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ONTOLOGY REPORT - ANNOTATIONS

Term:mismatch repair
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Accession:GO:0006298 term browser browse the term
Definition:A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
Synonyms:exact_synonym: MMR
 narrow_synonym: long patch mismatch repair system
 related_synonym: MutS/MutL/MutH pathway;   mismatch repair, MutL-like pathway
 alt_id: GO:0006300
 xref: Reactome:R-HSA-5358508 "Mismatch Repair";   Wikipedia:DNA_mismatch_repair


show annotations for term's descendants           Sort by:
mismatch repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENSRNOG00000064838 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002
G Exo1 exonuclease 1 involved_in ISO
IEA
IBA 		UniProtKB:P43246 (PMID:11809771), (PMID:14636568), (PMID:9788596)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:9788596 PMID:11809771 PMID:14636568 GO_REF:0000033 GO_REF:0000107 NCBI chr13:90,341,947...90,366,861
Ensembl chr13:90,342,018...90,366,861 		JBrowse link
G Mlh1 mutL homolog 1 involved_in
acts_upstream_of_or_within 		IEA
ISO
IBA 		GO_REF:0000002
MGI:1857946|MGI:1858054|MGI:1930998 (PMID:10096563), (PMID:10359802), (PMID:10429667), (PMID:10657972), (PMID:10747038), (PMID:10851078), (PMID:11313994), (PMID:16204034), (PMID:16728433), (PMID:8674118), (PMID:9500552), (PMID:9560238)
GO_REF:0000033
UniProtKB:P43246|UniProtKB:P52701 (PMID:23603115) 		InterPro
RGD
GO_Central		 PMID:8674118 PMID:9500552 PMID:9560238 PMID:10096563 PMID:10359802 More... GO_REF:0000002 GO_REF:0000033 NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:120,065,900...120,112,011 		JBrowse link
G Mlh3 mutL homolog 3 involved_in
acts_upstream_of_or_within 		IBA
ISO
IEA 		GO_REF:0000033
MGI:104288|MGI:2384218 (PMID:16204034)
GO_REF:0000002 		GO_Central
RGD
InterPro		 PMID:16204034 GO_REF:0000002 GO_REF:0000033 NCBI chr 6:110,612,535...110,649,408
Ensembl chr 6:110,612,535...110,648,999 		JBrowse link
G Msh2 mutS homolog 2 involved_in
acts_upstream_of_or_within 		IEA
ISO
IBA 		GO_REF:0000104
MGI:109519|MGI:1857940|MGI:1858055|MGI:2151801|MGI:2389314|MGI:2680817 (PMID:10581038), (PMID:10874005), (PMID:10992298), (PMID:11046134), (PMID:11890935), (PMID:12531017), (PMID:14744764), (PMID:16728433), (PMID:17331550), (PMID:23071719), (PMID:7628020), (PMID:8706033), (PMID:9157971), (PMID:9244348), (PMID:9288110), (PMID:9697842)
(PMID:17715146), (PMID:7923193), (PMID:9677427)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033
UniProtKB:P40692|UniProtKB:P52701 (PMID:11555625), (PMID:23603115) 		UniProt
RGD
Ensembl
InterPro
GO_Central		 PMID:7628020 PMID:7923193 PMID:8706033 PMID:9157971 PMID:9244348 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:12,567,368...12,626,503 		JBrowse link
G Msh3 mutS homolog 3 involved_in
acts_upstream_of_or_within 		ISO
IEA 		(PMID:17715146), (PMID:8782829), (PMID:9677427)
GO_REF:0000002
MGI:101816|MGI:1343961|MGI:1858056|MGI:88039 (PMID:10706084), (PMID:11691815), (PMID:16728433) 		RGD
InterPro		 PMID:8782829 PMID:9677427 PMID:10706084 PMID:11691815 PMID:16728433 More... GO_REF:0000002 NCBI chr 2:25,179,400...25,320,857
Ensembl chr 2:25,179,400...25,321,102 		JBrowse link
G Msh4 mutS homolog 4 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:245,445,118...245,504,493
Ensembl chr 2:245,452,240...245,503,358 		JBrowse link
G Msh5 mutS homolog 5 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:3,779,180...3,797,996
Ensembl chr20:3,781,578...3,797,994 		JBrowse link
G Msh6 mutS homolog 6 acts_upstream_of_or_within
involved_in 		ISO
IBA
IEA
IMP 		UniProtKB:P40692|UniProtKB:P43246 (PMID:23603115)
GO_REF:0000033
MGI:109519|MGI:1858014|MGI:2151803|MGI:3653701|MGI:88039 (PMID:11691815), (PMID:12370835), (PMID:15324697), (PMID:16728433), (PMID:23071719), (PMID:9390556)
(PMID:10871409), (PMID:17715146), (PMID:23622243), (PMID:8782829)
GO_REF:0000107
GO_REF:0000002 		RGD
GO_Central
Ensembl
InterPro		 PMID:8782829 PMID:9390556 PMID:10871409 PMID:11691815 PMID:12370835 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:2292505 NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:12,316,198...12,333,844 		JBrowse link
G Mutyh mutY DNA glycosylase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:135,510,666...135,522,777
Ensembl chr 5:135,517,695...135,522,776 		JBrowse link
G Pcna proliferating cell nuclear antigen involved_in ISO
IEA
IBA 		(PMID:11005803)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:11005803 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Pms1 PMS1 homolog 1, mismatch repair system component involved_in
acts_upstream_of_or_within 		IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000002
MGI:1857948 (PMID:9500552) 		GO_Central
InterPro
RGD		 PMID:9500552 GO_REF:0000002 GO_REF:0000033 NCBI chr 9:55,721,393...55,832,225
Ensembl chr 9:55,745,374...55,832,221 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in
acts_upstream_of_or_within 		ISO
IEA
IBA 		(PMID:10871409), (PMID:23709753), (PMID:9618520)
MGI:1353455|MGI:1857946|MGI:1857947 (PMID:10359802), (PMID:10429667), (PMID:11313994), (PMID:16204034), (PMID:16728433), (PMID:23071719), (PMID:9500552)
GO_REF:0000117
GO_REF:0000002
GO_REF:0000107
GO_REF:0000033 		RGD
UniProt
InterPro
Ensembl
GO_Central		 PMID:9500552 PMID:9618520 PMID:10359802 PMID:10429667 PMID:10871409 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr12:15,790,478...15,814,790
Ensembl chr12:15,790,478...15,815,248 		JBrowse link
G Rnaseh2a ribonuclease H2, subunit A acts_upstream_of_or_within
involved_in 		ISO
IEA
IBA 		(PMID:23603115)
GO_REF:0000117
GO_REF:0000033 		RGD
UniProt
GO_Central		 PMID:23603115 GO_REF:0000033 GO_REF:0000117 NCBI chr19:40,091,206...40,100,904
Ensembl chr19:40,091,210...40,100,899 		JBrowse link
G Rpa1 replication protein A1 involved_in ISO
IEA 		(PMID:9430682)
GO_REF:0000107 		RGD
Ensembl		 PMID:9430682 GO_REF:0000107 NCBI chr10:60,647,185...60,698,279
Ensembl chr10:60,647,185...60,698,279 		JBrowse link
G Rpa2 replication protein A2 involved_in ISS
ISO 		GO_REF:0000024
(PMID:9430682) 		UniProt
RGD		 PMID:9430682 GO_REF:0000024 NCBI chr 5:150,260,668...150,271,329
Ensembl chr 5:150,260,723...150,271,546 		JBrowse link
G Rpa3 replication protein A3 involved_in ISO
IBA 		(PMID:9430682)
GO_REF:0000033 		RGD
GO_Central		 PMID:9430682 GO_REF:0000033 NCBI chr 4:37,270,966...37,273,997
Ensembl chr 4:37,270,966...37,274,183 		JBrowse link
G Rpa3l1 replication protein A3 like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:51,568,413...51,568,839
Ensembl chr12:51,568,459...51,568,824 		JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase involved_in ISO
IEA 		(PMID:23622243)
GO_REF:0000107 		RGD
Ensembl		 PMID:23622243 GO_REF:0000107 NCBI chr 8:119,390,207...119,475,863
Ensembl chr 8:119,390,207...119,475,863 		JBrowse link
G Wrn WRN RecQ like helicase involved_in ISO (PMID:17715146) RGD PMID:17715146 NCBI chr16:65,466,552...65,602,951
Ensembl chr16:65,456,254...65,602,951 		JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:125,550,833...125,578,084
Ensembl chr 4:125,550,833...125,578,305 		JBrowse link
meiotic mismatch repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:16873062) 		Ensembl
RGD		 PMID:16873062 GO_REF:0000107 NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:120,065,900...120,112,011 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in IEA
ISO 		GO_REF:0000107
(PMID:16873062) 		Ensembl
RGD		 PMID:16873062 GO_REF:0000107 NCBI chr12:15,790,478...15,814,790
Ensembl chr12:15,790,478...15,815,248 		JBrowse link
mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mcm9 minichromosome maintenance 9 homologous recombination repair factor involved_in ISO
IEA 		(PMID:26300262)
GO_REF:0000107
GO_REF:0000117 		RGD
Ensembl
UniProt		 PMID:26300262 GO_REF:0000107 GO_REF:0000117 NCBI chr20:33,369,325...33,472,243
Ensembl chr20:33,387,611...33,472,243 		JBrowse link
positive regulation of mismatch repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac10 histone deacetylase 10 involved_in ISS
ISO 		GO_REF:0000024
(PMID:26221039) 		UniProt
RGD		 PMID:26221039 GO_REF:0000024 NCBI chr 7:122,078,768...122,084,457
Ensembl chr 7:122,078,768...122,083,870 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:15014079) RGD PMID:15014079 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327 		JBrowse link
G Prkcg protein kinase C, gamma involved_in ISO
IEA 		(PMID:15808853)
GO_REF:0000107 		RGD
Ensembl		 PMID:15808853 GO_REF:0000107 NCBI chr 1:74,748,272...74,777,611
Ensembl chr 1:74,748,272...74,774,814 		JBrowse link
regulation of mismatch repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axin2 axin 2 involved_in ISO
IEA 		(PMID:11017067)
GO_REF:0000107 		RGD
Ensembl		 PMID:11017067 GO_REF:0000107 NCBI chr10:94,393,379...94,426,579
Ensembl chr10:94,395,909...94,426,575 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19688
    response to stimulus 10793
      response to stress 4397
        cellular response to stress 2074
          DNA damage response 891
            DNA repair 572
              mismatch repair 26
                meiotic mismatch repair + 2
                mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication + 1
                negative regulation of mismatch repair 0
                positive regulation of mismatch repair 3
                regulation of mismatch repair + 4
Path 2
Term Annotations click to browse term
  biological_process 19688
    cellular process 18845
      metabolic process 11694
        primary metabolic process 10271
          nucleobase-containing compound metabolic process 5604
            nucleic acid metabolic process 5029
              DNA metabolic process 989
                DNA repair 572
                  mismatch repair 26
                    meiotic mismatch repair + 2
                    mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication + 1
                    negative regulation of mismatch repair 0
                    positive regulation of mismatch repair 3
                    regulation of mismatch repair + 4
paths to the root