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late onset Parkinson's disease - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:late onset Parkinson's disease
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Accession:DOID:0060892 term browser browse the term
Definition:A Parkinson's disease characterized by onset of motor symptoms typically after 60 years of age. (DO)
Synonyms:exact_synonym: PD;   late onset Parkinson disease;   late onset Parkinson disease, hereditary
 narrow_synonym: PARK;   PARK18;   PARK24
 broad_synonym: ATXN3-RELATED CONDITION
 related_synonym: EIF4G1-RELATED CONDITION;   Parkinson disease 18, autosomal dominant, susceptibility to;   Parkinson disease 24, autosomal dominant, susceptibility to;   Parkinson disease, late-onset, susceptibility to;   Parkinson's disease 18, autosomal dominant, susceptibility to;   Parkinson's disease, late-onset, susceptibility to
 xref: MIM:168600;   MIM:614251;   MIM:619491;   MONDO:0008199;   ORDO:411602

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late onset Parkinson's disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar
OMIM		 PMID:25741868 NCBI chr 2:229,470,703...229,482,291
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Atxn2 ataxin 2 susceptibility ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar
OMIM		 NCBI chr12:40,413,657...40,509,895
Ensembl chr12:34,754,137...34,851,479 		JBrowse link
G Atxn3 ataxin 3 ISO ClinVar Annotator: match by term: ATXN3-related condition ClinVar
OMIM		 PMID:24033266 PMID:25741868 PMID:37091313 NCBI chr 6:126,837,107...126,872,919
Ensembl chr 6:121,074,448...121,107,902 		JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar PMID:25741868 PMID:28492532 NCBI chr 4:6,010,081...6,232,052
Ensembl chr 4:5,452,683...5,556,659 		JBrowse link
G Dnajc13 DnaJ heat shock protein family (Hsp40) member C13 ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar PMID:24218364 PMID:25118025 PMID:27270108 NCBI chr 8:113,646,573...113,756,104
Ensembl chr 8:104,767,788...104,877,317 		JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4 gamma 1 ISO ClinVar Annotator: match by term: EIF4G1-related condition | ClinVar Annotator: match by term: Parkinson disease 18, autosomal dominant, susceptibility to OMIM
ClinVar		 PMID:21907011 PMID:23408866 PMID:25368108 PMID:25741868 PMID:28492532 NCBI chr11:93,726,322...93,746,387
Ensembl chr11:80,221,919...80,241,941 		JBrowse link
G Fgf20 fibroblast growth factor 20 ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar PMID:18252210 PMID:19133659 PMID:25741868 NCBI chr16:58,734,003...58,741,650
Ensembl chr16:52,010,194...52,038,204 		JBrowse link
G Gba1 glucosylceramidase beta 1 ISO ClinVar Annotator: match by term: Hereditary late onset Parkinson disease | ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar
OMIM		 PMID:1333717 PMID:1348297 PMID:1415223 PMID:1487244 PMID:1558964 More... NCBI chr 2:176,902,141...176,916,015
Ensembl chr 2:174,609,403...174,618,263 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 susceptibility ISO DNA:polymorphism:exon:A>G313 (human) RGD PMID:17250723 RGD:5148021 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar PMID:15680455 PMID:15680456 PMID:15680457 PMID:15726496 PMID:15732108 More... NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Mapt microtubule-associated protein tau ISO ClinVar Annotator: match by term: Hereditary late onset Parkinson disease | ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar
OMIM		 PMID:2273997 PMID:8673924 PMID:9382467 PMID:9629852 PMID:9641683 More... NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar PMID:8104867 PMID:15972314 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar PMID:12496759 PMID:15079038 PMID:15184637 PMID:19429166 PMID:23066323 More... NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Park7 Parkinsonism associated deglycase ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Pink1 PTEN induced kinase 1 ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Podxl podocalyxin-like ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar PMID:26864383 PMID:28492532 NCBI chr 4:61,102,434...61,149,131
Ensembl chr 4:60,135,109...60,181,899 		JBrowse link
G Psap prosaposin susceptibility ISO ClinVar Annotator: match by term: PARKINSON DISEASE 24, AUTOSOMAL DOMINANT, SUSCEPTIBILITY TO | ClinVar Annotator: match by term: Parkinson disease 24, autosomal dominant, susceptibility to | ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar
OMIM		 PMID:1350885 PMID:1371116 PMID:2019586 PMID:2302219 PMID:2320574 More... NCBI chr20:28,756,951...28,783,422
Ensembl chr20:28,214,271...28,240,498 		JBrowse link
G RT1-Da RT1 class II, locus Da ISO DNA:SNP:intron: (rs3129882) (human) RGD PMID:21791235 RGD:5490156 NCBI chr20:4,515,393...4,520,387
Ensembl chr20:4,512,911...4,518,455 		JBrowse link
G Sncaip synuclein, alpha interacting protein ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar PMID:12761037 PMID:18366718 PMID:25741868 PMID:28492532 NCBI chr18:48,402,164...48,542,246
Ensembl chr18:46,207,152...46,343,929 		JBrowse link
G Tbp TATA box binding protein susceptibility ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar
OMIM		 PMID:25741868 NCBI chr 1:65,136,420...65,153,515
Ensembl chr 1:56,463,618...56,510,016 		JBrowse link
G Vps35 VPS35 retromer complex component ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar NCBI chr19:37,938,989...37,974,887
Ensembl chr19:21,765,749...21,801,618 		JBrowse link
Parkinson's disease 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmrn1 multimerin 1 ISO ClinVar Annotator: match by term: Autosomal dominant Parkinson disease 1 ClinVar PMID:14593171 PMID:14755720 PMID:15451224 PMID:15451225 PMID:16358335 More... NCBI chr 4:89,875,408...89,950,814
Ensembl chr 4:89,903,174...89,950,474 		JBrowse link
G Snca synuclein alpha ISO
ISS		 ClinVar Annotator: match by term: Autosomal dominant Parkinson disease 1
OMIM:168601		 OMIM
ClinVar
MouseDO		 PMID:9197268 PMID:9462735 PMID:9499430 PMID:9506559 PMID:9827625 More... NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
Parkinson's disease 14 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pla2g6 phospholipase A2 group VI ISO
ISS		 OMIM:612953
ClinVar Annotator: match by term: Autosomal recessive Parkinson disease 14 | ClinVar Annotator: match by term: DYSTONIA-PARKINSONISM, ADULT-ONSET		 OMIM
MouseDO
ClinVar		 PMID:2668131 PMID:16783378 PMID:18359254 PMID:18414213 PMID:18443314 More... NCBI chr 7:112,731,803...112,771,978
Ensembl chr 7:110,851,378...110,891,114 		JBrowse link
G Slc39a14 solute carrier family 39 member 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:36152728 NCBI chr15:51,786,517...51,833,260
Ensembl chr15:45,376,917...45,423,524 		JBrowse link
Parkinson's disease 17 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mylk3 myosin light chain kinase 3 ISO ClinVar Annotator: match by term: Parkinson disease 17 ClinVar PMID:28492532 NCBI chr19:37,858,298...37,916,805
Ensembl chr19:21,691,929...21,742,954 		JBrowse link
G Orc6 origin recognition complex, subunit 6 ISO ClinVar Annotator: match by term: Parkinson disease 17 ClinVar PMID:25741868 PMID:28492532 NCBI chr19:21,757,867...21,765,638
Ensembl chr19:21,757,866...21,765,662 		JBrowse link
G Vps35 VPS35 retromer complex component ISO
ISS		 ClinVar Annotator: match by term: Parkinson disease 17 | ClinVar Annotator: match by term: VPS35-related condition
OMIM:614203		 OMIM
ClinVar
MouseDO		 PMID:9536098 PMID:17576681 PMID:18342564 PMID:21763482 PMID:21763483 More... NCBI chr19:37,938,989...37,974,887
Ensembl chr19:21,765,749...21,801,618 		JBrowse link
Parkinson's disease 21 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnajc13 DnaJ heat shock protein family (Hsp40) member C13 ISO ClinVar Annotator: match by term: Parkinson disease 21 ClinVar PMID:24218364 PMID:25118025 PMID:27270108 PMID:28492532 NCBI chr 8:113,646,573...113,756,104
Ensembl chr 8:104,767,788...104,877,317 		JBrowse link
Parkinson's disease 22 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chchd2 coiled-coil-helix-coiled-coil-helix domain containing 2 ISO ClinVar Annotator: match by term: CHCHD2-related condition | ClinVar Annotator: match by term: Parkinson disease 22, autosomal dominant OMIM
ClinVar		 PMID:23806086 PMID:24088041 PMID:25662902 PMID:25687216 PMID:25741868 More... NCBI chr12:32,464,847...32,470,871
Ensembl chr12:26,828,736...26,834,755 		JBrowse link
Parkinson's disease 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snca synuclein alpha ISO
ISS		 CTD Direct Evidence: marker/mechanism
OMIM:605543
ClinVar Annotator: match by term: Autosomal dominant Parkinson disease 4		 OMIM
CTD
MouseDO
ClinVar		 PMID:9197268 PMID:9499430 PMID:9506559 PMID:9827625 PMID:10417297 More... NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
Parkinson's disease 8 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrk2 leucine-rich repeat kinase 2 ISO
ISS		 DNA:missense mutation:cds:p.G2385R (human)
ClinVar Annotator: match by term: Autosomal dominant Parkinson disease 8 | ClinVar Annotator: match by term: LRRK2-related condition
OMIM:607060		 ClinVar
MouseDO
OMIM
RGD		 PMID:7898705 PMID:9276200 PMID:9536098 PMID:15541308 PMID:15541309 More... RGD:5508405 NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19140
    Nutritional and Metabolic Diseases 8545
      disease of metabolism 8545
        Proteostasis Deficiencies 811
          synucleinopathy 410
            Parkinson's disease 373
              late onset Parkinson's disease 28
                Parkinson's disease 1 2
                Parkinson's disease 14 2
                Parkinson's disease 17 3
                Parkinson's disease 21 1
                Parkinson's disease 22 1
                Parkinson's disease 3 0
                Parkinson's disease 4 1
                Parkinson's disease 8 1
Path 2
Term Annotations click to browse term
  disease 19140
    disease of anatomical entity 18453
      nervous system disease 14363
        central nervous system disease 12640
          brain disease 11858
            movement disease 2631
              Parkinsonism 455
                Parkinson's disease 373
                  late onset Parkinson's disease 28
                    Parkinson's disease 1 2
                    Parkinson's disease 14 2
                    Parkinson's disease 17 3
                    Parkinson's disease 21 1
                    Parkinson's disease 22 1
                    Parkinson's disease 3 0
                    Parkinson's disease 4 1
                    Parkinson's disease 8 1
paths to the root