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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isoimperatorin
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Accession:CHEBI:66071 term browser browse the term
Definition:A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 5. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.
Synonyms:exact_synonym: 4-[(3-methylbut-2-en-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one
 related_synonym: 7,4-[(3-methyl-2-butenyl)oxy]-7H-furo[3,2-g]-1-benzopyran-7-one;   Formula=C16H14O4;   InChI=1S/C16H14O4/c1-10(2)5-7-19-16-11-3-4-15(17)20-14(11)9-13-12(16)6-8-18-13/h3-6,8-9H,7H2,1-2H3;   InChIKey=IGWDEVSBEKYORK-UHFFFAOYSA-N;   SMILES=CC(C)=CCOc1c2ccoc2cc2oc(=O)ccc12
 xref: CAS:482-45-1;   KEGG:C16976
 xref_mesh: MESH:C055542
 xref: PMID:12510838;   PMID:17396918;   PMID:20964319;   PMID:21627108;   Patent:CN102188464;   Reaxys:1291723



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isoimperatorin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 increases expression ISO isoimperatorin results in increased expression of ABCC4 mRNA CTD PMID:22173200 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP isoimperatorin promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein] CTD PMID:16829687 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases oxidation ISO CYP1A2 protein results in increased oxidation of isoimperatorin CTD PMID:25500267 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases activity
ISO isoimperatorin inhibits the reaction [CYP1B1 protein results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol]
isoimperatorin results in decreased activity of CYP1B1 protein; isoimperatorin results in decreased activity of CYP1B1 protein polymorphism
CTD PMID:15861043 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases oxidation
multiple interactions
ISO CYP2B6 protein results in increased oxidation of isoimperatorin
[isoimperatorin co-treated with NADP] results in decreased activity of CYP2B6 protein; Mephenytoin inhibits the reaction [[isoimperatorin co-treated with NADP] results in decreased activity of CYP2B6 protein]
CTD PMID:25500267 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases oxidation ISO CYP2D6 protein results in increased oxidation of isoimperatorin CTD PMID:25500267 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO isoimperatorin results in increased expression of GSTA2 mRNA CTD PMID:16829687 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO isoimperatorin results in increased expression of HMOX1 CTD PMID:19642688 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization EXP isoimperatorin affects the localization of NFE2L2 protein CTD PMID:16829687 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Slc22a1 solute carrier family 22 member 1 increases expression ISO isoimperatorin results in increased expression of SLC22A1 protein CTD PMID:22173200 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a12 solute carrier family 22 member 12 decreases expression
increases expression
ISO isoimperatorin results in decreased expression of SLC22A12 mRNA
isoimperatorin results in increased expression of SLC22A12 protein
CTD PMID:22173200 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
JBrowse link
G Slc22a2 solute carrier family 22 member 2 increases expression
decreases expression
ISO isoimperatorin results in increased expression of SLC22A2 protein
isoimperatorin results in decreased expression of SLC22A2 mRNA
CTD PMID:22173200 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases expression ISO isoimperatorin results in increased expression of SLC22A5 protein CTD PMID:22173200 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases expression ISO isoimperatorin results in decreased expression of SLC22A6 protein CTD PMID:22173200 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases expression ISO isoimperatorin results in increased expression of SLC22A8 mRNA; isoimperatorin results in increased expression of SLC22A8 protein CTD PMID:22173200 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc2a9 solute carrier family 2 member 9 increases expression
decreases expression
ISO isoimperatorin results in increased expression of SLC2A9 mRNA
isoimperatorin results in decreased expression of SLC2A9 protein
CTD PMID:22173200 NCBI chr14:72,328,334...72,461,981
Ensembl chr14:72,328,320...72,461,981
JBrowse link

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  CHEBI ontology 19918
    role 19894
      biological role 19892
        biochemical role 19588
          metabolite 19574
            isoimperatorin 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic molecule 19758
                              organic cyclic compound 19565
                                organic heterocyclic compound 18906
                                  organic heteropolycyclic compound 18334
                                    organic heterotricyclic compound 15667
                                      furochromene 128
                                        furanocoumarin 128
                                          psoralens 119
                                            isoimperatorin 16
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