Wrn (WRN RecQ like helicase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Wrn (WRN RecQ like helicase) Rattus norvegicus
Analyze
Symbol: Wrn
Name: WRN RecQ like helicase
RGD ID: 1564788
Description: Enables chromatin binding activity. Predicted to be involved in several processes, including DNA metabolic process; G-quadruplex DNA unwinding; and cellular response to gamma radiation. Predicted to act upstream of or within several processes, including determination of adult lifespan; protein localization to nucleolus; and replicative senescence. Predicted to be located in centrosome; chromosome; and nuclear lumen. Predicted to be active in chromosome; cytoplasm; and nucleoplasm. Human ortholog(s) of this gene implicated in Werner syndrome; breast cancer; coronary artery disease (multiple); diffuse scleroderma; and senile cataract. Orthologous to human WRN (WRN RecQ like helicase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cisplatin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN; LOC290805; RGD1564788; similar to Werner syndrome helicase homolog; Werner syndrome ATP-dependent helicase; Werner syndrome RecQ like helicase; Werner syndrome, RecQ helicase-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81665,466,552 - 65,602,951 (+)NCBIGRCr8
mRatBN7.21658,763,517 - 58,898,604 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1658,763,504 - 58,895,450 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01662,483,773 - 62,619,018 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1662,483,761 - 62,615,375 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01662,148,560 - 62,283,748 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41662,535,144 - 62,668,700 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1656,796,927 - 56,929,877 (+)NCBICelera
Cytogenetic Map16q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Polymorphisms at the Werner locus: II. 1074Leu/Phe, 1367Cys/Arg, longevity, and atherosclerosis. Castro E, etal., Am J Med Genet. 2000 Dec 11;95(4):374-80.
2. Genetic variation in the premature aging gene WRN: a case-control study on breast cancer susceptibility. Ding SL, etal., Cancer Epidemiol Biomarkers Prev. 2007 Feb;16(2):263-9.
3. Lack of association of the WRN C1367T polymorphism with senile cataract in the Israeli population. Ehrenberg M, etal., Mol Vis. 2010 Aug 28;16:1771-5.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Analysis of Werner's expression within the brain and primary neuronal culture. Gee J, etal., Brain Res. 2002 Jun 14;940(1-2):44-8.
6. Significant elevation of IgG anti-WRN (RecQ3 RNA/DNA helicase) antibody in systemic sclerosis. Goto M, etal., Mod Rheumatol. 2006;16(4):229-34.
7. The spectrum of WRN mutations in Werner syndrome patients. Huang S, etal., Hum Mutat. 2006 Jun;27(6):558-67.
8. Polymorphisms of the WRN gene and DNA damage of peripheral lymphocytes in age-related cataract in a Han Chinese population. Jiang S, etal., Age (Dordr). 2013 Dec;35(6):2435-44. doi: 10.1007/s11357-013-9512-4. Epub 2013 Jan 20.
9. Werner's syndrome helicase participates in transcription of phenobarbital-inducible CYP2B genes in rat and mouse liver. Lachaud AA, etal., Biochem Pharmacol. 2010 Feb 1;79(3):463-70. doi: 10.1016/j.bcp.2009.09.002. Epub 2009 Sep 6.
10. Hyperinsulinemia and insulin resistance in Wrn null mice fed a diabetogenic diet. Moore G, etal., Mech Ageing Dev. 2008 Apr;129(4):201-6. doi: 10.1016/j.mad.2007.12.009. Epub 2008 Jan 17.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Werner's syndrome and restrictive cardiomyopathy. Theodoropoulos TA, etal., Int J Cardiol. 2006 Apr 4;108(2):284-5.
16. A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women. Wang Z, etal., Breast Cancer Res Treat. 2009 Nov;118(1):169-75. doi: 10.1007/s10549-009-0327-z. Epub 2009 Feb 10.
17. Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population. Ye L, etal., Am J Med Genet. 1997 Feb 11;68(4):494-8.
Additional References at PubMed
PMID:9288107   PMID:9618508   PMID:9681877   PMID:9789047   PMID:10373438   PMID:10757812   PMID:10783163   PMID:10871373   PMID:10871376   PMID:11420665   PMID:11433031   PMID:11735402  
PMID:11756244   PMID:12181313   PMID:12707040   PMID:12882351   PMID:12944467   PMID:15200954   PMID:15235603   PMID:15246744   PMID:15367665   PMID:16622405   PMID:17115688   PMID:17498979  
PMID:17563354   PMID:17611195   PMID:17715146   PMID:18203716   PMID:18212065   PMID:19554081   PMID:19734539   PMID:21639834   PMID:22039056   PMID:25801465   PMID:26195664   PMID:26420422  


Genomics

Comparative Map Data
Wrn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81665,466,552 - 65,602,951 (+)NCBIGRCr8
mRatBN7.21658,763,517 - 58,898,604 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1658,763,504 - 58,895,450 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01662,483,773 - 62,619,018 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1662,483,761 - 62,615,375 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01662,148,560 - 62,283,748 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41662,535,144 - 62,668,700 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1656,796,927 - 56,929,877 (+)NCBICelera
Cytogenetic Map16q12.3NCBI
WRN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38831,033,810 - 31,176,138 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl831,033,788 - 31,176,138 (+)EnsemblGRCh38hg38GRCh38
GRCh37830,891,326 - 31,033,654 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36831,010,320 - 31,150,818 (+)NCBINCBI36Build 36hg18NCBI36
Build 34831,010,319 - 31,150,818NCBI
Celera829,850,819 - 29,989,925 (+)NCBICelera
Cytogenetic Map8p12NCBI
HuRef829,435,610 - 29,576,278 (+)NCBIHuRef
CHM1_1831,092,222 - 31,232,737 (+)NCBICHM1_1
T2T-CHM13v2.0831,314,935 - 31,457,266 (+)NCBIT2T-CHM13v2.0
Wrn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39833,724,400 - 33,875,591 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl833,724,412 - 33,875,555 (-)EnsemblGRCm39 Ensembl
GRCm38833,234,372 - 33,385,543 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl833,234,384 - 33,385,527 (-)EnsemblGRCm38mm10GRCm38
MGSCv37834,344,845 - 34,495,999 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36834,700,308 - 34,851,437 (-)NCBIMGSCv36mm8
Celera835,829,900 - 36,023,160 (-)NCBICelera
Cytogenetic Map8A3NCBI
cM Map820.3NCBI
Wrn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554637,525,100 - 7,633,596 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554637,495,243 - 7,633,532 (+)NCBIChiLan1.0ChiLan1.0
WRN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2749,612,933 - 49,764,582 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1825,329,155 - 25,486,021 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0830,353,643 - 30,492,978 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1827,541,145 - 27,679,855 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl827,541,145 - 27,679,855 (+)Ensemblpanpan1.1panPan2
WRN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11633,164,662 - 33,304,466 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1633,167,364 - 33,304,625 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1633,688,179 - 33,763,508 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01635,190,440 - 35,330,557 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1635,190,442 - 35,331,243 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11633,288,917 - 33,429,126 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01633,863,786 - 34,003,844 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01633,981,929 - 34,122,272 (-)NCBIUU_Cfam_GSD_1.0
Wrn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494356,358,222 - 56,501,123 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936792862,383 - 1,005,755 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936792862,659 - 1,005,065 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WRN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1553,966,986 - 54,094,587 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11553,966,968 - 54,094,855 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21561,329,196 - 61,464,598 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WRN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1829,150,256 - 29,288,830 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl829,174,229 - 29,289,129 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605212,803,116 - 12,942,546 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wrn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478012,876,093 - 13,025,739 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478012,875,747 - 13,051,492 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wrn
848 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:60
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000058805, ENSRNOT00000075088
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat

Markers in Region
D16Nkg86  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21658,810,414 - 58,810,766 (+)MAPPERmRatBN7.2
Rnor_6.01662,530,672 - 62,531,024NCBIRnor6.0
Rnor_5.01662,195,484 - 62,195,836UniSTSRnor5.0
RGSC_v3.41662,582,669 - 62,583,020UniSTSRGSC3.4
Celera1656,843,859 - 56,844,210UniSTS
Cytogenetic Map16q12.3UniSTS
RH135009  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21658,780,670 - 58,780,874 (+)MAPPERmRatBN7.2
Rnor_6.01662,500,931 - 62,501,134NCBIRnor6.0
Rnor_5.01662,165,743 - 62,165,946UniSTSRnor5.0
RGSC_v3.41662,552,926 - 62,553,129UniSTSRGSC3.4
Celera1656,814,117 - 56,814,320UniSTS
RH 3.4 Map16561.31UniSTS
Cytogenetic Map16q12.3UniSTS
AU047467  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21658,838,265 - 58,838,449 (+)MAPPERmRatBN7.2
Rnor_6.01662,558,438 - 62,558,621NCBIRnor6.0
Rnor_5.01662,223,250 - 62,223,433UniSTSRnor5.0
RGSC_v3.41662,611,518 - 62,611,701UniSTSRGSC3.4
Celera1656,871,752 - 56,871,935UniSTS
Cytogenetic Map16q12.3UniSTS
UniSTS:488917  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21658,761,620 - 58,762,687 (+)MAPPERmRatBN7.2
Rnor_6.01662,481,884 - 62,482,950NCBIRnor6.0
Rnor_5.01662,146,696 - 62,147,762UniSTSRnor5.0
RGSC_v3.41662,533,879 - 62,534,945UniSTSRGSC3.4
Celera1656,795,038 - 56,796,104UniSTS
Cytogenetic Map16q12.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10 39 23 18 23 1 1 18 28 35 11 1
Low 3 33 18 18 1 18 7 9 56 7 6 7
Below cutoff 1

Sequence


RefSeq Acc Id: ENSRNOT00000058805   ⟹   ENSRNOP00000055596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1658,763,513 - 58,895,450 (+)Ensembl
Rnor_6.0 Ensembl1662,483,761 - 62,615,375 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108559   ⟹   ENSRNOP00000092712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1658,763,504 - 58,895,450 (+)Ensembl
RefSeq Acc Id: NM_001427071   ⟹   NP_001414000
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81665,466,552 - 65,602,951 (+)NCBI
RefSeq Acc Id: XM_039095090   ⟹   XP_038951018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81665,534,846 - 65,601,639 (+)NCBI
mRatBN7.21658,827,433 - 58,898,604 (+)NCBI
RefSeq Acc Id: XM_063275239   ⟹   XP_063131309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81665,485,142 - 65,601,639 (+)NCBI
RefSeq Acc Id: XM_063275240   ⟹   XP_063131310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81665,505,805 - 65,601,639 (+)NCBI
RefSeq Acc Id: XM_063275241   ⟹   XP_063131311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81665,485,142 - 65,537,908 (+)NCBI
RefSeq Acc Id: XR_005494933
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81665,485,142 - 65,581,799 (+)NCBI
mRatBN7.21658,789,185 - 58,878,763 (+)NCBI
RefSeq Acc Id: XR_005494935
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81665,485,142 - 65,570,267 (+)NCBI
mRatBN7.21658,789,185 - 58,867,230 (+)NCBI
RefSeq Acc Id: ENSRNOP00000055596   ⟸   ENSRNOT00000058805
RefSeq Acc Id: XP_038951018   ⟸   XM_039095090
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000092712   ⟸   ENSRNOT00000108559
RefSeq Acc Id: NP_001414000   ⟸   NM_001427071
- UniProtKB: A6IVT6 (UniProtKB/TrEMBL),   F1LTH9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131309   ⟸   XM_063275239
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063131311   ⟸   XM_063275241
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063131310   ⟸   XM_063275240
- Peptide Label: isoform X2
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LTH9-F1-model_v2 AlphaFold F1LTH9 1-1400 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700149
Promoter ID:EPDNEW_R10667
Type:multiple initiation site
Name:Wrn_1
Description:Werner syndrome RecQ like helicase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01662,483,771 - 62,483,831EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564788 AgrOrtholog
BioCyc Gene G2FUF-11109 BioCyc
Ensembl Genes ENSRNOG00000015440 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058805.6 UniProtKB/TrEMBL
  ENSRNOT00000108559.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  1.10.150.80 UniProtKB/TrEMBL
  3.30.420.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro 3'-5'_exonuclease_dom UniProtKB/TrEMBL
  DNA/RNA_helicase_DEAD/DEAH_N UniProtKB/TrEMBL
  DNA_helicase_ATP-dep_RecQ UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  Helicase_HTH UniProtKB/TrEMBL
  HRDC-like UniProtKB/TrEMBL
  HRDC_dom UniProtKB/TrEMBL
  HRDC_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  RecQ_Zn-bd UniProtKB/TrEMBL
  RNaseH-like_dom UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/TrEMBL
  RQC_domain UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:290805 UniProtKB/TrEMBL
NCBI Gene 290805 ENTREZGENE
PANTHER DNA HELICASE RECQ FAMILY MEMBER UniProtKB/TrEMBL
  WERNER SYNDROME ATP-DEPENDENT HELICASE UniProtKB/TrEMBL
Pfam DEAD UniProtKB/TrEMBL
  DNA_pol_A_exo1 UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  HRDC UniProtKB/TrEMBL
  HTH_40 UniProtKB/TrEMBL
  RecQ_Zn_bind UniProtKB/TrEMBL
  RQC UniProtKB/TrEMBL
PhenoGen Wrn PhenoGen
PROSITE HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
  HRDC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015440 RatGTEx
SMART 35EXOc UniProtKB/TrEMBL
  DEXDc UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
  HRDC UniProtKB/TrEMBL
  RQC UniProtKB/TrEMBL
Superfamily-SCOP HRDC_like UniProtKB/TrEMBL
  RNaseH_fold UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6AI75_RAT UniProtKB/TrEMBL
  A6IVT6 ENTREZGENE, UniProtKB/TrEMBL
  F1LTH9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-05 Wrn  WRN RecQ like helicase  Wrn  Werner syndrome RecQ like helicase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Wrn  Werner syndrome RecQ like helicase  Wrn  Werner syndrome, RecQ helicase-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-12 Wrn  Werner syndrome, RecQ helicase-like  RGD1564788  similar to Werner syndrome helicase homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1564788  similar to Werner syndrome helicase homolog   RGD1564788_predicted  similar to Werner syndrome helicase homolog (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564788_predicted  similar to Werner syndrome helicase homolog (predicted)  LOC290805  similar to Werner syndrome helicase homolog  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC290805  similar to Werner syndrome helicase homolog      Symbol and Name status set to provisional 70820 PROVISIONAL