The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A carbobicyclic compound that is prostaglandin I2 in which the endocyclic oxygen is replaced by a methylene group and in which the (1E,3S)-3-hydroxyoct-1-en-1-yl side chain is replaced by a (3R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl group. A synthetic analogue of prostacyclin, it is used as the trometamol salt (generally by intravenous infusion) for the treatment of peripheral vascular disease and pulmonary hypertension.
Iloprost inhibits the reaction [BMP4 protein results in increased expression of SMAD6 mRNA]; Iloprost promotes the reaction [BMP4 protein results in increased expression of ID1 mRNA]; Iloprost promotes the reaction [BMP4 protein results in increased expression of ID1 protein]
Iloprost inhibits the reaction [BMPR2 gene mutant form results in decreased expression of ID1 protein]; Iloprost promotes the reaction [BMP4 protein results in increased expression of ID1 mRNA]; Iloprost promotes the reaction [BMP4 protein results in increased expression of ID1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Iloprost results in increased expression of ID1 mRNA] Iloprost results in increased expression of ID1 mRNA; Iloprost results in increased expression of ID1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Iloprost results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Iloprost results in increased phosphorylation of and results in increased activity of MAPK1 protein; RTKI cpd inhibits the reaction [Iloprost results in increased phosphorylation of and results in increased activity of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Iloprost results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Iloprost results in increased phosphorylation of and results in increased activity of MAPK3 protein; RTKI cpd inhibits the reaction [Iloprost results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Iloprost promotes the reaction [Adenosine Triphosphate results in increased secretion of TAC1 protein]; Iloprost promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]; Iloprost promotes the reaction [Kallidin results in increased secretion of TAC1 protein]; Iloprost promotes the reaction [Potassium Chloride results in increased secretion of TAC1 protein]
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