epub 2010 Oct 18. |
6. | Rap1-induced p38 mitogen-activated protein kinase activation facilitates AMPA receptor trafficking via the GDI.Rab5 complex. Potential role in (S)-3,5-dihydroxyphenylglycene-induced long term depression. | Huang CC, etal., J Biol Chem 2004 Mar 26;279(13):12286-92. Epub 2004 Jan 6. |
7. | Alzheimer amyloid protein precursor is localized in nerve terminal preparations to Rab5-containing vesicular organelles distinct from those implicated in the synaptic vesicle pathway. | Ikin AF, etal., J Biol Chem. 1996 Dec 13;271(50):31783-6. |
8. | Rab proteins in endocytosis and Glut4 trafficking. | Kaddai V, etal., Acta Physiol (Oxf). 2008 Jan;192(1):75-88. |
9. | The proteins of synaptic vesicle membranes are affected during ageing of rat brain. | Lee SR, etal., Exp Mol Med 2001 Dec 31;33(4):220-5. |
10. | RNAi-mediated Rab5a suppression inhibits proliferation and migration of vascular smooth muscle cells. | Ma Z, etal., Acta Cardiol. 2010 Oct;65(5):507-14. |
11. | Overview of macroautophagy regulation in mammalian cells. | Mehrpour M, etal., Cell Res. 2010 Jul;20(7):748-62. Epub 2010 Jun 15. |
12. | Co-localization of rab4 with endocytosis-related proteins in the rat parotid glands. | Nashida T, etal., Arch Histol Cytol. 2003 Mar;66(1):45-52. |
13. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
14. | Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. | Pavlos NJ, etal., J Neurosci. 2010 Oct 6;30(40):13441-53. doi: 10.1523/JNEUROSCI.0907-10.2010. |
15. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
16. | GOA pipeline | RGD automated data pipeline |
17. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
18. | EARP is a multisubunit tethering complex involved in endocytic recycling. | Schindler C, etal., Nat Cell Biol. 2015 May;17(5):639-50. doi: 10.1038/ncb3129. Epub 2015 Mar 23. |
19. | Endocytosis-dominated membrane area decrease requires Rab5 protein in rat melanotrophs. | Sedej S, etal., Ann N Y Acad Sci. 2005 Jun;1048:272-80. |
20. | Molecular anatomy of a trafficking organelle. | Takamori S, etal., Cell. 2006 Nov 17;127(4):831-46. |
21. | A tubular endosomal fraction from rat liver: biochemical evidence of receptor sorting by default. | Verges M, etal., Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10146-51. |
22. | Identification of Rab 5 but not Rab 3A in rat pancreatic zymogen granule membranes. | Wagner AC, etal., Biochem Biophys Res Commun. 1994 Apr 15;200(1):542-8. |
23. | GLUT4 translocation: the last 200 nanometers. | Watson RT and Pessin JE, Cell Signal. 2007 Nov;19(11):2209-17. Epub 2007 Jun 21. |
24. | Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. | Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884. |
25. | EEA1, a tethering protein of the early sorting endosome, shows a polarized distribution in hippocampal neurons, epithelial cells, and fibroblasts. | Wilson JM, etal., Mol Biol Cell. 2000 Aug;11(8):2657-71. |
26. | Role of ARF6 in internalization of metal-binding proteins, metallothionein and transferrin, and cadmium-metallothionein toxicity in kidney proximal tubule cells. | Wolff NA, etal., Toxicol Appl Pharmacol. 2008 Jul 1;230(1):78-85. Epub 2008 Feb 20. |
27. | Serotonin facilitates long-term depression induction in prefrontal cortex via p38 MAPK/Rab5-mediated enhancement of AMPA receptor internalization. | Zhong P, etal., J Physiol. 2008 Sep 15;586(Pt 18):4465-79. Epub 2008 Jul 24. |
PMID:8197185 | PMID:9034150 | PMID:11092755 | PMID:12388596 | PMID:12446704 | PMID:12477932 | PMID:14668490 | PMID:14741744 | PMID:14978216 | PMID:15016378 | PMID:15039456 | PMID:15078902 |
PMID:15128739 | PMID:15378032 | PMID:16141272 | PMID:16380373 | PMID:16880210 | PMID:16890161 | PMID:16902405 | PMID:17267689 | PMID:17562788 | PMID:17716972 | PMID:17765678 | PMID:18034774 |
PMID:18504258 | PMID:18656450 | PMID:18767904 | PMID:18794329 | PMID:19013132 | PMID:19376974 | PMID:19509052 | PMID:19549681 | PMID:19966785 | PMID:20458337 | PMID:21266579 | PMID:21419809 |
PMID:21645192 | PMID:22279005 | PMID:22431521 | PMID:22493499 | PMID:22783020 | PMID:23382462 | PMID:23416069 | PMID:23687301 | PMID:24029230 | PMID:24035762 | PMID:24334765 | PMID:24891604 |
PMID:25161316 | PMID:25568335 | PMID:25592972 | PMID:25869668 | PMID:26005850 | PMID:26582200 | PMID:27390154 | PMID:27559088 | PMID:29476059 | PMID:30988348 | PMID:36062786 |
Rab5a (Rattus norvegicus - Norway rat) |
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RAB5A (Homo sapiens - human) |
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Rab5a (Mus musculus - house mouse) |
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Rab5a (Chinchilla lanigera - long-tailed chinchilla) |
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RAB5A (Pan paniscus - bonobo/pygmy chimpanzee) |
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RAB5A (Canis lupus familiaris - dog) |
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Rab5a (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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RAB5A (Sus scrofa - pig) |
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RAB5A (Chlorocebus sabaeus - green monkey) |
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Rab5a (Heterocephalus glaber - naked mole-rat) |
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Variants in Rab5a
103 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
RH136188 |
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RH136456 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 33 | 54 | 38 | 19 | 38 | 1 | 3 | 74 | 35 | 36 | 11 | 1 |
Low | 10 | 3 | 3 | 3 | 7 | 8 | 5 | 7 | |||||
Below cutoff |
RefSeq Transcripts | NM_022692 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_039084178 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039084181 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063267691 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063267692 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AF072935 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
BC072495 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC161848 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH474184 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000009 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000084261 ⟹ ENSRNOP00000070031 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000105898 ⟹ ENSRNOP00000087406 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000108726 ⟹ ENSRNOP00000080027 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_022692 ⟹ NP_073183 | ||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039084178 ⟹ XP_038940106 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039084181 ⟹ XP_038940109 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_063267691 ⟹ XP_063123761 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063267692 ⟹ XP_063123762 | ||||||||
Type: | CODING | ||||||||
Position: |
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Protein RefSeqs | NP_073183 | (Get FASTA) | NCBI Sequence Viewer |
XP_038940106 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038940109 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063123761 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063123762 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAC26004 | (Get FASTA) | NCBI Sequence Viewer |
AAH72495 | (Get FASTA) | NCBI Sequence Viewer | |
AAI61848 | (Get FASTA) | NCBI Sequence Viewer | |
EDL82849 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000070031.1 | ||
ENSRNOP00000080027.1 | |||
ENSRNOP00000087406 | |||
ENSRNOP00000087406.1 | |||
ENSRNOP00000096260.1 | |||
GenBank Protein | M0RC99 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_073183 ⟸ NM_022692 |
- UniProtKB: | A0A8I5ZS76 (UniProtKB/TrEMBL), A0A8I6A5S3 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_038940109 ⟸ XM_039084181 |
- Peptide Label: | isoform X3 |
RefSeq Acc Id: | XP_038940106 ⟸ XM_039084178 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A0A8I5ZS76 (UniProtKB/TrEMBL), A0A8I6A5S3 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | ENSRNOP00000080027 ⟸ ENSRNOT00000108726 |
RefSeq Acc Id: | ENSRNOP00000087406 ⟸ ENSRNOT00000105898 |
RefSeq Acc Id: | ENSRNOP00000070031 ⟸ ENSRNOT00000084261 |
RefSeq Acc Id: | XP_063123761 ⟸ XM_063267691 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A0A8I5ZS76 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_063123762 ⟸ XM_063267692 |
- Peptide Label: | isoform X2 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-M0RC99-F1-model_v2 | AlphaFold | M0RC99 | 1-215 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
Database | Acc Id | Source(s) |
AGR Gene | RGD:620936 | AgrOrtholog |
BioCyc Gene | G2FUF-28397 | BioCyc |
Ensembl Genes | ENSRNOG00000057056 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
ENSRNOG00000062595 | UniProtKB/Swiss-Prot | |
Ensembl Transcript | ENSRNOT00000084261.2 | UniProtKB/TrEMBL |
ENSRNOT00000100183.1 | UniProtKB/Swiss-Prot | |
ENSRNOT00000105898 | ENTREZGENE | |
ENSRNOT00000105898.1 | UniProtKB/TrEMBL | |
ENSRNOT00000108726.1 | UniProtKB/TrEMBL | |
Gene3D-CATH | 3.40.50.300 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
IMAGE_CLONE | IMAGE:9025210 | IMAGE-MGC_LOAD |
InterPro | P-loop_NTPase | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Small_GTP-bd_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Small_GTPase | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:100361891 | UniProtKB/Swiss-Prot |
rno:64633 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
MGC_CLONE | MGC:187370 | IMAGE-MGC_LOAD |
NCBI Gene | 64633 | ENTREZGENE |
PANTHER | PTHR47978 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
RAB43, MEMBER RAS ONCOGENE FAMILY | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RAS-RELATED PROTEIN RAB | UniProtKB/TrEMBL | |
RAS-RELATED PROTEIN RAB-31 ISOFORM X1 | UniProtKB/TrEMBL | |
Pfam | Ras | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PhenoGen | Rab5a | PhenoGen |
PRINTS | RASTRNSFRMNG | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PROSITE | RAB | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
RAS | UniProtKB/TrEMBL | |
RHO | UniProtKB/TrEMBL | |
RatGTEx | ENSRNOG00000057056 | RatGTEx |
ENSRNOG00000062595 | RatGTEx | |
SMART | RAB | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
RAN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RAS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RHO | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Superfamily-SCOP | SSF52540 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
UniProt | A0A8I5ZS76 | ENTREZGENE, UniProtKB/TrEMBL |
A0A8I6A5S3 | ENTREZGENE, UniProtKB/TrEMBL | |
M0RC99 | ENTREZGENE | |
Q6IN17_RAT | UniProtKB/TrEMBL | |
RAB5A_RAT | UniProtKB/Swiss-Prot | |
UniProt Secondary | O88565 | UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2004-09-10 | Rab5a | RAB5A, member RAS oncogene family | small GTP-binding protein rab5 | Name updated | 1299863 | APPROVED | |
2002-08-07 | Rab5a | small GTP-binding protein rab5 | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
Note Type | Note | Reference |
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gene_cellular_localization | localized to the synaptosome and to synaptic vesicles | 704358 |