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ONTOLOGY REPORT - ANNOTATIONS


Term:thyroid hormone metabolic process
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Accession:GO:0042403 term browser browse the term
Definition:The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.
Synonyms:exact_synonym: thyroid hormone metabolism



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thyroid hormone metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crym crystallin, mu involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:3703787 (MGI:3703173|PMID:17264173)
RGD PMID:17264173 PMID:21873635 MGI:3703173, RGD:13792537 NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633
JBrowse link
G Dio1 iodothyronine deiodinase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
JBrowse link
G Dio2 iodothyronine deiodinase 2 involved_in TAS
IBA
ISO
IDA
PMID:21873635
(PMID:19651899)
RGD PMID:19651899 PMID:11934678 PMID:21873635 PMID:15550511 RGD:628323, RGD:13792537, RGD:1626436 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
JBrowse link
G Dio3 iodothyronine deiodinase 3 involved_in TAS
IBA
ISO
PMID:21873635
UniProtKB:P36021 (PMID:26305885)
RGD PMID:26305885 PMID:7622463 PMID:21873635 RGD:68236, RGD:13792537 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
JBrowse link
G Duox2 dual oxidase 2 acts_upstream_of_or_within ISO MGI:3712359 (MGI:3712355|PMID:17440044) RGD PMID:17440044 MGI:3712355 NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902
JBrowse link
G Gcnt4 glucosaminyl (N-acetyl) transferase 4 acts_upstream_of_or_within ISO MGI:3849682 (MGI:3849361|PMID:19349303) RGD PMID:19349303 MGI:3849361 NCBI chr 2:28,253,311...28,329,381
Ensembl chr 2:28,252,860...28,283,082
JBrowse link
G Iyd iodotyrosine deiodinase involved_in IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:25395621)
UniProt
RGD
PMID:25395621 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 acts_upstream_of_or_within ISO MGI:1856525 RGD MGI:85368 NCBI chr11:34,061,705...34,309,128
Ensembl chr11:34,061,708...34,308,758
JBrowse link
G Reln reelin acts_upstream_of_or_within ISO MGI:1856398 RGD MGI:85368 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
JBrowse link
G Slc16a2 solute carrier family 16 member 2 acts_upstream_of ISO UniProtKB:P55073 (PMID:26305885) RGD PMID:26305885 NCBI chr  X:68,725,365...68,848,572
Ensembl chr  X:68,723,261...68,848,771
JBrowse link
G Slco4a1 solute carrier organic anion transporter family, member 4a1 IDA RGD PMID:11316767 RGD:727314 NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 involved_in ISO
IDA
(PMID:11368519)
PMID:8530477
(MGI:1276823|PMID:9644246)
(PMID:9443824), (PMID:9463486)
RGD PMID:9443824 PMID:9463486 PMID:9644246 PMID:11368519 PMID:8530477 MGI:1276823, RGD:1299515 NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 involved_in ISO (PMID:10199779) RGD PMID:10199779 NCBI chr 1:75,451,178...75,508,142
Ensembl chr 1:74,911,100...75,508,134
JBrowse link
G Tg thyroglobulin acts_upstream_of_or_within ISO MGI:1856829 (MGI:57033|PMID:3803305) RGD PMID:3803305 MGI:57033 NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210
JBrowse link
G Ttr transthyretin TAS RGD PMID:11995998 RGD:737655 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
JBrowse link
positive regulation of thyroid hormone generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata3 GATA binding protein 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:19248180), (PMID:19723756)
UniProt
RGD
PMID:19248180 PMID:19723756 GO_REF:0000024 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Hpn hepsin involved_in ISS
ISO
GO_REF:0000024
(MGI:3719967|PMID:17620368)
UniProt
RGD
PMID:17620368 GO_REF:0000024 MGI:3719967 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
JBrowse link
G Pax8 paired box 8 involved_in ISO
ISS
(PMID:15356023)
(MGI:3691903|PMID:12586753)
GO_REF:0000024
RGD
UniProt
PMID:12586753 PMID:15356023 GO_REF:0000024 MGI:3691903 NCBI chr 3:7,185,721...7,242,363
Ensembl chr 3:7,185,723...7,242,363
JBrowse link
G Slco1c1 solute carrier organic anion transporter family, member 1c1 involved_in ISO
IEA
(PMID:18566113)
GO_REF:0000107
RGD
Ensembl
PMID:18566113 GO_REF:0000107 NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289
JBrowse link
regulation of thyroid hormone generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Duoxa1 dual oxidase maturation factor 1 acts_upstream_of_or_within ISO MGI:1914061 (MGI:5544584|PMID:22301785) RGD PMID:22301785 MGI:5544584 NCBI chr 3:109,249,815...109,260,511
Ensembl chr 3:109,249,923...109,260,499
JBrowse link
G Duoxa2 dual oxidase maturation factor 2 acts_upstream_of_or_within ISO MGI:2384861 (MGI:5544584|PMID:22301785) RGD PMID:22301785 MGI:5544584 NCBI chr 3:109,245,476...109,248,844
Ensembl chr 3:109,245,476...109,248,968
JBrowse link
thyroid hormone catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dio2 iodothyronine deiodinase 2 acts_upstream_of_or_within ISO MGI:2182450 (MGI:2154044|PMID:11731615) RGD PMID:11731615 MGI:2154044 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
JBrowse link
G Dio3 iodothyronine deiodinase 3 involved_in
acts_upstream_of_or_within
ISO (MGI:4441081|PMID:20203194)
MGI:2664293 (MGI:3615073|PMID:16410833), (MGI:4441081|PMID:20203194), (MGI:5578402|PMID:25002520)
RGD PMID:16410833 PMID:20203194 PMID:25002520 MGI:3615073 MGI:4441081 MGI:5578402 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
JBrowse link
thyroid hormone generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cga glycoprotein hormones, alpha polypeptide involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1857152 (MGI:1316794|PMID:12114718)
RGD PMID:12114718 PMID:21873635 MGI:1316794, RGD:13792537 NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191
JBrowse link
G Cpq carboxypeptidase Q involved_in IDA
IBA
PMID:22127294
PMID:21873635
UniProt
GO_Central
PMID:22127294 PMID:21873635 RGD:8554022, RGD:13792537 NCBI chr 7:64,264,025...64,830,867
Ensembl chr 7:64,264,081...64,724,546
JBrowse link
G Ctsb cathepsin B involved_in IEA
ISO
GO_REF:0000107
(MGI:2664014|PMID:12782676)
Ensembl
RGD
PMID:12782676 GO_REF:0000107 MGI:2664014 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Ctsk cathepsin K involved_in ISO
ISS
(PMID:11082042)
(MGI:2664014|PMID:12782676)
GO_REF:0000024
RGD
UniProt
PMID:11082042 PMID:12782676 GO_REF:0000024 MGI:2664014 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Ctsl cathepsin L involved_in ISO (MGI:2664014|PMID:12782676) RGD PMID:12782676 MGI:2664014 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Dio2 iodothyronine deiodinase 2 IDA RGD PMID:15550511 RGD:1626436 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
JBrowse link
G Duox1 dual oxidase 1 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563
JBrowse link
G Duox2 dual oxidase 2 involved_in TAS
IEA
GO_REF:0000041 UniProt
RGD
PMID:12538618 GO_REF:0000041, RGD:632568 NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902
JBrowse link
G Foxe1 forkhead box E1 acts_upstream_of_or_within ISO MGI:2181780 (MGI:1276273|PMID:9697704) RGD PMID:9697704 MGI:1276273 NCBI chr 5:60,630,027...60,632,835
Ensembl chr 5:60,630,027...60,632,835
JBrowse link
G Med1 mediator complex subunit 1 acts_upstream_of_or_within ISO MGI:1861125 (MGI:1355642|PMID:10882104) RGD PMID:10882104 MGI:1355642 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299
JBrowse link
G Slc16a10 solute carrier family 16 member 10 involved_in
acts_upstream_of_or_within_negative_effect
IEA
ISO
GO_REF:0000107
MGI:1203732 (MGI:5604693|PMID:24248460)
Ensembl
RGD
PMID:24248460 GO_REF:0000107 MGI:5604693 NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839
JBrowse link
G Slc16a2 solute carrier family 16 member 2 involved_in
acts_upstream_of_or_within_negative_effect
IEA
ISO
GO_REF:0000107
MGI:1919722|MGI:3710233 (MGI:5604693|PMID:24248460)
Ensembl
RGD
PMID:24248460 GO_REF:0000107 MGI:5604693 NCBI chr  X:68,725,365...68,848,572
Ensembl chr  X:68,723,261...68,848,771
JBrowse link
G Slc5a5 solute carrier family 5 member 5 involved_in TAS
IEA
GO_REF:0000002 InterPro
RGD
PMID:8559252 GO_REF:0000002, RGD:68854 NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
JBrowse link
G Tg thyroglobulin involved_in TAS
ISO
IEA
IBA
IDA
(MGI:2664014|PMID:12782676)
GO_REF:0000107
(PMID:11082042), (PMID:12387814)
(PMID:32025030)
PMID:21873635
RGD
Ensembl
PMID:11082042 PMID:12387814 PMID:12782676 PMID:32025030 PMID:11884402 More... GO_REF:0000107 MGI:2664014, RGD:728752, RGD:13792537, RGD:1600150 NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210
JBrowse link
G Tpo thyroid peroxidase involved_in TAS
ISO
IEA
(PMID:12387814)
GO_REF:0000041
RGD
UniProt
PMID:12387814 PMID:15917231 GO_REF:0000041, RGD:1599649 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18737
    metabolic process 11461
      hormone metabolic process 246
        thyroid hormone metabolic process 33
          thyroid hormone catabolic process 2
          thyroid hormone generation + 21
Path 2
Term Annotations click to browse term
  biological_process 18737
    metabolic process 11461
      cellular metabolic process 9699
        cellular aromatic compound metabolic process 5557
          phenol-containing compound metabolic process 129
            thyroid hormone metabolic process 33
              thyroid hormone catabolic process 2
              thyroid hormone generation + 21
paths to the root