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ONTOLOGY REPORT - ANNOTATIONS


Term:aphidicolin
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Accession:CHEBI:2766 term browser browse the term
Definition:A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positions 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication.
Synonyms:exact_synonym: (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalene-3,9-diol
 related_synonym: (3alpha,4alpha,5alpha,17alpha)-3,17-dihydroxy-4-methyl-9,15-cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol;   Formula=C20H34O4;   InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1;   InChIKey=NOFOAYPPHIUXJR-APNQCZIXSA-N;   SMILES=[C@]12([C@]([C@@]([C@@H](CC1)O)(CO)C)(CC[C@@]3([C@@]24CC[C@]([C@H](C3)C4)(O)CO)[H])[H])C;   aphidocolin
 xref: Beilstein:4689958 "ChemIDplus";   CAS:38966-21-1 "ChemIDplus";   CAS:38966-21-1 "KEGG COMPOUND";   KEGG:C06088;   KNApSAcK:C00000873;   KNApSAcK:C00023944
 xref_mesh: MESH:D016590
 xref: MetaCyc:CPD-11426;   PMID:10592317 "Europe PMC";   PMID:1483268 "Europe PMC";   PMID:19735659 "Europe PMC";   PMID:21212237 "Europe PMC";   PMID:21444690 "Europe PMC";   PMID:21708134 "Europe PMC";   PMID:21812410 "Europe PMC";   PMID:21897020 "Europe PMC";   PMID:21917855 "Europe PMC";   PMID:22139884 "Europe PMC";   PMID:22210918 "Europe PMC";   PMID:22262459 "Europe PMC";   PMID:22293751 "Europe PMC";   PMID:22302683 "Europe PMC";   PMID:22339690 "Europe PMC";   PMID:22365495 "Europe PMC";   PMID:24492257 "Europe PMC";   PMID:25948499 "Europe PMC";   PMID:26255574 "Europe PMC";   PMID:26854444 "Europe PMC";   PMID:7478586 "Europe PMC";   Patent:US3761512;   Reaxys:2055641 "Reaxys";   Wikipedia:Aphidicolin


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aphidicolin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:6480464
G Atr ATR serine/threonine kinase JBrowse link 8 103,673,578 103,770,886 RGD:6480464
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin JBrowse link 1 225,035,956 225,046,137 RGD:6480464
G Ccna2 cyclin A2 JBrowse link 2 123,274,727 123,282,266 RGD:6480464
G Chek1 checkpoint kinase 1 JBrowse link 8 39,181,162 39,201,588 RGD:6480464
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:6480464
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 JBrowse link 1 256,382,861 256,386,729 RGD:6480464
G Fgf8 fibroblast growth factor 8 JBrowse link 1 265,492,949 265,498,965 RGD:6480464
G H2ax H2A.X variant histone JBrowse link 8 48,665,652 48,666,981 RGD:6480464
G Hoxb9 homeo box B9 JBrowse link 10 84,119,772 84,124,963 RGD:6480464
G Hoxc6 homeo box C6 JBrowse link 7 144,612,230 144,626,036 RGD:6480464
G Pola1 DNA polymerase alpha 1, catalytic subunit JBrowse link X 62,382,604 62,698,830 RGD:6480464
G Prkdc protein kinase, DNA-activated, catalytic subunit JBrowse link 11 89,293,547 89,510,948 RGD:6480464
G Rxra retinoid X receptor alpha JBrowse link 3 6,272,560 6,295,354 RGD:6480464
G Srxn1 sulfiredoxin 1 JBrowse link 3 147,608,850 147,614,410 RGD:6480464
G Tbx6 T-box transcription factor 6 JBrowse link 1 198,214,797 198,218,706 RGD:6480464
G Tnfrsf8 TNF receptor superfamily member 8 JBrowse link 5 163,186,349 163,231,578 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Trim28 tripartite motif-containing 28 JBrowse link 1 65,544,369 65,551,043 RGD:6480464
G Wnt3a Wnt family member 3A JBrowse link 10 45,598,898 45,643,151 RGD:6480464
G Xrcc4 X-ray repair cross complementing 4 JBrowse link 2 18,674,496 18,927,463 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        antimicrobial agent 17154
          aphidicolin 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    main group molecular entity 19539
                      s-block molecular entity 19322
                        hydrogen molecular entity 19312
                          hydrides 18241
                            organic hydride 17532
                              organic fundamental parent 17532
                                hydrocarbon 16937
                                  terpene 9232
                                    diterpene 8136
                                      diterpenoid 8136
                                        tetracyclic diterpenoid 1427
                                          aphidicolin 21
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.