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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sulfoxide
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Accession:CHEBI:22063 term browser browse the term
Definition:An organosulfur compound having the structure R2S=O or R2C=S=O (R =/= H).
Synonyms:related_synonym: S-oxides;   sulfoxides
 alt_id: CHEBI:35813


show annotations for term's descendants           Sort by:
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Omeprazole results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347 		JBrowse link
G SLC22A6 solute carrier family 22 member 6 multiple interactions EXP [Omeprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican CTD PMID:36243147 NCBI chr18:53,736,669...53,745,001
Ensembl chr18:53,736,959...53,744,396 		JBrowse link
allicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP allicin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir] CTD PMID:15266218 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
lansoprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A6 solute carrier family 22 member 6 multiple interactions EXP [Lansoprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican CTD PMID:36243147 NCBI chr18:53,736,669...53,745,001
Ensembl chr18:53,736,959...53,744,396 		JBrowse link
omeprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Omeprazole results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347 		JBrowse link
G SLC22A6 solute carrier family 22 member 6 multiple interactions EXP [Omeprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican CTD PMID:36243147 NCBI chr18:53,736,669...53,745,001
Ensembl chr18:53,736,959...53,744,396 		JBrowse link
pantoprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A6 solute carrier family 22 member 6 multiple interactions EXP [Pantoprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican CTD PMID:36243147 NCBI chr18:53,736,669...53,745,001
Ensembl chr18:53,736,959...53,744,396 		JBrowse link
sulindac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP Sulindac results in decreased expression of PTGS2 protein CTD PMID:12857884 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit decreases localization EXP Sulindac results in decreased localization of RELA protein CTD PMID:12857884 NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 501
    chemical entity 501
      atom 501
        nonmetal atom 494
          sulfur atom 194
            sulfur molecular entity 194
              organosulfur compound 189
                sulfoxide 5
                  (2,3-diphenylcyclopropyl)methyl phenyl sulfoxide 0
                  (E)-Ajoene 0
                  (Methylsulfinyl)(methylthio)methane 0
                  (Methylsulfinyl)methanide 0
                  (R)-N-acetyl-S-benzyl-L-cysteine sulfoxide(1-) 0
                  (R)-N-acetyl-S-methyl-L-cysteine sulfoxide(1-) 0
                  (Z)-Ajoene 0
                  (Z)-Methyl 3-(methylsulfinyl)-1-propenyl disulfide 0
                  (Z)-[3-(Methylsulfinyl)-1-propenyl] 2-propenyl disulfide 0
                  (Z)-alkanethial S-oxide + 0
                  (methylsulfinyl)benzene + 0
                  1-(1-Propenylsulfinyl)propyl propyl disulfide 0
                  1-(2-Propenylsulfinyl)propyl propyl disulfide 0
                  1-(Methylsulfinyl)propyl 1-propenyl disulfide 0
                  1-(Methylsulfinyl)propyl 2-propenyl disulfide 0
                  1-(Methylsulfinyl)propyl propyl disulfide 0
                  1-Propenyl 1-(1-propenylsulfinyl)propyl disulfide 0
                  1-Propenyl 1-(2-propenylsulfinyl)propyl disulfide 0
                  1-Propenyl 1-(propylsulfinyl)propyl disulfide 0
                  1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5-[(2-methylprop-2-en-1-yl)amino]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile + 0
                  1-cyano-8-(methylsulfinyl)heptane 0
                  1-cyano-8-(methylsulfinyl)octane 0
                  1-isothiocyanato-5-(methylsulfinyl)pentane 0
                  1-isothiocyanato-6-(methylsulfinyl)hexane 0
                  1-isothiocyanato-7-(methylsulfinyl)heptane 0
                  1-isothiocyanato-9-(methylsulfinyl)nonane 0
                  1H-Benzimidazole, 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfonyl]- 0
                  2,5-dihydroxy-3-methanesulfinylbenzyl alcohol 0
                  2-(2-phenoxyethylsulfonyl)-1H-benzimidazole 0
                  2-(ethanesulfinyl)ethanol + 0
                  2-Propenyl 1-(1-propenylsulfinyl)propyl disulfide 0
                  2-Propenyl 1-(2-propenylsulfinyl)propyl disulfide 0
                  2-Propenyl 1-(propylsulfinyl)propyl disulfide 0
                  2-[(diphenylmethyl)sulfinyl]acetamide + 0
                  2-[5-cyclopropyl-3-(ethylsulfonyl)pyridin-2-yl]-5-[(trifluoromethyl)sulfinyl]-1,3-benzoxazole + 0
                  2-methylsulfinyl-4-hydroxy-6-methylthiophenyl-1-azoformamide 0
                  3-Hydroxyomeprazole 0
                  4-(4-chlorophenyl)sulfinyl-6-(methoxymethyl)-2-methylpyrimidine 0
                  4-(methylsulfinyl)phenol + 0
                  4-Hydroxysulfinpyrazone 0
                  4-\{2-[(3-hydroxyphenyl)sulfanyl]ethyl\}-1,2-diphenylpyrazolidine-3,5-dione 0
                  5'-O-Desmethyl omeprazole 0
                  5'-deoxy-5'-(methylsulfinyl)adenosine 0
                  5'-hydroxyomeprazole 0
                  5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile + 0
                  5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole + 2
                  6-(benzenesulfinyl)tetrazolo[1,5-b]pyridazine 0
                  6-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methylsulfinyl]-1H-benzimidazole 0
                  6-sinapoylglucoraphenin 0
                  7-(methylsulfinyl)heptylamine 0
                  8-(methylsulfinyl)octyl isothiocyanate 0
                  8-(methylsulfinyl)octylamine 0
                  9-(methylsulfinyl)nonamide 0
                  9-(methylsulfinyl)nonanoic acid 0
                  Allyl methyl sulfoxide 0
                  Bissulfine 0
                  Camelinin 0
                  Diphenyl sulfoxide 0
                  Diptocarpilidine 0
                  GW 501516 sulfoxide + 0
                  Glucoarabin 0
                  Glucohirsutin 0
                  Methyl 1-(1-propenylsulfinyl)propyl disulfide 0
                  Methyl 1-(2-propenylsulfinyl)propyl disulfide 0
                  Methyl 1-(methylsulfinyl)propyl disulfide 0
                  Methyl 1-(propylsulfinyl)propyl disulfide 0
                  Methyl benzyl sulfoxide 0
                  N(alpha)-(L-gamma-glutamyl)-hercynyl-L-cysteine sulfoxide 0
                  N(alpha)-(L-gamma-glutamyl)-hercynyl-L-selenocysteine 0
                  N-acetyl-S-(1Z)-propenyl-cysteine-sulfoxide 0
                  N-acetylalliin 0
                  Omeprazole sodium 0
                  Omeprazole sulfone 0
                  Oxydeprofos 0
                  Polyhydroxylated cyclic sulfoxide 0
                  Propyl 1-(propylsulfinyl)propyl disulfide 0
                  Ralfuranone E 0
                  Ro 18-5364 0
                  S-(5-histidyl)cysteine sulfoxide 0
                  S-alkyl-L-cysteine S-oxide + 0
                  S-propyl propanethiosulfinate 0
                  SB 203580 0
                  Sulfinemycin 0
                  Z-4,9-Diene-2,3,7-trithiadeca-7-oxide 0
                  acetoprole 0
                  albendazole S-oxide + 0
                  allicin 1
                  alliin + 0
                  biotin sulfoxide + 0
                  cenicriviroc 0
                  cimetidine S-oxide 0
                  dexlansoprazole 0
                  dexrabeprazole 0
                  diafenthiuron-S-oxide 0
                  dimethyl sulfoxide + 0
                  dimethyl sulfoxide-d6 0
                  fensulfothion 0
                  fulvestrant 0
                  glucoibarin 0
                  glucoiberin 0
                  glucoraphanin 0
                  glucoraphenin + 0
                  hercynylcysteine sulfoxide 0
                  hexahomomethionine S-oxide 0
                  iberin 0
                  ilaprazole 0
                  isoprothiolane sulfoxide 0
                  lansoprazole 1
                  lehualide J 0
                  magnesium 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methylsulfinyl]benzimidazol-1-ide 0
                  mannostatin B 0
                  mesoridazine + 0
                  methiocarb-sulfoxide 0
                  nitrosulindac 0
                  omega-[(methylsulfinyl)alkyl]glucosinolic acid + 0
                  oxfendazole 0
                  pantoprazole 1
                  pentahomomethionine S-oxide 0
                  phakellistatin 14 0
                  promazine sulfoxide 0
                  propanethial S-oxide + 0
                  rabeprazole 0
                  ranitidine-S-oxide 0
                  sulfinalol 0
                  sulfinpyrazone 0
                  sulforaphane + 0
                  sulindac + 2
                  sulmazole 0
                  sydoxanthone C 0
                  thiodiacetic acid sulfoxide 0
                  ustiloxin B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 501
    subatomic particle 501
      composite particle 501
        hadron 501
          baryon 501
            nucleon 501
              atomic nucleus 501
                atom 501
                  main group element atom 494
                    p-block element atom 494
                      carbon group element atom 483
                        carbon atom 482
                          organic molecular entity 482
                            heteroorganic entity 476
                              organochalcogen compound 430
                                organosulfur compound 189
                                  sulfoxide 5
                                    (2,3-diphenylcyclopropyl)methyl phenyl sulfoxide 0
                                    (E)-Ajoene 0
                                    (Methylsulfinyl)(methylthio)methane 0
                                    (Methylsulfinyl)methanide 0
                                    (R)-N-acetyl-S-benzyl-L-cysteine sulfoxide(1-) 0
                                    (R)-N-acetyl-S-methyl-L-cysteine sulfoxide(1-) 0
                                    (Z)-Ajoene 0
                                    (Z)-Methyl 3-(methylsulfinyl)-1-propenyl disulfide 0
                                    (Z)-[3-(Methylsulfinyl)-1-propenyl] 2-propenyl disulfide 0
                                    (Z)-alkanethial S-oxide + 0
                                    (methylsulfinyl)benzene + 0
                                    1-(1-Propenylsulfinyl)propyl propyl disulfide 0
                                    1-(2-Propenylsulfinyl)propyl propyl disulfide 0
                                    1-(Methylsulfinyl)propyl 1-propenyl disulfide 0
                                    1-(Methylsulfinyl)propyl 2-propenyl disulfide 0
                                    1-(Methylsulfinyl)propyl propyl disulfide 0
                                    1-Propenyl 1-(1-propenylsulfinyl)propyl disulfide 0
                                    1-Propenyl 1-(2-propenylsulfinyl)propyl disulfide 0
                                    1-Propenyl 1-(propylsulfinyl)propyl disulfide 0
                                    1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5-[(2-methylprop-2-en-1-yl)amino]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile + 0
                                    1-cyano-8-(methylsulfinyl)heptane 0
                                    1-cyano-8-(methylsulfinyl)octane 0
                                    1-isothiocyanato-5-(methylsulfinyl)pentane 0
                                    1-isothiocyanato-6-(methylsulfinyl)hexane 0
                                    1-isothiocyanato-7-(methylsulfinyl)heptane 0
                                    1-isothiocyanato-9-(methylsulfinyl)nonane 0
                                    1H-Benzimidazole, 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfonyl]- 0
                                    2,5-dihydroxy-3-methanesulfinylbenzyl alcohol 0
                                    2-(2-phenoxyethylsulfonyl)-1H-benzimidazole 0
                                    2-(ethanesulfinyl)ethanol + 0
                                    2-Propenyl 1-(1-propenylsulfinyl)propyl disulfide 0
                                    2-Propenyl 1-(2-propenylsulfinyl)propyl disulfide 0
                                    2-Propenyl 1-(propylsulfinyl)propyl disulfide 0
                                    2-[(diphenylmethyl)sulfinyl]acetamide + 0
                                    2-[5-cyclopropyl-3-(ethylsulfonyl)pyridin-2-yl]-5-[(trifluoromethyl)sulfinyl]-1,3-benzoxazole + 0
                                    2-methylsulfinyl-4-hydroxy-6-methylthiophenyl-1-azoformamide 0
                                    3-Hydroxyomeprazole 0
                                    4-(4-chlorophenyl)sulfinyl-6-(methoxymethyl)-2-methylpyrimidine 0
                                    4-(methylsulfinyl)phenol + 0
                                    4-Hydroxysulfinpyrazone 0
                                    4-\{2-[(3-hydroxyphenyl)sulfanyl]ethyl\}-1,2-diphenylpyrazolidine-3,5-dione 0
                                    5'-O-Desmethyl omeprazole 0
                                    5'-deoxy-5'-(methylsulfinyl)adenosine 0
                                    5'-hydroxyomeprazole 0
                                    5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile + 0
                                    5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole + 2
                                    6-(benzenesulfinyl)tetrazolo[1,5-b]pyridazine 0
                                    6-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methylsulfinyl]-1H-benzimidazole 0
                                    6-sinapoylglucoraphenin 0
                                    7-(methylsulfinyl)heptylamine 0
                                    8-(methylsulfinyl)octyl isothiocyanate 0
                                    8-(methylsulfinyl)octylamine 0
                                    9-(methylsulfinyl)nonamide 0
                                    9-(methylsulfinyl)nonanoic acid 0
                                    Allyl methyl sulfoxide 0
                                    Bissulfine 0
                                    Camelinin 0
                                    Diphenyl sulfoxide 0
                                    Diptocarpilidine 0
                                    GW 501516 sulfoxide + 0
                                    Glucoarabin 0
                                    Glucohirsutin 0
                                    Methyl 1-(1-propenylsulfinyl)propyl disulfide 0
                                    Methyl 1-(2-propenylsulfinyl)propyl disulfide 0
                                    Methyl 1-(methylsulfinyl)propyl disulfide 0
                                    Methyl 1-(propylsulfinyl)propyl disulfide 0
                                    Methyl benzyl sulfoxide 0
                                    N(alpha)-(L-gamma-glutamyl)-hercynyl-L-cysteine sulfoxide 0
                                    N(alpha)-(L-gamma-glutamyl)-hercynyl-L-selenocysteine 0
                                    N-acetyl-S-(1Z)-propenyl-cysteine-sulfoxide 0
                                    N-acetylalliin 0
                                    Omeprazole sodium 0
                                    Omeprazole sulfone 0
                                    Oxydeprofos 0
                                    Polyhydroxylated cyclic sulfoxide 0
                                    Propyl 1-(propylsulfinyl)propyl disulfide 0
                                    Ralfuranone E 0
                                    Ro 18-5364 0
                                    S-(5-histidyl)cysteine sulfoxide 0
                                    S-alkyl-L-cysteine S-oxide + 0
                                    S-propyl propanethiosulfinate 0
                                    SB 203580 0
                                    Sulfinemycin 0
                                    Z-4,9-Diene-2,3,7-trithiadeca-7-oxide 0
                                    acetoprole 0
                                    albendazole S-oxide + 0
                                    allicin 1
                                    alliin + 0
                                    biotin sulfoxide + 0
                                    cenicriviroc 0
                                    cimetidine S-oxide 0
                                    dexlansoprazole 0
                                    dexrabeprazole 0
                                    diafenthiuron-S-oxide 0
                                    dimethyl sulfoxide + 0
                                    dimethyl sulfoxide-d6 0
                                    fensulfothion 0
                                    fulvestrant 0
                                    glucoibarin 0
                                    glucoiberin 0
                                    glucoraphanin 0
                                    glucoraphenin + 0
                                    hercynylcysteine sulfoxide 0
                                    hexahomomethionine S-oxide 0
                                    iberin 0
                                    ilaprazole 0
                                    isoprothiolane sulfoxide 0
                                    lansoprazole 1
                                    lehualide J 0
                                    magnesium 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methylsulfinyl]benzimidazol-1-ide 0
                                    mannostatin B 0
                                    mesoridazine + 0
                                    methiocarb-sulfoxide 0
                                    nitrosulindac 0
                                    omega-[(methylsulfinyl)alkyl]glucosinolic acid + 0
                                    oxfendazole 0
                                    pantoprazole 1
                                    pentahomomethionine S-oxide 0
                                    phakellistatin 14 0
                                    promazine sulfoxide 0
                                    propanethial S-oxide + 0
                                    rabeprazole 0
                                    ranitidine-S-oxide 0
                                    sulfinalol 0
                                    sulfinpyrazone 0
                                    sulforaphane + 0
                                    sulindac + 2
                                    sulmazole 0
                                    sydoxanthone C 0
                                    thiodiacetic acid sulfoxide 0
                                    ustiloxin B 0
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