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Gene: Mlh3 (mutL homolog 3) Rattus norvegicus
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Symbol: Mlh3
Name: mutL homolog 3
Description: Predicted to have ATPase activity; centromeric DNA binding activity; and chromatin binding activity. Predicted to be involved in meiotic nuclear division; mismatch repair; and protein localization. Predicted to localize to the mismatch repair complex and nucleus. Human ortholog(s) of this gene implicated in Lynch syndrome; endometrial cancer; and hereditary nonpolyposis colorectal cancer type 7. Orthologous to human MLH3 (mutL homolog 3); PARTICIPATES IN mismatch repair pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: DNA mismatch repair protein Mlh3; LOC314320; mutL homolog 3 (E. coli)
Orthologs:
Homo sapiens (human) : MLH3 (mutL homolog 3)  HGNC  Alliance
Mus musculus (house mouse) : Mlh3 (mutL homolog 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mlh3 (mutL homolog 3)
Pan paniscus (bonobo/pygmy chimpanzee) : MLH3 (mutL homolog 3)
Canis lupus familiaris (dog) : MLH3 (mutL homolog 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mlh3 (mutL homolog 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.06109,059,386 - 109,095,876 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6109,059,341 - 109,095,557 (-)Ensembl
Rnor_5.06116,461,410 - 116,497,654 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,280,910 - 109,318,893 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16109,285,219 - 109,322,303 (-)NCBI
Celera6102,704,430 - 102,740,558 (-)NCBICelera
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Mlh3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1309227
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.