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ONTOLOGY REPORT - ANNOTATIONS


Term:thyroid hormone metabolic process
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Accession:GO:0042403 term browser browse the term
Definition:The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.
Synonyms:exact_synonym: thyroid hormone metabolism


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thyroid hormone metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC118957.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 6:114,478,293...114,488,880 JBrowse link
G Crym crystallin, mu involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000107
MGI:3703787 (MGI:3703173|PMID:17264173)
PMID:21873635
Ensembl
RGD
PMID:17264173, PMID:21873635 GO_REF:0000107 MGI:3703173, RGD:13792537 NCBI chr 1:189,944,895...189,960,069
Ensembl chr 1:189,944,895...189,960,073
JBrowse link
G Dio1 iodothyronine deiodinase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dio2 iodothyronine deiodinase 2 involved_in TAS
IBA
ISO
IDA
PMID:21873635
(PMID:19651899)
RGD PMID:19651899, PMID:11934678, PMID:21873635, PMID:15550511 RGD:628323, RGD:13792537, RGD:1626436 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dio3 iodothyronine deiodinase 3 involved_in TAS
IBA
ISO
PMID:21873635
UniProtKB:P36021 (PMID:26305885)
RGD PMID:26305885, PMID:7622463, PMID:21873635 RGD:68236, RGD:13792537 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
JBrowse link
G Duox2 dual oxidase 2 acts_upstream_of_or_within ISO MGI:3712359 (MGI:3712355|PMID:17440044) RGD PMID:17440044 MGI:3712355 NCBI chr 3:114,218,187...114,237,808
Ensembl chr 3:114,218,193...114,235,933
JBrowse link
G Gcnt4 glucosaminyl (N-acetyl) transferase 4 acts_upstream_of_or_within ISO MGI:3849682 (MGI:3849361|PMID:19349303) RGD PMID:19349303 MGI:3849361 Ensembl chr 2:27,713,880...27,780,119 JBrowse link
G Iyd iodotyrosine deiodinase involved_in ISS
ISO
IBA
GO_REF:0000024
(PMID:25395621)
PMID:21873635
UniProt
RGD
PMID:25395621, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:40,086,513...40,100,966
Ensembl chr 1:40,086,470...40,101,840
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 acts_upstream_of_or_within ISO MGI:1856525 RGD MGI:85368 NCBI chr11:35,011,007...35,262,362
Ensembl chr11:35,024,196...35,099,383
JBrowse link
G Reln reelin acts_upstream_of_or_within ISO MGI:1856398 RGD MGI:85368 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670
JBrowse link
G Slc16a2 solute carrier family 16 member 2 acts_upstream_of ISO UniProtKB:P55073 (PMID:26305885) RGD PMID:26305885 NCBI chr  X:74,578,600...74,706,068
Ensembl chr  X:74,577,131...74,706,214
JBrowse link
G Slco4a1 solute carrier organic anion transporter family, member 4a1 IDA RGD PMID:11316767 RGD:727314 NCBI chr 3:175,838,994...175,857,985
Ensembl chr 3:175,838,994...175,857,983
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 involved_in ISO (PMID:9443824)
(PMID:11368519)
RGD PMID:9443824 PMID:11368519 NCBI chr14:22,142,412...22,155,246
Ensembl chr14:22,142,364...22,155,231
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 involved_in ISO (PMID:10199779) RGD PMID:10199779 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Tg thyroglobulin acts_upstream_of_or_within ISO MGI:1856829 (MGI:57033|PMID:3803305) RGD PMID:3803305 MGI:57033 NCBI chr 7:107,467,260...107,652,897
Ensembl chr 7:107,467,260...107,652,899
JBrowse link
G Ttr transthyretin TAS RGD PMID:11995998 RGD:737655 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
positive regulation of thyroid hormone generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata3 GATA binding protein 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:19248180), (PMID:19723756)
UniProt
RGD
PMID:19248180 PMID:19723756 GO_REF:0000024 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Hpn hepsin involved_in ISS
ISO
GO_REF:0000024
(MGI:3719967|PMID:17620368)
UniProt
RGD
PMID:17620368 GO_REF:0000024 MGI:3719967 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967
JBrowse link
G Pax8 paired box 8 involved_in ISO
ISS
(PMID:15356023)
(MGI:3691903|PMID:12586753)
GO_REF:0000024
RGD
UniProt
PMID:12586753 PMID:15356023 GO_REF:0000024 MGI:3691903 NCBI chr 3:1,527,316...1,586,019
Ensembl chr 3:1,527,279...1,584,946
JBrowse link
G Slco1c1 solute carrier organic anion transporter family, member 1c1 involved_in ISO
IEA
(PMID:18566113)
GO_REF:0000107
RGD
Ensembl
PMID:18566113 GO_REF:0000107 NCBI chr 4:175,729,709...175,776,749
Ensembl chr 4:175,729,726...175,776,808
JBrowse link
regulation of thyroid hormone generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Duoxa1 dual oxidase maturation factor 1 acts_upstream_of_or_within ISO MGI:1914061 (MGI:5544584|PMID:22301785) RGD PMID:22301785 MGI:5544584 NCBI chr 3:114,241,057...114,251,720
Ensembl chr 3:114,241,057...114,251,647
JBrowse link
G Duoxa2 dual oxidase maturation factor 2 acts_upstream_of_or_within ISO MGI:2384861 (MGI:5544584|PMID:22301785) RGD PMID:22301785 MGI:5544584 NCBI chr 3:114,236,718...114,240,086
Ensembl chr 3:114,236,718...114,240,086
JBrowse link
thyroid hormone catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dio2 iodothyronine deiodinase 2 acts_upstream_of_or_within ISO MGI:2182450 (MGI:2154044|PMID:11731615) RGD PMID:11731615 MGI:2154044 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dio3 iodothyronine deiodinase 3 involved_in
acts_upstream_of_or_within
ISO (MGI:4441081|PMID:20203194)
MGI:2664293 (MGI:3615073|PMID:16410833), (MGI:4441081|PMID:20203194), (MGI:5578402|PMID:25002520)
RGD PMID:16410833 PMID:20203194 PMID:25002520 MGI:3615073 MGI:4441081 MGI:5578402 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
JBrowse link
thyroid hormone generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cga glycoprotein hormones, alpha polypeptide involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1857152 (MGI:1316794|PMID:12114718)
RGD PMID:12114718, PMID:21873635 MGI:1316794, RGD:13792537 NCBI chr 5:50,362,491...50,393,368
Ensembl chr 5:50,381,244...50,393,367
JBrowse link
G Cpq carboxypeptidase Q involved_in IDA
IBA
PMID:22127294
PMID:21873635
UniProt
GO_Central
PMID:22127294, PMID:21873635 RGD:8554022, RGD:13792537 NCBI chr 7:71,709,174...72,167,413
Ensembl chr 7:71,709,157...72,167,417
JBrowse link
G Ctsb cathepsin B involved_in IEA
ISO
GO_REF:0000107
(MGI:2664014|PMID:12782676)
Ensembl
RGD
PMID:12782676 GO_REF:0000107 MGI:2664014 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Ctsk cathepsin K involved_in ISO
ISS
(PMID:11082042)
(MGI:2664014|PMID:12782676)
GO_REF:0000024
RGD
UniProt
PMID:11082042 PMID:12782676 GO_REF:0000024 MGI:2664014 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Ctsl cathepsin L involved_in ISO (MGI:2664014|PMID:12782676) RGD PMID:12782676 MGI:2664014 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Dio2 iodothyronine deiodinase 2 IDA RGD PMID:15550511 RGD:1626436 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Duox1 dual oxidase 1 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 3:114,251,794...114,286,827
Ensembl chr 3:114,253,637...114,286,802
JBrowse link
G Duox2 dual oxidase 2 involved_in TAS
IEA
GO_REF:0000041 UniProt PMID:12538618 GO_REF:0000041, RGD:632568 NCBI chr 3:114,218,187...114,237,808
Ensembl chr 3:114,218,193...114,235,933
JBrowse link
G Foxe1 forkhead box E1 acts_upstream_of_or_within ISO MGI:2181780 (MGI:1276273|PMID:9697704) RGD PMID:9697704 MGI:1276273 NCBI chr 5:61,954,549...61,957,357
Ensembl chr 5:61,954,549...61,957,357
JBrowse link
G Med1 mediator complex subunit 1 acts_upstream_of_or_within ISO MGI:1861125 (MGI:1355642|PMID:10882104) RGD PMID:10882104 MGI:1355642 NCBI chr10:86,101,560...86,145,271
Ensembl chr10:86,103,600...86,144,880
JBrowse link
G Slc16a10 solute carrier family 16 member 10 involved_in
acts_upstream_of_or_within_negative_effect
IEA
ISO
GO_REF:0000107
MGI:1203732 (MGI:5604693|PMID:24248460)
Ensembl
RGD
PMID:24248460 GO_REF:0000107 MGI:5604693 NCBI chr20:45,138,433...45,260,155
Ensembl chr20:45,143,453...45,260,119
JBrowse link
G Slc16a2 solute carrier family 16 member 2 involved_in
acts_upstream_of_or_within_negative_effect
IEA
ISO
GO_REF:0000107
MGI:1919722|MGI:3710233 (MGI:5604693|PMID:24248460)
Ensembl
RGD
PMID:24248460 GO_REF:0000107 MGI:5604693 NCBI chr  X:74,578,600...74,706,068
Ensembl chr  X:74,577,131...74,706,214
JBrowse link
G Slc5a5 solute carrier family 5 member 5 involved_in TAS
IEA
GO_REF:0000002 InterPro PMID:8559252 GO_REF:0000002, RGD:68854 NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400
JBrowse link
G Tg thyroglobulin involved_in TAS
ISO
IEA
IBA
IDA
(MGI:2664014|PMID:12782676)
GO_REF:0000107
(PMID:11082042), (PMID:12387814)
(PMID:32025030)
PMID:21873635
RGD
Ensembl
PMID:11082042 PMID:12387814 PMID:12782676 PMID:32025030, PMID:11884402, PMID:21873635, PMID:3953233 GO_REF:0000107 MGI:2664014, RGD:728752, RGD:13792537, RGD:1600150 NCBI chr 7:107,467,260...107,652,897
Ensembl chr 7:107,467,260...107,652,899
JBrowse link
G Tpo thyroid peroxidase involved_in TAS
ISO
IEA
(PMID:12387814)
GO_REF:0000041
RGD
UniProt
PMID:12387814, PMID:15917231 GO_REF:0000041, RGD:1599649 NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      hormone metabolic process 232
        thyroid hormone metabolic process 34
          thyroid hormone catabolic process 2
          thyroid hormone generation + 21
Path 2
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      cellular metabolic process 10755
        cellular aromatic compound metabolic process 5636
          phenol-containing compound metabolic process 126
            thyroid hormone metabolic process 34
              thyroid hormone catabolic process 2
              thyroid hormone generation + 21
paths to the root