Hspa4 (heat shock protein family A (Hsp70) member 4) - Rat Genome Database

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Gene: Hspa4 (heat shock protein family A (Hsp70) member 4) Rattus norvegicus
Analyze
Symbol: Hspa4
Name: heat shock protein family A (Hsp70) member 4
RGD ID: 628878
Description: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including neuron apoptotic process; positive regulation of angiogenesis; and regulation of microglial cell activation. Located in lipid droplet. Used to study adult respiratory distress syndrome and middle cerebral artery infarction. Biomarker of Parkinson's disease and liver benign neoplasm. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to human HSPA4 (heat shock protein family A (Hsp70) member 4); PARTICIPATES IN cortisol signaling pathway; estrogen signaling pathway; antigen processing and presentation pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: heat shock 70 kDa protein 4; heat shock protein 4; heat shock protein family A member 4; Hsp110; Hsp70; irp94; ischemia responsive 94 kDa protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81037,908,866 - 37,951,994 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1037,908,866 - 37,949,835 (-)EnsemblGRCr8
mRatBN7.21037,408,025 - 37,449,080 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,408,025 - 37,449,001 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1042,101,220 - 42,141,891 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,591,248 - 41,631,920 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,094,962 - 37,135,636 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01038,601,624 - 38,642,397 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,601,624 - 38,642,397 (-)Ensemblrn6Rnor6.0
Rnor_5.01038,383,101 - 38,424,016 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41038,705,629 - 38,749,058 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1036,756,477 - 36,796,741 (-)NCBICelera
RGSC_v3.11038,712,058 - 38,755,488 (-)NCBI
Cytogenetic Map10q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
3,3'-Dichlorobenzidine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
albendazole  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
casticin  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
clofibrate  (ISO)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
DDT  (EXP)
deguelin  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
gamma-hexachlorocyclohexane  (EXP)
geldanamycin  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
isobutyl nitrite  (ISO)
ivermectin  (ISO)
linalool  (ISO)
lycopene  (EXP)
manganese(II) sulfate  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
Mitotane  (EXP)
motexafin gadolinium  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosomorpholine  (EXP)
nitrates  (ISO)
nonanoic acid  (ISO)
Nonidet P-40  (ISO)
ochratoxin A  (ISO)
oxidopamine  (EXP)
paracetamol  (ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP)
propiconazole  (EXP)
Propiverine  (EXP)
prostaglandin A1  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
Soman  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tanespimycin  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IEA,ISO)
extracellular exosome  (IEA,ISO)
lipid droplet  (IDA)
nucleus  (IBA)
organelle  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Black currant phytoconstituents exert chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis by suppression of the inflammatory response. Bishayee A, etal., Mol Carcinog. 2011 Dec 27. doi: 10.1002/mc.21860.
2. Convergent sets of data from in vivo and in vitro methods point to an active role of Hsp60 in chronic obstructive pulmonary disease pathogenesis. Cappello F, etal., PLoS One. 2011;6(11):e28200. Epub 2011 Nov 28.
3. Administration of carnosine in the treatment of acute spinal cord injury. Di Paola R, etal., Biochem Pharmacol. 2011 Nov 15;82(10):1478-89. Epub 2011 Jul 20.
4. Short-term follow-up of chagasic patients after benznidazole treatment using multiple serological markers. Fernandez-Villegas A, etal., BMC Infect Dis. 2011 Jul 31;11:206.
5. BAG3 protein is overexpressed in human glioblastoma and is a potential target for therapy. Festa M, etal., Am J Pathol. 2011 Jun;178(6):2504-12. Epub 2011 May 10.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Elevated HSP27, HSP70 and HSP90 alpha in chronic obstructive pulmonary disease: markers for immune activation and tissue destruction. Hacker S, etal., Clin Lab. 2009;55(1-2):31-40.
9. Hsp70 regulates the interaction between the peroxisome targeting signal type 1 (PTS1)-receptor Pex5p and PTS1. Harano T, etal., Biochem J. 2001 Jul 1;357(Pt 1):157-65.
10. Riluzole prevents morphine-induced apoptosis in rat cerebral cortex. Hassanzadeh K, etal., Pharmacol Rep. 2011;63(3):697-707.
11. Mildronate as a regulator of protein expression in a rat model of Parkinson's disease. Isajevs S, etal., Medicina (Kaunas). 2011;47(10):552-9.
12. Heat shock protein 70 is translocated to lipid droplets in rat adipocytes upon heat stimulation. Jiang H, etal., Biochim Biophys Acta. 2007 Jan;1771(1):66-74. Epub 2006 Nov 15.
13. Developmental immunolocalization of heat shock protein 70 (HSP70) in epithelial cell of rat kidney. Kang SS, etal., Histol Histopathol. 2011 Nov;26(11):1363-73.
14. HSP70 protein promotes survival of C6 and U87 glioma cells by inhibition of ATF5 degradation. Li G, etal., J Biol Chem. 2011 Jun 10;286(23):20251-9. Epub 2011 Apr 25.
15. Therapeutic efficacy of trehalose eye drops for treatment of murine dry eye induced by an intelligently controlled environmental system. Li J, etal., Mol Vis. 2012;18:317-29. Epub 2012 Feb 4.
16. TLR2 ligand induces protection against cerebral ischemia/reperfusion injury via activation of phosphoinositide 3-kinase/Akt signaling. Lu C, etal., J Immunol. 2011 Aug 1;187(3):1458-66. Epub 2011 Jun 27.
17. Initiation but no execution - modulation of peripheral blood lymphocyte apoptosis in rheumatoid arthritis - a potential role for heat shock protein 70. Moodley D, etal., J Inflamm (Lond). 2011 Nov 3;8(1):30.
18. The dual behavior of heat shock protein 70 and asymmetric dimethylarginine in relation to serum CRP levels in type 2 diabetes. Nakhjavani M, etal., Gene. 2012 Feb 13.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. Chaperoning of glucocorticoid receptors. Pratt WB, etal., Handb Exp Pharmacol. 2006;(172):111-38.
21. Increase in periosteal angiogenesis through heat shock conditioning. Rana M, etal., Head Face Med. 2011 Nov 18;7:22.
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy and its regulation by lipoic acid. Santos JM and Kowluru RA, Invest Ophthalmol Vis Sci. 2011 Nov 11;52(12):8791-8. Print 2011.
26. Anti-inflammatory effects of -shogaol: potential roles of HDAC inhibition and HSP70 induction. Shim S, etal., Food Chem Toxicol. 2011 Nov;49(11):2734-40. Epub 2011 Aug 16.
27. Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions. Smith DF and Toft DO, Mol Endocrinol. 2008 Oct;22(10):2229-40. Epub 2008 May 1.
28. Hyperthermia assists survival of astrocytes from oxidative-mediated necrotic cell death. Thomas G, etal., Cell Mol Biol (Noisy-le-grand) 2002 Mar;48(2):191-8.
29. Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy. Tomasello G, etal., Eur J Histochem. 2011 Oct 24;55(4):e38. doi: 10.4081/ejh.2011.e38.
30. Hypobaric Hypoxia Preconditioning Attenuates Experimental Heatstroke Syndromes via Preinduction of Heat Shock Protein 70. Wang LC, etal., Am J Med Sci. 2012 Jan 12.
31. Adenoviral transfer of HSP-70 into pulmonary epithelium ameliorates experimental acute respiratory distress syndrome. Weiss YG, etal., J Clin Invest. 2002 Sep;110(6):801-6.
32. [Effect of benzo pyrene on HSP70 expression in rat cortical neurons in vitro]. Xu G and Zheng J, Wei Sheng Yan Jiu. 2011 Jul;40(4):437-40.
33. Molecular cloning of a novel member of the HSP110 family of genes, ischemia-responsive protein 94 kDa (irp94), expressed in rat brain after transient forebrain ischemia. Yagita Y, etal., J Neurochem 1999 Apr;72(4):1544-51.
34. Altered expression of heat shock protein 110 family members in mouse hippocampal neurons following trimethyltin treatment in vivo and in vitro. Yoneyama M, etal., Neuropharmacology. 2008 Oct;55(5):693-703. Epub 2008 Jun 13.
35. Valproic acid-mediated neuroprotection in retinal ischemia injury via histone deacetylase inhibition and transcriptional activation. Zhang Z, etal., Exp Eye Res. 2012 Jan;94(1):98-108. Epub 2011 Nov 28.
36. Immunolocalization of Toll-like receptors 2 and 4 as well as their endogenous ligand, heat shock protein 70, in rat traumatic brain injury. Zhang Z, etal., Neuroimmunomodulation. 2012;19(1):10-9. Epub 2011 Nov 7.
37. Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke. Zheng Z, etal., J Cereb Blood Flow Metab. 2008 Jan;28(1):53-63. Epub 2007 May 2.
Additional References at PubMed
PMID:9488468   PMID:12145311   PMID:12857439   PMID:12870667   PMID:14688209   PMID:15033773   PMID:15540463   PMID:15644312   PMID:15744251   PMID:15877948   PMID:16116448   PMID:16254606  
PMID:16291818   PMID:16297314   PMID:16297316   PMID:16472926   PMID:16710168   PMID:16731649   PMID:16781812   PMID:16854843   PMID:17103089   PMID:17278880   PMID:17441510   PMID:17552876  
PMID:17640624   PMID:17763949   PMID:18087244   PMID:18159002   PMID:18178852   PMID:18182047   PMID:18280260   PMID:18316783   PMID:18388575   PMID:18446816   PMID:18528785   PMID:18534054  
PMID:18601975   PMID:18644837   PMID:18668351   PMID:18759001   PMID:18856196   PMID:19095035   PMID:19182904   PMID:19208651   PMID:19244585   PMID:19268660   PMID:19333137   PMID:19352207  
PMID:19401463   PMID:19543852   PMID:19570893   PMID:19785543   PMID:19788071   PMID:19897899   PMID:20083167   PMID:20137302   PMID:20426530   PMID:20458337   PMID:20465949   PMID:20559625  
PMID:20971094   PMID:21097414   PMID:21109264   PMID:21231916   PMID:21276792   PMID:21356360   PMID:21391123   PMID:21439793   PMID:21499258   PMID:21515294   PMID:21913551   PMID:21941782  
PMID:21953294   PMID:22022600   PMID:22039956   PMID:22082260   PMID:22132083   PMID:22156356   PMID:22350213   PMID:22438294   PMID:22505291   PMID:22513040   PMID:22526757   PMID:22683596  
PMID:22871113   PMID:23064900   PMID:23315814   PMID:23356498   PMID:23479759   PMID:23612524   PMID:23965991   PMID:24141017   PMID:24496673   PMID:25002582   PMID:25412361   PMID:25470523  
PMID:25535743   PMID:25571843   PMID:26053851   PMID:26165998   PMID:26279425   PMID:26316108   PMID:26874210   PMID:26903063   PMID:27009470   PMID:27169499   PMID:27216364   PMID:28368329  
PMID:29037410   PMID:29374537   PMID:29476059   PMID:32357304   PMID:32917949   PMID:35456946   PMID:37200358   PMID:37865085   PMID:38597327  


Genomics

Comparative Map Data
Hspa4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81037,908,866 - 37,951,994 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1037,908,866 - 37,949,835 (-)EnsemblGRCr8
mRatBN7.21037,408,025 - 37,449,080 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,408,025 - 37,449,001 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1042,101,220 - 42,141,891 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,591,248 - 41,631,920 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,094,962 - 37,135,636 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01038,601,624 - 38,642,397 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,601,624 - 38,642,397 (-)Ensemblrn6Rnor6.0
Rnor_5.01038,383,101 - 38,424,016 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41038,705,629 - 38,749,058 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1036,756,477 - 36,796,741 (-)NCBICelera
RGSC_v3.11038,712,058 - 38,755,488 (-)NCBI
Cytogenetic Map10q22NCBI
HSPA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385133,052,013 - 133,106,449 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5133,051,946 - 133,106,449 (+)Ensemblhg38GRCh38
GRCh375132,387,705 - 132,442,141 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,415,561 - 132,468,608 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345132,415,560 - 132,468,608NCBI
Celera5128,517,326 - 128,569,460 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,579,243 - 127,632,290 (+)NCBIHuRef
CHM1_15131,820,919 - 131,874,036 (+)NCBICHM1_1
T2T-CHM13v2.05133,562,175 - 133,626,191 (+)NCBIT2T-CHM13v2.0
Hspa4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,150,641 - 53,191,306 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,150,641 - 53,191,284 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381153,259,814 - 53,300,479 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,259,814 - 53,300,457 (-)Ensemblmm10GRCm38
MGSCv371153,073,316 - 53,113,981 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361153,104,997 - 53,143,812 (-)NCBIMGSCv36mm8
Celera1157,839,531 - 57,880,195 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.91NCBI
Hspa4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554084,379,825 - 4,423,381 (+)Ensembl
ChiLan1.0NW_0049554084,379,825 - 4,422,710 (+)NCBIChiLan1.0ChiLan1.0
HSPA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24128,358,202 - 128,410,864 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15126,497,801 - 126,552,375 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05128,463,186 - 128,517,563 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,619,076 - 134,673,658 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,619,076 - 134,673,658 (+)EnsemblpanPan2panpan1.1
HSPA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11121,290,603 - 21,363,701 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1121,290,621 - 21,505,122 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1120,116,763 - 20,164,574 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01122,073,430 - 22,146,303 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1122,073,445 - 22,146,281 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,814,567 - 20,862,388 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,662,175 - 20,709,970 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01121,304,890 - 21,352,758 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hspa4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,084,886 - 115,130,573 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,087,604 - 2,133,355 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,087,650 - 2,133,343 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2135,345,867 - 135,391,108 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12135,345,724 - 135,391,112 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,866,335 - 140,911,632 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSPA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,862,817 - 35,917,490 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,862,814 - 35,918,287 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603442,023,595 - 42,078,723 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hspa4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473339,021,738 - 39,068,132 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473339,022,511 - 39,068,153 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Hspa4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1935,744,508 - 35,784,072 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hspa4
682 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir1rno-miR-1-3pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI17715156

Predicted Target Of
Summary Value
Count of predictions:197
Count of miRNA genes:141
Interacting mature miRNAs:167
Transcripts:ENSRNOT00000023628
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
AW535242  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21037,427,084 - 37,427,272 (+)MAPPERmRatBN7.2
Rnor_6.01038,620,867 - 38,621,054NCBIRnor6.0
Rnor_5.01038,402,344 - 38,402,531UniSTSRnor5.0
RGSC_v3.41038,726,246 - 38,726,433UniSTSRGSC3.4
Celera1036,775,119 - 36,775,306UniSTS
RH 3.4 Map10403.4UniSTS
Cytogenetic Map10q22UniSTS
RH65703  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21037,419,445 - 37,420,560 (+)MAPPERmRatBN7.2
Rnor_6.01038,613,230 - 38,614,344NCBIRnor6.0
Rnor_5.01038,394,707 - 38,395,821UniSTSRnor5.0
RGSC_v3.41038,717,051 - 38,718,165UniSTSRGSC3.4
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000023628   ⟹   ENSRNOP00000023628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1037,908,866 - 37,949,835 (-)Ensembl
mRatBN7.2 Ensembl1037,408,025 - 37,449,001 (-)Ensembl
Rnor_6.0 Ensembl1038,601,624 - 38,642,397 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094819   ⟹   ENSRNOP00000082426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1037,908,866 - 37,949,835 (-)Ensembl
mRatBN7.2 Ensembl1037,408,025 - 37,449,001 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111861   ⟹   ENSRNOP00000091981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1037,408,025 - 37,439,941 (-)Ensembl
RefSeq Acc Id: NM_153629   ⟹   NP_705893
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81037,908,866 - 37,949,835 (-)NCBI
mRatBN7.21037,408,025 - 37,449,001 (-)NCBI
Rnor_6.01038,601,624 - 38,642,397 (-)NCBI
Rnor_5.01038,383,101 - 38,424,016 (-)NCBI
RGSC_v3.41038,705,629 - 38,749,058 (-)RGD
Celera1036,756,477 - 36,796,741 (-)RGD
Sequence:
RefSeq Acc Id: XM_039085314   ⟹   XP_038941242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81037,908,866 - 37,951,994 (-)NCBI
mRatBN7.21037,409,756 - 37,449,080 (-)NCBI
RefSeq Acc Id: NP_705893   ⟸   NM_153629
- UniProtKB: O88600 (UniProtKB/Swiss-Prot),   F1LRV4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023628   ⟸   ENSRNOT00000023628
RefSeq Acc Id: XP_038941242   ⟸   XM_039085314
- Peptide Label: isoform X1
- UniProtKB: F1LRV4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082426   ⟸   ENSRNOT00000094819
Ensembl Acc Id: ENSRNOP00000091981   ⟸   ENSRNOT00000111861

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88600-F1-model_v2 AlphaFold O88600 1-840 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697173
Promoter ID:EPDNEW_R7697
Type:initiation region
Name:Hspa4_1
Description:heat shock protein family A member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01038,642,420 - 38,642,480EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628878 AgrOrtholog
BioCyc Gene G2FUF-25149 BioCyc
Ensembl Genes ENSRNOG00000016596 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000023628 ENTREZGENE
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot
  3.30.30.30 UniProtKB/Swiss-Prot
  3.30.420.40 UniProtKB/Swiss-Prot
  Actin, Chain A, domain 4 UniProtKB/Swiss-Prot
  Substrate Binding Domain Of DNAk, Chain A, domain 1 UniProtKB/Swiss-Prot
InterPro ATPase_NBD UniProtKB/Swiss-Prot
  Heat_shock_70_CS UniProtKB/Swiss-Prot
  HSP70_C_sf UniProtKB/Swiss-Prot
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot
  Hsp_70_fam UniProtKB/Swiss-Prot
  HSPA4_NBD UniProtKB/Swiss-Prot
KEGG Report rno:266759 UniProtKB/Swiss-Prot
NCBI Gene 266759 ENTREZGENE
PANTHER HEAT SHOCK 70 KDA PROTEIN 4 UniProtKB/Swiss-Prot
  HSC70CB, ISOFORM G-RELATED UniProtKB/Swiss-Prot
Pfam HSP70 UniProtKB/Swiss-Prot
PhenoGen Hspa4 PhenoGen
PRINTS HEATSHOCK70 UniProtKB/Swiss-Prot
PROSITE HSP70_2 UniProtKB/Swiss-Prot
  HSP70_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016596 RatGTEx
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot
  SSF100934 UniProtKB/Swiss-Prot
  SSF53067 UniProtKB/Swiss-Prot
UniProt A0A8I5ZTY1_RAT UniProtKB/TrEMBL
  A6HEB7_RAT UniProtKB/TrEMBL
  A6HEB8_RAT UniProtKB/TrEMBL
  A6HEB9_RAT UniProtKB/TrEMBL
  A6HEC1_RAT UniProtKB/TrEMBL
  F1LRV4 ENTREZGENE, UniProtKB/TrEMBL
  HSP74_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Hspa4  heat shock protein family A (Hsp70) member 4  Hspa4  heat shock protein family A member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Hspa4  heat shock protein family A member 4  Hspa4  heat shock protein 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Hspa4  heat shock protein 4    heat shock 70 kDa protein 4  Name updated 1299863 APPROVED
2003-02-27 Hspa4  heat shock 70 kDa protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is increased following exposure to elevated temperatures 633151