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ONTOLOGY REPORT - ANNOTATIONS

Term:thyroid hormone generation
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Accession:GO:0006590 term browser browse the term
Definition:The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.
Comment:Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis.


show annotations for term's descendants           Sort by:
thyroid hormone generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cga glycoprotein hormones, alpha polypeptide involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:1857152 (PMID:12114718)		 GO_Central
RGD		 PMID:12114718 GO_REF:0000033 NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191 		JBrowse link
G Cpq carboxypeptidase Q involved_in IDA
IBA		 PMID:22127294
GO_REF:0000033		 GO_Central PMID:22127294 GO_REF:0000033, RGD:8554022 NCBI chr 7:64,264,025...64,830,867
Ensembl chr 7:64,264,081...64,724,546 		JBrowse link
G Ctsb cathepsin B involved_in IEA
ISO		 GO_REF:0000107
(PMID:12782676)		 Ensembl
RGD		 PMID:12782676 GO_REF:0000107 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Ctsk cathepsin K involved_in ISO
ISS		 (PMID:11082042)
GO_REF:0000024
(PMID:12782676)		 RGD
UniProt		 PMID:11082042 PMID:12782676 GO_REF:0000024 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Ctsl cathepsin L involved_in ISO (PMID:12782676) RGD PMID:12782676 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Dio2 iodothyronine deiodinase 2 IDA RGD PMID:15550511 RGD:1626436 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Duox1 dual oxidase 1 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563 		JBrowse link
G Duox2 dual oxidase 2 involved_in TAS
IEA		 GO_REF:0000041 UniProt
RGD		 PMID:12538618 GO_REF:0000041, RGD:632568 NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902 		JBrowse link
G Foxe1 forkhead box E1 acts_upstream_of_or_within ISO MGI:2181780 (PMID:9697704) RGD PMID:9697704 NCBI chr 5:60,630,027...60,632,835
Ensembl chr 5:60,630,027...60,632,835 		JBrowse link
G Med1 mediator complex subunit 1 acts_upstream_of_or_within ISO MGI:1861125 (PMID:10882104) RGD PMID:10882104 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299 		JBrowse link
G Slc16a10 solute carrier family 16 member 10 acts_upstream_of_or_within_negative_effect ISO MGI:1203732 (PMID:24248460) RGD PMID:24248460 NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839 		JBrowse link
G Slc16a2 solute carrier family 16 member 2 acts_upstream_of_or_within_negative_effect ISO MGI:1919722|MGI:3710233 (PMID:24248460) RGD PMID:24248460 NCBI chr  X:68,725,365...68,848,572
Ensembl chr  X:68,723,261...68,848,771 		JBrowse link
G Slc26a7 solute carrier family 26 member 7 involved_in ISO (PMID:30333321) RGD PMID:30333321 NCBI chr 5:27,884,400...28,021,865
Ensembl chr 5:27,887,042...28,021,658 		JBrowse link
G Slc5a5 solute carrier family 5 member 5 involved_in TAS
IEA		 GO_REF:0000002 InterPro
RGD		 PMID:8559252 GO_REF:0000002, RGD:68854 NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697 		JBrowse link
G Tg thyroglobulin involved_in TAS
IDA
IEA
ISO
IBA		 GO_REF:0000107
(PMID:32025030)
(PMID:11082042), (PMID:12387814)
GO_REF:0000033
(PMID:12782676)		 Ensembl
RGD
GO_Central		 PMID:11082042 PMID:12387814 PMID:12782676 PMID:32025030 PMID:11884402 More... GO_REF:0000033 GO_REF:0000107, RGD:728752, RGD:1600150 NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210 		JBrowse link
G Tpo thyroid peroxidase involved_in TAS
IEA
ISO		 GO_REF:0000041
(PMID:12387814)		 UniProt
RGD		 PMID:12387814 PMID:15917231 GO_REF:0000041, RGD:1599649 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199 		JBrowse link
positive regulation of thyroid hormone generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter IMP RGD PMID:35695380 RGD:155630629 NCBI chr10:57,801,551...57,817,213
Ensembl chr10:57,801,456...57,817,120 		JBrowse link
G Gata3 GATA binding protein 3 involved_in ISO (PMID:19248180), (PMID:19723756) RGD PMID:19248180 PMID:19723756 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Hpn hepsin involved_in ISS
ISO		 GO_REF:0000024
(PMID:17620368)		 UniProt
RGD		 PMID:17620368 GO_REF:0000024 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811 		JBrowse link
G Pax8 paired box 8 involved_in ISO
ISS		 (PMID:15356023)
GO_REF:0000024
(PMID:12586753)		 RGD
UniProt		 PMID:12586753 PMID:15356023 GO_REF:0000024 NCBI chr 3:7,185,721...7,242,363
Ensembl chr 3:7,185,723...7,242,363 		JBrowse link
G Slco1c1 solute carrier organic anion transporter family, member 1c1 involved_in ISO
IEA		 (PMID:18566113)
GO_REF:0000107		 RGD
Ensembl		 PMID:18566113 GO_REF:0000107 NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289 		JBrowse link
regulation of thyroid hormone generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Duoxa1 dual oxidase maturation factor 1 acts_upstream_of_or_within ISO MGI:1914061 (PMID:22301785) RGD PMID:22301785 NCBI chr 3:109,249,815...109,260,511
Ensembl chr 3:109,249,923...109,260,499 		JBrowse link
G Duoxa2 dual oxidase maturation factor 2 acts_upstream_of_or_within ISO MGI:2384861 (PMID:22301785) RGD PMID:22301785 NCBI chr 3:109,245,337...109,249,055
Ensembl chr 3:109,245,476...109,248,968 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      metabolic process 11950
        hormone metabolic process 261
          thyroid hormone metabolic process 35
            thyroid hormone generation 23
              negative regulation of thyroid hormone generation 0
              positive regulation of thyroid hormone generation 5
              regulation of thyroid hormone generation + 7
Path 2
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      metabolic process 11950
        organic hydroxy compound metabolic process 585
          phenol-containing compound metabolic process 137
            thyroid hormone metabolic process 35
              thyroid hormone generation 23
                negative regulation of thyroid hormone generation 0
                positive regulation of thyroid hormone generation 5
                regulation of thyroid hormone generation + 7
paths to the root