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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyranoxanthones
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Accession:CHEBI:71238 term browser browse the term
Definition:Any organic heterotetracyclic compound that consists of a pyran ring fused onto a xanthone skeleton.


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(-)-gambogic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO [gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of CASP7 protein; [gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of PARP1 protein; Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of CASP7 protein]; Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of PARP1 protein]; gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin] CTD PMID:25824409 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO gambogic acid affects the localization of AIFM1 protein CTD PMID:19464570 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases activity
decreases expression
ISO gambogic acid results in decreased activity of AKT1 protein
gambogic acid results in decreased expression of AKT1 mRNA
CTD PMID:19433130 PMID:33533530 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt2 AKT serine/threonine kinase 2 decreases expression ISO gambogic acid results in decreased expression of AKT2 mRNA CTD PMID:33533530 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO gambogic acid results in increased expression of BAX mRNA CTD PMID:15968715 PMID:33533530 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
decreases expression
multiple interactions
ISO gambogic acid affects the expression of BCL2 protein
gambogic acid results in decreased expression of BCL2 mRNA
[Verapamil co-treated with gambogic acid] results in decreased expression of BCL2 protein; Fluorouracil promotes the reaction [gambogic acid results in decreased expression of BCL2 mRNA]
CTD PMID:15968715 PMID:19084572 PMID:19433130 PMID:24373880 PMID:33533530 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
affects expression
ISO [gambogic acid co-treated with Doxorubicin] affects the expression of BIRC5 protein; SB 203580 affects the reaction [[gambogic acid co-treated with Doxorubicin] affects the expression of BIRC5 protein]
gambogic acid affects the expression of BIRC5 protein
CTD PMID:25824409 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
ISO [gambogic acid co-treated with Bortezomib] results in increased activity of CASP3 protein; [Verapamil co-treated with gambogic acid] results in increased cleavage of and results in increased activity of CASP3 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[gambogic acid co-treated with Bortezomib] results in increased activity of CASP3 protein]; Fluorouracil promotes the reaction [gambogic acid results in decreased expression of CASP3 mRNA] CTD PMID:19084572 PMID:24291039 PMID:24373880 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions ISO [gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of CASP7 protein; Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of CASP7 protein] CTD PMID:25824409 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [gambogic acid co-treated with Bortezomib] results in increased activity of CASP8 protein; [Verapamil co-treated with gambogic acid] results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:24291039 PMID:24373880 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 decreases expression
multiple interactions
ISO gambogic acid results in decreased expression of CASP9 protein alternative form
[gambogic acid co-treated with Bortezomib] results in increased activity of CASP9 protein; [Verapamil co-treated with gambogic acid] results in increased cleavage of and results in increased activity of CASP9 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[gambogic acid co-treated with Bortezomib] results in increased activity of CASP9 protein]
CTD PMID:19464570 PMID:24291039 PMID:24373880 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO [Verapamil co-treated with gambogic acid] results in increased expression of DDIT3 protein; Bortezomib promotes the reaction [gambogic acid results in increased expression of DDIT3 protein]; gambogic acid promotes the reaction [Bortezomib results in increased expression of DDIT3 protein] CTD PMID:24291039 PMID:24373880 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity ISO gambogic acid results in decreased activity of GSK3B protein CTD PMID:19433130 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
ISO Bortezomib promotes the reaction [gambogic acid results in increased expression of HSPA5 protein]; gambogic acid promotes the reaction [Bortezomib results in increased expression of HSPA5 protein] CTD PMID:24291039 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Ncoa3 nuclear receptor coactivator 3 decreases expression ISO gambogic acid results in decreased expression of NCOA3 CTD PMID:19433130 NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
decreases expression
ISO gambogic acid results in increased cleavage of PARP1 protein
[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of PARP1 protein; [Verapamil co-treated with gambogic acid] results in increased cleavage of PARP1 protein; Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[Verapamil co-treated with gambogic acid] results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Bortezomib promotes the reaction [gambogic acid results in increased cleavage of PARP1 protein]]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [gambogic acid promotes the reaction [Bortezomib results in increased cleavage of PARP1 protein]]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [[Verapamil co-treated with gambogic acid] results in increased cleavage of PARP1 protein]; Bortezomib promotes the reaction [gambogic acid results in increased cleavage of PARP1 protein]; Fluorouracil promotes the reaction [gambogic acid results in decreased expression of PARP1 mRNA]; Fluorouracil promotes the reaction [gambogic acid results in increased cleavage of PARP1 protein]; gambogic acid promotes the reaction [Bortezomib results in increased cleavage of PARP1 protein]
CTD PMID:19084572 PMID:19464570 PMID:24291039 PMID:24373880 PMID:25824409 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases activity ISO gambogic acid results in decreased activity of RPS6KB1 protein CTD PMID:19433130 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Tyms thymidylate synthetase decreases expression
multiple interactions
ISO gambogic acid results in decreased expression of TYMS mRNA
gambogic acid inhibits the reaction [Fluorouracil results in increased expression of TYMS mRNA]
CTD PMID:19084572 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Umps uridine monophosphate synthetase multiple interactions
increases expression
ISO Fluorouracil promotes the reaction [gambogic acid results in increased expression of UMPS mRNA] CTD PMID:19084572 NCBI chr11:66,806,107...66,816,520
Ensembl chr11:66,806,045...66,821,903
JBrowse link
G Wnt5a Wnt family member 5A decreases expression ISO gambogic acid results in decreased expression of WNT5A mRNA; gambogic acid results in decreased expression of WNT5A protein CTD PMID:33533530 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      atom 19819
        nonmetal atom 19707
          oxygen atom 19445
            oxygen molecular entity 19445
              organooxygen compound 19014
                oxacycle 17587
                  pyranoxanthones 20
                    (-)-gambogic acid 20
                    1,5,6-trihydroxy-6',6'-dimethyl-2H-pyrano(2',3':3,4)-2-(3-methylbut-2-enyl)xanthone 0
                    1,6,7-trihydroxy-6',6'-dimethyl-2H-pyrano(2',3':3,2)-4-(3-methylbut-2-enyl)xanthone 0
                    6,11-Dihydroxy-2,2-dimethylpyrano[3,2-c]xanthen-7(2H)-one 0
                    6-Deoxyjacareubin 0
                    Artobiloxanthone 0
                    Artonin A 0
                    Artonin B 0
                    Artonin F 0
                    Artonol A 0
                    Artonol B 0
                    Atroviridin 0
                    Cycloartobiloxanthone 0
                    Cycloartomunoxanthone 0
                    Dehydrocycloguanandin 0
                    Dulxanthone E 0
                    Dulxanthone F 0
                    Dulxanthone G 0
                    Dulxanthone H 0
                    Isomorellic acid 0
                    Jacareubin 0
                    LSM-4437 0
                    Macluraxanthone 0
                    O-Demethylforbexanthone 0
                    artoindonesianin A 0
                    artonol C 0
                    blancoxanthone 0
                    brasixanthone B 0
                    brasixanthone C 0
                    brasixanthone D 0
                    cochinensoxanthone 0
                    jacarelhyperol A 0
                    jacarelhyperol B 0
                    yahyaxanthone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      ketone 16923
                                        cyclic ketone 15391
                                          pyranoxanthones 20
                                            (-)-gambogic acid 20
                                            1,5,6-trihydroxy-6',6'-dimethyl-2H-pyrano(2',3':3,4)-2-(3-methylbut-2-enyl)xanthone 0
                                            1,6,7-trihydroxy-6',6'-dimethyl-2H-pyrano(2',3':3,2)-4-(3-methylbut-2-enyl)xanthone 0
                                            6,11-Dihydroxy-2,2-dimethylpyrano[3,2-c]xanthen-7(2H)-one 0
                                            6-Deoxyjacareubin 0
                                            Artobiloxanthone 0
                                            Artonin A 0
                                            Artonin B 0
                                            Artonin F 0
                                            Artonol A 0
                                            Artonol B 0
                                            Atroviridin 0
                                            Cycloartobiloxanthone 0
                                            Cycloartomunoxanthone 0
                                            Dehydrocycloguanandin 0
                                            Dulxanthone E 0
                                            Dulxanthone F 0
                                            Dulxanthone G 0
                                            Dulxanthone H 0
                                            Isomorellic acid 0
                                            Jacareubin 0
                                            LSM-4437 0
                                            Macluraxanthone 0
                                            O-Demethylforbexanthone 0
                                            artoindonesianin A 0
                                            artonol C 0
                                            blancoxanthone 0
                                            brasixanthone B 0
                                            brasixanthone C 0
                                            brasixanthone D 0
                                            cochinensoxanthone 0
                                            jacarelhyperol A 0
                                            jacarelhyperol B 0
                                            yahyaxanthone 0
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