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ONTOLOGY REPORT - ANNOTATIONS

Term:sodium:proton antiporter activity
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Accession:GO:0015385 term browser browse the term
Definition:Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
Synonyms:exact_synonym: sodium/hydrogen antiporter activity;   sodium:hydrogen exchange activity;   sodium:hydrogen exchanger
 narrow_synonym: pH-dependent sodium:hydrogen antiporter activity;   pH-dependent sodium:proton antiporter activity
 alt_id: GO:0015502
 xref: MetaCyc:TRANS-RXN-129;   RHEA:29251;   Reactome:R-HSA-2889070 "SLC9B2 exchanges Na+ for H+";   Reactome:R-HSA-5661039 "Defective SLC9A6 does not exchange Na+ for H+ across the early endosome membrane";   Reactome:R-HSA-5661086 "Defective SLC9A9 does not exchange Na+ for H+ across the late endosome membrane";   reactome:R-HSA-2872444 "SLC9B1/C2 exchange Na+ for H+";   reactome:R-HSA-2872463 "SLC9C1 exchanges Na+ for H+";   reactome:R-HSA-425965 "SLC9A9 exchanges Na+ for H+ across the late endosome membrane";   reactome:R-HSA-425983 "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane";   reactome:R-HSA-425994 "Na+/H+ exchanger transport (at cell membrane)";   reactome:R-HSA-426015 "Na+/H+ exchanger transport (at trans-golgi membrane)"


show annotations for term's descendants           Sort by:
sodium:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chp1 calcineurin-like EF-hand protein 1 enables ISO MGI:5529475 (PMID:23904602) RGD PMID:23904602 NCBI chr 3:106,536,009...106,571,255
Ensembl chr 3:106,536,004...106,571,251 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 enables IMP
IDA
ISO
IBA		 PMID:18321853
(PMID:11350981), (PMID:24840010), (PMID:2536298), (PMID:8901634)
GO_REF:0000033
(PMID:10666043), (PMID:23677982)		 RGD
GO_Central		 PMID:2536298 PMID:8901634 PMID:10666043 PMID:11350981 PMID:23677982 More... GO_REF:0000033, RGD:1581387, RGD:8554433 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624 		JBrowse link
G Slc9a2 solute carrier family 9 member A2 enables IDA
IEA
IBA
ISO		 PMID:8244989
GO_REF:0000117
GO_REF:0000033
(PMID:10666043)		 UniProt
GO_Central
RGD		 PMID:10666043 PMID:7683411 PMID:8244989 GO_REF:0000033 GO_REF:0000117, RGD:729996, RGD:155888550 NCBI chr 9:42,932,001...43,014,447
Ensembl chr 9:42,931,346...43,014,444 		JBrowse link
G Slc9a3 solute carrier family 9 member A3 enables IDA
ISO
IEA
IBA		 (PMID:26358773)
GO_REF:0000117
GO_REF:0000033
(PMID:10666043)		 RGD
UniProt
GO_Central		 PMID:10666043 PMID:26358773 PMID:11880335 PMID:12907430 PMID:15265811 GO_REF:0000033 GO_REF:0000117, RGD:737665, RGD:1581380, RGD:1625070 NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417 		JBrowse link
G Slc9a4 solute carrier family 9 member A4 enables IEA
IDA
IBA		 GO_REF:0000117
PMID:8944646
GO_REF:0000033		 UniProt
GO_Central		 PMID:8944646 GO_REF:0000033 GO_REF:0000117, RGD:329955540 NCBI chr 9:42,825,334...42,879,729
Ensembl chr 9:42,825,064...42,879,422 		JBrowse link
G Slc9a5 solute carrier family 9 member A5 enables IDA
ISO
IBA		 (PMID:10692428)
GO_REF:0000033		 RGD
GO_Central		 PMID:10692428 PMID:9933642 GO_REF:0000033, RGD:634199 NCBI chr19:33,225,481...33,246,913
Ensembl chr19:33,226,816...33,246,903 		JBrowse link
G Slc9a6 solute carrier family 9 member A6 enables ISO
IBA		 (MGI:7387161|PMID:17005858)
GO_REF:0000033		 RGD
GO_Central		 PMID:17005858 GO_REF:0000033 MGI:7387161 NCBI chr  X:134,430,677...134,486,747
Ensembl chr  X:134,420,756...134,485,375 		JBrowse link
G Slc9a7 solute carrier family 9 member A7 enables ISO (PMID:11279194) RGD PMID:11279194 NCBI chr  X:2,214,064...2,395,052
Ensembl chr  X:2,214,441...2,388,012 		JBrowse link
G Slc9a8 solute carrier family 9 member A8 enables IDA
IBA
IEA
ISO		 PMID:18209477
GO_REF:0000033
GO_REF:0000117
(PMID:15522866)
PMID:22088432		 GO_Central
UniProt
RGD		 PMID:15522866 PMID:18209477 PMID:22088432 GO_REF:0000033 GO_REF:0000117, RGD:155663541, RGD:155663543 NCBI chr 3:156,147,855...156,198,497
Ensembl chr 3:156,148,104...156,198,471 		JBrowse link
G Slc9a9 solute carrier family 9 member A9 enables ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(MGI:7387161|PMID:17005858)		 UniProt
GO_Central
RGD		 PMID:17005858 GO_REF:0000024 GO_REF:0000033 MGI:7387161 NCBI chr 8:95,232,889...95,797,262
Ensembl chr 8:95,232,905...95,796,318 		JBrowse link
G Slc9b2 solute carrier family 9 member B2 enables ISO (PMID:18000046), (PMID:28154142), (PMID:36177733) RGD PMID:18000046 PMID:28154142 PMID:36177733 NCBI chr 2:223,726,982...223,761,234
Ensembl chr 2:223,736,354...223,761,225 		JBrowse link
G Slc9c1 solute carrier family 9 member C1 enables IEA
IBA		 GO_REF:0000117
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000117 NCBI chr11:55,211,774...55,278,285
Ensembl chr11:55,211,792...55,278,285 		JBrowse link
G Slc9c2 solute carrier family 9, member C2 (putative) enables IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr13:73,424,683...73,524,244
Ensembl chr13:73,451,115...73,524,239
Ensembl chr13:73,451,115...73,524,239 		JBrowse link
L-asparagine, sodium:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc38a3 solute carrier family 38, member 3 enables IDA
ISO
ISS		 PMID:28272791
(MGI:7310198|PMID:16249471)
GO_REF:0000024
PMID:19596860
PMID:11742981
PMID:21525297		 RGD
UniProt		 PMID:16249471 PMID:28272791 PMID:19596860 PMID:11742981 PMID:21525297 GO_REF:0000024 MGI:7310198, RGD:152995559, RGD:152995538, RGD:152995542, RGD:152995537 NCBI chr 8:108,323,889...108,339,959
Ensembl chr 8:108,323,894...108,339,988 		JBrowse link
L-glutamine, sodium:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc38a3 solute carrier family 38, member 3 enables IDA
ISO
ISS		 PMID:17148440
(MGI:7310198|PMID:16249471), (MGI:7310199|PMID:18689705)
GO_REF:0000024
PMID:29561757
PMID:19596860
PMID:11850497
PMID:11742981
PMID:28272791
PMID:21525297		 RGD
UniProt		 PMID:16249471 PMID:18689705 PMID:17148440 PMID:29561757 PMID:19596860 More... GO_REF:0000024 MGI:7310198 MGI:7310199, RGD:9999222, RGD:152995547, RGD:152995538, RGD:152995544, RGD:152995542, RGD:152995559, RGD:152995537 NCBI chr 8:108,323,889...108,339,959
Ensembl chr 8:108,323,894...108,339,988 		JBrowse link
G Slc38a5 solute carrier family 38, member 5 enables IDA
ISS
IEA
ISO		 PMID:16249471
PMID:15218073
PMID:22821889
GO_REF:0000024
GO_REF:0000107
(MGI:7310198|PMID:16249471), (MGI:7310199|PMID:18689705)		 UniProt
Ensembl
RGD		 PMID:16249471 PMID:18689705 PMID:16249471 PMID:15218073 PMID:22821889 GO_REF:0000024 GO_REF:0000107 MGI:7310198 MGI:7310199, RGD:152995568, RGD:15090853, RGD:153298961 NCBI chr  X:14,213,727...14,222,498
Ensembl chr  X:14,213,729...14,222,498 		JBrowse link
L-histidine, sodium:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc38a3 solute carrier family 38, member 3 enables IDA
ISO
ISS		 PMID:28272791
(MGI:7310200|PMID:15899884)
GO_REF:0000024
PMID:11742981		 RGD
UniProt		 PMID:15899884 PMID:28272791 PMID:11742981 GO_REF:0000024 MGI:7310200, RGD:152995559, RGD:152995542 NCBI chr 8:108,323,889...108,339,959
Ensembl chr 8:108,323,894...108,339,988 		JBrowse link
neutral amino acid, sodium:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc38a5 solute carrier family 38, member 5 enables ISS
IDA
ISO		 GO_REF:0000024
PMID:16629640
PMID:15218073
PMID:11698233
PMID:22821889
(PMID:11243884)		 UniProt
RGD		 PMID:11243884 PMID:16629640 PMID:15218073 PMID:11698233 PMID:22821889 GO_REF:0000024, RGD:152995548, RGD:15090853, RGD:628449, RGD:153298961 NCBI chr  X:14,213,727...14,222,498
Ensembl chr  X:14,213,729...14,222,498 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21010
    transporter activity 1259
      transmembrane transporter activity 1163
        inorganic molecular entity transmembrane transporter activity 712
          inorganic cation transmembrane transporter activity 599
            metal ion transmembrane transporter activity 461
              sodium ion transmembrane transporter activity 168
                sodium:proton antiporter activity 15
                  L-asparagine, sodium:proton antiporter activity 1
                  L-glutamine, sodium:proton antiporter activity 2
                  L-histidine, sodium:proton antiporter activity 1
                  neutral amino acid, sodium:proton antiporter activity 1
                  sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential 0
Path 2
Term Annotations click to browse term
  molecular_function 21010
    transporter activity 1259
      transmembrane transporter activity 1163
        active transmembrane transporter activity 448
          secondary active transmembrane transporter activity 292
            antiporter activity 128
              metal cation:monoatomic cation antiporter activity 41
                metal cation:proton antiporter activity 26
                  sodium:proton antiporter activity 15
                    L-asparagine, sodium:proton antiporter activity 1
                    L-glutamine, sodium:proton antiporter activity 2
                    L-histidine, sodium:proton antiporter activity 1
                    neutral amino acid, sodium:proton antiporter activity 1
                    sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential 0
paths to the root