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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyranoxanthones
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Accession:CHEBI:71238 term browser browse the term
Definition:Any organic heterotetracyclic compound that consists of a pyran ring fused onto a xanthone skeleton.


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(-)-gambogic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO [gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of CASP7 protein; [gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of PARP1 protein; Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of CASP7 protein]; Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of PARP1 protein]; gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin] CTD PMID:25824409 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO gambogic acid affects the localization of AIFM1 protein CTD PMID:19464570 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases activity ISO gambogic acid results in decreased activity of AKT1 protein CTD PMID:19433130 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO gambogic acid results in increased expression of BAX mRNA CTD PMID:15968715 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
decreases expression
multiple interactions
ISO gambogic acid affects the expression of BCL2 protein
gambogic acid results in decreased expression of BCL2 mRNA
[Verapamil co-treated with gambogic acid] results in decreased expression of BCL2 protein; Fluorouracil promotes the reaction [gambogic acid results in decreased expression of BCL2 mRNA]
CTD PMID:15968715, PMID:19084572, PMID:19433130, PMID:24373880 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
affects expression
ISO [gambogic acid co-treated with Doxorubicin] affects the expression of BIRC5 protein; SB 203580 affects the reaction [[gambogic acid co-treated with Doxorubicin] affects the expression of BIRC5 protein]
gambogic acid affects the expression of BIRC5 protein
CTD PMID:25824409 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
ISO [gambogic acid co-treated with Bortezomib] results in increased activity of CASP3 protein; [Verapamil co-treated with gambogic acid] results in increased cleavage of and results in increased activity of CASP3 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[gambogic acid co-treated with Bortezomib] results in increased activity of CASP3 protein]; Fluorouracil promotes the reaction [gambogic acid results in decreased expression of CASP3 mRNA] CTD PMID:19084572, PMID:24291039, PMID:24373880 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO [gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of CASP7 protein; Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of CASP7 protein] CTD PMID:25824409 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [gambogic acid co-treated with Bortezomib] results in increased activity of CASP8 protein; [Verapamil co-treated with gambogic acid] results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:24291039, PMID:24373880 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 decreases expression
multiple interactions
ISO gambogic acid results in decreased expression of CASP9 protein alternative form
[gambogic acid co-treated with Bortezomib] results in increased activity of CASP9 protein; [Verapamil co-treated with gambogic acid] results in increased cleavage of and results in increased activity of CASP9 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[gambogic acid co-treated with Bortezomib] results in increased activity of CASP9 protein]
CTD PMID:19464570, PMID:24291039, PMID:24373880 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO [Verapamil co-treated with gambogic acid] results in increased expression of DDIT3 protein; Bortezomib promotes the reaction [gambogic acid results in increased expression of DDIT3 protein]; gambogic acid promotes the reaction [Bortezomib results in increased expression of DDIT3 protein] CTD PMID:24291039, PMID:24373880 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity ISO gambogic acid results in decreased activity of GSK3B protein CTD PMID:19433130 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
ISO Bortezomib promotes the reaction [gambogic acid results in increased expression of HSPA5 protein]; gambogic acid promotes the reaction [Bortezomib results in increased expression of HSPA5 protein] CTD PMID:24291039 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ncoa3 nuclear receptor coactivator 3 decreases expression ISO gambogic acid results in decreased expression of NCOA3 CTD PMID:19433130 NCBI chr 3:162,692,176...162,788,582
Ensembl chr 3:162,692,185...162,787,548
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
decreases expression
ISO gambogic acid results in increased cleavage of PARP1 protein
[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of PARP1 protein; [Verapamil co-treated with gambogic acid] results in increased cleavage of PARP1 protein; Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[Verapamil co-treated with gambogic acid] results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Bortezomib promotes the reaction [gambogic acid results in increased cleavage of PARP1 protein]]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [gambogic acid promotes the reaction [Bortezomib results in increased cleavage of PARP1 protein]]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [[Verapamil co-treated with gambogic acid] results in increased cleavage of PARP1 protein]; Bortezomib promotes the reaction [gambogic acid results in increased cleavage of PARP1 protein]; Fluorouracil promotes the reaction [gambogic acid results in decreased expression of PARP1 mRNA]; Fluorouracil promotes the reaction [gambogic acid results in increased cleavage of PARP1 protein]; gambogic acid promotes the reaction [Bortezomib results in increased cleavage of PARP1 protein]
CTD PMID:19084572, PMID:19464570, PMID:24291039, PMID:24373880, PMID:25824409 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases activity ISO gambogic acid results in decreased activity of RPS6KB1 protein CTD PMID:19433130 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Tyms thymidylate synthetase decreases expression
multiple interactions
ISO gambogic acid results in decreased expression of TYMS mRNA
gambogic acid inhibits the reaction [Fluorouracil results in increased expression of TYMS mRNA]
CTD PMID:19084572 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
G Umps uridine monophosphate synthetase multiple interactions
increases expression
ISO Fluorouracil promotes the reaction [gambogic acid results in increased expression of UMPS mRNA] CTD PMID:19084572 NCBI chr11:70,034,181...70,044,590
Ensembl chr11:70,034,139...70,044,628
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      atom 19782
        nonmetal atom 19657
          oxygen atom 19321
            oxygen molecular entity 19321
              organooxygen compound 18777
                oxacycle 17181
                  pyranoxanthones 18
                    (-)-gambogic acid 18
                    1,5,6-trihydroxy-6',6'-dimethyl-2H-pyrano(2',3':3,4)-2-(3-methylbut-2-enyl)xanthone 0
                    1,6,7-trihydroxy-6',6'-dimethyl-2H-pyrano(2',3':3,2)-4-(3-methylbut-2-enyl)xanthone 0
                    6-Deoxyjacareubin 0
                    Dehydrocycloguanandin 0
                    Jacareubin 0
                    LSM-4437 0
                    Macluraxanthone 0
                    artoindonesianin A 0
                    artonol C 0
                    blancoxanthone 0
                    brasixanthone B 0
                    brasixanthone C 0
                    brasixanthone D 0
                    cochinensoxanthone 0
                    jacarelhyperol A 0
                    jacarelhyperol B 0
                    yahyaxanthone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      ketone 16140
                                        cyclic ketone 13810
                                          pyranoxanthones 18
                                            (-)-gambogic acid 18
                                            1,5,6-trihydroxy-6',6'-dimethyl-2H-pyrano(2',3':3,4)-2-(3-methylbut-2-enyl)xanthone 0
                                            1,6,7-trihydroxy-6',6'-dimethyl-2H-pyrano(2',3':3,2)-4-(3-methylbut-2-enyl)xanthone 0
                                            6-Deoxyjacareubin 0
                                            Dehydrocycloguanandin 0
                                            Jacareubin 0
                                            LSM-4437 0
                                            Macluraxanthone 0
                                            artoindonesianin A 0
                                            artonol C 0
                                            blancoxanthone 0
                                            brasixanthone B 0
                                            brasixanthone C 0
                                            brasixanthone D 0
                                            cochinensoxanthone 0
                                            jacarelhyperol A 0
                                            jacarelhyperol B 0
                                            yahyaxanthone 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.