Map3k14 (mitogen-activated protein kinase kinase kinase 14) - Rat Genome Database

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Gene: Map3k14 (mitogen-activated protein kinase kinase kinase 14) Rattus norvegicus
Analyze
Symbol: Map3k14
Name: mitogen-activated protein kinase kinase kinase 14
RGD ID: 1310487
Description: Enables protein kinase activity. Predicted to be involved in cellular response to mechanical stimulus; immune response; and intracellular signaling cassette. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MAP3K14 (mitogen-activated protein kinase kinase kinase 14); PARTICIPATES IN nuclear factor kappa B signaling pathway; apoptotic cell death pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-phenylprop-2-enal; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC360640
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81088,665,417 - 88,715,669 (-)NCBIGRCr8
mRatBN7.21088,165,349 - 88,215,558 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1088,165,351 - 88,215,523 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1093,201,107 - 93,251,268 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01092,668,001 - 92,718,220 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01088,061,351 - 88,111,570 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01091,303,428 - 91,353,601 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1091,303,428 - 91,353,601 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01091,074,396 - 91,121,436 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41092,406,098 - 92,456,276 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11092,421,198 - 92,444,501 (-)NCBI
Celera1086,866,471 - 86,916,375 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (EXP)
4-nitrophenol  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
dimethylarsinic acid  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
Fusarenone X  (ISO)
genistein  (ISO)
gentamycin  (EXP)
ibrutinib  (ISO)
indometacin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
mangiferin  (ISO)
mercury dibromide  (ISO)
metacetamol  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
o-anisidine  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
SM-164  (ISO)
sodium arsenite  (ISO)
sulfates  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
Tylophorine  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
zerumbone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Shared principles in NF-kappaB signaling. Hayden MS and Ghosh S, Cell. 2008 Feb 8;132(3):344-62.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Protective effect of Ginkgolids (A+B) is associated with inhibition of NIK/IKK/IkappaB/NF-kappaB signaling pathway in a rat model of permanent focal cerebral ischemia. Wang X, etal., Brain Res. 2008 Oct 9;1234:8-15. Epub 2008 Aug 5.
Additional References at PubMed
PMID:9520446   PMID:10094049   PMID:11239468   PMID:15001576   PMID:18056702   PMID:18305221   PMID:19593445   PMID:21478870   PMID:22871113  


Genomics

Comparative Map Data
Map3k14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81088,665,417 - 88,715,669 (-)NCBIGRCr8
mRatBN7.21088,165,349 - 88,215,558 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1088,165,351 - 88,215,523 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1093,201,107 - 93,251,268 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01092,668,001 - 92,718,220 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01088,061,351 - 88,111,570 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01091,303,428 - 91,353,601 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1091,303,428 - 91,353,601 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01091,074,396 - 91,121,436 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41092,406,098 - 92,456,276 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11092,421,198 - 92,444,501 (-)NCBI
Celera1086,866,471 - 86,916,375 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
MAP3K14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381745,263,119 - 45,317,020 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1745,263,119 - 45,317,029 (-)EnsemblGRCh38hg38GRCh38
GRCh371743,340,486 - 43,394,386 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361740,696,271 - 40,750,197 (-)NCBINCBI36Build 36hg18NCBI36
Build 341740,696,277 - 40,724,123NCBI
Celera1740,049,855 - 40,103,781 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1739,101,255 - 39,155,179 (-)NCBIHuRef
CHM1_11743,575,752 - 43,629,721 (-)NCBICHM1_1
T2T-CHM13v2.01746,116,902 - 46,170,784 (-)NCBIT2T-CHM13v2.0
Map3k14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911103,110,590 - 103,158,227 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11103,110,588 - 103,158,298 (-)EnsemblGRCm39 Ensembl
GRCm3811103,219,764 - 103,267,401 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11103,219,762 - 103,267,472 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711103,081,078 - 103,128,715 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611103,035,854 - 103,083,491 (-)NCBIMGSCv36mm8
Celera11114,933,508 - 114,981,179 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1166.8NCBI
Map3k14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545117,908,827 - 17,926,151 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545117,907,800 - 17,954,821 (-)NCBIChiLan1.0ChiLan1.0
MAP3K14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21919,521,228 - 19,575,128 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11721,489,935 - 21,543,815 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01712,011,037 - 12,064,978 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11712,183,243 - 12,237,131 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1712,183,243 - 12,237,131 (+)Ensemblpanpan1.1panPan2
MAP3K14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1918,255,416 - 18,302,405 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl918,280,198 - 18,302,401 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha917,640,218 - 17,687,188 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0918,928,453 - 18,975,466 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl918,928,497 - 18,975,502 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1917,806,803 - 17,853,778 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0917,985,479 - 18,032,427 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0918,141,265 - 18,188,242 (+)NCBIUU_Cfam_GSD_1.0
Map3k14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560217,602,812 - 17,645,706 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365411,548,875 - 1,591,833 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365411,548,892 - 1,591,770 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1218,142,952 - 18,182,928 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11218,142,899 - 18,182,931 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21218,391,601 - 18,431,641 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11661,100,298 - 61,153,984 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1661,100,352 - 61,155,052 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607731,837,235 - 31,890,835 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map3k14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624795167,990 - 203,784 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624795167,959 - 207,421 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Map3k14
336 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:534
Count of miRNA genes:254
Interacting mature miRNAs:300
Transcripts:ENSRNOT00000004532
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat

Markers in Region
D10Rat142  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21088,207,600 - 88,207,815 (+)MAPPERmRatBN7.2
Rnor_6.01091,345,679 - 91,345,893NCBIRnor6.0
Rnor_5.01091,113,514 - 91,113,728UniSTSRnor5.0
RGSC_v3.41092,448,353 - 92,448,568RGDRGSC3.4
RGSC_v3.41092,448,354 - 92,448,568UniSTSRGSC3.4
RGSC_v3.11092,462,723 - 92,462,938RGD
Celera1086,908,452 - 86,908,666UniSTS
RH 3.4 Map10899.0UniSTS
RH 3.4 Map10899.0RGD
SHRSP x BN Map1066.5UniSTS
SHRSP x BN Map1066.5RGD
Cytogenetic Map10q32.1UniSTS
RH144612  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21088,165,436 - 88,165,586 (+)MAPPERmRatBN7.2
Rnor_6.01091,303,514 - 91,303,663NCBIRnor6.0
Rnor_5.01091,074,482 - 91,074,631UniSTSRnor5.0
RGSC_v3.41092,406,184 - 92,406,333UniSTSRGSC3.4
Celera1086,866,557 - 86,866,706UniSTS
RH 3.4 Map10897.6UniSTS
Cytogenetic Map10q32.1UniSTS
RH141437  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21088,202,662 - 88,202,861 (+)MAPPERmRatBN7.2
Rnor_6.01091,340,741 - 91,340,939NCBIRnor6.0
Rnor_6.01090,862,005 - 90,862,203NCBIRnor6.0
Rnor_5.01090,637,644 - 90,637,842UniSTSRnor5.0
Rnor_5.01091,108,576 - 91,108,774UniSTSRnor5.0
RGSC_v3.41092,443,418 - 92,443,616UniSTSRGSC3.4
RH 3.4 Map10899.0UniSTS
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 5 14 2 3 1
Low 1 43 52 41 5 41 8 11 72 35 38 10 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000004532   ⟹   ENSRNOP00000004532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1088,165,351 - 88,215,523 (-)Ensembl
Rnor_6.0 Ensembl1091,303,428 - 91,353,601 (-)Ensembl
RefSeq Acc Id: NM_001108301   ⟹   NP_001101771
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,665,417 - 88,715,592 (-)NCBI
mRatBN7.21088,165,351 - 88,215,523 (-)NCBI
Rnor_6.01091,303,428 - 91,353,601 (-)NCBI
Rnor_5.01091,074,396 - 91,121,436 (-)NCBI
RGSC_v3.41092,406,098 - 92,456,276 (-)RGD
Celera1086,866,471 - 86,916,375 (-)RGD
Sequence:
RefSeq Acc Id: XM_039086417   ⟹   XP_038942345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,665,417 - 88,689,209 (-)NCBI
mRatBN7.21088,165,349 - 88,189,139 (-)NCBI
RefSeq Acc Id: XM_039086418   ⟹   XP_038942346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,677,670 - 88,715,669 (-)NCBI
mRatBN7.21088,179,274 - 88,215,558 (-)NCBI
RefSeq Acc Id: XM_039086419   ⟹   XP_038942347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,665,417 - 88,679,639 (-)NCBI
mRatBN7.21088,165,349 - 88,177,557 (-)NCBI
RefSeq Acc Id: NP_001101771   ⟸   NM_001108301
- UniProtKB: D3ZTD1 (UniProtKB/TrEMBL),   A6HJQ8 (UniProtKB/TrEMBL),   A6HJQ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004532   ⟸   ENSRNOT00000004532
RefSeq Acc Id: XP_038942345   ⟸   XM_039086417
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038942347   ⟸   XM_039086419
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038942346   ⟸   XM_039086418
- Peptide Label: isoform X2
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZTD1-F1-model_v2 AlphaFold D3ZTD1 1-942 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697809
Promoter ID:EPDNEW_R8334
Type:single initiation site
Name:Map3k14_1
Description:mitogen-activated protein kinase kinase kinase 14
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01091,353,570 - 91,353,630EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310487 AgrOrtholog
BioCyc Gene G2FUF-23049 BioCyc
Ensembl Genes ENSRNOG00000003278 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004532 ENTREZGENE
  ENSRNOT00000004532.6 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  M3K14_STKc UniProtKB/TrEMBL
  MAPKKK14 UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:360640 UniProtKB/TrEMBL
NCBI Gene 360640 ENTREZGENE
PANTHER MAP KINASE KINASE KINASE SSK2-RELATED-RELATED UniProtKB/TrEMBL
  PTHR48016:SF9 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Map3k14 PhenoGen
PIRSF MAPKKK14 UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003278 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A6HJQ8 ENTREZGENE, UniProtKB/TrEMBL
  A6HJQ9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZTD1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Map3k14  mitogen-activated protein kinase kinase kinase 14   Map3k14_predicted  mitogen-activated protein kinase kinase kinase 14 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Map3k14_predicted  mitogen-activated protein kinase kinase kinase 14 (predicted)      Symbol and Name status set to approved 70820 APPROVED