Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:metal cation:proton antiporter activity
go back to main search page
Accession:GO:0051139 term browser browse the term
Definition:Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in).
Synonyms:exact_synonym: metal ion:hydrogen antiporter activity;   metal ion:proton antiporter activity
 xref: reactome:R-HSA-435171 "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages"


show annotations for term's descendants           Sort by:
metal cation:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc11a1 solute carrier family 11 member 1 enables ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
(MGI:7484270|PMID:9730978)
UniProtKB:P38356 (PMID:17932044), (PMID:9730978)		 UniProt
GO_Central
Ensembl
RGD		 PMID:9730978 PMID:17932044 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:7484270 NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101 		JBrowse link
calcium:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ghitm growth hormone inducible transmembrane protein enables ISS
ISO		 GO_REF:0000024
(PMID:36321428)		 UniProt
RGD		 PMID:36321428 GO_REF:0000024 NCBI chr16:12,885,551...12,897,887
Ensembl chr16:12,885,553...12,897,879 		JBrowse link
G Letm1 leucine zipper and EF-hand containing transmembrane protein 1 enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5643854|PMID:23716663), (MGI:5897526|PMID:27669901)
(PMID:19797662)		 UniProt
Ensembl
RGD		 PMID:19797662 PMID:23716663 PMID:27669901 GO_REF:0000024 GO_REF:0000107 MGI:5643854 MGI:5897526 NCBI chr14:76,942,647...76,982,220
Ensembl chr14:76,942,729...76,984,904 		JBrowse link
L-asparagine, sodium:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc38a3 solute carrier family 38, member 3 enables IDA
ISO
ISS		 PMID:28272791
(MGI:7310198|PMID:16249471)
GO_REF:0000024
PMID:19596860
PMID:11742981
PMID:21525297		 RGD
UniProt		 PMID:16249471 PMID:28272791 PMID:19596860 PMID:11742981 PMID:21525297 GO_REF:0000024 MGI:7310198, RGD:152995559, RGD:152995538, RGD:152995542, RGD:152995537 NCBI chr 8:108,323,889...108,339,959
Ensembl chr 8:108,323,894...108,339,988 		JBrowse link
L-glutamine, sodium:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc38a3 solute carrier family 38, member 3 enables IDA
ISO
ISS		 PMID:17148440
(MGI:7310198|PMID:16249471), (MGI:7310199|PMID:18689705)
GO_REF:0000024
PMID:29561757
PMID:19596860
PMID:11850497
PMID:11742981
PMID:28272791
PMID:21525297		 RGD
UniProt		 PMID:16249471 PMID:18689705 PMID:17148440 PMID:29561757 PMID:19596860 More... GO_REF:0000024 MGI:7310198 MGI:7310199, RGD:9999222, RGD:152995547, RGD:152995538, RGD:152995544, RGD:152995542, RGD:152995559, RGD:152995537 NCBI chr 8:108,323,889...108,339,959
Ensembl chr 8:108,323,894...108,339,988 		JBrowse link
G Slc38a5 solute carrier family 38, member 5 enables IDA
ISS
IEA
ISO		 PMID:16249471
PMID:15218073
PMID:22821889
GO_REF:0000024
GO_REF:0000107
(MGI:7310198|PMID:16249471), (MGI:7310199|PMID:18689705)		 UniProt
Ensembl
RGD		 PMID:16249471 PMID:18689705 PMID:16249471 PMID:15218073 PMID:22821889 GO_REF:0000024 GO_REF:0000107 MGI:7310198 MGI:7310199, RGD:152995568, RGD:15090853, RGD:153298961 NCBI chr  X:14,213,727...14,222,498
Ensembl chr  X:14,213,729...14,222,498 		JBrowse link
L-histidine, sodium:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc38a3 solute carrier family 38, member 3 enables IDA
ISO
ISS		 PMID:28272791
(MGI:7310200|PMID:15899884)
GO_REF:0000024
PMID:11742981		 RGD
UniProt		 PMID:15899884 PMID:28272791 PMID:11742981 GO_REF:0000024 MGI:7310200, RGD:152995559, RGD:152995542 NCBI chr 8:108,323,889...108,339,959
Ensembl chr 8:108,323,894...108,339,988 		JBrowse link
lithium:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc9b2 solute carrier family 9 member B2 enables ISO (PMID:18000046), (PMID:28154142), (PMID:36177733) RGD PMID:18000046 PMID:28154142 PMID:36177733 NCBI chr 2:223,726,982...223,761,234
Ensembl chr 2:223,736,354...223,761,225 		JBrowse link
neutral amino acid, sodium:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc38a5 solute carrier family 38, member 5 enables ISS
IDA
ISO		 GO_REF:0000024
PMID:16629640
PMID:15218073
PMID:11698233
PMID:22821889
(PMID:11243884)		 UniProt
RGD		 PMID:11243884 PMID:16629640 PMID:15218073 PMID:11698233 PMID:22821889 GO_REF:0000024, RGD:152995548, RGD:15090853, RGD:628449, RGD:153298961 NCBI chr  X:14,213,727...14,222,498
Ensembl chr  X:14,213,729...14,222,498 		JBrowse link
potassium:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc17a6 solute carrier family 17 member 6 enables IDA
ISO		 PMID:25433636
(MGI:6838939|PMID:25433636)		 RGD PMID:25433636 PMID:25433636 MGI:6838939, RGD:152025511 NCBI chr 1:101,212,489...101,252,543
Ensembl chr 1:101,212,489...101,252,542 		JBrowse link
G Slc17a7 solute carrier family 17 member 7 enables IDA PMID:25433636 UniProt PMID:25433636 RGD:152025511 NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624 		JBrowse link
G Slc9a2 solute carrier family 9 member A2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:42,932,001...43,014,447
Ensembl chr 9:42,931,346...43,014,444 		JBrowse link
G Slc9a3 solute carrier family 9 member A3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417 		JBrowse link
G Slc9a4 solute carrier family 9 member A4 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:42,825,334...42,879,729
Ensembl chr 9:42,825,064...42,879,422 		JBrowse link
G Slc9a5 solute carrier family 9 member A5 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:33,225,481...33,246,913
Ensembl chr19:33,226,816...33,246,903 		JBrowse link
G Slc9a6 solute carrier family 9 member A6 enables ISO
IBA		 (MGI:7387161|PMID:17005858)
GO_REF:0000033		 RGD
GO_Central		 PMID:17005858 GO_REF:0000033 MGI:7387161 NCBI chr  X:134,430,677...134,486,747
Ensembl chr  X:134,420,756...134,485,375 		JBrowse link
G Slc9a7 solute carrier family 9 member A7 enables ISO (PMID:11279194) RGD PMID:11279194 NCBI chr  X:2,214,064...2,395,052
Ensembl chr  X:2,214,441...2,388,012 		JBrowse link
G Slc9a8 solute carrier family 9 member A8 enables IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
(PMID:15522866)		 Ensembl
GO_Central
RGD		 PMID:15522866 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:156,147,855...156,198,497
Ensembl chr 3:156,148,104...156,198,471 		JBrowse link
G Slc9a9 solute carrier family 9 member A9 enables ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(MGI:7387161|PMID:17005858)		 UniProt
GO_Central
RGD		 PMID:17005858 GO_REF:0000024 GO_REF:0000033 MGI:7387161 NCBI chr 8:95,232,889...95,797,262
Ensembl chr 8:95,232,905...95,796,318 		JBrowse link
G Slc9c1 solute carrier family 9 member C1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:55,211,774...55,278,285
Ensembl chr11:55,211,792...55,278,285 		JBrowse link
G Tmco3 transmembrane and coiled-coil domains 3 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:76,217,146...76,254,309
Ensembl chr16:76,217,201...76,254,107 		JBrowse link
sodium:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chp1 calcineurin-like EF-hand protein 1 enables ISO MGI:5529475 (PMID:23904602) RGD PMID:23904602 NCBI chr 3:106,536,009...106,571,255
Ensembl chr 3:106,536,004...106,571,251 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 enables IMP
IBA
ISO
IDA		 GO_REF:0000033
(PMID:10666043), (PMID:23677982)
(PMID:11350981), (PMID:24840010), (PMID:2536298), (PMID:8901634)
PMID:18321853		 GO_Central
RGD		 PMID:2536298 PMID:8901634 PMID:10666043 PMID:11350981 PMID:23677982 More... GO_REF:0000033, RGD:1581387, RGD:8554433 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624 		JBrowse link
G Slc9a2 solute carrier family 9 member A2 enables IDA
IBA
ISO
IEA		 GO_REF:0000033
(PMID:10666043)
GO_REF:0000117
PMID:8244989		 GO_Central
RGD
UniProt		 PMID:10666043 PMID:7683411 PMID:8244989 GO_REF:0000033 GO_REF:0000117, RGD:729996, RGD:155888550 NCBI chr 9:42,932,001...43,014,447
Ensembl chr 9:42,931,346...43,014,444 		JBrowse link
G Slc9a3 solute carrier family 9 member A3 enables IDA
IBA
ISO
IEA		 GO_REF:0000033
(PMID:10666043)
GO_REF:0000117
(PMID:26358773)		 GO_Central
RGD
UniProt		 PMID:10666043 PMID:26358773 PMID:11880335 PMID:15265811 PMID:12907430 GO_REF:0000033 GO_REF:0000117, RGD:737665, RGD:1625070, RGD:1581380 NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417 		JBrowse link
G Slc9a4 solute carrier family 9 member A4 enables IEA
IBA
IDA		 GO_REF:0000117
GO_REF:0000033
PMID:8944646		 UniProt
GO_Central		 PMID:8944646 GO_REF:0000033 GO_REF:0000117, RGD:329955540 NCBI chr 9:42,825,334...42,879,729
Ensembl chr 9:42,825,064...42,879,422 		JBrowse link
G Slc9a5 solute carrier family 9 member A5 enables IDA
IBA
ISO		 GO_REF:0000033
(PMID:10692428)		 GO_Central
RGD		 PMID:10692428 PMID:9933642 GO_REF:0000033, RGD:634199 NCBI chr19:33,225,481...33,246,913
Ensembl chr19:33,226,816...33,246,903 		JBrowse link
G Slc9a6 solute carrier family 9 member A6 enables ISO
IBA		 (MGI:7387161|PMID:17005858)
GO_REF:0000033		 RGD
GO_Central		 PMID:17005858 GO_REF:0000033 MGI:7387161 NCBI chr  X:134,430,677...134,486,747
Ensembl chr  X:134,420,756...134,485,375 		JBrowse link
G Slc9a7 solute carrier family 9 member A7 enables ISO (PMID:11279194) RGD PMID:11279194 NCBI chr  X:2,214,064...2,395,052
Ensembl chr  X:2,214,441...2,388,012 		JBrowse link
G Slc9a8 solute carrier family 9 member A8 enables IDA
IBA
IEA
ISO		 PMID:18209477
GO_REF:0000033
GO_REF:0000117
(PMID:15522866)
PMID:22088432		 GO_Central
UniProt
RGD		 PMID:15522866 PMID:18209477 PMID:22088432 GO_REF:0000033 GO_REF:0000117, RGD:155663541, RGD:155663543 NCBI chr 3:156,147,855...156,198,497
Ensembl chr 3:156,148,104...156,198,471 		JBrowse link
G Slc9a9 solute carrier family 9 member A9 enables ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(MGI:7387161|PMID:17005858)		 UniProt
GO_Central
RGD		 PMID:17005858 GO_REF:0000024 GO_REF:0000033 MGI:7387161 NCBI chr 8:95,232,889...95,797,262
Ensembl chr 8:95,232,905...95,796,318 		JBrowse link
G Slc9b2 solute carrier family 9 member B2 enables ISO (PMID:18000046), (PMID:28154142), (PMID:36177733) RGD PMID:18000046 PMID:28154142 PMID:36177733 NCBI chr 2:223,726,982...223,761,234
Ensembl chr 2:223,736,354...223,761,225 		JBrowse link
G Slc9c1 solute carrier family 9 member C1 enables IEA
IBA		 GO_REF:0000117
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000117 NCBI chr11:55,211,774...55,278,285
Ensembl chr11:55,211,792...55,278,285 		JBrowse link
G Slc9c2 solute carrier family 9, member C2 (putative) enables IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr13:73,424,683...73,524,244
Ensembl chr13:73,451,115...73,524,239
Ensembl chr13:73,451,115...73,524,239 		JBrowse link
zinc:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc30a1 solute carrier family 30 member 1 enables IDA PMID:24951051 UniProt PMID:24951051 RGD:155230788 NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910 		JBrowse link
G Slc30a2 solute carrier family 30 member 2 enables IC
IEA
ISO
ISS		 PMID:20133611
GO_REF:0000107
(PMID:30893306)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:30893306 PMID:20133611 GO_REF:0000024 GO_REF:0000107, RGD:155230688 NCBI chr 5:146,559,733...146,571,957
Ensembl chr 5:146,559,733...146,571,956 		JBrowse link
G Slc30a5 solute carrier family 30 member 5 enables ISO (PMID:19366695) RGD PMID:19366695 NCBI chr 2:31,945,745...31,975,969
Ensembl chr 2:31,945,729...31,975,934 		JBrowse link
G Slc30a6 solute carrier family 30 member 6 NOT|enables ISO (PMID:19366695) RGD PMID:19366695 NCBI chr 6:21,020,931...21,050,785
Ensembl chr 6:21,020,931...21,050,785 		JBrowse link
G Slc30a8 solute carrier family 30 member 8 enables ISS
ISO		 GO_REF:0000024
(PMID:32723473)		 UniProt
RGD		 PMID:32723473 GO_REF:0000024 NCBI chr 7:83,591,993...83,627,786
Ensembl chr 7:83,591,993...83,626,305 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20483
    transporter activity 1237
      transmembrane transporter activity 1143
        monoatomic ion transmembrane transporter activity 759
          monoatomic cation transmembrane transporter activity 637
            proton transmembrane transporter activity 163
              metal cation:proton antiporter activity 26
                calcium:proton antiporter activity 2
                lithium:proton antiporter activity 1
                manganese:proton antiporter activity 0
                potassium:proton antiporter activity 13
                sodium:proton antiporter activity + 15
                zinc:proton antiporter activity 5
Path 2
Term Annotations click to browse term
  molecular_function 20483
    transporter activity 1237
      transmembrane transporter activity 1143
        monoatomic ion transmembrane transporter activity 759
          monoatomic cation transmembrane transporter activity 637
            metal ion transmembrane transporter activity 452
              metal cation:monoatomic cation antiporter activity 41
                metal cation:proton antiporter activity 26
                  calcium:proton antiporter activity 2
                  lithium:proton antiporter activity 1
                  manganese:proton antiporter activity 0
                  potassium:proton antiporter activity 13
                  sodium:proton antiporter activity + 15
                  zinc:proton antiporter activity 5
paths to the root