Gene: Wrn (Werner syndrome RecQ like helicase) Rattus norvegicus
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Symbol: Wrn
Name: Werner syndrome RecQ like helicase
Description: ENCODES a protein that exhibits chromatin binding; 3'-5' DNA helicase activity (ortholog); 3'-5' exonuclease activity (ortholog); INVOLVED IN brain development; base-excision repair (ortholog); cell aging (ortholog); ASSOCIATED WITH breast cancer (ortholog); Breast Cancer, Familial (ortholog); coronary artery disease (ortholog); FOUND IN neuron projection; centrosome (ortholog); chromosome, telomeric region (ortholog); INTERACTS WITH cisplatin; endosulfan; ketamine
AGR Description: Exhibits chromatin binding activity; involved in brain development; localizes to the neuron projection; predicted to colocalize with the DNA replication factor A complex; orthologous to human WRN (Werner syndrome RecQ like helicase).
Merged Description: Exhibits chromatin binding activity; involved in brain development; localizes to the neuron projection; predicted to colocalize with the DNA replication factor A complex; orthologous to human WRN (Werner syndrome RecQ like helicase); INTERACTS WITH cisplatin; endosulfan; ketamine.
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC290805; RGD1564788; similar to Werner syndrome helicase homolog; Werner syndrome ATP-dependent helicase; Werner syndrome, RecQ helicase-like
Orthologs:
Homo sapiens (human) : WRN (WRN RecQ like helicase)  HGNC  Alliance
Mus musculus (house mouse) : Wrn (Werner syndrome RecQ like helicase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Wrn (Werner syndrome RecQ like helicase)
Pan paniscus (bonobo/pygmy chimpanzee) : WRN (Werner syndrome RecQ like helicase)
Canis lupus familiaris (dog) : WRN (Werner syndrome RecQ like helicase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Wrn (Werner syndrome RecQ like helicase)
Sus scrofa (pig) : WRN (Werner syndrome RecQ like helicase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01662,483,773 - 62,619,018 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01662,148,560 - 62,283,748 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41662,535,144 - 62,668,700 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1656,796,927 - 56,929,877 (+)NCBICelera
Cytogenetic Map16q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Wrn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1564788
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.