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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-alpha-tocopherol | multiple interactions | ISO | RGD:1552573 | 6480464 | alpha-Tocopherol inhibits the reaction [Glucose results in decreased expression of PAX3 mRNA] | CTD | PMID:12739027 | (+)-alpha-tocopherol | increases expression | ISO | RGD:1552573 | 6480464 | alpha-Tocopherol results in increased expression of PAX3 mRNA | CTD | PMID:12739027 | (S)-nicotine | decreases expression | EXP | | 6480464 | Nicotine results in decreased expression of PAX3 mRNA | CTD | PMID:20339300 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1351352 | 6480464 | Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PAX3 mRNA] | CTD | PMID:11007951 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1351352 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PAX3 mRNA | CTD | PMID:11007951 | 5-bromo-2'-deoxyuridine | increases response to substance | ISO | RGD:1552573 | 6480464 | PAX3 gene polymorphism results in increased susceptibility to Bromodeoxyuridine | CTD | PMID:3902948 | all-trans-retinoic acid | multiple interactions | ISO | RGD:1351352 | 6480464 | Tretinoin inhibits the reaction [PAX3 protein binds to DPYSL2 promoter] | CTD | PMID:17229153 | all-trans-retinoic acid | decreases expression | ISO | RGD:1351352 | 6480464 | Tretinoin results in decreased expression of PAX3 mRNA | CTD | PMID:17229153 PMID:21934132 | all-trans-retinoic acid | decreases expression | ISO | RGD:1351352 | 6480464 | Tretinoin results in decreased expression of PAX3 mRNA | CTD | PMID:21934132 PMID:17229153 | all-trans-retinoic acid | increases expression | ISO | RGD:1552573 | 6480464 | Tretinoin results in increased expression of PAX3 mRNA | CTD | PMID:17038669 | all-trans-retinoic acid | increases response to substance | ISO | RGD:1552573 | 6480464 | PAX3 gene mutant form results in increased susceptibility to Tretinoin | CTD | PMID:6385329 | all-trans-retinoic acid | increases response to substance | ISO | RGD:1552573 | 6480464 | PAX3 gene polymorphism results in increased susceptibility to Tretinoin | CTD | PMID:3902948 | all-trans-retinoic acid | decreases expression | ISO | RGD:1351352 | 6480464 | Tretinoin results in decreased expression of PAX3 mRNA | CTD | PMID:17229153 | all-trans-retinol | multiple interactions | EXP | | 6480464 | Vitamin A inhibits the reaction [nitrofen results in decreased expression of PAX3 mRNA] | CTD | PMID:16481245 | amiodarone | increases expression | ISO | RGD:1351352 | 6480464 | Amiodarone results in increased expression of PAX3 mRNA | CTD | PMID:19774075 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of PAX3 mRNA | CTD | PMID:16483693 | cadmium sulfate | increases response to substance | ISO | RGD:1552573 | 6480464 | PAX3 gene polymorphism results in increased susceptibility to cadmium sulfate | CTD | PMID:3902948 | choline | multiple interactions | ISO | RGD:1552573 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PAX3 gene | CTD | PMID:20938992 | copper(2+) sulfate | decreases expression | ISO | RGD:1351352 | 6480464 | Copper Sulfate results in decreased expression of PAX3 mRNA | CTD | PMID:19549813 | cycloheximide | multiple interactions | ISO | RGD:1351352 | 6480464 | Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PAX3 mRNA] | CTD | PMID:11007951 | D-glucose | multiple interactions | ISO | RGD:1552573 | 6480464 | alpha-Tocopherol inhibits the reaction [Glucose results in decreased expression of PAX3 mRNA]; more ... | CTD | PMID:12739027 | D-glucose | decreases expression | EXP | | 6480464 | Glucose results in decreased expression of PAX3 mRNA | CTD | PMID:21818840 | D-glucose | decreases expression | ISO | RGD:1552573 | 6480464 | Glucose results in decreased expression of PAX3 mRNA | CTD | PMID:12739027 | folic acid | multiple interactions | ISO | RGD:1552573 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PAX3 gene | CTD | PMID:20938992 | glucose | multiple interactions | ISO | RGD:1552573 | 6480464 | alpha-Tocopherol inhibits the reaction [Glucose results in decreased expression of PAX3 mRNA]; more ... | CTD | PMID:12739027 | glucose | decreases expression | EXP | | 6480464 | Glucose results in decreased expression of PAX3 mRNA | CTD | PMID:21818840 | glucose | decreases expression | ISO | RGD:1552573 | 6480464 | Glucose results in decreased expression of PAX3 mRNA | CTD | PMID:12739027 | L-methionine | multiple interactions | ISO | RGD:1552573 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PAX3 gene | CTD | PMID:20938992 | lithium chloride | increases expression | ISO | RGD:1351352 | 6480464 | Lithium Chloride results in increased expression of PAX3 protein | CTD | PMID:19101580 | methylmercury chloride | affects expression | ISO | RGD:1552573 | 6480464 | methylmercuric chloride affects the expression of PAX3 mRNA | CTD | PMID:21613230 | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | RGD:1552573 | 6480464 | Ethylnitrosourea results in increased mutagenesis of PAX3 gene | CTD | PMID:16724327 | phenytoin | decreases expression | ISO | RGD:1552573 | 6480464 | Phenytoin results in decreased expression of PAX3 mRNA | CTD | PMID:9118846 | valproic acid | increases expression | ISO | RGD:1351352 | 6480464 | Valproic Acid results in increased expression of PAX3 protein | CTD | PMID:19101580 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Transcriptional misregulation in cancer |
| Pathway Interaction Database | Regulation of retinoblastoma protein (PID:200223) |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Transcriptional misregulation in cancer |
| Pathway Interaction Database | Regulation of retinoblastoma protein (PID:200223) |
References - curated| 1. |
Gonzalez-Reyes S, etal., Pediatr Surg Int. 2005 Mar;21(3):203-7. Epub 2004 Dec 23. |
| 2. |
Kuhlbrodt K, etal., J Neurosci 1998 Jan 1;18(1):237-50. |
| 3. |
MGD data from the GO Consortium |
| 4. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 5. |
RGD automated data pipeline |
| 6. |
RGD automated import pipeline for gene-chemical interactions |
| 7. |
RGD Automated Pipelines |
| 8. |
Tassabehji M, etal., Hum Mol Genet. 1995 Nov;4(11):2131-7. |
| 9. |
Wachtel M, etal., Cancer Res. 2004 Aug 15;64(16):5539-45. |
| 10. |
Wollnik B, etal., Am J Med Genet A. 2003 Sep 15;122(1):42-5. |
References - uncurated
RGD Disease Portals| Pax3 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Pax3 (Rattus norvegicus) |
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| PAX3 (Homo sapiens) |
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| Pax3 (Mus musculus) |
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Position Markers| X59358 |
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| RH142754 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_053710 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06061166 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06061167 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06061168 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01060997 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01060998 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01060999 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01061000 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01061001 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01061002 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF390074 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY169320 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_053710 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_446162 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_446162 | (Get FASTA) |
| GenBank Protein | AAK70501 | (Get FASTA) |
| AAO17711 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000013670 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000018652 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000018652 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 114502 | ENTREZGENE |
| Gene3D-CATH | 0.10 | UniProtKB/TrEMBL |
| Homeodomain-rel | UniProtKB/TrEMBL | |
| HomoloGene Group ID | 22494 | ENTREZGENE |
| InterPro | Homeobox_CS | UniProtKB/TrEMBL |
| Homeodomain | UniProtKB/TrEMBL | |
| Homeodomain-like | UniProtKB/TrEMBL | |
| Paired_dom | UniProtKB/TrEMBL | |
| Pax7 | UniProtKB/TrEMBL | |
| WHTH_trsnscrt_rep_DNA-bd_dom | UniProtKB/TrEMBL | |
| KEGG Report | rno:114502 | ENTREZGENE |
| Pfam | Homeobox | UniProtKB/TrEMBL |
| PAX | UniProtKB/TrEMBL | |
| Pax7 | UniProtKB/TrEMBL | |
| PRINTS | PAIREDBOX | UniProtKB/TrEMBL |
| PROSITE | HOMEOBOX_1 | UniProtKB/TrEMBL |
| HOMEOBOX_2 | UniProtKB/TrEMBL | |
| PAIRED_1 | UniProtKB/TrEMBL | |
| PAIRED_2 | UniProtKB/TrEMBL | |
| SMART | HOX | UniProtKB/TrEMBL |
| PAX | UniProtKB/TrEMBL | |
| Superfamily-SCOP | Homeodomain_like | UniProtKB/TrEMBL |
| UniGene | Rn.225252 | ENTREZGENE |
| UniProt | F1LMV3_RAT | UniProtKB/TrEMBL |
| Q91XM5_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-10-30 | Pax3 | paired box 3 | Pax3 | paired box gene 3 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2005-01-20 | Pax3 | paired box gene 3 | Symbol and Name status set to approved | 10779 | APPROVED | ||
| 2002-08-07 | Pax3 | paired box gene 3 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on Pax3 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 620431 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




